AR119552A2 - Producción de una n-acetilgalactosamina-6-sulfatasa humana activa altamente fosforilada y sus usos - Google Patents

Producción de una n-acetilgalactosamina-6-sulfatasa humana activa altamente fosforilada y sus usos

Info

Publication number
AR119552A2
AR119552A2 ARP200102165A ARP200102165A AR119552A2 AR 119552 A2 AR119552 A2 AR 119552A2 AR P200102165 A ARP200102165 A AR P200102165A AR P200102165 A ARP200102165 A AR P200102165A AR 119552 A2 AR119552 A2 AR 119552A2
Authority
AR
Argentina
Prior art keywords
acetygalactosamine
sulfatase
production
active human
highly phosphorylated
Prior art date
Application number
ARP200102165A
Other languages
English (en)
Inventor
Michel Claude Vellard
Augustus O Okhamafe
Kidisti Araya
Vish Koppaka
Original Assignee
Biomarin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Publication of AR119552A2 publication Critical patent/AR119552A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06004—N-Acetylgalactosamine-6-sulfatase (3.1.6.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente proporciona composiciones de la N-aceltigalactosamina-6-sulfatasa (GALNS) humana activa altamente fosforilada y las composiciones y formulaciones farmacéuticas que la incluyen, los métodos para la producción y purificación de GALNS y su uso en el diagnóstico, profilaxis o tratamiento de enfermedades y condiciones, lo que en particular incluye las enfermedades por almacenamiento lisosomal que son ocasionadas por o están asociadas con una deficiencia en la enzima GALNS, por ejemplo, la Mucopolisacaridosis IVa (MPS IVa o síndrome de Morquio A).
ARP200102165A 2010-07-22 2020-07-31 Producción de una n-acetilgalactosamina-6-sulfatasa humana activa altamente fosforilada y sus usos AR119552A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36671410P 2010-07-22 2010-07-22

Publications (1)

Publication Number Publication Date
AR119552A2 true AR119552A2 (es) 2021-12-29

Family

ID=44543776

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP110102649A AR082319A1 (es) 2010-07-22 2011-07-21 Produccion de una n-acetilgalactosamina-6-sulfatasa humana activa altamente fosforilada y sus usos
ARP200102165A AR119552A2 (es) 2010-07-22 2020-07-31 Producción de una n-acetilgalactosamina-6-sulfatasa humana activa altamente fosforilada y sus usos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP110102649A AR082319A1 (es) 2010-07-22 2011-07-21 Produccion de una n-acetilgalactosamina-6-sulfatasa humana activa altamente fosforilada y sus usos

Country Status (28)

Country Link
US (3) US8765437B2 (es)
EP (1) EP2595650B1 (es)
JP (2) JP6030553B2 (es)
KR (2) KR101949906B1 (es)
CN (1) CN103037895B (es)
AR (2) AR082319A1 (es)
AU (1) AU2011280937B2 (es)
BR (1) BR112013001558B1 (es)
CA (2) CA2805673C (es)
CL (2) CL2013000219A1 (es)
CY (1) CY1118934T1 (es)
DK (1) DK2595650T3 (es)
ES (1) ES2616263T3 (es)
HR (1) HRP20170245T1 (es)
HU (1) HUE033163T2 (es)
IL (2) IL224125B (es)
LT (1) LT2595650T (es)
MX (1) MX341838B (es)
PE (3) PE20171799A1 (es)
PL (1) PL2595650T3 (es)
PT (1) PT2595650T (es)
RS (1) RS55669B1 (es)
RU (1) RU2607376C2 (es)
SG (1) SG187580A1 (es)
SI (1) SI2595650T1 (es)
SM (2) SMT201700106T1 (es)
WO (1) WO2012012718A2 (es)
ZA (1) ZA201300286B (es)

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US20130202633A1 (en) * 2012-02-07 2013-08-08 Saint Louis University, A Non-Profit Organization Determination of immunogenic peptides in lysosomal enzymes and induction of oral tolerance
KR101380740B1 (ko) 2012-06-29 2014-04-11 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 이듀로네이트-2-설파타제의 정제
US11529397B2 (en) 2018-01-22 2022-12-20 Saint Louis University Method of treating mucopolysaccharidosis type IVA
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CN109071634A (zh) 2016-04-26 2018-12-21 R.P.谢勒技术有限责任公司 抗体偶联物及其制备和使用方法
US11584777B2 (en) 2017-08-31 2023-02-21 Green Cross Corporation Method for purifying a sulfatase protein
CA3101659A1 (en) * 2018-05-30 2019-12-05 Esteve Pharmaceuticals, S.A. Adenoassociated virus vectors for the treatment of mucopolysaccharidoses type iv a
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WO2021216460A1 (en) * 2020-04-19 2021-10-28 Figene, Llc Gene modified fibroblasts for therapeutic applications
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TW202403043A (zh) * 2022-03-18 2024-01-16 美商健臻公司 重組人類酸性鞘磷脂酶醫藥組合物及方法

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Also Published As

Publication number Publication date
RS55669B1 (sr) 2017-06-30
DK2595650T3 (en) 2017-02-27
IL224125B (en) 2019-02-28
EP2595650A2 (en) 2013-05-29
RU2607376C2 (ru) 2017-01-10
US8940513B2 (en) 2015-01-27
WO2012012718A2 (en) 2012-01-26
HUE033163T2 (en) 2017-11-28
WO2012012718A3 (en) 2012-04-05
PL2595650T3 (pl) 2017-06-30
LT2595650T (lt) 2017-03-10
ZA201300286B (en) 2014-03-26
HRP20170245T1 (hr) 2017-04-21
CA2805673C (en) 2022-04-05
AU2011280937A1 (en) 2013-01-31
KR101949906B1 (ko) 2019-04-22
MX2013000908A (es) 2013-07-05
CN103037895A (zh) 2013-04-10
SMT201700106B (it) 2017-03-08
JP6030553B2 (ja) 2016-11-24
JP2016178950A (ja) 2016-10-13
US20140341878A1 (en) 2014-11-20
RU2013107765A (ru) 2014-08-27
CL2017000498A1 (es) 2017-11-24
PE20131140A1 (es) 2013-10-17
ES2616263T3 (es) 2017-06-12
BR112013001558B1 (pt) 2022-08-16
KR20150038715A (ko) 2015-04-08
EP2595650B1 (en) 2016-11-16
CA3146151A1 (en) 2012-01-26
BR112013001558A2 (pt) 2020-08-04
AR082319A1 (es) 2012-11-28
CN103037895B (zh) 2016-11-09
KR101598897B1 (ko) 2016-03-03
MX341838B (es) 2016-09-05
PE20171799A1 (es) 2017-12-28
AU2011280937B2 (en) 2016-06-09
KR20130105605A (ko) 2013-09-25
SI2595650T1 (sl) 2017-04-26
CL2013000219A1 (es) 2014-07-11
PE20171798A1 (es) 2017-12-28
US8765437B2 (en) 2014-07-01
CA2805673A1 (en) 2012-01-26
US20120189605A1 (en) 2012-07-26
JP2013532986A (ja) 2013-08-22
US20160186149A1 (en) 2016-06-30
SG187580A1 (en) 2013-03-28
PT2595650T (pt) 2017-02-22
IL260282A (en) 2018-07-31
US9567572B2 (en) 2017-02-14
IL260282B (en) 2020-05-31
SMT201700106T1 (it) 2017-03-08
CY1118934T1 (el) 2018-01-10

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