AR085844A1 - Derivados de piridopirazina y sus usos - Google Patents

Derivados de piridopirazina y sus usos

Info

Publication number
AR085844A1
AR085844A1 ARP120101163A ARP120101163A AR085844A1 AR 085844 A1 AR085844 A1 AR 085844A1 AR P120101163 A ARP120101163 A AR P120101163A AR P120101163 A ARP120101163 A AR P120101163A AR 085844 A1 AR085844 A1 AR 085844A1
Authority
AR
Argentina
Prior art keywords
alkyl
aryl
heteroaryl
cycloalkyl
heterocyclyl
Prior art date
Application number
ARP120101163A
Other languages
English (en)
Spanish (es)
Inventor
Matthias Gerlach
Irene Siepelt
Lars-Mller Gilbert Blumenstein
Eckhard Gnther
Tilmann Schuster
Michael Teifel
Original Assignee
Aeterna Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aeterna Zentaris Gmbh filed Critical Aeterna Zentaris Gmbh
Publication of AR085844A1 publication Critical patent/AR085844A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/14—Antivirals for RNA viruses
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
ARP120101163A 2011-04-06 2012-04-04 Derivados de piridopirazina y sus usos AR085844A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161472245P 2011-04-06 2011-04-06
EP11161248A EP2508184A1 (fr) 2011-04-06 2011-04-06 Dérivés de pyridopyrazine et leur utilisation

Publications (1)

Publication Number Publication Date
AR085844A1 true AR085844A1 (es) 2013-10-30

Family

ID=44350566

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP120101162A AR085843A1 (es) 2011-04-06 2012-04-04 Uso de derivados de piridopiridazina para tratar cancer, enfermedades autoinmunes, neurologicas o neurodegenerativas y/o enfermedades infecciosas e inflamatorias
ARP120101163A AR085844A1 (es) 2011-04-06 2012-04-04 Derivados de piridopirazina y sus usos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP120101162A AR085843A1 (es) 2011-04-06 2012-04-04 Uso de derivados de piridopiridazina para tratar cancer, enfermedades autoinmunes, neurologicas o neurodegenerativas y/o enfermedades infecciosas e inflamatorias

Country Status (19)

Country Link
US (2) US8791118B2 (fr)
EP (3) EP2508184A1 (fr)
JP (2) JP5963844B2 (fr)
KR (2) KR20140025443A (fr)
CN (2) CN103826636A (fr)
AR (2) AR085843A1 (fr)
AU (2) AU2012238681A1 (fr)
BR (1) BR112013025630A2 (fr)
CA (2) CA2832337A1 (fr)
ES (1) ES2552515T3 (fr)
IL (2) IL228436A0 (fr)
MX (2) MX2013011490A (fr)
NZ (1) NZ615578A (fr)
PL (1) PL2694067T3 (fr)
RU (2) RU2013146619A (fr)
SG (2) SG194097A1 (fr)
TW (2) TW201302742A (fr)
WO (2) WO2012136691A1 (fr)
ZA (2) ZA201306864B (fr)

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US20190008859A1 (en) 2015-08-21 2019-01-10 Acerta Pharma B.V. Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor
EP3373971A4 (fr) * 2015-11-13 2019-09-25 Massachusetts Institute of Technology Procédés et compositions pour détecter et moduler des cellules cancéreuses
CA3008171A1 (fr) 2015-12-22 2017-06-29 SHY Therapeutics LLC Composes pour le traitement du cancer et de maladies inflammatoires
WO2017180817A1 (fr) * 2016-04-15 2017-10-19 Musc Foundation For Research Development Traitement de la septicémie et du sdra à l'aide d'inhibiteurs d'erk
IL310023A (en) 2017-06-21 2024-03-01 SHY Therapeutics LLC Compounds interacting with the RAS superfamily for the treatment of cancer, inflammation, RAS pathology and fibrotic diseases
WO2018237383A1 (fr) * 2017-06-23 2018-12-27 The Trustees Of Columbia University In The City Of New York Procédés de prévention et de traitement de maladies caractérisées par un dysfonctionnement synaptique et une neurodégénérescence, y compris la maladie d'alzheimer
US20210238605A1 (en) * 2018-06-15 2021-08-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of pi3kc2b inhibitors for the preservation of vascular endothelial cell barrier integrity
CN112830897B (zh) * 2019-11-22 2022-09-09 石家庄以岭药业股份有限公司 含脲基苯并咪唑类衍生物及其制备方法和应用
EP4271675A1 (fr) * 2020-12-31 2023-11-08 Evrys Bio, LLC Compositions antitumorales et méthodes

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EP0735025B1 (fr) 1995-03-28 1998-07-01 Sumitomo Chemical Company Limited Procédé pour la préparation d'aminonitropyridines
UA71555C2 (en) 1997-10-06 2004-12-15 Zentaris Gmbh Methods for modulating function of serine/threonine protein kinases by 5-azaquinoline derivatives
WO1999032111A1 (fr) 1997-12-22 1999-07-01 Bayer Corporation Inhibition de l'activite de p38 kinase au moyen d'urees heterocycliques substituees
EP1429765A2 (fr) 2001-09-14 2004-06-23 Methylgene, Inc. Inhibiteurs de l'histone-deacetylase
US20040023961A1 (en) 2002-02-11 2004-02-05 Bayer Corporation Aryl ureas with raf kinase and angiogenisis inhibiting activity
JP4451136B2 (ja) 2002-04-08 2010-04-14 メルク エンド カムパニー インコーポレーテッド Ａｋｔ活性阻害薬
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CA2548172A1 (fr) 2003-12-04 2005-06-23 Vertex Pharmaceuticals Incorporated Quinoxalines utiles comme inhibiteurs des proteines kinases
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Also Published As

Publication number Publication date
BR112013025630A2 (pt) 2016-12-27
WO2012136691A1 (fr) 2012-10-11
CA2832321A1 (fr) 2012-10-11
RU2013146619A (ru) 2015-05-20
JP5963844B2 (ja) 2016-08-03
IL228433A0 (en) 2013-12-31
NZ615578A (en) 2015-08-28
JP2014510125A (ja) 2014-04-24
CA2832337A1 (fr) 2012-10-11
CN103501788A (zh) 2014-01-08
AU2012238678A1 (en) 2013-10-03
IL228436A0 (en) 2013-12-31
ZA201306864B (en) 2014-11-26
ZA201306862B (en) 2014-06-25
AR085843A1 (es) 2013-10-30
AU2012238678B2 (en) 2016-11-17
US8912189B2 (en) 2014-12-16
JP2014510124A (ja) 2014-04-24
TW201302743A (zh) 2013-01-16
US20120259151A1 (en) 2012-10-11
KR20140025442A (ko) 2014-03-04
SG193978A1 (en) 2013-11-29
MX2013011444A (es) 2013-10-17
KR20140025443A (ko) 2014-03-04
PL2694067T3 (pl) 2016-01-29
SG194097A1 (en) 2013-11-29
TWI564299B (zh) 2017-01-01
EP2508184A1 (fr) 2012-10-10
RU2013146618A (ru) 2015-05-20
EP2694068A1 (fr) 2014-02-12
US20120258080A1 (en) 2012-10-11
MX2013011490A (es) 2013-11-04
CN103826636A (zh) 2014-05-28
EP2694067A1 (fr) 2014-02-12
US8791118B2 (en) 2014-07-29
ES2552515T3 (es) 2015-11-30
EP2694067B1 (fr) 2015-08-26
WO2012136694A1 (fr) 2012-10-11
TW201302742A (zh) 2013-01-16
AU2012238681A1 (en) 2013-10-03

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