AR245720A1 - Preparacion de compuestos de 3h-imidazo¡1,2-c¿-pirazolo¡4,5-e¿pirimidina o 3h-diimidazo¡1,2,-c:4',5'-e¿pirimidina utiles como antagonistas de adenosina. - Google Patents

Preparacion de compuestos de 3h-imidazo¡1,2-c¿-pirazolo¡4,5-e¿pirimidina o 3h-diimidazo¡1,2,-c:4',5'-e¿pirimidina utiles como antagonistas de adenosina.

Info

Publication number
AR245720A1
AR245720A1 AR90316475A AR31647590A AR245720A1 AR 245720 A1 AR245720 A1 AR 245720A1 AR 90316475 A AR90316475 A AR 90316475A AR 31647590 A AR31647590 A AR 31647590A AR 245720 A1 AR245720 A1 AR 245720A1
Authority
AR
Argentina
Prior art keywords
hydrogen
formula
adenosine receptor
compound
selective adenosine
Prior art date
Application number
AR90316475A
Other languages
English (en)
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of AR245720A1 publication Critical patent/AR245720A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR COMPUESTOS DE 3H-IMIDAZO¡1,2-C¿-PIRAZOLO¡4,5- E¿PIRIMIDINA O 3H-DIIMIDAZO¡1,2-C:4',5'-E¿PIRIMIDINA, UTILES COMO ANTAGONISTAS DE ADENOSINA, DE FORMULA (I), EN LA QUE: R1 ES HIDROGENO, FENILO O BETA-D-RIBOFURANOSILO; R2 ES HIDROGENO O ALCOXI; Y ES -N= O -CH=; Z ES -N= O -CH=, CON LA CONDICION DE QUE Y Y Z NO PUEDEN SER IGUALES; N ES UN NUMERO DE 1 A 3; L ES HIDROGENO; M ES FENILO; QUE COMPRENDE HACER REACCIONAR UN AMINOALCOHOL DE FORMULA (IIIA), CON UN COMPUESTO DE FORMULA (IIA), R'2 ES HIDROGENO O CLORO Y R'1 ES 2,3,5-TRIBENZOIL-BETA-D- RIBOFURANOSILO, HIDROGENO O FENILO, PARA OBTENER UN COMPUESTO DE FORMULA (IVA) Y HACER REACCIONAR DICHO COMPUESTO CON CLORURO DE TIONILO, PARA OBTENER LOS COMPUESTOS DE FORMULA (IA).
AR90316475A 1989-03-29 1990-03-28 Preparacion de compuestos de 3h-imidazo¡1,2-c¿-pirazolo¡4,5-e¿pirimidina o 3h-diimidazo¡1,2,-c:4',5'-e¿pirimidina utiles como antagonistas de adenosina. AR245720A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33040089A 1989-03-29 1989-03-29

Publications (1)

Publication Number Publication Date
AR245720A1 true AR245720A1 (es) 1994-02-28

Family

ID=23289598

Family Applications (1)

Application Number Title Priority Date Filing Date
AR90316475A AR245720A1 (es) 1989-03-29 1990-03-28 Preparacion de compuestos de 3h-imidazo¡1,2-c¿-pirazolo¡4,5-e¿pirimidina o 3h-diimidazo¡1,2,-c:4',5'-e¿pirimidina utiles como antagonistas de adenosina.

Country Status (18)

Country Link
EP (1) EP0390111B1 (es)
JP (1) JP3014000B2 (es)
KR (1) KR0150635B1 (es)
CN (1) CN1029972C (es)
AR (1) AR245720A1 (es)
AT (1) ATE111466T1 (es)
AU (1) AU623755B2 (es)
CA (1) CA2013381C (es)
DE (1) DE69012388T2 (es)
ES (1) ES2063851T3 (es)
FI (1) FI95133C (es)
HU (1) HU203349B (es)
IE (1) IE63545B1 (es)
IL (1) IL93893A (es)
NO (1) NO173997C (es)
NZ (1) NZ233077A (es)
PT (1) PT93589B (es)
ZA (1) ZA902282B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE195739T1 (de) * 1989-10-20 2000-09-15 Kyowa Hakko Kogyo Kk Kondensierte purinderivate
IL98559A0 (en) * 1990-06-21 1992-07-15 Schering Corp Polycyclic guanine derivatives
DE19629378A1 (de) * 1996-07-20 1998-01-29 Boehringer Ingelheim Kg Neue Triazolopurine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2001047931A1 (fr) * 1999-12-24 2001-07-05 Kyowa Hakko Kogyo Co., Ltd. Derives de purine fondue

Also Published As

Publication number Publication date
CN1029972C (zh) 1995-10-11
FI95133B (fi) 1995-09-15
DE69012388D1 (de) 1994-10-20
NZ233077A (en) 1992-12-23
HU203349B (en) 1991-07-29
HU901857D0 (en) 1990-08-28
IE63545B1 (en) 1995-05-17
NO173997C (no) 1994-03-02
CA2013381C (en) 2000-06-20
EP0390111A3 (en) 1991-05-08
FI95133C (fi) 1995-12-27
CA2013381A1 (en) 1990-09-29
ATE111466T1 (de) 1994-09-15
NO901424D0 (no) 1990-03-28
HUT54160A (en) 1991-01-28
IE901142L (en) 1990-09-29
JP3014000B2 (ja) 2000-02-28
KR0150635B1 (ko) 1998-10-15
AU623755B2 (en) 1992-05-21
KR900014390A (ko) 1990-10-23
JPH02289574A (ja) 1990-11-29
FI901550A0 (fi) 1990-03-28
PT93589A (pt) 1990-11-20
ES2063851T3 (es) 1995-01-16
EP0390111B1 (en) 1994-09-14
EP0390111A2 (en) 1990-10-03
IL93893A (en) 1994-07-31
DE69012388T2 (de) 1995-04-27
NO173997B (no) 1993-11-22
NO901424L (no) 1990-10-01
PT93589B (pt) 1996-06-28
AU5218290A (en) 1990-10-04
CN1045974A (zh) 1990-10-10
IL93893A0 (en) 1990-12-23
ZA902282B (en) 1990-12-28

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