AT361455B - Verfahren zur herstellung von neuen substituierten 3-phenyl-cycloalkan- oder - -cycloalken-1-olen - Google Patents

Verfahren zur herstellung von neuen substituierten 3-phenyl-cycloalkan- oder - -cycloalken-1-olen

Info

Publication number
AT361455B
AT361455B AT658778A AT658778A AT361455B AT 361455 B AT361455 B AT 361455B AT 658778 A AT658778 A AT 658778A AT 658778 A AT658778 A AT 658778A AT 361455 B AT361455 B AT 361455B
Authority
AT
Austria
Prior art keywords
cycloalken
olen
cycloalkane
phenyl
producing new
Prior art date
Application number
AT658778A
Other languages
German (de)
English (en)
Other versions
ATA658778A (de
Inventor
Charles Armon Harbert
Michael Ross Johnson
Lawrence Sherman Melvin Jr
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to AT196080A priority Critical patent/AT363455B/de
Priority to AT195980A priority patent/AT366658B/de
Publication of ATA658778A publication Critical patent/ATA658778A/de
Application granted granted Critical
Publication of AT361455B publication Critical patent/AT361455B/de
Priority to AT212481A priority patent/ATA212481A/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/001Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
    • C07C37/002Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by transformation of a functional group, e.g. oxo, carboxyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C07C37/0555Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/17Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24Halogenated derivatives
    • C07C39/42Halogenated derivatives containing six-membered aromatic rings and other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/02Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains containing only carbon and hydrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01Preparation of ethers
    • C07C41/18Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48Preparation of compounds having groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48Preparation of compounds having groups
    • C07C41/50Preparation of compounds having groups by reactions producing groups
    • C07C41/56Preparation of compounds having groups by reactions producing groups by condensation of aldehydes, paraformaldehyde, or ketones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/30Compounds having groups
    • C07C43/315Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/95Esters of quinone carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/117Esters of phosphoric acids with cycloaliphatic alcohols
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/18Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT658778A 1977-09-13 1978-09-12 Verfahren zur herstellung von neuen substituierten 3-phenyl-cycloalkan- oder - -cycloalken-1-olen AT361455B (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AT196080A AT363455B (de) 1977-09-13 1980-04-10 Verfahren zur herstellung von neuen 3-(2-hydroxy-4-alkoxy oder -phenalkoxyphenyl)-cyclohexanonen
AT195980A AT366658B (de) 1977-09-13 1980-04-10 Verfahren zur herstellung von neuen 3-(2-hydroxy- oder 2-benzyloxy-4-substituierten-phenyl)cycloalkanonen und-alkenonen
AT212481A ATA212481A (de) 1977-09-13 1981-05-12 Verfahren zur herstellung von neuen 3-(2-hydroxy- oder 2-benzyloxy-4-substituierten-phenyl)cycloalkenonen und ihren ketalen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83310277A 1977-09-13 1977-09-13
US92668778A 1978-07-25 1978-07-25

Publications (2)

Publication Number Publication Date
ATA658778A ATA658778A (de) 1980-08-15
AT361455B true AT361455B (de) 1981-03-10

Family

ID=27125579

Family Applications (1)

Application Number Title Priority Date Filing Date
AT658778A AT361455B (de) 1977-09-13 1978-09-12 Verfahren zur herstellung von neuen substituierten 3-phenyl-cycloalkan- oder - -cycloalken-1-olen

Country Status (27)

Country Link
JP (1) JPS5448741A (no)
AR (1) AR224618A1 (no)
AT (1) AT361455B (no)
AU (1) AU513523B2 (no)
CA (1) CA1110261A (no)
CH (1) CH635812A5 (no)
DE (1) DE2839836C2 (no)
DK (1) DK400878A (no)
ES (3) ES473288A1 (no)
FI (1) FI66584C (no)
FR (1) FR2402639A1 (no)
GB (1) GB2004870B (no)
GR (1) GR74134B (no)
HK (1) HK13284A (no)
IE (1) IE47187B1 (no)
IL (1) IL55556A (no)
IN (1) IN150334B (no)
IT (1) IT1099054B (no)
KE (1) KE3352A (no)
LU (1) LU80220A1 (no)
MX (1) MX5306E (no)
MY (1) MY8500094A (no)
NL (2) NL7809274A (no)
NO (2) NO149426C (no)
NZ (1) NZ188391A (no)
PH (2) PH15252A (no)
SE (1) SE431085B (no)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0217135A1 (en) * 1985-09-05 1987-04-08 Hoechst-Roussel Pharmaceuticals Incorporated Spiro[benzofuran-2(3H), 1'cycloheptane]s, a process and intermediates for their preparation and their use as medicaments

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN162851B (no) * 1980-09-19 1988-07-16 Pfizer
US4285867A (en) * 1980-09-19 1981-08-25 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US5650270A (en) * 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis
US4709016A (en) * 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
JPS58201737A (ja) * 1982-05-18 1983-11-24 Mitsui Toatsu Chem Inc 新規芳香族アルカン誘導体、その製造法およびそれを有効成分とする殺虫、殺ダニ剤
GB8330099D0 (en) * 1983-11-11 1983-12-21 Ici Plc Cycloalkane derivatives
IL75480A0 (en) * 1985-06-11 1985-10-31 Yissum Res Dev Co Alkoxyphenol derivatives and pharmaceutical compositions containing them
IE70521B1 (en) * 1989-02-28 1996-12-11 Zeneca Pharma Sa Heterocycles with inhibitory activity of 5-lipoxygenase
IL144850A0 (en) * 1999-03-22 2002-06-30 Pfizer Resorcinol derivatives
US6828460B2 (en) 1999-03-22 2004-12-07 Pfizer Inc. Resorcinol derivatives
CA2648884C (en) * 2006-04-24 2015-10-13 Allergan, Inc. Abnormal cannabidiols as agents for lowering intraocular pressure
US7618966B2 (en) 2006-04-24 2009-11-17 Allergan, Inc. Abnormal Cannabidiols as agents for lowering intraocular pressure
US7612101B2 (en) 2006-04-24 2009-11-03 Allergan, Inc. Abnormal cannabidiols as agents for lowering intraocular pressure
US7718830B2 (en) 2006-04-24 2010-05-18 Allergan, Inc. Abnormal cannabidiols as agents for lowering intraocular pressure
CN109369514B (zh) * 2018-12-10 2021-10-26 天津科技大学 一种六元碳环衍生物的合成方法
WO2021007662A1 (en) * 2019-07-12 2021-01-21 Canopy Growth Corporation Cannabinoid derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU487907A1 (ru) * 1973-09-21 1975-10-15 Полоцкий Химический Комбинат Им. 50-Летия Белор.Сср Полимерна композици

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0217135A1 (en) * 1985-09-05 1987-04-08 Hoechst-Roussel Pharmaceuticals Incorporated Spiro[benzofuran-2(3H), 1'cycloheptane]s, a process and intermediates for their preparation and their use as medicaments

Also Published As

Publication number Publication date
NL8303358A (nl) 1984-02-01
ATA658778A (de) 1980-08-15
DE2839836A1 (de) 1979-03-15
NO149426B (no) 1984-01-09
HK13284A (en) 1984-02-24
ES473288A1 (es) 1980-03-01
IT7827558A0 (it) 1978-09-12
MY8500094A (en) 1985-12-31
NL7809274A (nl) 1979-03-15
AU513523B2 (en) 1980-12-04
FI66584B (fi) 1984-07-31
SE431085B (sv) 1984-01-16
CH635812A5 (fr) 1983-04-29
IE47187B1 (en) 1984-01-11
NZ188391A (en) 1984-05-31
CA1110261A (en) 1981-10-06
AU3981878A (en) 1980-03-20
ES480149A0 (es) 1980-11-01
LU80220A1 (fr) 1980-04-21
NO783087L (no) 1979-03-14
FR2402639A1 (fr) 1979-04-06
GR74134B (no) 1984-06-06
IN150334B (no) 1982-09-11
JPS5758329B2 (no) 1982-12-09
IT1099054B (it) 1985-09-18
SE7809060L (sv) 1979-03-14
DK400878A (da) 1979-03-14
ES8100795A1 (es) 1980-11-01
PH16597A (en) 1983-11-22
GB2004870A (en) 1979-04-11
MX5306E (es) 1983-06-14
FI782794A (fi) 1979-03-14
ES480150A1 (es) 1980-09-01
AR224618A1 (es) 1981-12-30
PH15252A (en) 1982-11-02
NO149426C (no) 1984-04-18
NO792840L (no) 1979-03-14
FI66584C (fi) 1984-11-12
IE781841L (en) 1979-03-13
GB2004870B (en) 1982-01-20
DE2839836C2 (de) 1983-01-27
JPS5448741A (en) 1979-04-17
IL55556A0 (en) 1978-12-17
IL55556A (en) 1982-11-30
KE3352A (en) 1983-12-16

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