AR095183A1 - Derivados de azetidina como agentes antiparasitarios - Google Patents

Derivados de azetidina como agentes antiparasitarios

Info

Publication number
AR095183A1
AR095183A1 ARP130101605A ARP130101605A AR095183A1 AR 095183 A1 AR095183 A1 AR 095183A1 AR P130101605 A ARP130101605 A AR P130101605A AR P130101605 A ARP130101605 A AR P130101605A AR 095183 A1 AR095183 A1 AR 095183A1
Authority
AR
Argentina
Prior art keywords
alkyl
cyano
haloalkyl
hydroxyl
cycloalkyl
Prior art date
Application number
ARP130101605A
Other languages
English (en)
Inventor
M K Sheehan Susan
Vaillancourt Valerie
Original Assignee
Zoetis Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoetis Llc filed Critical Zoetis Llc
Publication of AR095183A1 publication Critical patent/AR095183A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/20—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom three- or four-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/44—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom three- or four-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Composiciones del mismo y su uso como parasiticidas en animales. Reivindicación1: Un compuesto caracterizado porque tiene la fórmula (1), en la que A es fenilo, naftilo o heteroarilo, en el que dicho heteroarilo contiene de 1 a 4 heteroátomos, cada uno seleccionado de forma independiente de N, O y S; B es un compuesto del grupo de fórmulas (2); en donde ~~~ representa el punto de unión; R¹ᵃ, R¹ᵇ y R¹ᶜ son, cada uno de forma independiente, hidrógeno, halógeno, hidroxilo, ciano, nitro, alquilo C₁₋₆, haloalquilo C₁₋₆, alcoxi C₁₋₆, alquilo C₀₋₃-cicloalquilo C₃₋₆, haloalcoxi C₁₋₆, -C(O)NH₂, -SF₅ o -S(O)ₚR; R² es halógeno, ciano, alquilo C₁₋₆, haloalquilo C₁₋₆, nitro, hidroxilo, -C(O)NRᵃRᵇ, alquenilo C₂₋₆, alquinilo C₂₋₆, -S(O)ₚR o -OR; R³ es hidrógeno, halógeno, hidroxilo, ciano, alquilo C₁₋₆, haloalquilo C₁₋₆, alquilo C₀₋₃-cicloalquilo C₃₋₆, -C(O)NH₂, nitro, -SC(O)R, -C(O)NRᵃRᵇ, alquilo C₀₋₃NRᵃR⁴, NRᵃNRᵇR⁴, NRᵃORᵇ, ONRᵃRᵇ, N₃, -NHR⁴, -OR o -S(O)ₚR; R⁴ es hidrógeno, alquilo C₁₋₆, alquilo C₀₋₆-cicloalquilo C₃₋₆, -C(O)R⁵, -C(S)R⁵, -C(O)NRᵃR⁵, -C(O)C(O)NRᵃR⁵, -S(O)ₚRᶜ, -S(O)₂NRᵃR⁵, -C(NR⁷)R⁵, -C(NR⁷)NRᵃR⁵, alquilfenilo C₀₋₆, alquilheteroarilo C₀₋₆ o alquilheterociclo C₀₋₆; R⁵ es hidrógeno, alquilo C₁₋₆, alquenilo C₂₋₆, alquilo C₀₋₆-cicloalquilo C₃₋₆, alquilfenilo C₀₋₆, alquilheteroarilo C₀₋₆ o alquilheterociclo C₀₋₆; R⁶ es ciano, alquilo C₁₋₆, haloalquilo C₁₋₆, -C(O)NRᵃRᵇ, alquenilo C₂₋₆, alquinilo C₂₋₆, haloalquenilo C₂₋₆ o haloalquinilo C₂₋₆; R⁷ es hidrógeno, alquilo C₁₋₆, hidroxilo, ciano, nitro, -S(O)ₚRᶜ o alcoxi C₁₋₆; R⁸ es hidrógeno, alquilo C₁₋₆, hidroxilo, ciano, -S(O)ₚRᶜ o alcoxi C₁₋₆; R es alquilo C₁₋₆ o cicloalquilo C₃₋₆ cada uno sustituido opcionalmente con al menos un halógeno; Rᵃ es hidrógeno, alquilo C₁₋₆ o alquilo C₀₋₃-cicloalquilo C₃₋₆; en donde el alquilo y el alquilcicloalquilo están sustituidos opcionalmente con ciano o al menos un sustituyente halo; Rᵇ es hidrógeno, alquilo C₁₋₆, cicloalquilo C₃₋₆, alquilfenilo C₀₋₃, alquilheteroarilo C₀₋₃ o alquilheterociclo C₀₋₃, cada uno opcionalmente sustituido, cuando es químicamente posible, con al menos un sustituyente seleccionado de hidroxilo, ciano, halo o -S(O)ₙR; Rᶜ es alquilo C₁₋₆, haloalquilo C₁₋₆, haloalquilo C₁₋₆-cicloalquilo C₃₋₆, alquilo C₀₋₃-cicloalquilo C₃₋₆, alquilfenilo C₀₋₃, alquilheteroarilo C₀₋₃ o alquilheterociclo C₀₋₃ cada uno sustituido opcionalmente con al menos un sustituyente seleccionado de ciano, halo, hidroxilo, oxo, alquilo C₁₋₆, alcoxi C₁₋₆ haloalcoxi C₁₋₆, haloalquilo C₁₋₆, -S(O)ₚR, -SH, -S(O)ₚNRᵃRᵇ, -NRᵃRᵇ, -NRᵃC(O)Rᵇ, -SC(O)Rᵇ, -SCN o -C(O)NRᵃRᵇ; cada uno de R⁴ y R⁵ alquilo C₁₋₆ o alquilo C₀₋₆-cicloalquilo C₃₋₆ se pueden sustituir opcional e independientemente con al menos un sustituyente seleccionado de alquilo C₁₋₆ ciano, halo, hidroxilo, hidroxialquilo C₁₋₆ oxo, alcoxi C₁₋₆, haloalcoxi C₁₋₆, alquilo C₁₋₆, haloalquilo C₁₋₆, -S(O)ₚRᶜ, -SH, -S(O)ₚNRᵃRᵇ, -NRᵃRᵇ, -NRᵃC(O)Rᵇ, -SC(O)Rᶜ, -SCN o -C(O)NRᵃRᵇ; y en donde los restos R⁴ y R⁵, alquilfenilo C₀₋₆, alquilheteroarilo C₀₋₆ o alquilheterociclo C₀₋₆ pueden estar además opcionalmente sustituidos con al menos un sustituyente seleccionado de alquilo C₁₋₆, ciano, halo, oxo, =S, =NR⁷, hidroxilo, hidroxialquilo C₁₋₆, alcoxi C₁₋₆, alquilo C₁₋₆, haloalquilo C₁₋₆, -SH, -S(O)ₚR y haloalcoxi C₁₋₆; n es el número entero 0, 1 ó 2 y cuando n es 2, cada R² pueden ser idénticos o diferentes entre sí; y p es el número entero 0, 1 ó 2, estereoisómeros del mismo y sales farmacéutica o veterinariamente aceptables del mismo.
ARP130101605A 2012-05-09 2013-05-08 Derivados de azetidina como agentes antiparasitarios AR095183A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261644512P 2012-05-09 2012-05-09

Publications (1)

Publication Number Publication Date
AR095183A1 true AR095183A1 (es) 2015-09-30

Family

ID=48407836

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130101605A AR095183A1 (es) 2012-05-09 2013-05-08 Derivados de azetidina como agentes antiparasitarios

Country Status (13)

Country Link
US (1) US9073912B2 (es)
EP (1) EP2855457A1 (es)
JP (1) JP6049866B2 (es)
CN (1) CN104271568B (es)
AR (1) AR095183A1 (es)
AU (1) AU2013259847B2 (es)
BR (1) BR112014027805A2 (es)
CA (1) CA2872989A1 (es)
CL (1) CL2014002868A1 (es)
CO (1) CO7141427A2 (es)
MX (1) MX336431B (es)
WO (1) WO2013169622A1 (es)
ZA (1) ZA201407696B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11253499B2 (en) * 2017-08-16 2022-02-22 Glaxosmithkline Intellectual Property Development Limited Compounds
US20230365566A1 (en) * 2020-02-28 2023-11-16 Remix Therapeutics Inc. Heterocyclic amides and their use for modulating splicing
CN111388513A (zh) * 2020-04-14 2020-07-10 无锡派维药业科技有限公司 一种动物外用抗寄生物组合物及其制备方法
AU2022291768A1 (en) 2021-06-16 2023-11-30 Celgene Corporation Azetidinyl compounds comprising a carboxylic acid group for the treatment of neurodegenerative diseases

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10158250A (ja) * 1995-12-21 1998-06-16 Sumitomo Chem Co Ltd トリアゾール誘導体およびその用途
TW524667B (en) 1996-12-05 2003-03-21 Pfizer Parasiticidal pyrazoles
GB0329314D0 (en) 2003-12-18 2004-01-21 Pfizer Ltd Substituted arylpyrazoles
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
CN101331127B (zh) * 2005-12-16 2012-05-23 杜邦公司 用于防治无脊椎害虫的5-芳基异噁唑啉
JP2008266230A (ja) 2007-04-23 2008-11-06 Bayer Cropscience Ag 殺虫性アリールピロリジン類
CN102770419A (zh) 2010-02-22 2012-11-07 先正达参股股份有限公司 作为杀虫化合物的二氢呋喃衍生物
WO2011124998A1 (en) 2010-04-08 2011-10-13 Pfizer Inc. Substituted 3,5- di phenyl - isoxazoline derivatives as insecticides and acaricides
JP2011219431A (ja) 2010-04-13 2011-11-04 Bayer Cropscience Ag 新規アリールニトロアルカン誘導体
MX2012013130A (es) * 2010-05-13 2013-04-11 Amgen Inc Compuestos heterociclicos de nitrogeno utiles como inhibidores de pde10.
TW201211057A (en) 2010-06-11 2012-03-16 Syngenta Participations Ag Process for the preparation of dihydropyrrole derivatives
JP2012031148A (ja) 2010-06-28 2012-02-16 Nissan Chem Ind Ltd 動物の寄生虫防除剤
EP2601190B1 (en) * 2010-08-05 2018-07-04 Zoetis Services LLC Isoxazoline derivatives as antiparasitic agents
JP2012082186A (ja) 2010-09-15 2012-04-26 Bayer Cropscience Ag 殺虫性アリールピロリジン類
CA2863629A1 (en) * 2012-02-03 2013-08-08 Denis Billen Process for the preparation of chiral isoxazoline azetidine derivatives as antiparasitic agents
ES2571444T3 (es) * 2012-02-03 2016-05-25 Zoetis Services Llc Derivados de dihidrofurano-azetadina como agentes antiparasitarios

Also Published As

Publication number Publication date
CA2872989A1 (en) 2013-11-14
JP2015516424A (ja) 2015-06-11
CN104271568A (zh) 2015-01-07
CN104271568B (zh) 2016-05-04
WO2013169622A1 (en) 2013-11-14
US20150119377A1 (en) 2015-04-30
ZA201407696B (en) 2016-05-25
US9073912B2 (en) 2015-07-07
EP2855457A1 (en) 2015-04-08
AU2013259847A1 (en) 2014-10-30
BR112014027805A2 (pt) 2017-06-27
MX336431B (es) 2016-01-18
CL2014002868A1 (es) 2014-12-19
AU2013259847B2 (en) 2015-09-03
CO7141427A2 (es) 2014-12-12
JP6049866B2 (ja) 2016-12-21
MX2014013594A (es) 2014-12-04

Similar Documents

Publication Publication Date Title
AR118123A2 (es) Derivados de isoxazolidina, proceso para preparar dichos compuestos, composición farmacéutica y combinación
AR090862A1 (es) Compuestos de tetrazolinona y su uso para combatir plagas
AR061974A1 (es) Derivados de pirimidina como inhibidores de alk, composiciones farmaceuticas y procesos de obtencion
AR082562A1 (es) Derivados de isoxazolina como agentes antiparasitarios
UY38525A (es) 1,3,4-oxadiazoles y derivados de éstos como nuevos agentes fungicidas
AR100775A1 (es) Compuestos pesticidas y procedimientos relacionados con los mismos
AR095311A1 (es) 3-pirimidin-4-il-oxazolidin-2-onas como inhibidores de idh mutante
AR072906A1 (es) Nucleosidos modificados utiles como antivirales
CR20120302A (es) Derivados bencimidazol-imidazol
AR089143A1 (es) Triazolopiridinas sustituidas con actividad inhibidora de ttk
AR107170A1 (es) Compuestos heterocíclicos tricíclicos condesados como inhibidores de integrasa del vih
AR091156A1 (es) Nucleosidos de espirooxetano de uracilo
AR091981A1 (es) Dihidropiridona p1 como inhibidores del factor xia
AR091279A1 (es) Inhibidores macrociclicos de virus flaviviridae
BR112014006660A2 (pt) novos derivados de dihidroquinolina-2-ona bicíclicos
AR100808A1 (es) Inhibidores de fosfatidilinositol 3-quinasa
AR089776A1 (es) 5,8-dihidro-6h-pirazolo[3,4-h]quinazolinas como inhibidores de igf-1r/ir
AR072726A1 (es) Derivados de indol macrociclicos utiles como inhibidores del virus de la hepatitis c
AR103742A1 (es) Derivados de trifluorometilpropanamida
ECSP088963A (es) Aminopirazolopiridinas sustituidas y sus sales, sus preparaciones y composiciones farmacéuticas que las comprenden
AR097866A1 (es) Derivados de 4-azaindol
PE20151892A1 (es) Compuestos tetraciclicos sustituidos con heterociclo y metodos de uso de los mismos para el tratamiento de enfermedades viricas
AR100714A1 (es) Derivados de alquilo y arilo de compuestos de 1-oxa-4,9-diazaespiro undecano que tienen actividad multimodal contra el dolor
AR097138A1 (es) Compuestos plaguicidas
AR095183A1 (es) Derivados de azetidina como agentes antiparasitarios

Legal Events

Date Code Title Description
FB Suspension of granting procedure