AR115080A1 - Forma cristalina de tetracloruro de trietilentetramina y usos farmacéuticos de la misma - Google Patents

Forma cristalina de tetracloruro de trietilentetramina y usos farmacéuticos de la misma

Info

Publication number
AR115080A1
AR115080A1 ARP190101194A ARP190101194A AR115080A1 AR 115080 A1 AR115080 A1 AR 115080A1 AR P190101194 A ARP190101194 A AR P190101194A AR P190101194 A ARP190101194 A AR P190101194A AR 115080 A1 AR115080 A1 AR 115080A1
Authority
AR
Argentina
Prior art keywords
crystalline form
tetrachloride
trietilethetramine
pharmaceutical uses
triethylenetetramine tetrachloride
Prior art date
Application number
ARP190101194A
Other languages
English (en)
Inventor
Naseem Amin
Ronnie Maxwell Lawrence
Timothy James Morley
Original Assignee
Gmp Orphan Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62455418&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR115080(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gmp Orphan Sa filed Critical Gmp Orphan Sa
Publication of AR115080A1 publication Critical patent/AR115080A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/84—Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Una forma cristalina de tetracloruro de trietilentetramina que tiene estabilidad mejorada a temperatura ambiente respecto a formas conocidas y respecto a la sal dicloruro. La forma cristalina se caracteriza por tener picos en un espectro de XRPD a 22,9, 25,4, 25,8, 26,6, 34,6 y 35,3 ± 0,1º2q y desplazamientos de Raman 943, 1173, 1527 y 1612 ± 5 cm⁻¹. La forma cristalina de tetracloruro de trietilentetramina es útil en el tratamiento de la enfermedad de Wilson.
ARP190101194A 2018-05-04 2019-05-06 Forma cristalina de tetracloruro de trietilentetramina y usos farmacéuticos de la misma AR115080A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18290048 2018-05-04

Publications (1)

Publication Number Publication Date
AR115080A1 true AR115080A1 (es) 2020-11-25

Family

ID=62455418

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190101194A AR115080A1 (es) 2018-05-04 2019-05-06 Forma cristalina de tetracloruro de trietilentetramina y usos farmacéuticos de la misma

Country Status (16)

Country Link
US (4) US10988436B2 (es)
EP (1) EP3652145A1 (es)
JP (1) JP2021531322A (es)
KR (1) KR20210005270A (es)
CN (2) CN114394904A (es)
AR (1) AR115080A1 (es)
AU (1) AU2019263969A1 (es)
CA (1) CA3096423A1 (es)
CO (1) CO2020013806A2 (es)
DE (1) DE19724752T1 (es)
EA (1) EA202092241A1 (es)
ES (1) ES2769049T1 (es)
MA (2) MA51919A1 (es)
SG (1) SG11202010785UA (es)
TW (1) TW202002956A (es)
WO (1) WO2019211464A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19724752T1 (de) 2018-05-04 2020-07-09 Gmp-Orphan Sa Kristalline form von triethylentetramin-tetrahydrochlorid und seine pharmazeutische verwendung
KR102489293B1 (ko) * 2020-10-15 2023-01-17 (주) 에프엔지리서치 공업용 등급의 트리에틸렌테트라민의 고순도 정제 방법
WO2022229154A1 (en) 2021-04-26 2022-11-03 Orphalan S.A. Non-ceruloplasmin bound copper level monitoring
CN116675607A (zh) * 2022-02-23 2023-09-01 裕捷股份有限公司 一种三亚乙基四胺四氢氯化物及其制备方法与组合物
TWI819502B (zh) * 2022-02-23 2023-10-21 裕捷股份有限公司 一種三伸乙基四胺四氫氯化物及其製備方法與組合物
WO2024018394A1 (en) * 2022-07-19 2024-01-25 Biophore India Pharmaceuticals Pvt. Ltd A process for the preparation of crystalline form a of n, n'-bis(2-aminoethyl)-1,2-ethanediamine tetrahydrochloride

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1078731A (en) 1976-12-16 1980-06-03 Charles E. Frosst And Co. Skeletal imaging kit utilizing triethylene tetramine hexa (methylene phosphonic acid)
CS197093B1 (cs) * 1978-06-16 1980-04-30 Ivo Kuhr Způsob přípravy čistého dihydrochloridu triethylentetraminu
DE19724752A1 (de) 1997-04-24 1998-11-05 Boehringer Mannheim Gmbh Verwendung von Carbazolyl-(4)-oxy-propanolamin-Derivaten zur topischen Behandlung von Entzündungen und Wunden der Haut
WO1999051213A2 (en) 1998-04-03 1999-10-14 Theodore Toney Ilenchuk The use of polyamines in the treatment of dermatological symptoms
JP4369003B2 (ja) 2000-02-23 2009-11-18 ハリマ化成株式会社 ハンダ付け用フラックス
DK2500018T3 (en) 2002-03-08 2017-10-02 Philera New Zealand Ltd Prevention and / or treatment of cardiovascular disease and / or associated heart failure
WO2003075910A1 (en) 2002-03-08 2003-09-18 Protemix Corporation Limited Preventing and/or treating vascular disease, cardiomyopathy and/or associated heart failure
WO2004017957A1 (en) 2002-08-20 2004-03-04 Protemix Corporation Limited Preventing and/or treating cardiovascular disease and/or associated heart failure
NZ545724A (en) 2003-03-18 2007-11-30 Protemix Corp Ltd Use of a copper chelator for preventing and/or treating cardiovascular disease and/or associated heart failure
EP1778618B1 (en) 2004-07-19 2013-12-25 PhilERA New Zealand Limited Synthesis of triethylenetetramines
CN106278907B (zh) * 2014-12-17 2019-06-21 四川科瑞德凯华制药有限公司 一种盐酸曲恩汀化合物
JP6326477B2 (ja) 2015-12-25 2018-05-16 三洋化成工業株式会社 高分子凝集剤
DE19724752T1 (de) 2018-05-04 2020-07-09 Gmp-Orphan Sa Kristalline form von triethylentetramin-tetrahydrochlorid und seine pharmazeutische verwendung
WO2020006027A1 (en) 2018-06-29 2020-01-02 Sharp Laboratories Of America, Inc. Ultra-reliability design for physical uplink control channel (pucch) in 5th generation (5g) new radio (nr)
CN109076617B (zh) 2018-07-25 2022-08-19 北京小米移动软件有限公司 Mtc系统的随机接入方法、装置及存储介质
TWI819502B (zh) 2022-02-23 2023-10-21 裕捷股份有限公司 一種三伸乙基四胺四氫氯化物及其製備方法與組合物

Also Published As

Publication number Publication date
US11117855B2 (en) 2021-09-14
EP3652145A1 (en) 2020-05-20
CO2020013806A2 (es) 2021-01-29
US11072577B2 (en) 2021-07-27
JP2021531322A (ja) 2021-11-18
DE19724752T1 (de) 2020-07-09
BR112020018451A2 (pt) 2020-12-29
US20200392068A1 (en) 2020-12-17
ES2769049T1 (es) 2020-06-24
MA51919A1 (fr) 2021-11-30
US20220169594A1 (en) 2022-06-02
SG11202010785UA (en) 2020-11-27
US20210188761A1 (en) 2021-06-24
WO2019211464A1 (en) 2019-11-07
KR20210005270A (ko) 2021-01-13
EA202092241A1 (ru) 2021-04-01
MA58726A1 (fr) 2023-09-27
CA3096423A1 (en) 2019-11-07
US20210163398A1 (en) 2021-06-03
CN114394904A (zh) 2022-04-26
TW202002956A (zh) 2020-01-16
AU2019263969A1 (en) 2020-10-22
US10988436B2 (en) 2021-04-27
CN111479798A (zh) 2020-07-31

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