MA71715B1 - Génération de cellules bêta fonctionnelles dérivées de cellules souches pluripotentes humaines présentant une réponse de respiration mitochondriale dépendant du glucose et de sécrétion d'insuline en deux phases - Google Patents

Génération de cellules bêta fonctionnelles dérivées de cellules souches pluripotentes humaines présentant une réponse de respiration mitochondriale dépendant du glucose et de sécrétion d'insuline en deux phases

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Publication number
MA71715B1
MA71715B1 MA71715A MA71715A MA71715B1 MA 71715 B1 MA71715 B1 MA 71715B1 MA 71715 A MA71715 A MA 71715A MA 71715 A MA71715 A MA 71715A MA 71715 B1 MA71715 B1 MA 71715B1
Authority
MA
Morocco
Prior art keywords
glucose
beta cells
pluripotent stem
insulin secretion
generation
Prior art date
Application number
MA71715A
Other languages
English (en)
French (fr)
Other versions
MA71715A (fr
Inventor
Sebastian Rieck
Alireza Rezania
Original Assignee
Janssen Biotech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech, Inc. filed Critical Janssen Biotech, Inc.
Publication of MA71715A publication Critical patent/MA71715A/fr
Publication of MA71715B1 publication Critical patent/MA71715B1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K35/39—Pancreas; Islets of Langerhans
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
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MA71715A 2016-06-21 2017-06-14 Génération de cellules bêta fonctionnelles dérivées de cellules souches pluripotentes humaines présentant une réponse de respiration mitochondriale dépendant du glucose et de sécrétion d'insuline en deux phases MA71715B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662352968P 2016-06-21 2016-06-21
EP22213072.6A EP4194548B1 (en) 2016-06-21 2017-06-14 Generation of human pluripotent stem cell derived functional beta cells showing a glucose-dependent mitochondrial respiration and two-phase insulin secretion response

Publications (2)

Publication Number Publication Date
MA71715A MA71715A (fr) 2025-05-30
MA71715B1 true MA71715B1 (fr) 2026-01-30

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Application Number Title Priority Date Filing Date
MA71715A MA71715B1 (fr) 2016-06-21 2017-06-14 Génération de cellules bêta fonctionnelles dérivées de cellules souches pluripotentes humaines présentant une réponse de respiration mitochondriale dépendant du glucose et de sécrétion d'insuline en deux phases
MA045502A MA45502A (fr) 2016-06-21 2017-06-14 Génération de cellules bêta fonctionnelles dérivées de cellules souches pluripotentes humaines ayant une respiration mitochondriale glucose-dépendante et une réponse en sécrétion d'insuline en deux phases

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MA045502A MA45502A (fr) 2016-06-21 2017-06-14 Génération de cellules bêta fonctionnelles dérivées de cellules souches pluripotentes humaines ayant une respiration mitochondriale glucose-dépendante et une réponse en sécrétion d'insuline en deux phases

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HR (1) HRP20260022T1 (enExample)
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MA (2) MA71715B1 (enExample)
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PT (1) PT4194548T (enExample)
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SG11202001906PA (en) * 2017-09-11 2020-04-29 Novo Nordisk As Enrichment of nkx6.1 and c-peptide co-expressing cells derived in vitro from stem cells
WO2019099725A1 (en) 2017-11-15 2019-05-23 Semma Therapeutics, Inc. Islet cell manufacturing compositions and methods of use
WO2019169351A1 (en) * 2018-03-02 2019-09-06 Semma Therapeutics, Inc. Methods of enhancing stem cell differentiation into beta cells
WO2019208788A1 (ja) * 2018-04-27 2019-10-31 株式会社カネカ 膵臓β細胞の製造方法
JP2021522819A (ja) * 2018-05-07 2021-09-02 プレジデント アンド フェローズ オブ ハーバード カレッジ インビトロベータ細胞分化に関連する細胞集団および遺伝子発現
WO2019217875A1 (en) * 2018-05-11 2019-11-14 Cornell University Method of differentiation of human pluripotent stem cells to monohormonal cells
EP3833365A4 (en) * 2018-08-10 2022-05-11 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
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