AU3981878A - Analgesic 3-[2-hydroxy-4-(substituted)phenyl1] cycloalkanones and cycloalkanols, and intermediates therefor - Google Patents

Analgesic 3-[2-hydroxy-4-(substituted)phenyl1] cycloalkanones and cycloalkanols, and intermediates therefor

Info

Publication number
AU3981878A
AU3981878A AU39818/78A AU3981878A AU3981878A AU 3981878 A AU3981878 A AU 3981878A AU 39818/78 A AU39818/78 A AU 39818/78A AU 3981878 A AU3981878 A AU 3981878A AU 3981878 A AU3981878 A AU 3981878A
Authority
AU
Australia
Prior art keywords
cycloalkanones
cycloalkanols
phenyl1
analgesic
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU39818/78A
Other versions
AU513523B2 (en
Inventor
C. A. Johnson MR. and Melvin L. S. Harbert, Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of AU3981878A publication Critical patent/AU3981878A/en
Application granted granted Critical
Publication of AU513523B2 publication Critical patent/AU513523B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
    • C07C37/002—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by transformation of a functional group, e.g. oxo, carboxyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/42—Halogenated derivatives containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/02—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains containing only carbon and hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C07C41/50—Preparation of compounds having groups by reactions producing groups
    • C07C41/56—Preparation of compounds having groups by reactions producing groups by condensation of aldehydes, paraformaldehyde, or ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/95—Esters of quinone carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
AU39818/78A 1977-09-13 1978-09-13 Analgesic 3-[2-hydroxy-4-(substituted)phenyl1] cycloalkanones and cycloalkanols, and intermediates therefor Expired AU513523B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US83310277A 1977-09-13 1977-09-13
USUS833102 1977-09-13
US92668778A 1978-07-25 1978-07-25
USUS926687 1978-07-25

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU56183/80A Division AU535918B2 (en) 1977-09-13 1980-03-05 Selective alkylation of dihydroxy phenyl cycloalkanones and cyclic ketal intermediates

Publications (2)

Publication Number Publication Date
AU3981878A true AU3981878A (en) 1980-03-20
AU513523B2 AU513523B2 (en) 1980-12-04

Family

ID=27125579

Family Applications (1)

Application Number Title Priority Date Filing Date
AU39818/78A Expired AU513523B2 (en) 1977-09-13 1978-09-13 Analgesic 3-[2-hydroxy-4-(substituted)phenyl1] cycloalkanones and cycloalkanols, and intermediates therefor

Country Status (27)

Country Link
JP (1) JPS5448741A (en)
AR (1) AR224618A1 (en)
AT (1) AT361455B (en)
AU (1) AU513523B2 (en)
CA (1) CA1110261A (en)
CH (1) CH635812A5 (en)
DE (1) DE2839836C2 (en)
DK (1) DK400878A (en)
ES (3) ES473288A1 (en)
FI (1) FI66584C (en)
FR (1) FR2402639A1 (en)
GB (1) GB2004870B (en)
GR (1) GR74134B (en)
HK (1) HK13284A (en)
IE (1) IE47187B1 (en)
IL (1) IL55556A (en)
IN (1) IN150334B (en)
IT (1) IT1099054B (en)
KE (1) KE3352A (en)
LU (1) LU80220A1 (en)
MX (1) MX5306E (en)
MY (1) MY8500094A (en)
NL (2) NL7809274A (en)
NO (2) NO149426C (en)
NZ (1) NZ188391A (en)
PH (2) PH15252A (en)
SE (1) SE431085B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU627275B2 (en) * 1989-02-28 1992-08-20 Astrazeneca Ab Heterocycles

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN162851B (en) * 1980-09-19 1988-07-16 Pfizer
US4285867A (en) * 1980-09-19 1981-08-25 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4709016A (en) * 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
US5650270A (en) * 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis
JPS58201737A (en) * 1982-05-18 1983-11-24 Mitsui Toatsu Chem Inc Novel aromatic alkane derivative, its preparation and insecticide and acaricide containing the same as active constituent
GB8330099D0 (en) * 1983-11-11 1983-12-21 Ici Plc Cycloalkane derivatives
IL75480A0 (en) * 1985-06-11 1985-10-31 Yissum Res Dev Co Alkoxyphenol derivatives and pharmaceutical compositions containing them
US4623657A (en) * 1985-09-05 1986-11-18 Hoechst-Roussel Pharmaceuticals Inc. Spiro [benzofuran-2(3H),1'-cycloheptane]s and their therapeutic use
US6828460B2 (en) 1999-03-22 2004-12-07 Pfizer Inc. Resorcinol derivatives
AP2001002274A0 (en) * 1999-03-22 2001-09-30 Pfizer Rescorcinol derivatives.
US7718830B2 (en) 2006-04-24 2010-05-18 Allergan, Inc. Abnormal cannabidiols as agents for lowering intraocular pressure
CA2823724A1 (en) * 2006-04-24 2007-11-08 Allergan, Inc. Abnormal cannabidiols as agents for lowering intraocular pressure
US7618966B2 (en) 2006-04-24 2009-11-17 Allergan, Inc. Abnormal Cannabidiols as agents for lowering intraocular pressure
US7612101B2 (en) 2006-04-24 2009-11-03 Allergan, Inc. Abnormal cannabidiols as agents for lowering intraocular pressure
CN109369514B (en) * 2018-12-10 2021-10-26 天津科技大学 Synthetic method of six-membered carbocyclic ring derivative
JP2022540585A (en) * 2019-07-12 2022-09-16 キャノピー グロウス コーポレイション cannabinoid derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU487907A1 (en) * 1973-09-21 1975-10-15 Полоцкий Химический Комбинат Им. 50-Летия Белор.Сср Polymer composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU627275B2 (en) * 1989-02-28 1992-08-20 Astrazeneca Ab Heterocycles

Also Published As

Publication number Publication date
SE7809060L (en) 1979-03-14
GB2004870A (en) 1979-04-11
FR2402639A1 (en) 1979-04-06
FI66584B (en) 1984-07-31
ES473288A1 (en) 1980-03-01
NL7809274A (en) 1979-03-15
SE431085B (en) 1984-01-16
LU80220A1 (en) 1980-04-21
NO783087L (en) 1979-03-14
NO792840L (en) 1979-03-14
IN150334B (en) 1982-09-11
IT1099054B (en) 1985-09-18
GR74134B (en) 1984-06-06
CA1110261A (en) 1981-10-06
KE3352A (en) 1983-12-16
FI66584C (en) 1984-11-12
HK13284A (en) 1984-02-24
ES480149A0 (en) 1980-11-01
FI782794A (en) 1979-03-14
IL55556A0 (en) 1978-12-17
PH15252A (en) 1982-11-02
PH16597A (en) 1983-11-22
JPS5758329B2 (en) 1982-12-09
JPS5448741A (en) 1979-04-17
CH635812A5 (en) 1983-04-29
IT7827558A0 (en) 1978-09-12
MY8500094A (en) 1985-12-31
DE2839836C2 (en) 1983-01-27
MX5306E (en) 1983-06-14
AT361455B (en) 1981-03-10
NO149426B (en) 1984-01-09
IE47187B1 (en) 1984-01-11
ES8100795A1 (en) 1980-11-01
NO149426C (en) 1984-04-18
DK400878A (en) 1979-03-14
GB2004870B (en) 1982-01-20
ATA658778A (en) 1980-08-15
DE2839836A1 (en) 1979-03-15
AR224618A1 (en) 1981-12-30
IL55556A (en) 1982-11-30
IE781841L (en) 1979-03-13
ES480150A1 (en) 1980-09-01
AU513523B2 (en) 1980-12-04
NL8303358A (en) 1984-02-01
NZ188391A (en) 1984-05-31

Similar Documents

Publication Publication Date Title
AU513523B2 (en) Analgesic 3-[2-hydroxy-4-(substituted)phenyl1] cycloalkanones and cycloalkanols, and intermediates therefor
AU529303B2 (en) Personal care emulsion
AU3882778A (en) Sheetmetal nail
GB2004548A (en) 3-(2-hydroxy-4-(substituted)phenyl)azacyloalkanes and derivatives thereof as analgesic agents and intermediates therefor
ZA785180B (en) 3-(2-hydroxy-4-(substituted)phenyl)-cyclo-alkanone and cycloalkanol analgesic agents and intermediates therefor
AU500636B2 (en) Isocephalosporins and intermediates
AU512675B2 (en) Chromium-free catalyst and dehydrogenation process
AU521533B2 (en) 1, 2-benzisoxazolozyacetic acids and related compounds
AU521995B2 (en) 2-deoxyfortimicin a, 4-n-alkyl and 4-n-acyl-2 deoxyfortimicin b derivatives and intermediates therefor v'i
AU517973B2 (en) Metal phosphatizing composition, use thereof
NL188579C (en) 3- (TETRAZOL-5-YL) -1-AZAXANTHONE, AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS.
AU5236879A (en) 2,5-inter-o-phenylene-3,4-dinor-pgf and pgi compounds
AU500164B2 (en) 3, 4, 5-substituted benzenesulfonformamidines
AU5606580A (en) Coated steel strip
ZA816492B (en) Pharmacologically active 2-hydroxy-4-(substituted)phenyl cycloalkanes,derivatives thereof and intermediates therefor
IL53350A (en) 4,5-disubstituted imidazole-2-thiones and their use as intermediates for preparing pharmaceutically active compounds
NL7901970A (en) NEW DERIVATIVES OF 2-PHENYL-5.6-DIHYDRO-4-PYRON AND HERBICIDE PREPARATIONS CONTAINING THESE COMPOUNDS.
NL7804620A (en) NEW 3,5-DIMETHYL-PIPERIDINE-4-ONES AND FUNGICIDE PREPARATIONS CONTAINING THESE COMPOUNDS.
AU5360579A (en) Spiro-derivatives of 3-(3,5-dihalogeno-phenyl)-oxazolidine -2,4-diones
AU488524B2 (en) 1, 9-dihydroxyhexanhydrobibenzo [b,d] pyrans, intermediates therefor and derivatives thereof
AU2516277A (en) 9-hydroxyhexahydrobenzol c quinolines and intermediates therefor
AU3584278A (en) Veterinary use of cromoglycate-i. ike compounds
AU493668B2 (en) 9-hydroxyhexahydrobenzol c quinolines and intermediates therefor
AU532025B2 (en) Preparation of 3-(4-pyridinyl)-2-cyclohexen-1-one oxime
AU496030B2 (en) Preparation of quinoxaline-1, 4 dioxides and intermediates thereof