AR221203A1 - Un compuesto intermediario sin actividad terapeutica que consiste en un derivado de la tieno(4,5)benzodiazepina,y un procedimiento para preparar una tieno-(1,5)benzodiazepina partiendo de dicho intermediario - Google Patents

Un compuesto intermediario sin actividad terapeutica que consiste en un derivado de la tieno(4,5)benzodiazepina,y un procedimiento para preparar una tieno-(1,5)benzodiazepina partiendo de dicho intermediario

Info

Publication number
AR221203A1
AR221203A1 AR261340A AR26134075A AR221203A1 AR 221203 A1 AR221203 A1 AR 221203A1 AR 261340 A AR261340 A AR 261340A AR 26134075 A AR26134075 A AR 26134075A AR 221203 A1 AR221203 A1 AR 221203A1
Authority
AR
Argentina
Prior art keywords
benzodiazepina
tieno
intermediary
derivative
preparing
Prior art date
Application number
AR261340A
Other languages
English (en)
Spanish (es)
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10459213&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR221203(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Application granted granted Critical
Publication of AR221203A1 publication Critical patent/AR221203A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AR261340A 1974-11-26 1975-11-25 Un compuesto intermediario sin actividad terapeutica que consiste en un derivado de la tieno(4,5)benzodiazepina,y un procedimiento para preparar una tieno-(1,5)benzodiazepina partiendo de dicho intermediario AR221203A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB51240/74A GB1533235A (en) 1974-11-26 1974-11-26 Benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
AR221203A1 true AR221203A1 (es) 1981-01-15

Family

ID=10459213

Family Applications (1)

Application Number Title Priority Date Filing Date
AR261340A AR221203A1 (es) 1974-11-26 1975-11-25 Un compuesto intermediario sin actividad terapeutica que consiste en un derivado de la tieno(4,5)benzodiazepina,y un procedimiento para preparar una tieno-(1,5)benzodiazepina partiendo de dicho intermediario

Country Status (30)

Country Link
JP (1) JPS6044314B2 (esLanguage)
AR (1) AR221203A1 (esLanguage)
AT (1) AT351547B (esLanguage)
AU (1) AU506340B2 (esLanguage)
BE (1) BE835932A (esLanguage)
BG (1) BG29573A3 (esLanguage)
CA (1) CA1075687A (esLanguage)
CH (2) CH613454A5 (esLanguage)
CS (1) CS236753B2 (esLanguage)
DD (1) DD123343A5 (esLanguage)
DE (1) DE2552403C2 (esLanguage)
DK (1) DK146887C (esLanguage)
ES (1) ES443011A1 (esLanguage)
FR (1) FR2292479A1 (esLanguage)
GB (1) GB1533235A (esLanguage)
HK (1) HK58681A (esLanguage)
HU (1) HU172493B (esLanguage)
IE (1) IE42564B1 (esLanguage)
IL (1) IL48502A (esLanguage)
KE (1) KE3163A (esLanguage)
MY (1) MY8200149A (esLanguage)
NL (1) NL186088C (esLanguage)
NZ (1) NZ179335A (esLanguage)
PH (2) PH11669A (esLanguage)
PL (1) PL100135B1 (esLanguage)
RO (1) RO69912A (esLanguage)
SE (2) SE421209B (esLanguage)
SU (2) SU629879A3 (esLanguage)
YU (1) YU298375A (esLanguage)
ZA (1) ZA757344B (esLanguage)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL62792A (en) * 1980-05-07 1985-02-28 Byk Gulden Lomberg Chem Fab Acylated dihydrothienodiazepinone compounds,process for their preparation,and medicaments containing them
GB8819059D0 (en) * 1988-08-11 1988-09-14 Lilly Industries Ltd Benzodiazepine compounds & their use as pharmaceuticals
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
DE69329887T2 (de) * 1992-05-29 2001-05-23 Eli Lilly And Co., Ltd. Thienobenzodiazepinderivate zur Behandlung von Störungen des Zentralnervensystems
WO1997016430A1 (en) * 1995-11-01 1997-05-09 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
AU739385B2 (en) * 1997-09-02 2001-10-11 Mitsubishi Pharma Corporation Condensed thiophene compounds and pharmaceutical use thereof
RU2185383C1 (ru) * 2001-05-22 2002-07-20 Институт молекулярной генетики РАН ВЫСОКОМЕЧЕННЫЙ ТРИТИЕМ 2-МЕТИЛ-4-(4-МЕТИЛ-1-ПИПЕРАЗИНИЛ)-10Н-ТИЕНО[2,3-b][1,5]БЕНЗОДИАЗЕПИН
PL199016B1 (pl) * 2002-06-20 2008-08-29 Adamed Sp Z Oo Sposób wytwarzania olanzapiny
SI21270A (sl) 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalne oblike olanzapina in postopki za njihovo pripravo
DE10301923B3 (de) * 2003-01-17 2004-09-16 Krka Tovarna Zdravil, D.D. Verfahren und Zwischenprodukte zur Herstellung von Olanzapin
EP1720885A1 (en) * 2004-01-27 2006-11-15 Synthon B.V. A process for making olanzapine in a polymorph form i
AR048272A1 (es) 2004-03-18 2006-04-12 Lek Pharmaceuticals Sintesis de 2 metil - 4- (4- metil -1- piperazinil) - 10 h- tieno ( 2,3-b) (1,5) benzodiazepina y sus sales, metodos para su preparacion, composiciones farmaceuticas que la contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mentales.
KR101216984B1 (ko) * 2004-06-30 2013-01-02 아더시스 인코포레이티드 세로토닌 수용체 조절자로서의 치환된 아제핀 유도체
EP2292624A1 (en) 2009-07-20 2011-03-09 LEK Pharmaceuticals d.d. Process for the purification of olanzapine

Also Published As

Publication number Publication date
NL7513833A (nl) 1976-05-31
AU8685875A (en) 1977-05-26
JPS5176296A (en) 1976-07-01
GB1533235A (en) 1978-11-22
HK58681A (en) 1981-12-04
DK146887B (da) 1984-01-30
DK524175A (da) 1976-05-27
SU629879A3 (ru) 1978-10-25
AT351547B (de) 1979-07-25
CH613455A5 (en) 1979-09-28
IE42564L (en) 1976-05-26
CA1075687A (en) 1980-04-15
ATA898275A (de) 1979-01-15
SE7812194L (sv) 1978-11-27
NL186088B (nl) 1990-04-17
ES443011A1 (es) 1977-07-01
AU506340B2 (en) 1979-12-20
YU298375A (en) 1982-10-31
CH613454A5 (en) 1979-09-28
BE835932A (fr) 1976-05-25
DE2552403C2 (de) 1986-06-19
PH24534A (en) 1990-08-03
CS236753B2 (en) 1985-05-15
NZ179335A (en) 1978-11-13
RO69912A (ro) 1980-08-15
FR2292479A1 (fr) 1976-06-25
HU172493B (hu) 1978-09-28
SE421209B (sv) 1981-12-07
PH11669A (en) 1978-05-19
MY8200149A (en) 1982-12-31
KE3163A (en) 1981-10-16
FR2292479B1 (esLanguage) 1978-07-28
BG29573A3 (en) 1980-12-12
DE2552403A1 (de) 1976-08-12
IL48502A0 (en) 1976-01-30
DD123343A5 (esLanguage) 1976-12-12
ZA757344B (en) 1976-11-24
IL48502A (en) 1980-01-31
PL100135B1 (pl) 1978-09-30
NL186088C (nl) 1990-09-17
DK146887C (da) 1984-07-09
SE429045B (sv) 1983-08-08
IE42564B1 (en) 1980-09-10
SU626702A3 (ru) 1978-09-30
SE7513185L (sv) 1976-05-27
JPS6044314B2 (ja) 1985-10-02

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