AR108847A1 - GENERACIÓN DE CÉLULAS MADRE PLURIPOTENTES HUMANAS DERIVADAS DE CÉLULAS FUNCIONALES b CON RESPIRACIÓN MITOCONDRIAL DEPENDIENTE DE GLUCOSA Y CON RESPUESTA EN DOS FASES DE SECRECIÓN DE INSULINA - Google Patents
GENERACIÓN DE CÉLULAS MADRE PLURIPOTENTES HUMANAS DERIVADAS DE CÉLULAS FUNCIONALES b CON RESPIRACIÓN MITOCONDRIAL DEPENDIENTE DE GLUCOSA Y CON RESPUESTA EN DOS FASES DE SECRECIÓN DE INSULINAInfo
- Publication number
- AR108847A1 AR108847A1 ARP170101710A ARP170101710A AR108847A1 AR 108847 A1 AR108847 A1 AR 108847A1 AR P170101710 A ARP170101710 A AR P170101710A AR P170101710 A ARP170101710 A AR P170101710A AR 108847 A1 AR108847 A1 AR 108847A1
- Authority
- AR
- Argentina
- Prior art keywords
- glucose
- cells
- insulin secretion
- mitocondrial
- phases
- Prior art date
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title abstract 3
- 239000008103 glucose Substances 0.000 title abstract 3
- 230000001419 dependent effect Effects 0.000 title abstract 2
- 230000003914 insulin secretion Effects 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 title 1
- 230000029058 respiratory gaseous exchange Effects 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 abstract 3
- 102100028096 Homeobox protein Nkx-6.2 Human genes 0.000 abstract 1
- 101000578254 Homo sapiens Homeobox protein Nkx-6.1 Proteins 0.000 abstract 1
- 101000578258 Homo sapiens Homeobox protein Nkx-6.2 Proteins 0.000 abstract 1
- 101000971533 Homo sapiens Killer cell lectin-like receptor subfamily G member 1 Proteins 0.000 abstract 1
- 101000979205 Homo sapiens Transcription factor MafA Proteins 0.000 abstract 1
- 101000939387 Homo sapiens Urocortin-3 Proteins 0.000 abstract 1
- 102100021457 Killer cell lectin-like receptor subfamily G member 1 Human genes 0.000 abstract 1
- 102100041030 Pancreas/duodenum homeobox protein 1 Human genes 0.000 abstract 1
- 101710183548 Pyridoxal 5'-phosphate synthase subunit PdxS Proteins 0.000 abstract 1
- 102100029794 Urocortin-3 Human genes 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 210000003890 endocrine cell Anatomy 0.000 abstract 1
- OGQSCIYDJSNCMY-UHFFFAOYSA-H iron(3+);methyl-dioxido-oxo-$l^{5}-arsane Chemical compound [Fe+3].[Fe+3].C[As]([O-])([O-])=O.C[As]([O-])([O-])=O.C[As]([O-])([O-])=O OGQSCIYDJSNCMY-UHFFFAOYSA-H 0.000 abstract 1
- 210000004153 islets of langerhan Anatomy 0.000 abstract 1
- 230000006540 mitochondrial respiration Effects 0.000 abstract 1
- 230000009996 pancreatic endocrine effect Effects 0.000 abstract 1
- 210000001778 pluripotent stem cell Anatomy 0.000 abstract 1
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
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- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662352968P | 2016-06-21 | 2016-06-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR108847A1 true AR108847A1 (es) | 2018-10-03 |
Family
ID=60659269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170101710A AR108847A1 (es) | 2016-06-21 | 2017-06-21 | GENERACIÓN DE CÉLULAS MADRE PLURIPOTENTES HUMANAS DERIVADAS DE CÉLULAS FUNCIONALES b CON RESPIRACIÓN MITOCONDRIAL DEPENDIENTE DE GLUCOSA Y CON RESPUESTA EN DOS FASES DE SECRECIÓN DE INSULINA |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US10633635B2 (enExample) |
| EP (2) | EP3472303B1 (enExample) |
| JP (4) | JP7044726B2 (enExample) |
| KR (5) | KR102376911B1 (enExample) |
| CN (2) | CN109415693B (enExample) |
| AR (1) | AR108847A1 (enExample) |
| AU (3) | AU2017282638C1 (enExample) |
| CA (1) | CA3027879A1 (enExample) |
| DK (1) | DK3472303T3 (enExample) |
| ES (1) | ES2939233T3 (enExample) |
| FI (1) | FI4194548T3 (enExample) |
| MA (2) | MA71715A (enExample) |
| RU (1) | RU2752499C2 (enExample) |
| SG (1) | SG11201810550WA (enExample) |
| TW (1) | TW201809266A (enExample) |
| WO (1) | WO2017222879A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL308120B2 (en) | 2017-06-14 | 2024-12-01 | Vertex Pharma | Devices and methods for delivering therapeutics |
| AU2018330499B2 (en) * | 2017-09-11 | 2025-01-30 | Novo Nordisk A/S | Enrichment of NKX6.1 and C-peptide co-expressing cells derived in vitro from stem cells |
| AU2018370029B2 (en) | 2017-11-15 | 2024-11-07 | Vertex Pharmaceuticals Incorporated | Islet cell manufacturing compositions and methods of use |
| IL277025B2 (en) * | 2018-03-02 | 2024-04-01 | Vertex Pharma | Methods of enhancing stem cell differentiation into beta cells |
| EP3786286A4 (en) * | 2018-04-27 | 2022-01-26 | Kaneka Corporation | PRODUCTION PROCESS FOR PANCREATIC BETA CELLS |
| WO2019217493A2 (en) * | 2018-05-07 | 2019-11-14 | President And Fellows Of Harvard College | Cell populations and gene expression associated with in vitro beta cell differentiation |
| US12421499B2 (en) | 2018-05-11 | 2025-09-23 | Cornell University | Method of differentiation of human pluripotent stem cells to monohormonal cells |
| AU2019320072A1 (en) | 2018-08-10 | 2021-02-25 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| CA3139585C (en) | 2019-05-31 | 2024-01-23 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
| AU2020283056B2 (en) | 2019-05-31 | 2023-06-08 | Viacyte, Inc. | A biocompatible membrane composite |
| US20220234006A1 (en) | 2019-05-31 | 2022-07-28 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
| CA3139292C (en) | 2019-05-31 | 2025-06-10 | Viacyte, Inc. | CELL ENCAPSULATION DEVICES WITH REGULATED OXYGEN DIFFUSION DISTANCES |
| CA3144948A1 (en) * | 2019-06-25 | 2020-12-30 | Vertex Pharmaceuticals Incorporated | Enhanced differentiation of beta cells |
| WO2020264172A1 (en) * | 2019-06-27 | 2020-12-30 | Dana-Farber Cancer Institute, Inc. | Compounds, compositions, and methods for protein degradation |
| CA3150233A1 (en) | 2019-09-05 | 2021-03-11 | Alireza Rezania | Universal donor cells |
| US20230014430A1 (en) * | 2019-11-20 | 2023-01-19 | Washington University | Methods and Compositions for Generating Functionally Mature Beta Cells and Uses Thereof |
| WO2021233116A1 (zh) * | 2020-05-21 | 2021-11-25 | 北京大学 | 多能干细胞的成分明确、无异源的培养系统 |
| EP4189067A4 (en) | 2020-07-31 | 2024-10-23 | Vertex Pharmaceuticals Incorporated | DIFFERENTIATION OF PANCREATIC ENDOCRINE CELLS |
| AU2021414405A1 (en) | 2020-12-31 | 2023-08-10 | Crispr Therapeutics Ag | Universal donor cells |
| CN114958726B (zh) * | 2021-02-23 | 2025-03-21 | 海门雨霖细胞科技有限责任公司 | 化学诱导成纤维细胞重编程为肺干细胞的化学小分子组合物及其应用 |
| US20240182864A1 (en) * | 2021-03-24 | 2024-06-06 | Salk Institute For Biological Studies | Novel chemical combinations and methods of use thereof, towards differentiation of human progenitor cells into functional beta cells |
| WO2022236173A1 (en) * | 2021-05-07 | 2022-11-10 | Mayo Foundation For Medical Education And Research | Treating liver disease |
| US20220403340A1 (en) * | 2021-06-11 | 2022-12-22 | Washington University | Media for cryopreserved cells and methods of making and using same |
| AU2022377078A1 (en) | 2021-11-01 | 2024-04-04 | Vertex Pharmaceuticals Incorporated | Stem cell derived pancreatic islet differentiation |
| CN114317401B (zh) * | 2021-12-07 | 2022-10-04 | 浙江大学 | 一种促进胰岛前体细胞长期稳定传代的方法 |
| KR102848180B1 (ko) * | 2021-12-15 | 2025-08-19 | 한국화학연구원 | 오로라 키나아제 억제제를 이용하는 심근세포 및 심장 오가노이드의 제조방법 |
| WO2025117331A1 (en) | 2023-12-01 | 2025-06-05 | Eli Lilly And Company | Methods of making stem cell-derived islet-like cells, as well as populations and compositions including the same |
| WO2025119299A1 (en) * | 2023-12-08 | 2025-06-12 | Hangzhou Reprogenix Bioscience, Inc. | Method for differentiating pancreatic beta cells |
| WO2025202874A1 (en) | 2024-03-25 | 2025-10-02 | Crispr Therapeutics Ag | Genetically modified cells expressing glp-1 receptor agonist |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| PL1641916T3 (pl) | 2003-06-27 | 2016-08-31 | Depuy Synthes Products Inc | Regeneracja i naprawa tkanki nerwowej z wykorzystaniem komórek poporodowych |
| SG149061A1 (en) | 2003-12-23 | 2009-01-29 | Cythera Inc | Definitive endoderm |
| WO2007059007A2 (en) * | 2005-11-14 | 2007-05-24 | Cythera, Inc. | Markers of definitive endoderm |
| US20050266554A1 (en) | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
| CN101589137B (zh) | 2005-03-31 | 2013-06-05 | 斯丹姆涅恩有限公司 | 羊膜来源的细胞组合物及其制备方法和用途 |
| AU2006202209B2 (en) | 2005-05-27 | 2011-04-14 | Lifescan, Inc. | Amniotic fluid derived cells |
| US7807459B2 (en) | 2005-09-27 | 2010-10-05 | Reneuron, Inc. | EphA4-positive human adult pancreatic endocrine progenitor cells |
| US7695965B2 (en) | 2006-03-02 | 2010-04-13 | Cythera, Inc. | Methods of producing pancreatic hormones |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| WO2008011518A2 (en) * | 2006-07-19 | 2008-01-24 | Diakine Therapeutics, Inc. | Encapsulation system |
| AU2007277364B2 (en) | 2006-07-26 | 2010-08-12 | Viacyte, Inc. | Methods of producing pancreatic hormones |
| CA2954431C (en) | 2007-11-27 | 2021-08-24 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic cells |
| US8338170B2 (en) | 2008-04-21 | 2012-12-25 | Viacyte, Inc. | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
| WO2009132083A2 (en) | 2008-04-22 | 2009-10-29 | President And Fellows Of Harvard College | Compositions and methods for promoting the generation of pdx1+ pancreatic cells |
| EP2942392B1 (en) | 2008-06-30 | 2018-10-03 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| RU2011103183A (ru) | 2008-06-30 | 2012-08-10 | Сентокор Орто Байотек Инк. (Us) | Дифференцирование плюрипотентных стволовых клеток |
| MX2011004565A (es) * | 2008-10-31 | 2011-07-28 | Centocor Ortho Biotech Inc | Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico. |
| US8895300B2 (en) | 2008-11-04 | 2014-11-25 | Viacyte, Inc. | Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof |
| US8008075B2 (en) | 2008-11-04 | 2011-08-30 | Viacyte, Inc. | Stem cell aggregate suspension compositions and methods of differentiation thereof |
| PL2494035T3 (pl) | 2009-10-29 | 2018-07-31 | Janssen Biotech, Inc. | Pluripotencjalne komórki macierzyste |
| MX343786B (es) | 2009-12-23 | 2016-11-22 | Janssen Biotech Inc | Diferenciacion de celulas madre embrionarias humanas. |
| NZ607608A (en) | 2010-08-09 | 2014-03-28 | Takeda Pharmaceuticals Co | Method of producing pancreatic hormone-producing cells |
| MX2014007744A (es) * | 2011-12-22 | 2015-01-12 | Janssen Biotech Inc | Diferenciacion de celulas madre embrionicas humanas en celulas individuales positivas de insulina hormonal. |
| DK3450542T3 (da) * | 2012-06-08 | 2021-11-01 | Janssen Biotech Inc | Differentiering af humane embryonale stamceller til endokrine pancreatiske celler |
| WO2014033322A1 (en) | 2012-09-03 | 2014-03-06 | Novo Nordisk A/S | Generation of pancreatic endoderm from pluripotent stem cells using small molecules |
| JP6316822B2 (ja) * | 2012-12-26 | 2018-04-25 | 国立大学法人京都大学 | 膵外分泌細胞の誘導方法 |
| ES2942484T3 (es) | 2012-12-31 | 2023-06-01 | Janssen Biotech Inc | Diferenciación de células madre embrionarias humanas en células endocrinas pancreáticas usando reguladores de HB9 |
| RU2687379C2 (ru) | 2012-12-31 | 2019-05-13 | Янссен Байотек, Инк. | Суспендирование и кластеризация плюрипотентных клеток человека с целью их дифференцировки в панкреатические эндокринные клетки |
| US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
| US10344264B2 (en) | 2012-12-31 | 2019-07-09 | Janssen Biotech, Inc. | Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells |
| US20140329704A1 (en) * | 2013-03-28 | 2014-11-06 | President And Fellows Of Harvard College | Markers for mature beta-cells and methods of using the same |
| DE112014002780B4 (de) * | 2013-06-11 | 2025-05-22 | President And Fellows Of Harvard College | SC-ß-Zellen und Zusammensetzungen und Verfahren zur Erzeugung der Zellen |
| JP6588969B2 (ja) | 2014-05-16 | 2019-10-09 | ヤンセン バイオテツク，インコーポレーテツド | 膵内分泌細胞内のｍａｆａ発現を強化するための小分子の使用 |
| WO2017120543A1 (en) * | 2016-01-08 | 2017-07-13 | Massachusetts Institute Of Technology | Production of differentiated enteroendocrine cells and insulin producing cells |
| MA45747A (fr) * | 2016-02-24 | 2019-01-02 | Novo Nordisk As | Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humaines |
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