AT501955B1 - Mutierte aox1-promotoren - Google Patents

Mutierte aox1-promotoren Download PDF

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Publication number
AT501955B1
AT501955B1 AT0030405A AT3042005A AT501955B1 AT 501955 B1 AT501955 B1 AT 501955B1 AT 0030405 A AT0030405 A AT 0030405A AT 3042005 A AT3042005 A AT 3042005A AT 501955 B1 AT501955 B1 AT 501955B1
Authority
AT
Austria
Prior art keywords
promoter
nucleotides
cell
nucleic acid
expression
Prior art date
Application number
AT0030405A
Other languages
German (de)
English (en)
Other versions
AT501955A1 (de
Inventor
Franz Hartner
Anton Mag Dr Glieder
Original Assignee
Univ Graz Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AT0030405A priority Critical patent/AT501955B1/de
Application filed by Univ Graz Tech filed Critical Univ Graz Tech
Priority to ES06704721T priority patent/ES2356127T3/es
Priority to NZ585821A priority patent/NZ585821A/en
Priority to KR1020077021821A priority patent/KR101352399B1/ko
Priority to DK06704721.7T priority patent/DK1851312T5/da
Priority to CN2010101738787A priority patent/CN101935657B/zh
Priority to PCT/AT2006/000079 priority patent/WO2006089329A2/en
Priority to EP10155180A priority patent/EP2199389B1/en
Priority to DE602006018113T priority patent/DE602006018113D1/de
Priority to HK08108778.3A priority patent/HK1113172B/xx
Priority to PL10155180T priority patent/PL2199389T3/pl
Priority to AT06704721T priority patent/ATE487788T1/de
Priority to PL06704721T priority patent/PL1851312T3/pl
Priority to DE602006019789T priority patent/DE602006019789D1/de
Priority to UAA201012563A priority patent/UA98604C2/ru
Priority to AT10155180T priority patent/ATE496125T1/de
Priority to AU2006216094A priority patent/AU2006216094B2/en
Priority to SI200630919T priority patent/SI1851312T1/sl
Priority to IN6694DEN2012 priority patent/IN2012DN06694A/en
Priority to HR20110084T priority patent/HRP20110084T2/hr
Priority to NZ560542A priority patent/NZ560542A/en
Priority to US11/817,005 priority patent/US9012175B2/en
Priority to KR1020127018581A priority patent/KR101358663B1/ko
Priority to ES10155180T priority patent/ES2358086T3/es
Priority to DK10155180.2T priority patent/DK2199389T3/da
Priority to BRPI0606179-6A priority patent/BRPI0606179B1/pt
Priority to CA2785161A priority patent/CA2785161C/en
Priority to UAA200710436A priority patent/UA94399C2/ru
Priority to PT06704721T priority patent/PT1851312E/pt
Priority to SI200630962T priority patent/SI2199389T1/sl
Priority to CA2598514A priority patent/CA2598514C/en
Priority to EP06704721A priority patent/EP1851312B9/en
Priority to JP2007556461A priority patent/JP5497986B2/ja
Priority to CN2006800058881A priority patent/CN101128581B/zh
Publication of AT501955A1 publication Critical patent/AT501955A1/de
Application granted granted Critical
Publication of AT501955B1 publication Critical patent/AT501955B1/de
Priority to HK11102457.9A priority patent/HK1148313B/xx
Priority to US12/759,763 priority patent/US9279129B2/en
Priority to AU2011200187A priority patent/AU2011200187B2/en
Priority to HR20110254T priority patent/HRP20110254T1/hr
Priority to JP2011245688A priority patent/JP5552107B2/ja

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/03Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
    • C12Y101/03013Alcohol oxidase (1.1.3.13)

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Enzymes And Modification Thereof (AREA)
AT0030405A 2005-02-23 2005-02-23 Mutierte aox1-promotoren AT501955B1 (de)

Priority Applications (39)

Application Number Priority Date Filing Date Title
AT0030405A AT501955B1 (de) 2005-02-23 2005-02-23 Mutierte aox1-promotoren
US11/817,005 US9012175B2 (en) 2005-02-23 2006-02-23 Mutant AOX1 promoters
KR1020077021821A KR101352399B1 (ko) 2005-02-23 2006-02-23 돌연변이 aox1 프로모터
DK06704721.7T DK1851312T5 (da) 2005-02-23 2006-02-23 Mutant AOX 1 promotorer
CN2010101738787A CN101935657B (zh) 2005-02-23 2006-02-23 突变aox1启动子
PCT/AT2006/000079 WO2006089329A2 (en) 2005-02-23 2006-02-23 Mutant aox 1 promoters
EP10155180A EP2199389B1 (en) 2005-02-23 2006-02-23 Mutant AOX1 promoters
DE602006018113T DE602006018113D1 (de) 2005-02-23 2006-02-23 Mutierte aox1 promotoren
HK08108778.3A HK1113172B (en) 2005-02-23 2006-02-23 Mutant aox 1 promoters
PL10155180T PL2199389T3 (pl) 2005-02-23 2006-02-23 Zmutowane promotory AOX1
AT06704721T ATE487788T1 (de) 2005-02-23 2006-02-23 Mutierte aox1 promotoren
PL06704721T PL1851312T3 (pl) 2005-02-23 2006-02-23 Zmutowane promotory AOX1
DE602006019789T DE602006019789D1 (de) 2005-02-23 2006-02-23 Mutant AOX1 Promotoren
UAA201012563A UA98604C2 (ru) 2005-02-23 2006-02-23 Мутантные промоторы аох1
AT10155180T ATE496125T1 (de) 2005-02-23 2006-02-23 Mutant aox1 promotoren
AU2006216094A AU2006216094B2 (en) 2005-02-23 2006-02-23 Mutant AOX 1 promoters
SI200630919T SI1851312T1 (sl) 2005-02-23 2006-02-23 Mutantni AOX 1 promotorji
IN6694DEN2012 IN2012DN06694A (https=) 2005-02-23 2006-02-23
ES06704721T ES2356127T3 (es) 2005-02-23 2006-02-23 Promotores mutantes de aox 1.
NZ560542A NZ560542A (en) 2005-02-23 2006-02-23 Mutant AOX 1 promoters
ES10155180T ES2358086T3 (es) 2005-02-23 2006-02-23 Promotores aox1 mutantes.
NZ585821A NZ585821A (en) 2005-02-23 2006-02-23 Mutant AOX 1 promoters
KR1020127018581A KR101358663B1 (ko) 2005-02-23 2006-02-23 돌연변이 aox1 프로모터
DK10155180.2T DK2199389T3 (da) 2005-02-23 2006-02-23 Mutant AOX1 promotere
BRPI0606179-6A BRPI0606179B1 (pt) 2005-02-23 2006-02-23 Promotor isolado de álcool oxidase 1 (aox1) de pichia pastoris, vetor, célula, kit, método para a expressão de uma proteína recombinante, peptídeo ou ácido nucléico funcional, em uma célula, método para a expressão de uma molécula de ácido nucleico para a expressão de uma proteína, peptídeo ou ácido nucléico funcional, e método para o isolamento de clones de superexpressão
CA2785161A CA2785161C (en) 2005-02-23 2006-02-23 Mutant aox1 promoters
UAA200710436A UA94399C2 (ru) 2005-02-23 2006-02-23 Мутантные промоторы аох1
PT06704721T PT1851312E (pt) 2005-02-23 2006-02-23 Promotores de aox1 mutantes
SI200630962T SI2199389T1 (sl) 2005-02-23 2006-02-23 Mutantni AOX1 promotorji
CA2598514A CA2598514C (en) 2005-02-23 2006-02-23 Mutant aox 1 promoters
EP06704721A EP1851312B9 (en) 2005-02-23 2006-02-23 Mutant aox 1 promoters
JP2007556461A JP5497986B2 (ja) 2005-02-23 2006-02-23 突然変異体aox1プロモーター
CN2006800058881A CN101128581B (zh) 2005-02-23 2006-02-23 突变aox1启动子
HR20110084T HRP20110084T2 (hr) 2005-02-23 2006-02-23 Promotori mutantne aox1
HK11102457.9A HK1148313B (en) 2005-02-23 2008-08-08 Mutant aox 1 promoters
US12/759,763 US9279129B2 (en) 2005-02-23 2010-04-14 Mutant AOX1 promoters
AU2011200187A AU2011200187B2 (en) 2005-02-23 2011-01-18 Mutant AOX 1 Promoters
HR20110254T HRP20110254T1 (hr) 2005-02-23 2011-04-08 Promotori mutantne aox1
JP2011245688A JP5552107B2 (ja) 2005-02-23 2011-11-09 突然変異体aox1プロモーター

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0030405A AT501955B1 (de) 2005-02-23 2005-02-23 Mutierte aox1-promotoren

Publications (2)

Publication Number Publication Date
AT501955A1 AT501955A1 (de) 2006-12-15
AT501955B1 true AT501955B1 (de) 2007-08-15

Family

ID=36927772

Family Applications (3)

Application Number Title Priority Date Filing Date
AT0030405A AT501955B1 (de) 2005-02-23 2005-02-23 Mutierte aox1-promotoren
AT10155180T ATE496125T1 (de) 2005-02-23 2006-02-23 Mutant aox1 promotoren
AT06704721T ATE487788T1 (de) 2005-02-23 2006-02-23 Mutierte aox1 promotoren

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT10155180T ATE496125T1 (de) 2005-02-23 2006-02-23 Mutant aox1 promotoren
AT06704721T ATE487788T1 (de) 2005-02-23 2006-02-23 Mutierte aox1 promotoren

Country Status (20)

Country Link
US (2) US9012175B2 (https=)
EP (2) EP2199389B1 (https=)
JP (2) JP5497986B2 (https=)
KR (2) KR101352399B1 (https=)
CN (2) CN101128581B (https=)
AT (3) AT501955B1 (https=)
AU (2) AU2006216094B2 (https=)
BR (1) BRPI0606179B1 (https=)
CA (2) CA2598514C (https=)
DE (2) DE602006018113D1 (https=)
DK (2) DK1851312T5 (https=)
ES (2) ES2356127T3 (https=)
HR (2) HRP20110084T2 (https=)
IN (1) IN2012DN06694A (https=)
NZ (2) NZ585821A (https=)
PL (2) PL2199389T3 (https=)
PT (1) PT1851312E (https=)
SI (2) SI1851312T1 (https=)
UA (2) UA98604C2 (https=)
WO (1) WO2006089329A2 (https=)

Families Citing this family (39)

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BRPI0906241B8 (pt) * 2008-03-27 2019-02-19 Alliance Sustainable Energy molécula de ácido nucleico, gene quimérico, vetor e método de transformação de uma célula bacteriana
WO2010004042A2 (en) * 2008-07-11 2010-01-14 Novozymes A/S Pichia pastoris das promoter variants
EP2258855A1 (en) 2009-05-28 2010-12-08 Universität für Bodenkultur Wien Expression sequences
US20140011236A1 (en) * 2011-03-22 2014-01-09 Merch Sharp & Dohme Corp. Promoters for high level recombinant expression in fungal host cells
GB201113419D0 (en) * 2011-08-04 2011-09-21 Fujifilm Diosynth Biotechnologies Uk Ltd Yeast vector
EP2565262A1 (en) 2011-08-31 2013-03-06 VTU Holding GmbH Protein expression
TWI560272B (en) 2011-10-07 2016-12-01 Lonza Ag Regulatable promoter
WO2014088563A1 (en) * 2012-12-05 2014-06-12 Exxonmobil Research And Engineering Company Nannochloropsis kozak consensus sequence
DK3527667T3 (da) 2013-03-08 2021-02-22 Biogrammatics Inc Gærpromotorer til proteinekspression
ES2738181T3 (es) 2013-03-08 2020-01-20 Keck Graduate Inst Of Applied Life Sciences Promotores de levadura de Pichia pastoris
US9150870B2 (en) 2013-03-15 2015-10-06 Lonza Ltd. Constitutive promoter
JP6698352B2 (ja) 2013-03-15 2020-05-27 ロンザ リミテッドLonza Limited 構成的プロモーター
JP2018501814A (ja) 2014-11-11 2018-01-25 クララ フーズ カンパニー 卵白タンパク質産生のための方法および組成物
EP3294762B1 (en) 2015-05-11 2022-01-19 Impossible Foods Inc. Expression constructs and methods of genetically engineering methylotrophic yeast
DK3332005T3 (da) 2015-08-05 2022-01-03 Lonza Ag Promotorvarianter
CN108728477B (zh) * 2017-04-24 2022-02-22 华东理工大学 一种高效的转座突变系统及构建方法
KR102596200B1 (ko) * 2017-06-30 2023-10-30 다우 글로벌 테크놀로지스 엘엘씨 알데히드 개선을 위한 코팅 및 이의 제조 방법
EP3802832A1 (en) 2018-06-07 2021-04-14 Basf Se Promoter for yeast
EP3824083A4 (en) * 2018-09-24 2022-01-05 Orta Dogu Teknik Universitesi Design of alcohol dehydrogenase 2 (adh2) promoter variants by promoter engineering
JP2022502018A (ja) * 2018-09-24 2022-01-11 オルタ ドグ テクニク ユニヴェルシテシ 改変されたaox1プロモータバリアント
CN110029122B (zh) * 2019-03-19 2022-03-01 青岛蔚蓝生物集团有限公司 一种甘露聚糖酶高产菌株及其应用
CN109735547B (zh) * 2019-03-19 2022-05-31 青岛蔚蓝生物集团有限公司 一种提高毕赤酵母外源蛋白表达量的启动子及其应用
CN110029120B (zh) * 2019-03-19 2022-03-01 青岛蔚蓝生物集团有限公司 一种植酸酶高产菌株及其应用
KR20210153106A (ko) * 2019-04-17 2021-12-16 임파서블 푸즈 인크. 단백질 생산을 위한 물질 및 방법
CN110106168B (zh) * 2019-05-27 2021-07-13 西南大学 基于转录因子间的互作关系构建双激素响应启动子的方法
US12096784B2 (en) 2019-07-11 2024-09-24 Clara Foods Co. Protein compositions and consumable products thereof
BR112022000545A2 (pt) 2019-07-11 2022-04-05 Clara Foods Co Composições de proteína e produtos de consumo destas
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes
CN110724720A (zh) * 2019-11-01 2020-01-24 山东仙普爱瑞科技股份有限公司 一种猪α-干扰素的发酵工艺
EP3922726A1 (en) * 2020-06-10 2021-12-15 Erber Aktiengesellschaft Truncated promoter for recombinant gene expression
IL304910A (en) 2021-02-12 2023-10-01 Boehringer Ingelheim Rcv Gmbh Signal peptides for increased protein secretion
CA3131181C (en) * 2021-06-24 2023-03-07 BioBoost Synbio Consulting Inc. Method for methanol free culturing of methylotrophic yeast for the biosynthesis of added value products
EP4726051A1 (en) 2023-06-06 2026-04-15 FUJIFILM Corporation Recombinant yeast, method for producing target protein, and kit and method for producing recombinant yeast
CN121358867A (zh) * 2023-06-15 2026-01-16 丹斯塔发酵股份公司 C2碳源响应性启动子
CN117417934B (zh) * 2023-10-27 2024-09-13 江南大学 跨菌种启动子、多菌种穿梭质粒及其应用
WO2025104126A1 (en) 2023-11-14 2025-05-22 Boehringer Ingelheim Rcv Gmbh & Co Kg Tags for enhanced expression of recombinant proteins
WO2025163019A1 (en) 2024-02-01 2025-08-07 Boehringer Ingelheim Rcv Gmbh & Co Kg Tags for enhanced expression of recombinant proteins
WO2026027251A1 (en) 2024-08-01 2026-02-05 Boehringer Ingelheim Rcv Gmbh & Co Kg Signal peptides for increased protein secretion
CN118599913B (zh) * 2024-08-07 2024-12-27 南昌大学 醛氧化酶Aox1基因敲除动物模型的构建方法及应用

Citations (9)

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US5610036A (en) * 1991-03-27 1997-03-11 The Green Cross Corporation Mutant AOX2 promoter, microorganism carrying same, method of preparation thereof and production of heterologous protein using such microorganism
US5641661A (en) * 1993-03-25 1997-06-24 Biosource Technologies, Inc. Pichia pastoris alcohol oxidase ZZA1 and ZZA2 regulatory regions for heterologous gene expression
US5643792A (en) * 1993-01-13 1997-07-01 The Green Cross Corporation Mutant strain of Pichia pastoris which utilizes methanol in the presence of glucose
EP0510693B1 (en) * 1991-04-25 1999-03-03 Research Corporation Technologies, Inc. Expression of human serum albumin in pichia pastoris
EP0931837A1 (en) * 1998-01-27 1999-07-28 Mitsui Chemicals, Inc. Method for producing phytase
EP0967275A1 (en) * 1997-08-29 1999-12-29 Kirin Beer Kabushiki Kaisha Dna sequences enhancing promoter activity
WO2000056903A2 (en) * 1999-03-22 2000-09-28 Zymogenetics, Inc. IMPROVED METHODS FOR PRODUCING PROTEINS IN TRANSFORMED $i(PICHIA)
US6699691B2 (en) * 2001-04-05 2004-03-02 The Board Of Regents Of The University Of Nebraska Alcohol oxidase 1 regulatory nucleotide sequences for heterologous gene expression in yeast
EP1431387A1 (en) * 2002-12-20 2004-06-23 Roche Diagnostics GmbH Heat-labile desoxyribonculease I variants

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CN1188524C (zh) * 2001-02-28 2005-02-09 珠江医院 人SP-A1在pichia pastoris中的表达

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610036A (en) * 1991-03-27 1997-03-11 The Green Cross Corporation Mutant AOX2 promoter, microorganism carrying same, method of preparation thereof and production of heterologous protein using such microorganism
EP0506040B1 (en) * 1991-03-27 1998-07-01 The Green Cross Corporation Mutant AOX2 promotor, microorganism carrying same, method of preparation thereof and production of heterologous protein using such microorganism
EP0510693B1 (en) * 1991-04-25 1999-03-03 Research Corporation Technologies, Inc. Expression of human serum albumin in pichia pastoris
US5643792A (en) * 1993-01-13 1997-07-01 The Green Cross Corporation Mutant strain of Pichia pastoris which utilizes methanol in the presence of glucose
US5641661A (en) * 1993-03-25 1997-06-24 Biosource Technologies, Inc. Pichia pastoris alcohol oxidase ZZA1 and ZZA2 regulatory regions for heterologous gene expression
EP0967275A1 (en) * 1997-08-29 1999-12-29 Kirin Beer Kabushiki Kaisha Dna sequences enhancing promoter activity
EP0931837A1 (en) * 1998-01-27 1999-07-28 Mitsui Chemicals, Inc. Method for producing phytase
WO2000056903A2 (en) * 1999-03-22 2000-09-28 Zymogenetics, Inc. IMPROVED METHODS FOR PRODUCING PROTEINS IN TRANSFORMED $i(PICHIA)
US6699691B2 (en) * 2001-04-05 2004-03-02 The Board Of Regents Of The University Of Nebraska Alcohol oxidase 1 regulatory nucleotide sequences for heterologous gene expression in yeast
EP1431387A1 (en) * 2002-12-20 2004-06-23 Roche Diagnostics GmbH Heat-labile desoxyribonculease I variants

Also Published As

Publication number Publication date
ES2358086T3 (es) 2011-05-05
KR101352399B1 (ko) 2014-02-18
ES2356127T3 (es) 2011-04-05
US20100196913A1 (en) 2010-08-05
AU2011200187B2 (en) 2012-01-19
DE602006018113D1 (de) 2010-12-23
PL1851312T3 (pl) 2011-05-31
HRP20110254T1 (hr) 2011-05-31
NZ560542A (en) 2010-06-25
US20080153126A1 (en) 2008-06-26
ES2356127T9 (es) 2011-05-30
CA2785161C (en) 2020-03-31
HK1113172A1 (en) 2008-09-26
AU2006216094B2 (en) 2010-10-21
DK1851312T3 (da) 2011-02-28
UA94399C2 (ru) 2011-05-10
NZ585821A (en) 2011-02-25
CN101128581B (zh) 2012-04-18
EP2199389B1 (en) 2011-01-19
US9279129B2 (en) 2016-03-08
US9012175B2 (en) 2015-04-21
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