TWI560196B - Caprylate viral deactivation - Google Patents
Caprylate viral deactivationInfo
- Publication number
- TWI560196B TWI560196B TW102125863A TW102125863A TWI560196B TW I560196 B TWI560196 B TW I560196B TW 102125863 A TW102125863 A TW 102125863A TW 102125863 A TW102125863 A TW 102125863A TW I560196 B TWI560196 B TW I560196B
- Authority
- TW
- Taiwan
- Prior art keywords
- viral deactivation
- caprylate
- caprylate viral
- deactivation
- viral
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
- C12N7/06—Inactivation or attenuation by chemical treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
- C12N2760/20261—Methods of inactivation or attenuation
- C12N2760/20263—Methods of inactivation or attenuation by chemical treatment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
- C12N2770/24361—Methods of inactivation or attenuation
- C12N2770/24363—Methods of inactivation or attenuation by chemical treatment
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261681265P | 2012-08-09 | 2012-08-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
TW201416372A TW201416372A (zh) | 2014-05-01 |
TWI560196B true TWI560196B (en) | 2016-12-01 |
Family
ID=48795471
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW102125863A TWI560196B (en) | 2012-08-09 | 2013-07-19 | Caprylate viral deactivation |
Country Status (24)
Country | Link |
---|---|
US (1) | US9023797B2 (zh) |
EP (1) | EP2695620B1 (zh) |
JP (1) | JP5926218B2 (zh) |
KR (1) | KR101798386B1 (zh) |
CN (1) | CN103570823A (zh) |
AR (1) | AR091850A1 (zh) |
AU (1) | AU2013205138B2 (zh) |
BR (1) | BR102013018882A2 (zh) |
CA (1) | CA2822229C (zh) |
CL (1) | CL2013002073A1 (zh) |
ES (1) | ES2590150T3 (zh) |
HK (1) | HK1194679A1 (zh) |
HU (1) | HUE029160T2 (zh) |
IL (1) | IL227638A (zh) |
MX (1) | MX340056B (zh) |
MY (1) | MY161287A (zh) |
NZ (1) | NZ613554A (zh) |
PL (1) | PL2695620T3 (zh) |
PT (1) | PT2695620T (zh) |
RU (1) | RU2633059C2 (zh) |
SG (1) | SG2013056387A (zh) |
TW (1) | TWI560196B (zh) |
UY (1) | UY34949A (zh) |
ZA (1) | ZA201305639B (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10435670B2 (en) | 2014-04-15 | 2019-10-08 | Boehringer Ingelheim International Gmbh | Methods, apparatuses, and systems for continuously inactivating a virus during manufacture of a biological product |
WO2015166072A1 (en) * | 2014-04-30 | 2015-11-05 | Novo Nordisk A/S | Methods for the purification of proteins using caprylic acid |
GB201611365D0 (en) | 2016-06-30 | 2016-08-17 | Devenish Nutrition Ltd | A composition for use in treating rotavirus infection |
CN111973582A (zh) * | 2020-06-29 | 2020-11-24 | 浙江大学 | 一种正辛酸或正辛酸钠在杀灭冠状病毒中的应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1479393A1 (en) * | 2002-02-28 | 2004-11-24 | Nipro Corporation | Stabilized albumin preparations |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2469193A (en) | 1942-02-09 | 1949-05-03 | Research Corp | Protein fractionation |
US2390074A (en) | 1942-02-09 | 1945-12-04 | Research Corp | Protein product and process |
US2710293A (en) | 1953-10-30 | 1955-06-07 | Olin Mathieson | Blood fractionation |
US2710294A (en) | 1953-11-02 | 1955-06-07 | Olin Mathieson | Blood fractionation |
US4939176A (en) | 1988-12-20 | 1990-07-03 | Miles Inc. | Viral inactivation process |
US5250663A (en) | 1990-04-19 | 1993-10-05 | Miles Inc. | Preparing essentially monomeric normal human serum albumin |
US5440018A (en) | 1992-05-20 | 1995-08-08 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
US5521287A (en) * | 1992-05-20 | 1996-05-28 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
US5561115A (en) | 1994-08-10 | 1996-10-01 | Bayer Corporation | Low temperature albumin fractionation using sodium caprylate as a partitioning agent |
AUPO410696A0 (en) | 1996-12-06 | 1997-01-09 | Csl Limited | Inactivation of viruses by incubation with caprylate |
US5886154A (en) * | 1997-06-20 | 1999-03-23 | Lebing; Wytold R. | Chromatographic method for high yield purification and viral inactivation of antibodies |
WO2000056768A2 (en) | 1999-03-19 | 2000-09-28 | Bayer Corporation | Chromatographic albumin process |
RS20060077A (en) * | 2003-08-12 | 2008-08-07 | Octapharma Ag., | Process for preparing an alpha-1-antitrypsin solution |
KR101206788B1 (ko) * | 2004-02-27 | 2012-11-30 | 옥타파르마 아게 | 정제된, 바이러스 안전한 항체 제제를 제공하는 방법 |
ES2294976B1 (es) * | 2007-11-12 | 2008-12-16 | Grifols, S.A. | "procedimiento de obtencion de albumina humana de alta eficacia para su uso en terapia de detoxificacion". |
-
2013
- 2013-04-13 AU AU2013205138A patent/AU2013205138B2/en active Active
- 2013-07-18 EP EP13177014.1A patent/EP2695620B1/en active Active
- 2013-07-18 ES ES13177014.1T patent/ES2590150T3/es active Active
- 2013-07-18 HU HUE13177014A patent/HUE029160T2/hu unknown
- 2013-07-18 PT PT131770141T patent/PT2695620T/pt unknown
- 2013-07-18 PL PL13177014.1T patent/PL2695620T3/pl unknown
- 2013-07-18 CL CL2013002073A patent/CL2013002073A1/es unknown
- 2013-07-18 MX MX2013008365A patent/MX340056B/es active IP Right Grant
- 2013-07-19 CN CN201310306682.4A patent/CN103570823A/zh active Pending
- 2013-07-19 TW TW102125863A patent/TWI560196B/zh not_active IP Right Cessation
- 2013-07-22 JP JP2013151298A patent/JP5926218B2/ja active Active
- 2013-07-22 AR ARP130102588A patent/AR091850A1/es active IP Right Grant
- 2013-07-22 MY MYPI2013701284A patent/MY161287A/en unknown
- 2013-07-24 NZ NZ613554A patent/NZ613554A/en not_active IP Right Cessation
- 2013-07-24 BR BR102013018882-4A patent/BR102013018882A2/pt not_active Application Discontinuation
- 2013-07-24 IL IL227638A patent/IL227638A/en active IP Right Grant
- 2013-07-24 RU RU2013134696A patent/RU2633059C2/ru active
- 2013-07-24 KR KR1020130087090A patent/KR101798386B1/ko active IP Right Grant
- 2013-07-24 SG SG2013056387A patent/SG2013056387A/en unknown
- 2013-07-25 UY UY0001034949A patent/UY34949A/es active IP Right Grant
- 2013-07-25 US US13/951,070 patent/US9023797B2/en active Active
- 2013-07-25 ZA ZA2013/05639A patent/ZA201305639B/en unknown
- 2013-07-25 CA CA2822229A patent/CA2822229C/en active Active
-
2014
- 2014-08-08 HK HK14108176.3A patent/HK1194679A1/zh not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1479393A1 (en) * | 2002-02-28 | 2004-11-24 | Nipro Corporation | Stabilized albumin preparations |
Non-Patent Citations (3)
Title |
---|
Johnston A et al., "Low pH, caprylate incubation as a second viral inactivation step in the manufacture of albumin: Parametric and validation studies", Biologicals, vol.31, no.3, pages 213–221, 2003/09/01 * |
Korneyeva M et al., "Enveloped virus inactivation by caprylate: a robust alternative to solvent-detergent treatment in plasma derived intermediates", Biologicals, vol.30, no.2, pages 153–162, 2002/06/01 * |
Mpandi M et al., "Partitioning and inactivation of viruses by the caprylic acid precipitation followed by a terminal pasteurization in the manufacturing process of horse immunoglobulins", Biologicals, vol.35, no.4, pages 335–341, 2007/10/01 * |
Also Published As
Publication number | Publication date |
---|---|
JP5926218B2 (ja) | 2016-05-25 |
KR101798386B1 (ko) | 2017-11-16 |
RU2013134696A (ru) | 2015-01-27 |
UY34949A (es) | 2014-03-31 |
MY161287A (en) | 2017-04-14 |
EP2695620A1 (en) | 2014-02-12 |
CL2013002073A1 (es) | 2014-02-07 |
PT2695620T (pt) | 2016-07-15 |
CA2822229A1 (en) | 2014-02-09 |
KR20140020746A (ko) | 2014-02-19 |
MX2013008365A (es) | 2014-03-05 |
SG2013056387A (en) | 2014-03-28 |
AU2013205138A1 (en) | 2014-02-27 |
ZA201305639B (en) | 2017-08-30 |
NZ613554A (en) | 2015-01-30 |
US20140163101A1 (en) | 2014-06-12 |
JP2014034575A (ja) | 2014-02-24 |
CA2822229C (en) | 2018-10-30 |
ES2590150T3 (es) | 2016-11-18 |
MX340056B (es) | 2016-06-22 |
EP2695620B1 (en) | 2016-06-15 |
AR091850A1 (es) | 2015-03-04 |
RU2633059C2 (ru) | 2017-10-11 |
TW201416372A (zh) | 2014-05-01 |
US9023797B2 (en) | 2015-05-05 |
AU2013205138B2 (en) | 2015-06-25 |
CN103570823A (zh) | 2014-02-12 |
PL2695620T3 (pl) | 2016-12-30 |
IL227638A (en) | 2017-06-29 |
HK1194679A1 (zh) | 2014-10-24 |
HUE029160T2 (hu) | 2017-02-28 |
BR102013018882A2 (pt) | 2014-10-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Annulment or lapse of patent due to non-payment of fees |