FR2402639A1 - CYCLOALCANONES AND CYCLOALCANOLS SUBSTITUTED IN POSITION 3 BY A 2-HYDROXYPHENYL GROUP SUBSTITUTED IN POSITION 4 AND PHARMACEUTICAL COMPOSITION CONTAINING THEM - Google Patents
CYCLOALCANONES AND CYCLOALCANOLS SUBSTITUTED IN POSITION 3 BY A 2-HYDROXYPHENYL GROUP SUBSTITUTED IN POSITION 4 AND PHARMACEUTICAL COMPOSITION CONTAINING THEMInfo
- Publication number
- FR2402639A1 FR2402639A1 FR7826194A FR7826194A FR2402639A1 FR 2402639 A1 FR2402639 A1 FR 2402639A1 FR 7826194 A FR7826194 A FR 7826194A FR 7826194 A FR7826194 A FR 7826194A FR 2402639 A1 FR2402639 A1 FR 2402639A1
- Authority
- FR
- France
- Prior art keywords
- substituted
- cycloalcanols
- cycloalcanones
- pharmaceutical composition
- composition containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 2-HYDROXYPHENYL GROUP Chemical group 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
- C07C37/002—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by transformation of a functional group, e.g. oxo, carboxyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
- C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/17—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings containing other rings in addition to the six-membered aromatic rings, e.g. cyclohexylphenol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/24—Halogenated derivatives
- C07C39/42—Halogenated derivatives containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/02—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains containing only carbon and hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/48—Preparation of compounds having groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/48—Preparation of compounds having groups
- C07C41/50—Preparation of compounds having groups by reactions producing groups
- C07C41/56—Preparation of compounds having groups by reactions producing groups by condensation of aldehydes, paraformaldehyde, or ketones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/95—Esters of quinone carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention a trait au domaine de la chimie médicale. Elle concerne, à titre de composés nouveaux des cycloalcanones, des cycloalcanols et leurs analogues substitués dont chacun porte en position 3 un groupe 2-hydroxyphényle substitué en position 4 avec un groupe alkyle dont la chaîne peut comporter un atome d'oxygène ou avec un groupe aralkyle dont la chaîne alkyle peut comporter un atome d'oxygène. Les composés de l'invention sont doués de propriétés analgésiques.The invention relates to the field of medical chemistry. It relates, as new compounds, to cycloalkanones, cycloalkanols and their substituted analogues, each of which carries in position 3 a 2-hydroxyphenyl group substituted in position 4 with an alkyl group whose chain may contain an oxygen atom or with a group aralkyl in which the alkyl chain may contain an oxygen atom. The compounds of the invention are endowed with analgesic properties.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83310277A | 1977-09-13 | 1977-09-13 | |
US92668778A | 1978-07-25 | 1978-07-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2402639A1 true FR2402639A1 (en) | 1979-04-06 |
Family
ID=27125579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7826194A Withdrawn FR2402639A1 (en) | 1977-09-13 | 1978-09-12 | CYCLOALCANONES AND CYCLOALCANOLS SUBSTITUTED IN POSITION 3 BY A 2-HYDROXYPHENYL GROUP SUBSTITUTED IN POSITION 4 AND PHARMACEUTICAL COMPOSITION CONTAINING THEM |
Country Status (27)
Country | Link |
---|---|
JP (1) | JPS5448741A (en) |
AR (1) | AR224618A1 (en) |
AT (1) | AT361455B (en) |
AU (1) | AU513523B2 (en) |
CA (1) | CA1110261A (en) |
CH (1) | CH635812A5 (en) |
DE (1) | DE2839836C2 (en) |
DK (1) | DK400878A (en) |
ES (3) | ES473288A1 (en) |
FI (1) | FI66584C (en) |
FR (1) | FR2402639A1 (en) |
GB (1) | GB2004870B (en) |
GR (1) | GR74134B (en) |
HK (1) | HK13284A (en) |
IE (1) | IE47187B1 (en) |
IL (1) | IL55556A (en) |
IN (1) | IN150334B (en) |
IT (1) | IT1099054B (en) |
KE (1) | KE3352A (en) |
LU (1) | LU80220A1 (en) |
MX (1) | MX5306E (en) |
MY (1) | MY8500094A (en) |
NL (2) | NL7809274A (en) |
NO (2) | NO149426C (en) |
NZ (1) | NZ188391A (en) |
PH (2) | PH15252A (en) |
SE (1) | SE431085B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2583042A1 (en) * | 1985-06-11 | 1986-12-12 | Yissum Res Dev Co | ANALGESIC COMPOSITIONS BASED ON (ALKOXY-ALKYL-HYDROXY-PHENYL) CYCLOHEXANOL |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN162851B (en) * | 1980-09-19 | 1988-07-16 | Pfizer | |
US4285867A (en) * | 1980-09-19 | 1981-08-25 | Pfizer Inc. | Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor |
US5650270A (en) * | 1982-02-01 | 1997-07-22 | Northeastern University | Molecular analytical release tags and their use in chemical analysis |
US4709016A (en) * | 1982-02-01 | 1987-11-24 | Northeastern University | Molecular analytical release tags and their use in chemical analysis |
JPS58201737A (en) * | 1982-05-18 | 1983-11-24 | Mitsui Toatsu Chem Inc | Novel aromatic alkane derivative, its preparation and insecticide and acaricide containing the same as active constituent |
GB8330099D0 (en) * | 1983-11-11 | 1983-12-21 | Ici Plc | Cycloalkane derivatives |
US4623657A (en) * | 1985-09-05 | 1986-11-18 | Hoechst-Roussel Pharmaceuticals Inc. | Spiro [benzofuran-2(3H),1'-cycloheptane]s and their therapeutic use |
IE70521B1 (en) * | 1989-02-28 | 1996-12-11 | Zeneca Pharma Sa | Heterocycles with inhibitory activity of 5-lipoxygenase |
GEP20043202B (en) * | 1999-03-22 | 2004-03-25 | Pfizer | Resorcinol Derivatives |
US6828460B2 (en) | 1999-03-22 | 2004-12-07 | Pfizer Inc. | Resorcinol derivatives |
US7612101B2 (en) | 2006-04-24 | 2009-11-03 | Allergan, Inc. | Abnormal cannabidiols as agents for lowering intraocular pressure |
US7618966B2 (en) | 2006-04-24 | 2009-11-17 | Allergan, Inc. | Abnormal Cannabidiols as agents for lowering intraocular pressure |
CA2648884C (en) * | 2006-04-24 | 2015-10-13 | Allergan, Inc. | Abnormal cannabidiols as agents for lowering intraocular pressure |
US7718830B2 (en) | 2006-04-24 | 2010-05-18 | Allergan, Inc. | Abnormal cannabidiols as agents for lowering intraocular pressure |
CN109369514B (en) * | 2018-12-10 | 2021-10-26 | 天津科技大学 | Synthetic method of six-membered carbocyclic ring derivative |
WO2021007662A1 (en) * | 2019-07-12 | 2021-01-21 | Canopy Growth Corporation | Cannabinoid derivatives |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU487907A1 (en) * | 1973-09-21 | 1975-10-15 | Полоцкий Химический Комбинат Им. 50-Летия Белор.Сср | Polymer composition |
-
1978
- 1978-08-28 SE SE7809060A patent/SE431085B/en unknown
- 1978-09-01 IN IN649/DEL/78A patent/IN150334B/en unknown
- 1978-09-06 CA CA310,713A patent/CA1110261A/en not_active Expired
- 1978-09-11 GR GR57203A patent/GR74134B/el unknown
- 1978-09-12 IL IL55556A patent/IL55556A/en unknown
- 1978-09-12 IE IE1841/78A patent/IE47187B1/en unknown
- 1978-09-12 FI FI782794A patent/FI66584C/en not_active IP Right Cessation
- 1978-09-12 NZ NZ188391A patent/NZ188391A/en unknown
- 1978-09-12 JP JP11217078A patent/JPS5448741A/en active Granted
- 1978-09-12 IT IT27558/78A patent/IT1099054B/en active
- 1978-09-12 DK DK400878A patent/DK400878A/en not_active Application Discontinuation
- 1978-09-12 AT AT658778A patent/AT361455B/en not_active IP Right Cessation
- 1978-09-12 ES ES473288A patent/ES473288A1/en not_active Expired
- 1978-09-12 NO NO783087A patent/NO149426C/en unknown
- 1978-09-12 NL NL7809274A patent/NL7809274A/en not_active Application Discontinuation
- 1978-09-12 LU LU80220A patent/LU80220A1/en unknown
- 1978-09-12 GB GB7836418A patent/GB2004870B/en not_active Expired
- 1978-09-12 FR FR7826194A patent/FR2402639A1/en not_active Withdrawn
- 1978-09-13 AU AU39818/78A patent/AU513523B2/en not_active Expired
- 1978-09-13 MX MX787390U patent/MX5306E/en unknown
- 1978-09-13 DE DE2839836A patent/DE2839836C2/en not_active Expired
- 1978-09-13 AR AR273693A patent/AR224618A1/en active
- 1978-09-13 PH PH21596A patent/PH15252A/en unknown
- 1978-09-13 CH CH955678A patent/CH635812A5/en not_active IP Right Cessation
-
1979
- 1979-05-02 ES ES480150A patent/ES480150A1/en not_active Expired
- 1979-05-02 ES ES480149A patent/ES8100795A1/en not_active Expired
- 1979-09-03 NO NO792840A patent/NO792840L/en unknown
- 1979-10-09 PH PH23144A patent/PH16597A/en unknown
-
1983
- 1983-09-30 NL NL8303358A patent/NL8303358A/en not_active Application Discontinuation
- 1983-11-22 KE KE3352A patent/KE3352A/en unknown
-
1984
- 1984-02-16 HK HK132/84A patent/HK13284A/en unknown
-
1985
- 1985-12-30 MY MY94/85A patent/MY8500094A/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2583042A1 (en) * | 1985-06-11 | 1986-12-12 | Yissum Res Dev Co | ANALGESIC COMPOSITIONS BASED ON (ALKOXY-ALKYL-HYDROXY-PHENYL) CYCLOHEXANOL |
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