AR246971A1 - Procedimiento para la preparacion de heteroalquilen quinolinaminas fusionadas. - Google Patents

Procedimiento para la preparacion de heteroalquilen quinolinaminas fusionadas.

Info

Publication number
AR246971A1
AR246971A1 AR88310621A AR31062188A AR246971A1 AR 246971 A1 AR246971 A1 AR 246971A1 AR 88310621 A AR88310621 A AR 88310621A AR 31062188 A AR31062188 A AR 31062188A AR 246971 A1 AR246971 A1 AR 246971A1
Authority
AR
Argentina
Prior art keywords
compound
formula
hydrogen
preparation
quinolinamines
Prior art date
Application number
AR88310621A
Other languages
English (en)
Original Assignee
Hoechst Rousel Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Rousel Pharmaceuticals filed Critical Hoechst Rousel Pharmaceuticals
Application granted granted Critical
Publication of AR246971A1 publication Critical patent/AR246971A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN COMPUESTO DE LA FORMULA (I), DONDE N ES 1-3; R1 ES HIDROGENO, ALQUILO O FENILALQUILO; A ES UN ENLACE DIRECTO O -CH2; X ES HIDROGENO, ALQUILO, HALOGENO O TRIFLUORMETILO; Y ES O O S; UN ESTEREO ISOMERO, ISOMERO OPTICO O GEOMETRICO RESPECTIVO, O UNA SAL DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE RESPECTIVA, QUE COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE LA FORMULA (VI), CON TETRAHIDRO-4H-PIRAN-4 ONA O CON TETRAHIDRO-4H-TIOPIRAN-2-3- O 4-ONA PARA PROPORCIONAR UN COMPUESTO DE FORMULA (I), DONDE R1 ES HIDROGENO Y B) OPCIONALMENTE REACCIONAR UN COMPUESTO DE LA FORMULA (I) DONDE R1 ES HIDROGENO, CON FENIL ALCANOILO Y REDUCIR EL COMPUESTO OBTENIDO PARA PROPORCIONAR UN COMPUESTO DE FORMULA (I) DONDE R1 ES FENILALQUILO(C1-C6)
AR88310621A 1987-04-23 1988-04-21 Procedimiento para la preparacion de heteroalquilen quinolinaminas fusionadas. AR246971A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4156287A 1987-04-23 1987-04-23

Publications (1)

Publication Number Publication Date
AR246971A1 true AR246971A1 (es) 1994-10-31

Family

ID=21917178

Family Applications (1)

Application Number Title Priority Date Filing Date
AR88310621A AR246971A1 (es) 1987-04-23 1988-04-21 Procedimiento para la preparacion de heteroalquilen quinolinaminas fusionadas.

Country Status (18)

Country Link
EP (1) EP0287977B1 (es)
JP (1) JP2835050B2 (es)
KR (1) KR960006392B1 (es)
AR (1) AR246971A1 (es)
AT (1) ATE107930T1 (es)
AU (1) AU609122B2 (es)
CA (1) CA1322368C (es)
DE (1) DE3850436T2 (es)
DK (1) DK174628B1 (es)
ES (1) ES2056849T3 (es)
FI (1) FI89801C (es)
IE (1) IE64197B1 (es)
IL (1) IL86158A (es)
NO (1) NO166324C (es)
NZ (1) NZ224313A (es)
PH (1) PH24884A (es)
PT (1) PT87287B (es)
ZA (1) ZA882811B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL87861A0 (en) * 1987-10-05 1989-03-31 Pfizer 4-aminopyridine derivatives
US5202440A (en) * 1987-10-05 1993-04-13 Pfizer Inc. Certain 9-amino-2-(or 4)-oxa 1,2,3,4-tetrahydro- or 1,2,3,4,5,6,7,8-octahydro-acridines
JP2720517B2 (ja) * 1989-05-31 1998-03-04 三菱化学株式会社 ９―アシルアミノーテトラヒドロアクリジン誘導体および該誘導体を有効成分とする記憶障害改善剤
ES2042384B1 (es) * 1991-12-26 1994-06-01 Boehringer Ingelheim Espana Procedimiento para obtener derivados bis-piridinicos.
KR100639543B1 (ko) 1998-09-30 2006-10-31 다케다 야쿠힌 고교 가부시키가이샤 방광 배출력 개선제

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3674790A (en) * 1970-05-01 1972-07-04 American Home Prod 2,10-disubstituted-1,2,3,4-tetrahydrobenzo(bhq (1,6)naphthyridines useful as cns depressants
ES431307A1 (es) * 1973-11-16 1976-09-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos derivados de quinoleina.
GB8610980D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Heterocyclic fused tricyclic compounds
JPS63264485A (ja) * 1986-12-29 1988-11-01 Sumitomo Pharmaceut Co Ltd アミノキノリン誘導体

Also Published As

Publication number Publication date
FI89801C (fi) 1993-11-25
ATE107930T1 (de) 1994-07-15
DK174628B1 (da) 2003-07-28
ZA882811B (en) 1988-10-20
FI881873A (fi) 1988-10-24
DK222888A (da) 1988-10-24
PH24884A (en) 1990-12-26
EP0287977A2 (en) 1988-10-26
IE881214L (en) 1988-10-23
IL86158A (en) 1994-08-26
DE3850436T2 (de) 1994-11-17
PT87287A (pt) 1988-05-01
AU609122B2 (en) 1991-04-26
FI881873A0 (fi) 1988-04-21
JPS63284175A (ja) 1988-11-21
NO166324B (no) 1991-03-25
KR880012606A (ko) 1988-11-28
DE3850436D1 (de) 1994-08-04
IE64197B1 (en) 1995-07-12
NO881775D0 (no) 1988-04-22
CA1322368C (en) 1993-09-21
EP0287977A3 (en) 1989-09-06
FI89801B (fi) 1993-08-13
NZ224313A (en) 1991-01-29
NO881775L (no) 1988-10-24
DK222888D0 (da) 1988-04-22
KR960006392B1 (ko) 1996-05-15
ES2056849T3 (es) 1994-10-16
PT87287B (pt) 1992-08-31
JP2835050B2 (ja) 1998-12-14
AU1509988A (en) 1988-10-27
NO166324C (no) 1991-07-03
EP0287977B1 (en) 1994-06-29
IL86158A0 (en) 1988-11-15

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