PE20081387A1 - Proceso de preparacion del acido 1-(2-etil-butil)-ciclohexanocarboxilico - Google Patents
Proceso de preparacion del acido 1-(2-etil-butil)-ciclohexanocarboxilicoInfo
- Publication number
- PE20081387A1 PE20081387A1 PE2007001808A PE2007001808A PE20081387A1 PE 20081387 A1 PE20081387 A1 PE 20081387A1 PE 2007001808 A PE2007001808 A PE 2007001808A PE 2007001808 A PE2007001808 A PE 2007001808A PE 20081387 A1 PE20081387 A1 PE 20081387A1
- Authority
- PE
- Peru
- Prior art keywords
- lithium
- cyclohexanocarboxyl
- formula
- acid
- butyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/06—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols from sulfides, hydropolysulfides or polysulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/48—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/08—Saturated compounds having a carboxyl group bound to a six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE REFIERE A UN PROCESO DE PREPARACION DEL ACIDO 1-(2-ETIL-BUTIL)-CICLOHEXANOCARBOXILICO DE FORMULA (I) QUE COMPRENDE: A) HACER REACCIONAR UN DERIVADO DE ACIDO CICLOHEXANOCARBOXILICO DE FORMULA (II) CON UN AGENTE ALQUILANTE TAL COMO 1-BROMO-2-ETILBUTANO EN PRESENCIA DE UNA AMINA SECUNDARIA TAL COMO DIETILAMINA, UN DISOLVENTE ORGANICO TAL COMO TETRAHIDROFURANO Y ALQUIL(C1-C6)-LITIO, CICLOALQUIL(C3-C6)-LITIO O FENIL-LITIO, DONDE Y ES UN METAL ALCALINO TAL COMO SODIO; B) PURIFICAR EL COMPUESTO DE FORMULA (I) POR EXTRACCION EN PRESENCIA DE UNA SOLUCION ACUOSA TAL COMO BICARBONATO SODICO, HIDROXIDO SODICO O UNA MEZCLA DE LOS MISMOS QUE TIENE UN pH ENTRE 7,5 Y 11. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION DE 2-METILPROPANOTIOATO DE S-[2-([[1-(2-ETILBUTIL)-CICLOHEXIL]-CARBONIL]-AMINO)FENIL]. DICHO COMPUESTO DE FORMULA (I) ES UTIL COMO COMPUESTO INTERMEDIO PARA LO OBTENCION DE COMPUESTOS ACTIVOS FARMACEUTICOS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06126724A EP1935867A1 (en) | 2006-12-20 | 2006-12-20 | Process for preparing 1-(2-ethyl-butyl)-cyclohexanecarboxylic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20081387A1 true PE20081387A1 (es) | 2008-10-17 |
Family
ID=38121659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007001808A PE20081387A1 (es) | 2006-12-20 | 2007-12-14 | Proceso de preparacion del acido 1-(2-etil-butil)-ciclohexanocarboxilico |
Country Status (16)
Country | Link |
---|---|
US (2) | US20080154059A1 (es) |
EP (2) | EP1935867A1 (es) |
JP (1) | JP5236659B2 (es) |
KR (2) | KR20120057660A (es) |
CN (1) | CN101573319B (es) |
AR (1) | AR064422A1 (es) |
AU (1) | AU2007336349B2 (es) |
BR (1) | BRPI0720848B1 (es) |
CA (1) | CA2672505C (es) |
CL (1) | CL2007003696A1 (es) |
ES (1) | ES2392898T3 (es) |
IL (1) | IL198971A (es) |
MX (1) | MX2009006207A (es) |
PE (1) | PE20081387A1 (es) |
TW (1) | TW200833657A (es) |
WO (1) | WO2008074677A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2395167T3 (es) * | 2007-04-25 | 2013-02-08 | F. Hoffmann-La Roche Ag | Nuevo proceso para la obtención de cloruros de ácido |
JP5564487B2 (ja) * | 2008-04-04 | 2014-07-30 | エフ.ホフマン−ラ ロシュ アーゲー | シクロヘキサンカルボン酸誘導体の新規な製造方法 |
BRPI0911170B1 (pt) * | 2008-04-04 | 2018-05-29 | F. Hoffmann-La Roche Ag | Processo para a preparação de derivados do ácido ciclo-hexanocarboxílico via o correpondente derivado de ciclo-hexanocarboxamida |
JP5325980B2 (ja) | 2008-06-17 | 2013-10-23 | エフ.ホフマン−ラ ロシュ アーゲー | 薬学的に活性なアミドの製造における中間体としての1−(2−エチル−ブチル)−シクロヘキサンカルボン酸エステル |
US20110004011A1 (en) | 2009-07-01 | 2011-01-06 | Declan Costello | Novel process |
KR101113584B1 (ko) | 2009-09-07 | 2012-02-22 | 현대자동차주식회사 | 변속케이블의 노이즈 저감장치 |
GB201008047D0 (en) * | 2010-05-14 | 2010-06-30 | Ge Healthcare Ltd | Method of synthesis |
NZ609529A (en) | 2010-11-04 | 2015-06-26 | Hoffmann La Roche | A composition comprising s-[2-([[1-(2-ethylbutyl)-cyclohexyl]-carbonyl]amino)phenyl] 2-methylpropanethioate and croscarmellose sodium |
CA2818018C (en) | 2010-12-08 | 2016-02-02 | F. Hoffmann-La Roche Ag | Liposomal formulation of dalcetrapib |
TR201818880T4 (tr) * | 2010-12-16 | 2019-01-21 | Hoffmann La Roche | Disülfürlerin hidrojenasyonu yoluyla aromatik tiyol türevlerinin hazırlanması prosesi. |
KR20140006879A (ko) | 2011-02-17 | 2014-01-16 | 에프. 호프만-라 로슈 아게 | 고온 용융 압출에 의해 활성 약학 성분을 과냉된 액체 상태로부터 제어되는 방식으로 결정화시키는 방법 |
CN104244946A (zh) | 2012-04-30 | 2014-12-24 | 霍夫曼-拉罗奇有限公司 | 新制剂 |
CN111073974B (zh) | 2013-03-27 | 2024-04-09 | 豪夫迈·罗氏有限公司 | 用于预测对于治疗的响应性的遗传标记 |
MX2016005505A (es) | 2013-12-19 | 2016-07-22 | Hoffmann La Roche | Modulador de la proteina de transferencia de ester de colesterilo (cetp) para usarse en el tratamiento de enfermedades oculares. |
MX2017000582A (es) | 2014-07-30 | 2017-04-27 | Hoffmann La Roche | Marcadores geneticos para predecir la reactividad a terapia con agente que eleva la lipoproteina de alta densidad (hdl) o que imita la lipoproteina de alta densidad (hdl). |
CN112892485B (zh) * | 2020-12-29 | 2023-03-28 | 生态环境部土壤与农业农村生态环境监管技术中心 | 一种土壤气被动采样用吸附剂及其制备和使用方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH641756A5 (fr) * | 1978-04-27 | 1984-03-15 | Sanofi Sa | Composes derives de l'acide cyclohexylcarboxylique, et medicaments les contenant. |
JPH0269432A (ja) * | 1988-09-05 | 1990-03-08 | Wako Pure Chem Ind Ltd | α−分枝長鎖脂肪酸の製造法 |
JP2894445B2 (ja) * | 1997-02-12 | 1999-05-24 | 日本たばこ産業株式会社 | Cetp活性阻害剤として有効な化合物 |
-
2006
- 2006-12-20 EP EP06126724A patent/EP1935867A1/en not_active Withdrawn
-
2007
- 2007-12-06 US US11/951,444 patent/US20080154059A1/en not_active Abandoned
- 2007-12-10 KR KR1020127011363A patent/KR20120057660A/ko not_active Application Discontinuation
- 2007-12-10 EP EP07848018A patent/EP2094636B1/en active Active
- 2007-12-10 WO PCT/EP2007/063582 patent/WO2008074677A1/en active Application Filing
- 2007-12-10 ES ES07848018T patent/ES2392898T3/es active Active
- 2007-12-10 MX MX2009006207A patent/MX2009006207A/es active IP Right Grant
- 2007-12-10 CA CA2672505A patent/CA2672505C/en active Active
- 2007-12-10 KR KR1020097012630A patent/KR101412908B1/ko active IP Right Grant
- 2007-12-10 BR BRPI0720848A patent/BRPI0720848B1/pt active IP Right Grant
- 2007-12-10 AU AU2007336349A patent/AU2007336349B2/en active Active
- 2007-12-10 CN CN2007800478280A patent/CN101573319B/zh active Active
- 2007-12-10 JP JP2009541970A patent/JP5236659B2/ja active Active
- 2007-12-14 PE PE2007001808A patent/PE20081387A1/es not_active Application Discontinuation
- 2007-12-18 AR ARP070105699A patent/AR064422A1/es unknown
- 2007-12-18 TW TW096148522A patent/TW200833657A/zh unknown
- 2007-12-19 CL CL200703696A patent/CL2007003696A1/es unknown
-
2009
- 2009-05-26 IL IL198971A patent/IL198971A/en active IP Right Grant
- 2009-05-29 US US12/474,328 patent/US7863474B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
ES2392898T3 (es) | 2012-12-14 |
US7863474B2 (en) | 2011-01-04 |
KR20090083934A (ko) | 2009-08-04 |
KR20120057660A (ko) | 2012-06-05 |
CA2672505C (en) | 2015-01-27 |
JP2010513371A (ja) | 2010-04-30 |
CL2007003696A1 (es) | 2008-07-04 |
BRPI0720848A2 (pt) | 2014-03-04 |
CN101573319B (zh) | 2013-04-03 |
EP1935867A1 (en) | 2008-06-25 |
JP5236659B2 (ja) | 2013-07-17 |
CA2672505A1 (en) | 2008-06-26 |
CN101573319A (zh) | 2009-11-04 |
US20080154059A1 (en) | 2008-06-26 |
TW200833657A (en) | 2008-08-16 |
IL198971A (en) | 2012-10-31 |
WO2008074677A1 (en) | 2008-06-26 |
AR064422A1 (es) | 2009-04-01 |
AU2007336349B2 (en) | 2012-03-08 |
BRPI0720848B1 (pt) | 2018-12-18 |
EP2094636A1 (en) | 2009-09-02 |
IL198971A0 (en) | 2010-02-17 |
AU2007336349A1 (en) | 2008-06-26 |
US20090240080A1 (en) | 2009-09-24 |
KR101412908B1 (ko) | 2014-06-26 |
EP2094636B1 (en) | 2012-10-24 |
MX2009006207A (es) | 2009-06-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |