SG10201903621SA - Tricyclic atropisomer compounds - Google Patents
Tricyclic atropisomer compoundsInfo
- Publication number
- SG10201903621SA SG10201903621SA SG10201903621SA SG10201903621SA SG10201903621SA SG 10201903621S A SG10201903621S A SG 10201903621SA SG 10201903621S A SG10201903621S A SG 10201903621SA SG 10201903621S A SG10201903621S A SG 10201903621SA SG 10201903621S A SG10201903621S A SG 10201903621SA
- Authority
- SG
- Singapore
- Prior art keywords
- compounds
- tricyclic
- atropisomer
- disclosed
- atropisomer compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102000001714 Agammaglobulinaemia Tyrosine Kinase Human genes 0.000 abstract 1
- 108010029445 Agammaglobulinaemia Tyrosine Kinase Proteins 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/47—Quinolines; Isoquinolines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C07—ORGANIC CHEMISTRY
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
TRICYCLIC ATROPISOMER COMPOUNDS Disclosed are compounds of Formula (I): (I) 5 or a salt thereof, wherein Q is: , , R4 N O R5 , or ; and X, R1a, R1b, R3, R4, and R5 are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, 10 preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease. [No Figure]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201462068244P | 2014-10-24 | 2014-10-24 |
Publications (1)
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SG10201903621SA true SG10201903621SA (en) | 2019-05-30 |
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ID=54477309
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SG10201903621SA SG10201903621SA (en) | 2014-10-24 | 2015-10-23 | Tricyclic atropisomer compounds |
SG11201703186RA SG11201703186RA (en) | 2014-10-24 | 2015-10-23 | Tricyclic atropisomer compounds |
Family Applications After (1)
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SG11201703186RA SG11201703186RA (en) | 2014-10-24 | 2015-10-23 | Tricyclic atropisomer compounds |
Country Status (14)
Country | Link |
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US (1) | US10023534B2 (en) |
EP (1) | EP3209652B1 (en) |
JP (1) | JP6592512B2 (en) |
KR (1) | KR102519536B1 (en) |
CN (1) | CN107108555B (en) |
AU (1) | AU2015335783B2 (en) |
BR (1) | BR112017007563A2 (en) |
CA (1) | CA2965516A1 (en) |
EA (1) | EA031614B1 (en) |
ES (1) | ES2800173T3 (en) |
IL (1) | IL251801A0 (en) |
MX (1) | MX2017005060A (en) |
SG (2) | SG10201903621SA (en) |
WO (1) | WO2016065222A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
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PT3209651T (en) * | 2014-10-24 | 2019-12-30 | Bristol Myers Squibb Co | Carbazole derivatives |
CA2965516A1 (en) * | 2014-10-24 | 2016-04-28 | Bristol-Myers Squibb Company | Tricyclic atropisomer compounds |
KR102545594B1 (en) | 2018-07-31 | 2023-06-21 | 록쏘 온콜로지, 인코포레이티드 | (S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl Spray-dried dispersions and formulations of )-1H-pyrazole-4-carboxamide |
CN114364798A (en) | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | Combination of Dbait molecules with kinase inhibitors for the treatment of cancer |
AU2020378630A1 (en) | 2019-11-08 | 2022-05-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
BR112022020342A2 (en) * | 2020-04-10 | 2022-12-13 | Gb005 Inc | KINASE INHIBITORS |
WO2022140246A1 (en) | 2020-12-21 | 2022-06-30 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
US11773092B1 (en) | 2023-03-27 | 2023-10-03 | King Faisal University | Pyrido[3,4-b]indol-1-one compounds as antibacterial agents |
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-
2015
- 2015-10-23 CA CA2965516A patent/CA2965516A1/en not_active Abandoned
- 2015-10-23 KR KR1020177013608A patent/KR102519536B1/en active IP Right Grant
- 2015-10-23 EP EP15791146.2A patent/EP3209652B1/en active Active
- 2015-10-23 CN CN201580070254.3A patent/CN107108555B/en active Active
- 2015-10-23 WO PCT/US2015/057046 patent/WO2016065222A1/en active Application Filing
- 2015-10-23 MX MX2017005060A patent/MX2017005060A/en unknown
- 2015-10-23 AU AU2015335783A patent/AU2015335783B2/en not_active Ceased
- 2015-10-23 US US15/521,201 patent/US10023534B2/en active Active
- 2015-10-23 EA EA201790870A patent/EA031614B1/en not_active IP Right Cessation
- 2015-10-23 SG SG10201903621SA patent/SG10201903621SA/en unknown
- 2015-10-23 BR BR112017007563A patent/BR112017007563A2/en not_active Application Discontinuation
- 2015-10-23 JP JP2017522121A patent/JP6592512B2/en active Active
- 2015-10-23 SG SG11201703186RA patent/SG11201703186RA/en unknown
- 2015-10-23 ES ES15791146T patent/ES2800173T3/en active Active
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2017
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US20170355673A1 (en) | 2017-12-14 |
IL251801A0 (en) | 2017-06-29 |
WO2016065222A1 (en) | 2016-04-28 |
EP3209652A1 (en) | 2017-08-30 |
EP3209652B1 (en) | 2020-04-15 |
AU2015335783A1 (en) | 2017-06-08 |
MX2017005060A (en) | 2017-07-05 |
CN107108555B (en) | 2020-12-01 |
BR112017007563A2 (en) | 2017-12-19 |
KR102519536B1 (en) | 2023-04-06 |
KR20170068596A (en) | 2017-06-19 |
JP2017531680A (en) | 2017-10-26 |
AU2015335783B2 (en) | 2019-10-03 |
SG11201703186RA (en) | 2017-05-30 |
CN107108555A (en) | 2017-08-29 |
JP6592512B2 (en) | 2019-10-16 |
EA201790870A1 (en) | 2017-08-31 |
CA2965516A1 (en) | 2016-04-28 |
EA031614B1 (en) | 2019-01-31 |
ES2800173T3 (en) | 2020-12-28 |
US10023534B2 (en) | 2018-07-17 |
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