AR091850A1 - Inactivacion viral por caprilato - Google Patents

Inactivacion viral por caprilato

Info

Publication number
AR091850A1
AR091850A1 ARP130102588A ARP130102588A AR091850A1 AR 091850 A1 AR091850 A1 AR 091850A1 AR P130102588 A ARP130102588 A AR P130102588A AR P130102588 A ARP130102588 A AR P130102588A AR 091850 A1 AR091850 A1 AR 091850A1
Authority
AR
Argentina
Prior art keywords
solution
approximately
albumin
caprilato
viral inactivation
Prior art date
Application number
ARP130102588A
Other languages
English (en)
Inventor
Hotta Joann
Lebing Wytold
Burns Doug
Roth Nathan
Original Assignee
Grifols Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48795471&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR091850(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Grifols Sa filed Critical Grifols Sa
Publication of AR091850A1 publication Critical patent/AR091850A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/06—Inactivation or attenuation by chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20261—Methods of inactivation or attenuation
    • C12N2760/20263—Methods of inactivation or attenuation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24361—Methods of inactivation or attenuation
    • C12N2770/24363—Methods of inactivation or attenuation by chemical treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Reivindicación 1: Procedimiento de preparación de albúmina a partir de una solución que comprende albúmina que comprende: ajustar la concentración de proteínas de la solución a menos de aproximadamente el 5%; ajustar el pH de la solución a aproximadamente pH 5 o menos; añadir ácido caprílico (ácido octanoico) o caprilato de sodio; aumentar la temperatura de la solución a más de aproximadamente 20ºC; e incubar la solución. Reivindicación 15: Procedimiento de inactivación de virus en una solución que comprende albúmina, comprendiendo el procedimiento: ajustar la concentración de proteínas de la solución a aproximadamente el 5% de proteínas; ajustar el pH de la solución aproximadamente a pH 5; añadir ácido caprílico (ácido octanoico) o caprilato de sodio; aumentar la temperatura de la solución a más de aproximadamente 20ºC; e incubar la solución. Reivindicación 16: Procedimiento, según la reivindicación 15, en el que los virus son virus con envoltura lipídica.
ARP130102588A 2012-08-09 2013-07-22 Inactivacion viral por caprilato AR091850A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261681265P 2012-08-09 2012-08-09

Publications (1)

Publication Number Publication Date
AR091850A1 true AR091850A1 (es) 2015-03-04

Family

ID=48795471

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130102588A AR091850A1 (es) 2012-08-09 2013-07-22 Inactivacion viral por caprilato

Country Status (24)

Country Link
US (1) US9023797B2 (es)
EP (1) EP2695620B1 (es)
JP (1) JP5926218B2 (es)
KR (1) KR101798386B1 (es)
CN (1) CN103570823A (es)
AR (1) AR091850A1 (es)
AU (1) AU2013205138B2 (es)
BR (1) BR102013018882A2 (es)
CA (1) CA2822229C (es)
CL (1) CL2013002073A1 (es)
ES (1) ES2590150T3 (es)
HK (1) HK1194679A1 (es)
HU (1) HUE029160T2 (es)
IL (1) IL227638A (es)
MX (1) MX340056B (es)
MY (1) MY161287A (es)
NZ (1) NZ613554A (es)
PL (1) PL2695620T3 (es)
PT (1) PT2695620T (es)
RU (1) RU2633059C2 (es)
SG (1) SG2013056387A (es)
TW (1) TWI560196B (es)
UY (1) UY34949A (es)
ZA (1) ZA201305639B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3131589T3 (da) 2014-04-15 2023-08-07 Boehringer Ingelheim Int Fremgangsmåde og anvendelse til fortløbende inaktivering af en virus under tilvejebringelse af et biologisk produkt
ES2857582T3 (es) * 2014-04-30 2021-09-29 Novo Nordisk As Métodos para la purificación de proteínas mediante el uso de ácido caprílico
GB201611365D0 (en) * 2016-06-30 2016-08-17 Devenish Nutrition Ltd A composition for use in treating rotavirus infection
CN111973582A (zh) * 2020-06-29 2020-11-24 浙江大学 一种正辛酸或正辛酸钠在杀灭冠状病毒中的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2469193A (en) 1942-02-09 1949-05-03 Research Corp Protein fractionation
US2390074A (en) 1942-02-09 1945-12-04 Research Corp Protein product and process
US2710293A (en) 1953-10-30 1955-06-07 Olin Mathieson Blood fractionation
US2710294A (en) 1953-11-02 1955-06-07 Olin Mathieson Blood fractionation
US4939176A (en) 1988-12-20 1990-07-03 Miles Inc. Viral inactivation process
US5250663A (en) 1990-04-19 1993-10-05 Miles Inc. Preparing essentially monomeric normal human serum albumin
US5440018A (en) 1992-05-20 1995-08-08 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
US5521287A (en) * 1992-05-20 1996-05-28 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
US5561115A (en) * 1994-08-10 1996-10-01 Bayer Corporation Low temperature albumin fractionation using sodium caprylate as a partitioning agent
AUPO410696A0 (en) 1996-12-06 1997-01-09 Csl Limited Inactivation of viruses by incubation with caprylate
US5886154A (en) * 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
AU3624400A (en) 1999-03-19 2000-10-09 Bayer Corporation Chromatographic albumin process
CA2477557C (en) * 2002-02-28 2011-01-25 Nipro Corporation Stabilized albumin preparations
US20060194300A1 (en) * 2003-08-12 2006-08-31 Octapharma Ag Process for preparing an alpha-1-antitrypsin solution
CN1922207B (zh) * 2004-02-27 2012-06-06 奥克特珐玛股份有限公司 提供纯化的、病毒安全的抗体制剂的方法
ES2294976B1 (es) * 2007-11-12 2008-12-16 Grifols, S.A. "procedimiento de obtencion de albumina humana de alta eficacia para su uso en terapia de detoxificacion".

Also Published As

Publication number Publication date
MX340056B (es) 2016-06-22
KR20140020746A (ko) 2014-02-19
JP2014034575A (ja) 2014-02-24
IL227638A (en) 2017-06-29
ZA201305639B (en) 2017-08-30
BR102013018882A2 (pt) 2014-10-29
ES2590150T3 (es) 2016-11-18
TWI560196B (en) 2016-12-01
EP2695620B1 (en) 2016-06-15
UY34949A (es) 2014-03-31
CA2822229C (en) 2018-10-30
PL2695620T3 (pl) 2016-12-30
US20140163101A1 (en) 2014-06-12
PT2695620T (pt) 2016-07-15
CA2822229A1 (en) 2014-02-09
HK1194679A1 (zh) 2014-10-24
RU2633059C2 (ru) 2017-10-11
KR101798386B1 (ko) 2017-11-16
HUE029160T2 (hu) 2017-02-28
SG2013056387A (en) 2014-03-28
EP2695620A1 (en) 2014-02-12
CL2013002073A1 (es) 2014-02-07
NZ613554A (en) 2015-01-30
US9023797B2 (en) 2015-05-05
MX2013008365A (es) 2014-03-05
JP5926218B2 (ja) 2016-05-25
MY161287A (en) 2017-04-14
AU2013205138B2 (en) 2015-06-25
TW201416372A (zh) 2014-05-01
RU2013134696A (ru) 2015-01-27
AU2013205138A1 (en) 2014-02-27
CN103570823A (zh) 2014-02-12

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