WO2010121122A3 - Biomechanical induction of hematopoiesis - Google Patents

Biomechanical induction of hematopoiesis Download PDF

Info

Publication number
WO2010121122A3
WO2010121122A3 PCT/US2010/031382 US2010031382W WO2010121122A3 WO 2010121122 A3 WO2010121122 A3 WO 2010121122A3 US 2010031382 W US2010031382 W US 2010031382W WO 2010121122 A3 WO2010121122 A3 WO 2010121122A3
Authority
WO
WIPO (PCT)
Prior art keywords
hematopoiesis
cells
biomechanical
induction
hematopoietic progenitor
Prior art date
Application number
PCT/US2010/031382
Other languages
French (fr)
Other versions
WO2010121122A2 (en
Inventor
George Daley
Olaia Naveiras
Guillermo Garcia-Cardena
Luigi Adamo
Original Assignee
The Brigham And Women's Hospital, Inc.
Children's Medical Center Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Brigham And Women's Hospital, Inc., Children's Medical Center Corporation filed Critical The Brigham And Women's Hospital, Inc.
Priority to US13/264,898 priority Critical patent/US20120195862A1/en
Publication of WO2010121122A2 publication Critical patent/WO2010121122A2/en
Publication of WO2010121122A3 publication Critical patent/WO2010121122A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces

Abstract

The present invention provides methods and compositions for increasing the hematopoietic potential of a population of hematopoietic progenitor cells, vascular cells, and or hemogenic endothelium, by exposing the cells to at least one external biomechanical stimulus. More specifically, the application of shear stress to hematopoietic progenitor cells or endothelial cells stimulates hematopoiesis, with or without concurrent application of other extrinsic modulators of hematopoiesis.
PCT/US2010/031382 2009-04-17 2010-04-16 Biomechanical induction of hematopoiesis WO2010121122A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/264,898 US20120195862A1 (en) 2009-04-17 2010-04-16 Biomechanical induction of hematopoiesis

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US17048009P 2009-04-17 2009-04-17
US61/170,480 2009-04-17
US17249209P 2009-04-24 2009-04-24
US61/172,492 2009-04-24
US17824709P 2009-05-14 2009-05-14
US61/178,247 2009-05-14

Publications (2)

Publication Number Publication Date
WO2010121122A2 WO2010121122A2 (en) 2010-10-21
WO2010121122A3 true WO2010121122A3 (en) 2011-03-31

Family

ID=42983161

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/031382 WO2010121122A2 (en) 2009-04-17 2010-04-16 Biomechanical induction of hematopoiesis

Country Status (2)

Country Link
US (1) US20120195862A1 (en)
WO (1) WO2010121122A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010096264A2 (en) * 2009-02-03 2010-08-26 Children's Medical Center Corporation Methods for enhancing hematopoietic stem/progenitor cell engraftment
WO2010091052A2 (en) 2009-02-03 2010-08-12 Children's Medical Center Corporation Methods for enhancing hematopoietic stem/progenitor cell engraftment
WO2014190541A1 (en) * 2013-05-31 2014-12-04 中国科学院深圳先进技术研究院 Wall shear stress phase angle measurement method and system
US10538738B2 (en) 2014-05-19 2020-01-21 Eleftherios Papoutsakis Megakaryocytic particles and microparticles for cell therapy and fate modification of stem and progenitor cells
ES2964374T3 (en) * 2016-03-17 2024-04-05 Synova Life Sciences Inc Isolation of stem cells from adipose tissue
JP2021527397A (en) * 2018-06-07 2021-10-14 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． Methods for producing hematopoietic stem cells
US20230256029A1 (en) * 2020-06-25 2023-08-17 Angiocrine Bioscience, Inc. Endothelial cells for mitigation of chemotherapy-induced toxicity

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605822A (en) * 1989-06-15 1997-02-25 The Regents Of The University Of Michigan Methods, compositions and devices for growing human hematopoietic cells
US20050031598A1 (en) * 2002-12-10 2005-02-10 Shulamit Levenberg Engineering three-dimensional tissue structures using differentiating embryonic stem cells
WO2007112084A2 (en) * 2006-03-24 2007-10-04 Children's Medical Center Corporation Method to modulate hematopoietic stem cell growth

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001643A (en) * 1997-08-04 1999-12-14 C-Med Inc. Controlled hydrodynamic cell culture environment for three dimensional tissue growth
US7354763B2 (en) * 2002-04-16 2008-04-08 Technion Research & Development Foundation Ltd. Generating vascular smooth muscle cells in vitro from ES cells

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605822A (en) * 1989-06-15 1997-02-25 The Regents Of The University Of Michigan Methods, compositions and devices for growing human hematopoietic cells
US20020022270A1 (en) * 1989-06-15 2002-02-21 The Regents Of The University Of Michigan Methods, compositions and devices for growing hematopoietics cells
US20050031598A1 (en) * 2002-12-10 2005-02-10 Shulamit Levenberg Engineering three-dimensional tissue structures using differentiating embryonic stem cells
WO2007112084A2 (en) * 2006-03-24 2007-10-04 Children's Medical Center Corporation Method to modulate hematopoietic stem cell growth

Also Published As

Publication number Publication date
US20120195862A1 (en) 2012-08-02
WO2010121122A2 (en) 2010-10-21

Similar Documents

Publication Publication Date Title
WO2010121122A3 (en) Biomechanical induction of hematopoiesis
WO2010141801A3 (en) Reprogramming t cells and hematophietic cells
PH12015501470A1 (en) Compositions and methods for the control of nematodes and soil borne diseases
NZ622566A (en) Chromobacterium bioactive compositions and metabolites
UA104005C2 (en) 2-oxo-1,2-dihydro-quinoline modulators of immune function
EA201590590A1 (en) ANDROGEN RECEPTOR MODULATORS AND THEIR APPLICATION
WO2010079468A3 (en) Delivery particle
UA109123C2 (en) PROBIOTIC COMPOSITION FOR THE APPLICATION IN THE TREATMENT OF INTESTINAL INFLAMMATION
JO3118B1 (en) Compositions and methods for antibodies targeting complement protein c5
WO2010084480A3 (en) Delivery particles
WO2010079467A3 (en) Delivery particles
WO2010079466A3 (en) Delivery particles
EP2569330A4 (en) Chlorotoxin variants, conjugates, and methods for their use
WO2008121894A3 (en) Endogenous expression of hla-g and/or hla-e by mesenchymal cells
EP2558124A4 (en) Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
WO2011140341A3 (en) Cosmetic compositions containing acrylic thickener
MX2012004078A (en) Compounds and compositions as modulators of gpr119 activity.
WO2010147830A3 (en) Aminothiazole modulators of beta-3-adrenoreceptor
MX336787B (en) Genetically engineered microorganisms comprising 4-hydroxybenzoly-coa thioesterases and methods of using the same for producing free fatty acids and fatty acid derivatives.
LT2013016A (en) A method of increasing the effect of an activated-potentiated form of an antibody
AU2010286532A8 (en) Methods of treatment using anti-oxidized LDL antibodies
IN2012DN03404A (en)
MX2014004439A (en) Denture adhesive compositions.
MX2014006574A (en) Acamprosate formulations, methods of using the same, and combinations comprising the same.
RS54412B1 (en) Honey composition with l-alanyl-l-glutamine

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10765253

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 13264898

Country of ref document: US

122 Ep: pct application non-entry in european phase

Ref document number: 10765253

Country of ref document: EP

Kind code of ref document: A2