AR092967A1 - Procedimientos y sistemas para optimizar el sistema de cultivo de celulas de perfusion - Google Patents
Procedimientos y sistemas para optimizar el sistema de cultivo de celulas de perfusionInfo
- Publication number
- AR092967A1 AR092967A1 ARP130103674A ARP130103674A AR092967A1 AR 092967 A1 AR092967 A1 AR 092967A1 AR P130103674 A ARP130103674 A AR P130103674A AR P130103674 A ARP130103674 A AR P130103674A AR 092967 A1 AR092967 A1 AR 092967A1
- Authority
- AR
- Argentina
- Prior art keywords
- procedures
- systems
- optimize
- initial
- cell culture
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000010412 perfusion Effects 0.000 title abstract 3
- 238000004113 cell culture Methods 0.000 title 1
- 230000014759 maintenance of location Effects 0.000 abstract 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 239000012531 culture fluid Substances 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 238000005457 optimization Methods 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/14—Bioreactors or fermenters specially adapted for specific uses for producing enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/02—Percolation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/10—Separation or concentration of fermentation products
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261712190P | 2012-10-10 | 2012-10-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR092967A1 true AR092967A1 (es) | 2015-05-06 |
Family
ID=49448331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130103674A AR092967A1 (es) | 2012-10-10 | 2013-10-10 | Procedimientos y sistemas para optimizar el sistema de cultivo de celulas de perfusion |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20150299638A1 (https=) |
| EP (1) | EP2906677A1 (https=) |
| JP (1) | JP6393267B2 (https=) |
| KR (1) | KR20150063541A (https=) |
| CN (1) | CN104822821A (https=) |
| AR (1) | AR092967A1 (https=) |
| AU (1) | AU2013329318A1 (https=) |
| CA (1) | CA2887581A1 (https=) |
| HK (1) | HK1213285A1 (https=) |
| IL (1) | IL238179A0 (https=) |
| MX (1) | MX2015004516A (https=) |
| RU (1) | RU2015117547A (https=) |
| SG (2) | SG11201502741WA (https=) |
| TW (1) | TW201418455A (https=) |
| WO (1) | WO2014059035A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9944894B2 (en) | 2015-01-16 | 2018-04-17 | General Electric Company | Pluripotent stem cell expansion and passage using a rocking platform bioreactor |
| CN105385731B (zh) * | 2015-12-25 | 2018-10-30 | 上海莱士血液制品股份有限公司 | 一种表达重组八因子的灌注培养方法 |
| ITUB20160272A1 (it) * | 2016-01-22 | 2017-07-22 | Univ Degli Studi Di Palermo | Bioreattore a perfusione autosufficiente monouso per crescite cellulari 3D |
| JP6943449B2 (ja) * | 2016-03-21 | 2021-09-29 | グローバル・ライフ・サイエンシズ・ソリューションズ・ユーエスエー・エルエルシー | 撹拌タンクバイオリアクタを用いた多能性幹細胞の増殖および継代 |
| WO2019071076A1 (en) | 2017-10-06 | 2019-04-11 | Lonza Ltd. | AUTOMATED CONTROL OF CELL CULTURE BY SPECTROSCOPY RAMAN |
| IL315801A (en) | 2017-10-16 | 2024-11-01 | Regeneron Pharma | Perfusion bioreactor and methods of using it |
| WO2019226618A1 (en) * | 2018-05-22 | 2019-11-28 | Nantkwest, Inc. | Methods and systems for cell bed formation during bioprocessing |
| US20210214702A1 (en) * | 2018-06-01 | 2021-07-15 | Gennova Biopharmaceuticals Limited | Process for production of recombinant tnk-tpa by packed-bed perfusion system |
| EP3875595A4 (en) * | 2018-11-02 | 2022-07-13 | Kyowa Kirin Co., Ltd. | Liquid medium preparation method |
| GB201903813D0 (en) * | 2019-03-20 | 2019-05-01 | Cn Bio Innovations Ltd | Dual circulation microphysiological system |
| WO2020232183A1 (en) * | 2019-05-15 | 2020-11-19 | Life Technologies Corporation | Cell settler apparatus systems and methods for perfusion processes |
| CN114599775B (zh) * | 2019-11-07 | 2025-07-22 | 默克专利股份公司 | 用于进行灌注细胞培养的方法和系统 |
| US12529024B2 (en) | 2019-11-15 | 2026-01-20 | Lonza Ltd | Process and system for producing an inoculum |
| WO2021110870A1 (en) | 2019-12-05 | 2021-06-10 | Acib Gmbh | Method for producing a fermentation product |
| KR20220120606A (ko) * | 2019-12-19 | 2022-08-30 | 우니베르지태트 퓌르 보덴쿨투르 빈 | 고체로부터 공정 재료의 연속 재구성 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6338964B1 (en) | 1999-05-07 | 2002-01-15 | Bayer Corporation | Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration |
| US20040185534A1 (en) * | 2000-10-02 | 2004-09-23 | Knudsen Ida Molgaard | Industrial-scale serum-free production of recombinant proteins in mammalian cells |
| JP2007510416A (ja) * | 2003-11-03 | 2007-04-26 | セントカー・インコーポレーテツド | バイオプロセッシングシステムにおいて低剪断を維持する方法 |
| WO2007071072A1 (en) * | 2005-12-22 | 2007-06-28 | Corporation De L'ecole Polytechnique De Montreal | High-rate perfusion bioreactor |
| WO2007124106A2 (en) * | 2006-04-21 | 2007-11-01 | Bayer Healthcare Llc | Application of antl-apoptotic genes in mammalian cells for perfusion culture. |
| WO2009023562A2 (en) * | 2007-08-09 | 2009-02-19 | Wyeth | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
| UA106047C2 (uk) * | 2008-06-13 | 2014-07-25 | Сентокор Орто Байотек Інк. | Спосіб отримання високої щільності життєздатних клітин в культурі клітин ссавців |
| CN103415610B (zh) * | 2011-03-18 | 2016-10-19 | 通用电气健康护理生物科学股份公司 | 用于培养细胞的弹性袋 |
-
2013
- 2013-10-09 WO PCT/US2013/064159 patent/WO2014059035A1/en not_active Ceased
- 2013-10-09 RU RU2015117547A patent/RU2015117547A/ru not_active Application Discontinuation
- 2013-10-09 KR KR1020157011445A patent/KR20150063541A/ko not_active Withdrawn
- 2013-10-09 CN CN201380064458.7A patent/CN104822821A/zh active Pending
- 2013-10-09 CA CA2887581A patent/CA2887581A1/en not_active Abandoned
- 2013-10-09 HK HK16101154.2A patent/HK1213285A1/zh unknown
- 2013-10-09 SG SG11201502741WA patent/SG11201502741WA/en unknown
- 2013-10-09 US US14/434,913 patent/US20150299638A1/en not_active Abandoned
- 2013-10-09 AU AU2013329318A patent/AU2013329318A1/en not_active Abandoned
- 2013-10-09 TW TW102136546A patent/TW201418455A/zh unknown
- 2013-10-09 JP JP2015536869A patent/JP6393267B2/ja not_active Expired - Fee Related
- 2013-10-09 US US14/049,676 patent/US20140099711A1/en not_active Abandoned
- 2013-10-09 SG SG10201705806YA patent/SG10201705806YA/en unknown
- 2013-10-09 EP EP13780035.5A patent/EP2906677A1/en not_active Withdrawn
- 2013-10-09 MX MX2015004516A patent/MX2015004516A/es unknown
- 2013-10-10 AR ARP130103674A patent/AR092967A1/es unknown
-
2015
- 2015-04-12 IL IL238179A patent/IL238179A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1213285A1 (zh) | 2016-06-30 |
| SG10201705806YA (en) | 2017-08-30 |
| AU2013329318A1 (en) | 2015-05-14 |
| WO2014059035A1 (en) | 2014-04-17 |
| SG11201502741WA (en) | 2015-05-28 |
| EP2906677A1 (en) | 2015-08-19 |
| KR20150063541A (ko) | 2015-06-09 |
| US20140099711A1 (en) | 2014-04-10 |
| CN104822821A (zh) | 2015-08-05 |
| JP6393267B2 (ja) | 2018-09-19 |
| US20150299638A1 (en) | 2015-10-22 |
| RU2015117547A (ru) | 2016-12-10 |
| CA2887581A1 (en) | 2014-04-17 |
| IL238179A0 (en) | 2015-05-31 |
| TW201418455A (zh) | 2014-05-16 |
| MX2015004516A (es) | 2015-10-14 |
| JP2015531241A (ja) | 2015-11-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |