ATE190842T1 - Arzneizusammensetzungen enthaltend argatrobananaloge - Google Patents
Arzneizusammensetzungen enthaltend argatrobananalogeInfo
- Publication number
- ATE190842T1 ATE190842T1 AT94101055T AT94101055T ATE190842T1 AT E190842 T1 ATE190842 T1 AT E190842T1 AT 94101055 T AT94101055 T AT 94101055T AT 94101055 T AT94101055 T AT 94101055T AT E190842 T1 ATE190842 T1 AT E190842T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- polycyclic compound
- compound residue
- benzene ring
- condensed polycyclic
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- KXNPVXPOPUZYGB-IOVMHBDKSA-N (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid Chemical class OC(=O)[C@H]1C[C@H](C)CCN1C(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)C1=CC=CC2=C1NCC(C)C2 KXNPVXPOPUZYGB-IOVMHBDKSA-N 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- -1 polycyclic compound Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000004019 antithrombin Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5010063A JPH06219949A (ja) | 1993-01-25 | 1993-01-25 | 抗トロンビン剤及びその製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE190842T1 true ATE190842T1 (de) | 2000-04-15 |
Family
ID=11739928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94101055T ATE190842T1 (de) | 1993-01-25 | 1994-01-25 | Arzneizusammensetzungen enthaltend argatrobananaloge |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5565471A (de) |
| EP (1) | EP0608831B1 (de) |
| JP (1) | JPH06219949A (de) |
| AT (1) | ATE190842T1 (de) |
| CA (1) | CA2114152A1 (de) |
| DE (1) | DE69423529T2 (de) |
| ES (1) | ES2145068T3 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2839201B2 (ja) * | 1990-07-30 | 1998-12-16 | 株式会社日立製作所 | 仮想計算機システム |
| US5474979A (en) * | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
| US5840733A (en) * | 1996-07-01 | 1998-11-24 | Redcell, Canada, Inc. | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
| JPH10218760A (ja) * | 1997-02-04 | 1998-08-18 | Nobel Igaku Kenkyusho:Kk | ドライアイ治療用の微量油添加目薬 |
| MX2008002177A (es) * | 2005-09-01 | 2008-04-22 | Baxter Healthcare Sa | Formulacion de argatroban. |
| US7687516B2 (en) | 2006-09-27 | 2010-03-30 | Eagle Pharmaceuticals, Inc. | Alcohol free formulation of argatroban |
| US7589106B2 (en) | 2006-09-27 | 2009-09-15 | Eagle Pharmaceuticals, Inc. | Alcohol free formulation of argatroban |
| US7754956B2 (en) * | 2007-12-12 | 2010-07-13 | Force Ten International Llc | Programmable system to integrate generated signals with signals from a musical instrument |
| US7915290B2 (en) * | 2008-02-29 | 2011-03-29 | Baxter International Inc. | Argatroban formulations and methods for making and using same |
| RU2539566C2 (ru) * | 2009-12-24 | 2015-01-20 | Торэй Индастриз, Инк. | Гидрофильное полимерное соединение, имеющее антикоагулянтный эффект |
| CN107773533A (zh) * | 2016-08-26 | 2018-03-09 | 四川科瑞德制药股份有限公司 | 一种新型凝血酶抑制剂及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4258192A (en) * | 1977-12-16 | 1981-03-24 | Mitsubishi Chemical Industries Limited | N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof |
| IE48623B1 (en) * | 1978-08-31 | 1985-03-20 | Mitsubishi Chem Ind | Alpha-(n-arylsulfonyl-l-argininamides,processes for their preparation and pharmaceutical compositions containing these substances |
| JPS6431727A (en) * | 1987-07-28 | 1989-02-02 | Mitsubishi Chem Ind | Dissolution of argininamide and drug composition containing argininamides |
| JPH02129123A (ja) * | 1988-11-07 | 1990-05-17 | Mitsubishi Kasei Corp | 抗血液凝固剤 |
| TW225477B (de) * | 1992-03-18 | 1994-06-21 | Mitsubishi Kakoki Kk |
-
1993
- 1993-01-25 JP JP5010063A patent/JPH06219949A/ja active Pending
-
1994
- 1994-01-25 ES ES94101055T patent/ES2145068T3/es not_active Expired - Lifetime
- 1994-01-25 AT AT94101055T patent/ATE190842T1/de not_active IP Right Cessation
- 1994-01-25 US US08/186,018 patent/US5565471A/en not_active Expired - Fee Related
- 1994-01-25 CA CA002114152A patent/CA2114152A1/en not_active Abandoned
- 1994-01-25 DE DE69423529T patent/DE69423529T2/de not_active Expired - Fee Related
- 1994-01-25 EP EP94101055A patent/EP0608831B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5565471A (en) | 1996-10-15 |
| ES2145068T3 (es) | 2000-07-01 |
| EP0608831B1 (de) | 2000-03-22 |
| DE69423529D1 (de) | 2000-04-27 |
| CA2114152A1 (en) | 1994-07-26 |
| JPH06219949A (ja) | 1994-08-09 |
| EP0608831A1 (de) | 1994-08-03 |
| DE69423529T2 (de) | 2000-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |