AR121901A1 - Moduladores gpr52 y métodos de uso - Google Patents

Moduladores gpr52 y métodos de uso

Info

Publication number
AR121901A1
AR121901A1 ARP210101068A ARP210101068A AR121901A1 AR 121901 A1 AR121901 A1 AR 121901A1 AR P210101068 A ARP210101068 A AR P210101068A AR P210101068 A ARP210101068 A AR P210101068A AR 121901 A1 AR121901 A1 AR 121901A1
Authority
AR
Argentina
Prior art keywords
alkyl
haloalkyl
optionally substituted
halogen
hydrogen
Prior art date
Application number
ARP210101068A
Other languages
English (en)
Inventor
Juan Pablo Cueva-Garcia
Neil J Ashweek
Collin Regan
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of AR121901A1 publication Critical patent/AR121901A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente revelación se refiere a compuestos de fórmula (1) que modulan la actividad de receptor 52 acoplado a proteína G (GPR52), sales farmacéuticamente aceptables de compuestos de fórmula (1), y composiciones farmacéuticas de los mismos. Compuestos, sales farmacéuticas de compuestos, y composiciones farmacéuticas de la presente revelación están dirigidos a métodos de utilidad en el tratamiento o profilaxis de una enfermedad neurológica o trastorno y a afecciones relacionadas a la misma. Reivindicación 1: Un compuesto de fórmula (1), o una sal farmacéuticamente aceptable del mismo, donde: X, Y¹ y Y² son independientemente N (nitrógeno) o CH; Z es N o CR¹, donde al menos uno de Z, X, Y¹ y Y² es N (nitrógeno); Z¹ es un compuesto de fórmula (2) ó (3); Z² es un compuesto de fórmula (4), (5) ó (6); Q¹ es N (nitrógeno) o CR⁴; Q² es N (nitrógeno) o CR⁵; R¹ es hidrógeno, halógeno, alquilo C₁-C₆ o haloalquilo C₁-C₆; R² es hidrógeno, halógeno, alquilo C₁-C₆, haloalquilo C₁-C₆, o -ORA; R³ es hidrógeno, halógeno, alquilo C₁-C₆, o haloalquilo C₁-C₆; i) R⁴, R⁵, R⁶, y R⁷, son independientemente hidrógeno, halógeno, -(CH₂)ₙ-CN, nitro, haloalquilo C₁-C₆, cicloalquilo C₃-C₈, -NHC(=O)RB, -ORB, -S(O)ₘRB, -(CH₂)ₘC(=O)RB, -S(O)ₚN(RBRC), o alquilo C₁-C₆ opcionalmente sustituido con hidroxilo; o ii) R⁴ y R⁵, junto con los átomos de carbono a los cuales están adheridos, forman un grupo arilo de 6 miembros, un grupo heteroarilo de 5 - 6 miembros opcionalmente sustituido con alquilo C₁-C₆, un grupo cicloalquilo de 5 - 6 miembros opcionalmente sustituido con =O, o un grupo heterociclilo de 5 - 6 miembros, y R⁶ y R⁷ son independientemente hidrógeno, halógeno, -(CH₂)ₙ-CN, nitro, alquilo C₁-C₆ opcionalmente sustituido con hidroxilo, haloalquilo C₁-C₆, cicloalquilo C₃-C₈, -NHC(=O)RB, -ORB, -S(O)ₘRB, -(CH₂)ₘC(=O)RB o -S(O)ₚN(RBRC); o iii) R⁵ y R⁶, junto con los átomos de carbono a los cuales están adheridos, forman un grupo arilo de 6 miembros, un grupo heteroarilo de 5 - 6 miembros opcionalmente sustituido con alquilo C₁-C₆, un grupo cicloalquilo de 5 - 6 miembros opcionalmente sustituido con =O, o un grupo heterociclilo de 5 - 6 miembros, y R⁴ y R⁷, son independientemente hidrógeno, halógeno, -(CH₂)ₙ-CN, nitro, alquilo C₁-C₆ opcionalmente sustituido con hidroxilo, haloalquilo C₁-C₆, cicloalquilo C₃-C₈, -NHC(=O)RB, -ORB, -S(O)ₘRB, -(CH₂)ₘC(=O)RB o -S(O)ₚN(RBRC); o iv) R⁶ y R⁷, junto con los átomos de carbono a los cuales están adheridos, forman un grupo arilo de 6 miembros, un grupo heteroarilo de 5 - 6 miembros opcionalmente sustituido con alquilo C₁-C₆, un grupo cicloalquilo de 5 - 6 miembros opcionalmente sustituido con =O, o un grupo heterociclilo de 5 - 6 miembros, y R⁴ y R⁵, son independientemente hidrógeno, halógeno, -(CH₂)ₙ-CN, nitro, alquilo C₁-C₆ opcionalmente sustituido con hidroxilo, haloalquilo C₁-C₆, cicloalquilo C₃-C₈, -NHC(=O)RB, -ORB, -S(O)ₘRB, -(CH₂)ₘC(=O)RB o -S(O)ₚN(RBRC); uno de R⁸ y R⁹ es -(CH₂)ₙC(=O)N(RERF) y el otro de R⁸ y R⁹ es hidrógeno, halógeno, alquilo C₁-C₆, haloalquilo C₁-C₆, -C(=O)RD, o -ORE; o R⁸ y R⁹ junto con el átomo de carbono al cual están adheridos, forman un grupo heterociclilo de 5 - 6 miembros, dicho grupo heterociclilo de 5 - 6 miembros opcionalmente sustituido con =O; R¹⁰ es hidrógeno, halógeno, alquilo C₁-C₆, haloalquilo C₁-C₆, -C(=O)RD, o -ORE; cada RA, RB, RC, es independientemente hidrógeno, alquilo C₁-C₆, o haloalquilo C₁-C₆; cada RD es independientemente hidrógeno, alquilo C₁-C₆, haloalquilo C₁-C₆, -NH₂, o -NH(CH₂)qOH; cada RE, y RF, es independientemente hidrógeno, alquilo C₁-C₆, o haloalquilo C₁-C₆; o RE y RF, junto con el átomo de nitrógeno al cual están adheridos, forman un grupo heterociclilo de 5 - 6 miembros; cada m es independientemente 0, 1, 2 ó 3; cada n es independientemente 0, 1, 2 ó 3; cada p es independientemente 1 ó 2; y cada q es independientemente 2, 3 ó 4.
ARP210101068A 2020-04-22 2021-04-21 Moduladores gpr52 y métodos de uso AR121901A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202063013862P 2020-04-22 2020-04-22

Publications (1)

Publication Number Publication Date
AR121901A1 true AR121901A1 (es) 2022-07-20

Family

ID=75850724

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP210101068A AR121901A1 (es) 2020-04-22 2021-04-21 Moduladores gpr52 y métodos de uso

Country Status (5)

Country Link
US (1) US20230234925A1 (es)
EP (1) EP4139284A1 (es)
AR (1) AR121901A1 (es)
TW (1) TW202206413A (es)
WO (1) WO2021216705A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240208907A1 (en) * 2021-04-26 2024-06-27 Neurocrine Biosciences, Inc. Gpr52 modulators and methods of use
CN117940420A (zh) 2021-09-14 2024-04-26 勃林格殷格翰国际有限公司 3-苯氧基氮杂环丁烷-1-基-杂芳基吡咯烷衍生物及其作为药物的用途
WO2024091542A1 (en) * 2022-10-26 2024-05-02 Neurocrine Biosciences, Inc. Compounds and compositions as gpr52 modulators
WO2024091538A1 (en) * 2022-10-26 2024-05-02 Neurocrine Biosciences, Inc. Compounds and compositions as gpr52 modulators
WO2024091541A1 (en) * 2022-10-26 2024-05-02 Neurocrine Biosciences, Inc. Compounds and compositions as gpr52 modulators

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
WO2006098520A1 (ja) 2005-03-18 2006-09-21 Takeda Pharmaceutical Company Limited スクリーニング方法
JPWO2009107391A1 (ja) * 2008-02-27 2011-06-30 武田薬品工業株式会社 ６員芳香環含有化合物
WO2011145735A1 (ja) * 2010-05-21 2011-11-24 武田薬品工業株式会社 チアゾール誘導体
WO2012020738A1 (ja) * 2010-08-09 2012-02-16 武田薬品工業株式会社 複素環化合物およびその用途
ES2784316T3 (es) 2015-04-29 2020-09-24 Arena Pharm Inc 1-Heteroaril-indolin-4-carboxamidas como moduladores de GPR52 útiles para el tratamiento o la prevención de trastornos relacionados con el mismo

Also Published As

Publication number Publication date
TW202206413A (zh) 2022-02-16
EP4139284A1 (en) 2023-03-01
US20230234925A1 (en) 2023-07-27
WO2021216705A1 (en) 2021-10-28

Similar Documents

Publication Publication Date Title
AR121901A1 (es) Moduladores gpr52 y métodos de uso
AR115993A2 (es) Composiciones de pirrolopirrol como activadores de piruvato quinasa (pkr)
AR114254A1 (es) Moduladores del regulador de conductancia transmembrana de fibrosis quística, composiciones farmacéuticas, métodos de tratamiento y proceso de preparación de los moduladores
AR095430A1 (es) Compuestos de pirimidina y piridina y su uso como inhibidores de la actividad de fgfr
AR087127A1 (es) Compuestos que se unen a fxr (nr1h4) y modulan su actividad
AR107714A1 (es) Derivados de pirazolo[1,5-a]pirazin-4-ilo
AR090230A1 (es) Derivados macrociclicos para el tratamiento de enfermedades
AR116913A1 (es) Inhibidores de apol1 y sus métodos de uso
AR113299A1 (es) Compuestos de isoindolina
AR062050A1 (es) Derivados de amina utiles como agentes anti-cancerigenos
AR119234A1 (es) Derivados de imidazo[1,2-a]piridinilo y su uso en el tratamiento de enfermedades
AR034390A1 (es) Derivados de 1-sulfonil-tetrahidro quinolinas sustituidas, composiciones farmaceuticas y el uso de las mismas para la elaboracion de medicamentos como inhibidores de la gama secretasa
AR087793A1 (es) Compuestos de benzofurano sustituido y metodos para el uso de los mismos en el tratamiento de enfermedades virales
AR123848A1 (es) Compuestos espiro heterocíclicos y métodos de uso
AR100713A1 (es) Derivados de amida de compuestos de 1-oxa-4,9-diazaespiro undeceno que tienen actividad multimodal contra el dolor
AR119244A1 (es) Derivados de 2h-indazol y su uso en el tratamiento de enfermedades
AR126693A1 (es) Compuestos de pirazolopiridinona
AR116400A1 (es) Compuesto de imidazopiridinona
AR112794A1 (es) Compuestos heteroaromáticos sustituidos con cicloolefinas y su uso en el tratamiento de enfermedades inducidas por mutaciones idh
AR120556A1 (es) Compuestos heterocíclicos como inhibidores de delta-5 desaturasa y métodos de uso
AR123701A1 (es) Preparación de derivados de oxindol como nuevos inhibidores de la diacilglicerol o-aciltransferasa 2
AR119149A1 (es) Derivados de isoquinolina como moduladores de la progranulina
AR100126A1 (es) Activadores de herg policíclicos
AR121554A1 (es) Azálidos de urea inmunoduladores
AR089360A1 (es) Derivados de heterociclilo y su uso como moduladores del receptor d₂ de prostaglandina

Legal Events

Date Code Title Description
FB Suspension of granting procedure