DE69423529D1 - Arzneizusammensetzungen enthaltend Argatrobananaloge - Google Patents

Arzneizusammensetzungen enthaltend Argatrobananaloge

Info

Publication number
DE69423529D1
DE69423529D1 DE69423529T DE69423529T DE69423529D1 DE 69423529 D1 DE69423529 D1 DE 69423529D1 DE 69423529 T DE69423529 T DE 69423529T DE 69423529 T DE69423529 T DE 69423529T DE 69423529 D1 DE69423529 D1 DE 69423529D1
Authority
DE
Germany
Prior art keywords
group
polycyclic compound
compound residue
benzene ring
condensed polycyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69423529T
Other languages
English (en)
Other versions
DE69423529T2 (de
Inventor
Keiko Ozaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Chemical Corp filed Critical Mitsubishi Chemical Corp
Publication of DE69423529D1 publication Critical patent/DE69423529D1/de
Application granted granted Critical
Publication of DE69423529T2 publication Critical patent/DE69423529T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
DE69423529T 1993-01-25 1994-01-25 Arzneizusammensetzungen enthaltend Argatrobananaloge Expired - Fee Related DE69423529T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5010063A JPH06219949A (ja) 1993-01-25 1993-01-25 抗トロンビン剤及びその製造方法

Publications (2)

Publication Number Publication Date
DE69423529D1 true DE69423529D1 (de) 2000-04-27
DE69423529T2 DE69423529T2 (de) 2000-08-31

Family

ID=11739928

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69423529T Expired - Fee Related DE69423529T2 (de) 1993-01-25 1994-01-25 Arzneizusammensetzungen enthaltend Argatrobananaloge

Country Status (7)

Country Link
US (1) US5565471A (de)
EP (1) EP0608831B1 (de)
JP (1) JPH06219949A (de)
AT (1) ATE190842T1 (de)
CA (1) CA2114152A1 (de)
DE (1) DE69423529T2 (de)
ES (1) ES2145068T3 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2839201B2 (ja) * 1990-07-30 1998-12-16 株式会社日立製作所 仮想計算機システム
US5474979A (en) * 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
JPH10218760A (ja) * 1997-02-04 1998-08-18 Nobel Igaku Kenkyusho:Kk ドライアイ治療用の微量油添加目薬
MX2008002177A (es) 2005-09-01 2008-04-22 Baxter Healthcare Sa Formulacion de argatroban.
CA2669727C (en) * 2006-09-27 2014-10-28 Eagle Pharmaceuticals, Inc. Alcohol free formulation of argatroban
US7687516B2 (en) 2006-09-27 2010-03-30 Eagle Pharmaceuticals, Inc. Alcohol free formulation of argatroban
US7754956B2 (en) * 2007-12-12 2010-07-13 Force Ten International Llc Programmable system to integrate generated signals with signals from a musical instrument
US7915290B2 (en) 2008-02-29 2011-03-29 Baxter International Inc. Argatroban formulations and methods for making and using same
US20120271010A1 (en) * 2009-12-24 2012-10-25 Toray Industries, Inc. Hydrophilic polymer compound having anticoagulation effect
CN107773533A (zh) * 2016-08-26 2018-03-09 四川科瑞德制药股份有限公司 一种新型凝血酶抑制剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4258192A (en) * 1977-12-16 1981-03-24 Mitsubishi Chemical Industries Limited N2 -Arylsulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof
IE48623B1 (en) * 1978-08-31 1985-03-20 Mitsubishi Chem Ind Alpha-(n-arylsulfonyl-l-argininamides,processes for their preparation and pharmaceutical compositions containing these substances
JPS6431727A (en) * 1987-07-28 1989-02-02 Mitsubishi Chem Ind Dissolution of argininamide and drug composition containing argininamides
JPH02129123A (ja) * 1988-11-07 1990-05-17 Mitsubishi Kasei Corp 抗血液凝固剤
TW225477B (de) * 1992-03-18 1994-06-21 Mitsubishi Kakoki Kk

Also Published As

Publication number Publication date
ES2145068T3 (es) 2000-07-01
ATE190842T1 (de) 2000-04-15
JPH06219949A (ja) 1994-08-09
CA2114152A1 (en) 1994-07-26
EP0608831B1 (de) 2000-03-22
EP0608831A1 (de) 1994-08-03
DE69423529T2 (de) 2000-08-31
US5565471A (en) 1996-10-15

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee