AR094565A1 - Compuestos y métodos para tratar infecciones bacterianas - Google Patents
Compuestos y métodos para tratar infecciones bacterianasInfo
- Publication number
- AR094565A1 AR094565A1 ARP140100208A ARP140100208A AR094565A1 AR 094565 A1 AR094565 A1 AR 094565A1 AR P140100208 A ARP140100208 A AR P140100208A AR P140100208 A ARP140100208 A AR P140100208A AR 094565 A1 AR094565 A1 AR 094565A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- compounds
- methods
- con
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Reivindicación 1: Un compuesto, o una de sus sales farmacéuticamente aceptables, donde el compuesto presenta la estructura de fórmula (1) donde X es flúor o cloro; R¹ se selecciona del grupo constituido por hidrógeno, fenilo, -CºN, tetrahidropiranilo, N-metil-1,2,4-triazolilo, pirimidinilo, piridinilo, pirazinilo, ciclopropilo, -CºCH, -CH=CH₂ y alquilo C₁₋₃, donde el alquilo C₁₋₃ está opcionalmente sustituido con uno o más de los siguientes grupos: -OR¹⁰, halógeno, -CºN, -N₃, -SO₂CH₃, -SCH₃, -CH=CH₂, -CH=NOR¹¹ y fenilo; R² se selecciona del grupo constituido por hidrógeno, -CºN, piridinilo, alquilo C₁₋₃, donde el alquilo C₁₋₃ está opcionalmente sustituido con uno o más de los siguientes grupos: halógeno, -OR²⁰ y -CH=NOR²¹; R³ es hidrógeno o alquilo C₁₋₃; R¹⁰ se selecciona independientemente en cada caso del grupo constituido por hidrógeno, alquilo C₁₋₄ y -(CH₂)₂OCH₃; y R¹¹, R²⁰ y R²¹ se seleccionan independientemente en cada caso entre hidrógeno o alquilo C₁₋₄.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361755537P | 2013-01-23 | 2013-01-23 | |
| US201361859910P | 2013-07-30 | 2013-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR094565A1 true AR094565A1 (es) | 2015-08-12 |
Family
ID=50033593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140100208A AR094565A1 (es) | 2013-01-23 | 2014-01-23 | Compuestos y métodos para tratar infecciones bacterianas |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US8889671B2 (es) |
| EP (1) | EP2948461B1 (es) |
| JP (1) | JP6285960B2 (es) |
| KR (1) | KR102149567B1 (es) |
| CN (1) | CN105229012B (es) |
| AR (1) | AR094565A1 (es) |
| AU (1) | AU2014208965B2 (es) |
| BR (1) | BR112015017519B1 (es) |
| CA (1) | CA2897887C (es) |
| CY (1) | CY1122805T1 (es) |
| DK (1) | DK2948461T3 (es) |
| EA (1) | EA026901B1 (es) |
| ES (1) | ES2780824T3 (es) |
| HK (1) | HK1218293A1 (es) |
| HR (1) | HRP20200401T1 (es) |
| HU (1) | HUE048990T2 (es) |
| IL (1) | IL239860A0 (es) |
| LT (1) | LT2948461T (es) |
| ME (1) | ME03676B (es) |
| MX (1) | MX360650B (es) |
| MY (1) | MY192765A (es) |
| NZ (1) | NZ710091A (es) |
| PH (1) | PH12015501588A1 (es) |
| PL (1) | PL2948461T3 (es) |
| PT (1) | PT2948461T (es) |
| RS (1) | RS60078B1 (es) |
| SG (1) | SG11201505462YA (es) |
| SI (1) | SI2948461T1 (es) |
| TW (1) | TWI603973B (es) |
| UY (1) | UY35274A (es) |
| WO (1) | WO2014114929A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9040528B2 (en) * | 2008-10-14 | 2015-05-26 | Astrazeneca Ab | Chemical compounds 542 |
| US8889671B2 (en) * | 2013-01-23 | 2014-11-18 | Astrazeneca Ab | Compounds and methods for treating bacterial infections |
| WO2015181637A1 (en) * | 2014-05-29 | 2015-12-03 | Entasis Therapeutics Limited | Fused, spirocyclic heteroaromatic compounds for the treatment of bacterial infections |
| US10660933B2 (en) * | 2015-10-29 | 2020-05-26 | University Of Maryland, College Park | Compositions and methods for inhibition of bacterial infections in human endocervix |
| CN106632298B (zh) | 2015-11-03 | 2021-06-01 | 上海科胜药物研发有限公司 | 一种泰地唑胺的制备方法及其中间体 |
| AU2018275552B2 (en) | 2017-06-01 | 2022-01-20 | Bristol-Myers Squibb Company | Substituted nitrogen containing compounds |
| WO2018233670A1 (zh) * | 2017-06-22 | 2018-12-27 | 中国科学院上海药物研究所 | 苯并异噁唑螺嘧啶三酮类化合物及制备方法和用途 |
| CN109111466B (zh) * | 2017-06-22 | 2022-08-02 | 中国科学院上海药物研究所 | 苯并异噁唑螺嘧啶三酮类化合物及制备方法和用途 |
| CN109111465B (zh) * | 2017-06-22 | 2021-01-12 | 中国科学院上海药物研究所 | 噻唑烷酮螺嘧啶三酮类化合物及制备方法和用途 |
| CN108060207B (zh) * | 2017-12-29 | 2021-10-15 | 河南科技大学 | 一种基于微量天然化合物的最小杀菌浓度测定方法 |
| US11905286B2 (en) | 2018-08-09 | 2024-02-20 | Antabio Sas | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
| CN111559985A (zh) * | 2020-05-13 | 2020-08-21 | 河南科技大学第一附属医院 | 具有杀菌作用的噁唑酮类化合物及其制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0759570B2 (ja) | 1986-05-06 | 1995-06-28 | 三井東圧化学株式会社 | ２−オキサゾリジノン類の製造方法 |
| US7208490B2 (en) | 2002-10-07 | 2007-04-24 | Pharmacia & Upjohn Company Llc | Tricyclic tetrahydroquinoline antibacterial agents |
| WO2005016929A1 (en) | 2003-08-15 | 2005-02-24 | Astrazeneca Ab | Fused heterocylcles as inhibitors of glutamate racemase (muri) |
| WO2005066119A2 (en) | 2003-12-31 | 2005-07-21 | Schering-Plough Ltd. | Antibacterial 1-(4-mono-and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoropropanols and preparation thereof |
| WO2006120563A2 (en) | 2005-05-09 | 2006-11-16 | Warner-Lambert Company Llc | Antibacterial agents |
| DOP2006000268A (es) | 2005-12-22 | 2007-07-31 | Pfizer Prod Inc | Agentes antibacterianos |
| CL2007003332A1 (es) * | 2006-11-24 | 2008-06-20 | Actelion Pharmaceuticals Ltd | Compuestos derivados de heterociclos condensados; compuestos intermediarios; composicion farmaceutica; y uso en la prevencion o tratamiento de infecciones bacterianas. |
| KR20100046165A (ko) | 2007-07-02 | 2010-05-06 | 아스트라제네카 아베 | 3-스피로피리미딘트리온-퀴놀린 유도체 및 항박테리아제로서의 이들의 용도 |
| US9040528B2 (en) | 2008-10-14 | 2015-05-26 | Astrazeneca Ab | Chemical compounds 542 |
| EA201100613A1 (ru) * | 2008-10-14 | 2011-12-30 | Астразенека Аб | Конденсированные, спироциклические гетероароматические соединения для лечения бактериальных инфекций |
| US8952149B2 (en) | 2012-09-26 | 2015-02-10 | Zoetis Llc | Tricyclic tetrahydroquinoline antibacterial agents |
| US8889671B2 (en) * | 2013-01-23 | 2014-11-18 | Astrazeneca Ab | Compounds and methods for treating bacterial infections |
-
2014
- 2014-01-21 US US14/159,773 patent/US8889671B2/en active Active
- 2014-01-22 SG SG11201505462YA patent/SG11201505462YA/en unknown
- 2014-01-22 MX MX2015009479A patent/MX360650B/es active IP Right Grant
- 2014-01-22 BR BR112015017519-8A patent/BR112015017519B1/pt active IP Right Grant
- 2014-01-22 WO PCT/GB2014/050164 patent/WO2014114929A1/en active Application Filing
- 2014-01-22 MY MYPI2015001807A patent/MY192765A/en unknown
- 2014-01-22 RS RS20200292A patent/RS60078B1/sr unknown
- 2014-01-22 EP EP14702642.1A patent/EP2948461B1/en active Active
- 2014-01-22 SI SI201431524T patent/SI2948461T1/sl unknown
- 2014-01-22 ES ES14702642T patent/ES2780824T3/es active Active
- 2014-01-22 PT PT147026421T patent/PT2948461T/pt unknown
- 2014-01-22 ME MEP-2020-55A patent/ME03676B/me unknown
- 2014-01-22 EA EA201591362A patent/EA026901B1/ru unknown
- 2014-01-22 CN CN201480017715.6A patent/CN105229012B/zh active Active
- 2014-01-22 KR KR1020157022580A patent/KR102149567B1/ko active IP Right Grant
- 2014-01-22 DK DK14702642.1T patent/DK2948461T3/da active
- 2014-01-22 AU AU2014208965A patent/AU2014208965B2/en active Active
- 2014-01-22 HU HUE14702642A patent/HUE048990T2/hu unknown
- 2014-01-22 PL PL14702642T patent/PL2948461T3/pl unknown
- 2014-01-22 NZ NZ710091A patent/NZ710091A/en unknown
- 2014-01-22 LT LTEP14702642.1T patent/LT2948461T/lt unknown
- 2014-01-22 JP JP2015554245A patent/JP6285960B2/ja active Active
- 2014-01-22 CA CA2897887A patent/CA2897887C/en active Active
- 2014-01-23 UY UY0001035274A patent/UY35274A/es not_active Application Discontinuation
- 2014-01-23 AR ARP140100208A patent/AR094565A1/es active IP Right Grant
- 2014-01-23 TW TW103102537A patent/TWI603973B/zh active
- 2014-10-16 US US14/515,684 patent/US9187495B2/en active Active
-
2015
- 2015-07-09 IL IL239860A patent/IL239860A0/en active IP Right Grant
- 2015-07-20 PH PH12015501588A patent/PH12015501588A1/en unknown
- 2015-10-13 US US14/881,595 patent/US9540394B2/en active Active
-
2016
- 2016-06-01 HK HK16106237.2A patent/HK1218293A1/zh unknown
- 2016-11-16 US US15/353,325 patent/US9839641B2/en active Active
-
2020
- 2020-03-11 HR HRP20200401TT patent/HRP20200401T1/hr unknown
- 2020-03-12 CY CY20201100217T patent/CY1122805T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |