RU2752499C2 - Генерация функциональных бета-клеток, полученных из человеческой плюрипотентной стволовой клетки, демонстрирующих реакцию в виде глюкозозависимого митохондриального дыхания и двухфазной секреции инсулина - Google Patents

Генерация функциональных бета-клеток, полученных из человеческой плюрипотентной стволовой клетки, демонстрирующих реакцию в виде глюкозозависимого митохондриального дыхания и двухфазной секреции инсулина Download PDF

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RU2752499C2
RU2752499C2 RU2019101200A RU2019101200A RU2752499C2 RU 2752499 C2 RU2752499 C2 RU 2752499C2 RU 2019101200 A RU2019101200 A RU 2019101200A RU 2019101200 A RU2019101200 A RU 2019101200A RU 2752499 C2 RU2752499 C2 RU 2752499C2
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cells
medium
inhibitor
stage
cell
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RU2019101200A3 (enExample
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Себастьян РИК
Алиреза РЕЗАНИА
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Янссен Байотек, Инк.
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RU2019101200A 2016-06-21 2017-06-14 Генерация функциональных бета-клеток, полученных из человеческой плюрипотентной стволовой клетки, демонстрирующих реакцию в виде глюкозозависимого митохондриального дыхания и двухфазной секреции инсулина RU2752499C2 (ru)

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US201662352968P 2016-06-21 2016-06-21
US62/352,968 2016-06-21
PCT/US2017/037373 WO2017222879A1 (en) 2016-06-21 2017-06-14 Generation of human pluripotent stem cell derived functional beta cells showing a glucose-dependent mitochondrial respiration and two-phase insulin secretion response

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RU2019101200A3 RU2019101200A3 (enExample) 2021-01-18
RU2752499C2 true RU2752499C2 (ru) 2021-07-28

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IL308120B2 (en) 2017-06-14 2024-12-01 Vertex Pharma Devices and methods for delivering therapeutics
AU2018330499B2 (en) * 2017-09-11 2025-01-30 Novo Nordisk A/S Enrichment of NKX6.1 and C-peptide co-expressing cells derived in vitro from stem cells
AU2018370029B2 (en) 2017-11-15 2024-11-07 Vertex Pharmaceuticals Incorporated Islet cell manufacturing compositions and methods of use
IL277025B2 (en) * 2018-03-02 2024-04-01 Vertex Pharma Methods of enhancing stem cell differentiation into beta cells
EP3786286A4 (en) * 2018-04-27 2022-01-26 Kaneka Corporation PRODUCTION PROCESS FOR PANCREATIC BETA CELLS
WO2019217493A2 (en) * 2018-05-07 2019-11-14 President And Fellows Of Harvard College Cell populations and gene expression associated with in vitro beta cell differentiation
US12421499B2 (en) 2018-05-11 2025-09-23 Cornell University Method of differentiation of human pluripotent stem cells to monohormonal cells
AU2019320072A1 (en) 2018-08-10 2021-02-25 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
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