AR246965A1 - Procedimiento para fabricar un derivado del acido 1-3-dioxan-alquenoico. - Google Patents

Procedimiento para fabricar un derivado del acido 1-3-dioxan-alquenoico.

Info

Publication number
AR246965A1
AR246965A1 AR89313211A AR31321189A AR246965A1 AR 246965 A1 AR246965 A1 AR 246965A1 AR 89313211 A AR89313211 A AR 89313211A AR 31321189 A AR31321189 A AR 31321189A AR 246965 A1 AR246965 A1 AR 246965A1
Authority
AR
Argentina
Prior art keywords
formula
alkyl
hydroxy
ethyl
methyl
Prior art date
Application number
AR89313211A
Other languages
English (en)
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888803516A external-priority patent/GB8803516D0/en
Priority claimed from GB888824666A external-priority patent/GB8824666D0/en
Application filed by Ici Plc filed Critical Ici Plc
Application granted granted Critical
Publication of AR246965A1 publication Critical patent/AR246965A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PREPARACION DE UN DERIVADO DE ACIDO 1,3-DIOXAN-ALQUENOICO DE FORMULA (I), DONDE: A1 ES ALQUILENO; R1 ES ALQUILO, TRIFLUORMETILO, CICLOALQUILO COALCOXI-ALQUILO, O ES UN GRUPO DE FORMULA R3A2- DONDE R3 ES PIRIDILO, FENILO SUSTITUIDO O NO CON HALOGENOS, TRIFLUORMETILOS, NITROS O CIANOS Y DONDE A2 ES ALQUILENO, OXI-ALQUILENO, ALQUENILENO O UN ENLACE DIRECTO A R3; R2 ES HIDROXI O ALCOXI; Y ES VINILENO; Y N ES 1 O 2; EN DONDE: (A)UN 1,3- DIOXANO DE FORMULA (VII), DONDE RA Y RB ES HIDROGENO, METILO O ETILO Y EL OTRO ES METILO O ETILO SE HACE REACCIONAR CON UN EXCESO DE UN ALDEHIDO DE FORMULA R1.CHO, O CON UN HIDRATO, ACETAL O HEMIACETAL DEL MISMO, EN PRESENCIA DE UN ACIDO; Y (B) PREPARACION DE UN COMPUESTO DE FORMULA (I) DONDE R2 ES HIDROXI, SE HIDROLIZA UN ESTER DE FORMULA (VIII), EN LA CUAL R6 ES ALQUILO, FENILO O BENCILO, SUSTITUIDOS O NO CON 1 O 2 SUSTITUYENTES HALOGENO, ALQUILO O ALCOXI.
AR89313211A 1988-02-16 1989-02-14 Procedimiento para fabricar un derivado del acido 1-3-dioxan-alquenoico. AR246965A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888803516A GB8803516D0 (en) 1988-02-16 1988-02-16 Heterocyclic compounds
GB888824666A GB8824666D0 (en) 1988-10-21 1988-10-21 Pyridine derivatives

Publications (1)

Publication Number Publication Date
AR246965A1 true AR246965A1 (es) 1994-10-31

Family

ID=26293498

Family Applications (1)

Application Number Title Priority Date Filing Date
AR89313211A AR246965A1 (es) 1988-02-16 1989-02-14 Procedimiento para fabricar un derivado del acido 1-3-dioxan-alquenoico.

Country Status (24)

Country Link
US (1) US5166213A (es)
EP (1) EP0329360B1 (es)
JP (1) JP2812697B2 (es)
KR (1) KR0145725B1 (es)
CN (1) CN1040753C (es)
AR (1) AR246965A1 (es)
AT (1) ATE109478T1 (es)
AU (1) AU626534B2 (es)
CA (1) CA1335816C (es)
DE (1) DE68917170T2 (es)
DK (1) DK66989A (es)
ES (1) ES2057104T3 (es)
FI (1) FI93216C (es)
GB (1) GB8901201D0 (es)
HU (1) HU209700B (es)
IE (1) IE63825B1 (es)
IL (1) IL89214A (es)
MY (1) MY103699A (es)
NO (1) NO172491C (es)
NZ (1) NZ227880A (es)
PH (1) PH26227A (es)
PL (1) PL158201B1 (es)
PT (1) PT89703B (es)
ZW (1) ZW1789A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8709794D0 (en) * 1987-04-24 1987-05-28 Ici Plc Heterocyclic acids
IE81170B1 (en) * 1988-10-21 2000-05-31 Zeneca Ltd Pyridine derivatives
GB9021571D0 (en) * 1990-10-04 1990-11-21 Ici Plc Heterocyclic acids
EP2363127A1 (en) * 2006-01-18 2011-09-07 Evolva SA PPAR Modulators
EP2150111B1 (en) * 2007-01-18 2016-10-19 Evolva SA Substituted 1,3-dioxanes useful as ppar modulators
US20120142766A1 (en) * 2007-11-21 2012-06-07 Evolva Sa Substituted 1,3-dioxanes and their uses

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3262096D1 (en) * 1981-03-30 1985-03-14 Hoffmann La Roche 1,3-dioxolane derivatives, their preparation, fungicidal agents containing those compounds as active agents and use of such compounds or agents in combating fungi in agriculture and in gardening
GB8310407D0 (en) * 1982-05-12 1983-05-25 Ici Plc 1 3 - dioxan -5- ylalkenoic acids
GB8330120D0 (en) * 1983-11-11 1983-12-21 Ici Plc Chemical process
GB8330099D0 (en) * 1983-11-11 1983-12-21 Ici Plc Cycloalkane derivatives
GB8330094D0 (en) * 1983-11-11 1983-12-21 Ici Plc Diphenyl compounds
US4554011A (en) * 1984-08-24 1985-11-19 Chevron Research Company Herbicidal 2S-(2β,4β,5β)-5-Arylmethoxy-4-substituted 2-alkyl-1,3-dioxane derivatives
GB8511890D0 (en) * 1985-05-10 1985-06-19 Ici Plc Benzene derivatives
US4824858A (en) * 1985-05-10 1989-04-25 Imperial Chemical Industries Plc 1,3-Dioxolane-5-yl-hexenoic acid derivatives
GB8511892D0 (en) * 1985-05-10 1985-06-19 Ici Plc Fluoralkane derivatives
GB8511891D0 (en) * 1985-05-10 1985-06-19 Ici Plc Alkenoic acids
GB8511894D0 (en) * 1985-05-10 1985-06-19 Ici Plc Phenol derivatives
GB8511895D0 (en) * 1985-05-10 1985-06-19 Ici Plc Heterocyclic compounds
HU198706B (en) * 1985-05-10 1989-11-28 Ici Plc Process for producing 1,3-dioxan-ethers and pharmaceutical compositions containing them
GB8611174D0 (en) * 1986-05-08 1986-06-18 Ici Plc Amide derivatives
ATE56967T1 (de) * 1985-11-12 1990-10-15 Ici Plc Amidderivate.
GB8531892D0 (en) * 1985-12-30 1986-02-05 Ici Plc Carboxylic acids
GB8626297D0 (en) * 1986-11-04 1986-12-03 Ici Plc Pharmaceutical compositions
GB8626296D0 (en) * 1986-11-04 1986-12-03 Ici Plc Therapeutic agents
GB8709794D0 (en) * 1987-04-24 1987-05-28 Ici Plc Heterocyclic acids
IE81170B1 (en) * 1988-10-21 2000-05-31 Zeneca Ltd Pyridine derivatives

Also Published As

Publication number Publication date
PT89703B (pt) 1994-04-29
DK66989A (da) 1989-08-17
EP0329360A3 (en) 1990-09-05
IE63825B1 (en) 1995-06-14
IE890392L (en) 1989-08-16
FI93216C (fi) 1995-03-10
DK66989D0 (da) 1989-02-13
CA1335816C (en) 1995-06-06
EP0329360B1 (en) 1994-08-03
NZ227880A (en) 1991-10-25
KR0145725B1 (ko) 1998-08-17
ATE109478T1 (de) 1994-08-15
NO890607L (no) 1989-08-17
IL89214A (en) 1994-01-25
JP2812697B2 (ja) 1998-10-22
DE68917170D1 (de) 1994-09-08
ZW1789A1 (en) 1990-03-21
GB8901201D0 (en) 1989-03-15
KR890013005A (ko) 1989-09-20
FI93216B (fi) 1994-11-30
DE68917170T2 (de) 1994-12-15
NO172491C (no) 1993-07-28
US5166213A (en) 1992-11-24
PH26227A (en) 1992-04-01
MY103699A (en) 1993-08-28
ES2057104T3 (es) 1994-10-16
PT89703A (pt) 1989-10-04
CN1035115A (zh) 1989-08-30
NO172491B (no) 1993-04-19
AU626534B2 (en) 1992-08-06
FI890678A0 (fi) 1989-02-13
AU2990889A (en) 1989-08-17
CN1040753C (zh) 1998-11-18
NO890607D0 (no) 1989-02-13
FI890678A (fi) 1989-08-17
EP0329360A2 (en) 1989-08-23
HUT54143A (en) 1991-01-28
HU209700B (en) 1994-10-28
PL158201B1 (pl) 1992-08-31
JPH01249770A (ja) 1989-10-05

Similar Documents

Publication Publication Date Title
LU91275I2 (fr) Entecavir et ses dérivés pharmaceutiquement acceptables - baraclude
FI874115A (fi) Foerfarande foer framstaellning av etynylfenylhaltiga retinolsyraderivat.
ES8307719A1 (es) "procedimiento de preparar amidoaminoacidos n-substituidos".
AR241532A1 (es) Procedimiento para preparar nuevos derivados de acido-tiazolidin-4(s)-carboxilico.
ES2012467B3 (es) Compuesto de embulsion del tipo o/w
AR246965A1 (es) Procedimiento para fabricar un derivado del acido 1-3-dioxan-alquenoico.
KR850003539A (ko) 밀베마이신 5-카르보네이트 유도체의 제조방법
KR920004381A (ko) 치환된 피리미딘 유도체, 이의 제조방법 및 약제로서의 이의 용도
DK663588A (da) Purinderivater
KR850004959A (ko) 아릴옥시-n-(아미노알킬)-1-피롤리딘 및 피페리딘 카복스 아미드 및 카보티오 아미드의 제조방법
KR920012052A (ko) 심장혈관계에 작용하는 벤즈옥사지논 및 벤조티아지논 유도체
ES2149354T3 (es) Solucion acuosa, estable de folinato.
ATE55598T1 (de) 6-ketoprostaglandin-e1-derivate.
WO1993004059A1 (en) 4-acylaminoimidazole derivative
ES8301931A1 (es) Un procedimiento para la preparacion de nuevos imidazoles.
ATE112779T1 (de) Verfahren zur herstellung von 6-(d(-)-alpha-(4- äthyl-2,3-dioxo-1-piperazin-carboxamido)- phenylacetamido>penicillansäure.
KR930016414A (ko) 신규의 4-신놀리닐-및 4-나프티리디닐-디히드로피리딘, 그들의 제조 방법 및 약제로서 그들의 용도
ES2096628T3 (es) Derivados heterociclicos.
FI822133A0 (fi) Nya 1-benzyl-3,4-dihydro-isokinolinderivat
ES8608489A1 (es) Procedimiento para la obtencion de esteres del acido 1,4-di-hidro-2,6-dimetil-4-(3-nitrofenil)-3,5-piridinodicarboxilico
ATE135571T1 (de) Organogermaniumderivate enthaltende zubereitungen zur therapeutischen verwendung
HUT40100A (en) Process for producing quinolin-carboxylic acid derivatives
ES8603861A1 (es) Un procedimiento para preparar derivados sustituidos de 1,3 -dioxano
GB1103155A (en) Improvements in and relating to quinazolines
KR830005151A (ko) 헤테로 시클릭 화합물의 제조 방법 및 이것의 조성물