AR093572A1 - Inhibidores del cotransportador de sodio glucosa tipo 1 - Google Patents

Inhibidores del cotransportador de sodio glucosa tipo 1

Info

Publication number
AR093572A1
AR093572A1 ARP130104292A ARP130104292A AR093572A1 AR 093572 A1 AR093572 A1 AR 093572A1 AR P130104292 A ARP130104292 A AR P130104292A AR P130104292 A ARP130104292 A AR P130104292A AR 093572 A1 AR093572 A1 AR 093572A1
Authority
AR
Argentina
Prior art keywords
independently
alkyl
optionally substituted
halo
optional substitution
Prior art date
Application number
ARP130104292A
Other languages
English (en)
Inventor
Gordon Carson Kenneth
Cathleen Goodwin Nicole
alden harrison Bryce
Brent Rawlins David
Strobel Eric
Zambrowicz Brian
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of AR093572A1 publication Critical patent/AR093572A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium

Abstract

Reivindicación 1: Un compuesto de la fórmula (1) o una sal, dímero o trímero del mismo, farmacéuticamente aceptable, en donde: R¹ es hidrógeno o alquilo C₁₋₁₀, cicloalquilo C₁₋₅ o heterociclo de 5 miembros opcionalmente sustituidos, en donde la sustitución opcional es con uno o más R¹A; cada R¹A es, de manera independiente, amino, éster, amida, tiol, ácido carboxílico, ciano, halo, hidroxilo o alcoxi C₁₋₄, cicloalquilo C₁₋₅ o heterociclo de 5 miembros, opcionalmente sustituidos, en donde la sustitución opcional es con uno o más R¹B; cada R¹B es, de manera independiente, alquilo C₁₋₄, halo o hidroxilo; n es 0, 1 ó 2; cada R² es, de manera independiente, F u OR²A, en donde cada R²A es, de manera independiente, hidrógeno, alquilo C₁₋₄ o acilo; cada R³ es, de manera independiente, halo, hidroxilo o alquilo C₁₋₁₀ o alcoxi C₁₋₁₀ opcionalmente sustituidos, en donde la sustitución opcional es con uno o más R³A; cada R³A es, de manera independiente, amino, éster, amida, tiol, ácido carboxílico, ciano, halo, hidroxilo o alcoxi C₁₋₄, cicloalquilo C₁₋₅ o heterociclo de 5 miembros, opcionalmente sustituidos, en donde la sustitución opcional que es con uno o más R³B; cada R³B es, de manera independiente, alquilo C₁₋₄, amino, ciano, halo o hidroxilo; p es 0, 1 ó 2; cada R⁴ es, de manera independiente, R⁴A, -N(R⁴A)(R⁴B), -OR⁴A, -SR⁴A, -S(O)R⁴A o -S(O)₂R⁴A; R⁴A es alquilo C₄₋₂₀ o heteroalquilo de 4 - 20 miembros, opcionalmente sustituidos, en donde la sustitución opcional es con uno o más R⁴C, el cual se encuentra opcionalmente unido a otro resto R⁴A para dar un dímero o trímero; R⁴B es hidrógeno o R⁴A; cada R⁴C es, de manera independiente, amino, amido, azo, carbonilo, carboxilo, ciano, formilo, guanidino, halo, hidroxilo, imido, imino, isotiocianato, nitrilo, nitro, nitroso, nitroxi, oxo, sulfanilo, sulfinilo, sulfonilo, tial, tiocianato, tiona, tiourea, urea o X¹, X¹-L¹-X² o X¹-L¹-X²-L²-X³, en donde cada uno de X¹, X² y X³ es, de manera independiente, arilo, cicloalquilo C₁₋₆ o heterociclo de 5 ó 6 miembros, opcionalmente sustituidos, en donde la sustitución opcional es con uno o más R⁴D y cada uno de L¹ y L² es, de manera independiente, alquilo C₁₋₆ o heteroalquilo de 1 - 10 miembros, opcionalmente sustituidos, en donde la sustitución opcional es con uno o más de R⁴E; cada R⁴D es, de manera independiente, R⁴E o alquilo C₁₋₆ opcionalmente sustituido con uno o más de R⁴E; cada R⁴E es, de manera independiente, amino, amido, azo, carbonilo, carboxilo, ciano, formilo, guanidino, halo, hidroxilo, imido, imino, isotiocianato, nitrilo, nitro, nitroso, nitroxi, oxo, sulfanilo, sulfinilo, sulfonilo, tial, tiocianato, tiona o urea; y m es 1, 2 ó 3.
ARP130104292A 2012-11-20 2013-11-20 Inhibidores del cotransportador de sodio glucosa tipo 1 AR093572A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261728373P 2012-11-20 2012-11-20

Publications (1)

Publication Number Publication Date
AR093572A1 true AR093572A1 (es) 2015-06-10

Family

ID=49753472

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130104292A AR093572A1 (es) 2012-11-20 2013-11-20 Inhibidores del cotransportador de sodio glucosa tipo 1

Country Status (24)

Country Link
US (3) US9200025B2 (es)
EP (2) EP2925735B1 (es)
JP (1) JP6278971B2 (es)
KR (1) KR102165224B1 (es)
CN (1) CN108440614A (es)
AR (1) AR093572A1 (es)
AU (1) AU2013348233C1 (es)
CA (1) CA2891773C (es)
DK (2) DK2925735T3 (es)
ES (2) ES2728246T3 (es)
HK (2) HK1208458A1 (es)
HU (2) HUE043868T2 (es)
IL (1) IL238590B (es)
MX (1) MX365753B (es)
NZ (1) NZ707859A (es)
PL (2) PL3489226T3 (es)
PT (2) PT3489226T (es)
RU (1) RU2015123738A (es)
SG (1) SG11201503923XA (es)
TR (1) TR201908247T4 (es)
TW (1) TWI636058B (es)
UA (1) UA117574C2 (es)
WO (1) WO2014081660A1 (es)
ZA (1) ZA201503331B (es)

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DK2925735T3 (da) 2012-11-20 2019-06-17 Lexicon Pharmaceuticals Inc Inhibitorer for natriumglucose-cotransporter 1
SG10201700267PA (en) 2013-02-04 2017-02-27 Taisho Pharmaceutical Co Ltd Prophylactic or therapeutic drug for constipation
CN104478675B (zh) * 2015-01-15 2016-01-06 佛山市赛维斯医药科技有限公司 一类含烷氧苯基和三氟甲苯基丙二醇结构的衍生物和用途
CN104478674B (zh) * 2015-01-15 2016-03-09 佛山市赛维斯医药科技有限公司 一类烷氧苯基丙二醇衍生物和用途
CN104478671B (zh) * 2015-01-15 2016-03-09 佛山市赛维斯医药科技有限公司 一类双烷氧苯基丙二醇衍生物和用途
CN107540685B (zh) * 2017-09-04 2020-05-05 杭州科巢生物科技有限公司 一种Sotagliflozin的制备方法及其中间体
CN110066302B (zh) * 2018-01-23 2022-12-27 广东东阳光药业有限公司 吡喃葡萄糖基衍生物及其用途
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WO2019191352A1 (en) 2018-03-28 2019-10-03 Avolynt Method for treating post-prandial hypoglycemia
CA3113037A1 (en) * 2018-09-26 2020-04-02 Lexicon Pharmaceuticals, Inc. Crystalline forms of n-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oopropan-2-yl)-4-(4-(2-methyl-5-(2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2h-pyran-2-yl)benzyl)phenl)butanamide and methods of their synthesis
CN113825750B (zh) * 2019-03-29 2022-07-12 南京明德新药研发有限公司 作为sglt1抑制剂的葡糖苷类衍生物及其应用
TW202116746A (zh) * 2019-07-10 2021-05-01 大陸商廣東東陽光藥業有限公司 吡喃葡萄糖基衍生物及其用途
WO2021018044A1 (zh) * 2019-07-26 2021-02-04 南京明德新药研发有限公司 一种sglt2/dpp4抑制剂及其应用
EP4005568A4 (en) * 2019-07-26 2023-09-06 Dongbao Purple Star (Hangzhou) Biopharmaceutical Co., Ltd. SGLTS/DPP4 INHIBITOR AND USE THEREOF
EP4163287A1 (en) * 2020-05-15 2023-04-12 Shanghai Zheye Biotechnology Co., Ltd. A class of aryl glucoside derivatives, preparation method therefor and application thereof
CN117599188A (zh) * 2020-07-06 2024-02-27 诺未科技（北京）有限公司 组合物及其在制备治疗癌症的药物中的应用
CN116322675A (zh) * 2020-09-27 2023-06-23 南京明德新药研发有限公司 葡糖苷类化合物的晶型及其应用

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