AT413078B - Verwendung eines puffers auf basis von apfelsäure für die herstellung einer nasal applizierbaren zubereitung - Google Patents
Verwendung eines puffers auf basis von apfelsäure für die herstellung einer nasal applizierbaren zubereitung Download PDFInfo
- Publication number
- AT413078B AT413078B AT0154002A AT15402002A AT413078B AT 413078 B AT413078 B AT 413078B AT 0154002 A AT0154002 A AT 0154002A AT 15402002 A AT15402002 A AT 15402002A AT 413078 B AT413078 B AT 413078B
- Authority
- AT
- Austria
- Prior art keywords
- sep
- malic acid
- solution
- nasal
- acid buffer
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title description 13
- 238000004519 manufacturing process Methods 0.000 title description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 30
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 29
- 239000001630 malic acid Substances 0.000 claims description 29
- 235000011090 malic acid Nutrition 0.000 claims description 29
- 239000000872 buffer Substances 0.000 claims description 28
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 20
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 17
- 239000011780 sodium chloride Substances 0.000 claims description 10
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- CNIIGCLFLJGOGP-UHFFFAOYSA-N 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole Chemical compound C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 CNIIGCLFLJGOGP-UHFFFAOYSA-N 0.000 claims description 4
- HUCJFAOMUPXHDK-UHFFFAOYSA-N Xylometazoline Chemical compound CC1=CC(C(C)(C)C)=CC(C)=C1CC1=NCCN1 HUCJFAOMUPXHDK-UHFFFAOYSA-N 0.000 claims description 4
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0154002A AT413078B (de) | 2002-10-10 | 2002-10-10 | Verwendung eines puffers auf basis von apfelsäure für die herstellung einer nasal applizierbaren zubereitung |
| AU2003266811A AU2003266811A1 (en) | 2002-10-10 | 2003-10-09 | Nasallly applicable pharmaceutical preparation and the production thereof |
| JP2004542079A JP2006503868A (ja) | 2002-10-10 | 2003-10-09 | 鼻に投与可能な製薬学的調剤およびその製造 |
| PCT/AT2003/000306 WO2004032896A1 (de) | 2002-10-10 | 2003-10-09 | Nasal applizierbare pharmazeutische zubereitung und deren herstellung |
| US10/530,969 US20060127317A1 (en) | 2002-10-10 | 2003-10-09 | Nasallly applicable pharmaceutical preparation and the production thereof |
| EP03747695A EP1549288A1 (de) | 2002-10-10 | 2003-10-09 | Nasal applizierbare pharmazeutische zubereitung und deren herstellung |
| CA002501760A CA2501760A1 (en) | 2002-10-10 | 2003-10-09 | Nasally applicable pharmaceutical preparation and the production thereof |
| PL03375762A PL375762A1 (en) | 2002-10-10 | 2003-10-09 | Nasallly applicable pharmaceutical preparation and the production thereof |
| NO20052251A NO20052251L (no) | 2002-10-10 | 2005-05-09 | Nasalt anvendbart farmasoytisk preparat og fremstilling derav. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0154002A AT413078B (de) | 2002-10-10 | 2002-10-10 | Verwendung eines puffers auf basis von apfelsäure für die herstellung einer nasal applizierbaren zubereitung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA15402002A ATA15402002A (de) | 2005-04-15 |
| AT413078B true AT413078B (de) | 2005-11-15 |
Family
ID=32074994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0154002A AT413078B (de) | 2002-10-10 | 2002-10-10 | Verwendung eines puffers auf basis von apfelsäure für die herstellung einer nasal applizierbaren zubereitung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060127317A1 (enExample) |
| EP (1) | EP1549288A1 (enExample) |
| JP (1) | JP2006503868A (enExample) |
| AT (1) | AT413078B (enExample) |
| AU (1) | AU2003266811A1 (enExample) |
| CA (1) | CA2501760A1 (enExample) |
| NO (1) | NO20052251L (enExample) |
| PL (1) | PL375762A1 (enExample) |
| WO (1) | WO2004032896A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007006122A1 (de) * | 2007-02-02 | 2008-08-07 | Krewel Meuselbach Gmbh | Cistusextrakte |
| US20130213393A1 (en) | 2009-12-22 | 2013-08-22 | Evoke Pharma, Inc. | Nasal formulations of metoclopramide |
| WO2015054429A1 (en) * | 2013-10-08 | 2015-04-16 | Innopharma, Inc | Aprepitant oral liquid formulations |
| WO2018112061A1 (en) | 2016-12-15 | 2018-06-21 | Evoke Pharma, Inc. | Treatment of moderate and severe gastroparesis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT409081B (de) * | 2000-02-16 | 2002-05-27 | Gebro Pharma Gmbh | Stabile, nasal, oral oder sublingual anwendbare pharmazeutische zubereitung |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5514670A (en) * | 1993-08-13 | 1996-05-07 | Pharmos Corporation | Submicron emulsions for delivery of peptides |
-
2002
- 2002-10-10 AT AT0154002A patent/AT413078B/de active
-
2003
- 2003-10-09 CA CA002501760A patent/CA2501760A1/en not_active Abandoned
- 2003-10-09 PL PL03375762A patent/PL375762A1/xx not_active Application Discontinuation
- 2003-10-09 AU AU2003266811A patent/AU2003266811A1/en not_active Abandoned
- 2003-10-09 WO PCT/AT2003/000306 patent/WO2004032896A1/de not_active Ceased
- 2003-10-09 JP JP2004542079A patent/JP2006503868A/ja not_active Withdrawn
- 2003-10-09 US US10/530,969 patent/US20060127317A1/en not_active Abandoned
- 2003-10-09 EP EP03747695A patent/EP1549288A1/de not_active Withdrawn
-
2005
- 2005-05-09 NO NO20052251A patent/NO20052251L/no not_active Application Discontinuation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT409081B (de) * | 2000-02-16 | 2002-05-27 | Gebro Pharma Gmbh | Stabile, nasal, oral oder sublingual anwendbare pharmazeutische zubereitung |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006503868A (ja) | 2006-02-02 |
| AU2003266811A1 (en) | 2004-05-04 |
| PL375762A1 (en) | 2005-12-12 |
| NO20052251L (no) | 2005-05-09 |
| CA2501760A1 (en) | 2004-04-22 |
| US20060127317A1 (en) | 2006-06-15 |
| ATA15402002A (de) | 2005-04-15 |
| WO2004032896A1 (de) | 2004-04-22 |
| EP1549288A1 (de) | 2005-07-06 |
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