AR056216A1 - Derivados de piridopirazina y su uso - Google Patents
Derivados de piridopirazina y su usoInfo
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- AR056216A1 AR056216A1 ARP060104948A ARP060104948A AR056216A1 AR 056216 A1 AR056216 A1 AR 056216A1 AR P060104948 A ARP060104948 A AR P060104948A AR P060104948 A ARP060104948 A AR P060104948A AR 056216 A1 AR056216 A1 AR 056216A1
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- alkyl
- aryl
- heteroaryl
- cycloalkyl
- heterocyclyl
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Abstract
La presente pone a disposicion compuestos de piridopirazina, que son apropiados para el tratamiento o la prevencion de estados fisiologicos y/o patofisiologicos en mamíferos mediados y/o modulados por vías de transduccion de senales y/o enzimas, en especial en el ser humano. Reivindicacion 1: Uso de un compuesto de acuerdo con la formula general (1) en donde los sustituyentes R1, R2, R3, R4 tienen el siguiente significado: R1 y R2 pueden ser, de modo independiente entre sí: (i) hidrogeno, (ii) hidroxilo, (iii) halogeno, (iv) alquilo, en donde el radical alquilo está saturado y puede estar compuesto de 1 a 8 átomos de C, (v) arilo no sustituido o sustituido, en donde el radical arilo puede estar mono- o polisustituido con F, Cl, Br, I, CF3, CN, NH2, NH-alquilo, NH-cicloalquilo, NH-heterociclilo, NH-arilo, NH-heteroarilo, NH-alquil-cicloalquilo, NH-alquil-heterociclilo, NH-alquil-arilo, NH-alquil-heteroarilo, NH-alquil-NH2, NH-alquil-OH, N(alquilo)2, NHC(O)-alquilo, NHC(O)- cicloalquilo, NHC(O)-heterociclilo, NHC(O)-arilo, NHC(O)-heteroarilo, NHC(O)-alquil-arilo, NHC(O)-alquilheteroarilo, NHSO2-alquilo, NHSO2-cicloalquilo, NHSO2-heterociclilo, NHSO2-arilo, NHSO2-heteroarilo, NHSO2-alquil-arilo, NHSO2-alquil- heteroarilo, NO2, SH, S-alquilo, S-arilo, S-heteroarilo, OH, OCF3, O-alquilo, O-cicloalquilo, O-heterociclilo, O-arilo, O-heteroarilo, O-alquil-cicloalquilo, O-alquil-heterociclilo, O-alquilarilo, O-alquilheteroarilo, O-alquil-OH, O-(CH2)n-O, OC(O)- alquilo, OC(O)-cicloalquilo, OC(O)-heterociclilo, OC(O)-arilo, OC(O)-heteroarilo, OC(O)-alquilarilo, OC(O)-alquil-heteroarilo, OSO3H, OSO2-alquilo, OSO2-cicloalquilo, OSO2-heterociclilo, OSO2-arilo, OSO2-heteroarilo, OSO2-alquil-arilo, OSO2-alquil- heteroarilo, OP(O)(OH)2, C(O)-alquilo, C(O)-arilo, C(O)-heteroarilo, CO2H, CO2-alquilo, CO2-cicloalquilo, CO2-heterociclilo, CO2-arilo, CO2-heteroarilo, CO2-alquil-cicloalquilo, CO2-alquil-heterociclilo, CO2-alquil-arilo, CO2-alquil-heteroarilo, C(O)-NH2, C(O)NH-alquilo, C(O)NH-cicloalquilo, C(O)NH-heterociclilo, C(O)NH-arilo, C(O)NH-heteroarilo, C(O)NH-alquil-cicloalquilo, C(O)NH-alquil-heterociclilo, C(O)NH-alquil-heteroarilo, C(O)N(alquilo)2, C(O)N(cicloalquilo)2, C(O)N(heteroarilo)2, C(O)N(arilo)2, SO-alquilo, SO-arilo, SO2-alquilo, SO2-arilo, SO2NH2, SO2NH-alquilo, SO2NH-arilo, SO2NH-heteroarilo, SO2NH-alquil-arilo, SO3H, SO2O-alquilo, SO2O-arilo, SO2O-alquil-arilo, alquilo, cicloalquilo, heterociclilo, arilo o heteroarilo, igual o diferente, n puede adoptar el valor 1, 2 o 3, y los sustituyentes de alquilo, cicloalquilo, heterociclilo, arilo, heteroarilo, alquil-cicloalquilo, alquil-heterociclilo, alquil-arilo y alquil-heteroarilo pueden estar, a su vez, sustituidos, (vi) heteroarilo no sustituido o sustituido, en donde el radical heteroarilo puede estar mono- o polisustituido con F, Cl, Br, I, CF3, CN, NH2, NH-alquilo, NH-cicloalquilo, NH-heterociclilo, NH-arilo, NH-heteroarilo, NH-alquil-cicloalquilo, NH- alquil-heterociclilo, NH-alquil-arilo, NH-alquil-heteroarilo, NH-alquil-NH2, NH-alquil-OH, N(alquilo)2, NHC(O)-alquilo, NHC(O)-cicloalquilo, NHC(O)-heterociclilo, NHC(O)-arilo, NHC(O)-heteroarilo, NHC(O)-alquil-arilo, NHC(O)-alquil-heteroarilo, NHSO2-alquilo, NHSO2-cicloalquilo, NHSO2-heterociclilo, NHSO2-arilo, NHSO2-heteroarilo, NHSO2-alquil-arilo, NHSO2-alquil-heteroarilo, NO2, SH, S-alquilo, S-arilo, S-heteroarilo, OH, OCF3, O-alquilo, O-cicloalquilo, O-arilo, O-heteroarilo, O-alquil- cicloalquilo, O-alquil-heterociclilo, O-alquil-arilo, O-alquil-heteroarilo, OC(O)-alquilo, OC(O)-cicloalquilo, OC(O)-heterociclilo, OC(O)-arilo, OC(O)-heteroarilo, OC(O)-alquil-heteroarilo, OSO3H, OSO2-alquilo, OSO2-cicloalquilo, OSO2-heterociclilo, OSO2-arilo, OSO2-heteroarilo, OSO2-alquil-arilo, OSO2-alquil-heteroarilo, OP(O)(OH)2, C(O)-alquilo, C(O)-arilo, C(O)-heteroarilo, CO2H, CO2-alquilo, CO2-cicloalquilo, CO2-heterociclilo, CO2-arilo, CO2-heteroarilo, CO2-alquil-cicloalquilo, CO2-alquil- heterociclilo, CO2-alquil-arilo, CO2-alquil-heteroarilo, C(O)-NH2, C(O)NH-alquilo, C(O)NH-cicloalquilo, C(O)NH-heterociclilo, C(O)NH-arilo, C(O)NH-heteroarilo, C(O)NH-alquil-cicloalquilo, C(O)NH-alquil-heterociclilo, C(O)NH-alquil-arilo, C(O)NH- alquil-heteroarilo, C(O)N(alquilo)2, C(O)N(cicloalquilo)2, C(O)N(arilo)2, C(O)N(heteroarilo)2, SO2NH2, SO2NH-alquilo, SO2NH-arilo, SO2NH-heteroarilo, SO2NH-alquil-arilo, SO3H, SO2O-alquilo, SO2O-arilo, SO2O-alquil-arilo, alquilo, cicloalquilo, heterociclilo, arilo o heteroarilo, igual o diferente, y los sustituyentes de alquilo, cicloalquilo, heterociclilo, arilo y heteroarilo pueden estar, a su vez, sustituidos, (vii) OR5, en donde R5 puede ser alquilo, cicloalquilo, heterociclilo, arilo, heteroarilo, alquilcicloalquilo, alquil-heterociclilo, alquil-arilo o alquil-heteroarilo, y los sustituyentes de alquilo, cicloalquilo, heterociclilo, arilo, heteroarilo, alquil-cicloalquilo, alquil-heterociclilo, alquilarilo o alquil- heteroarilo pueden estar, a su vez, sustituidos, (viii) SR6, en donde R6 puede ser alquilo, cicloalquilo, heterociclilo, arilo, heteroarilo, alquil-cicloalquilo, alquil-heterociclilo, alquil-arilo o alquil-heteroarilo, y los sustituyentes de alquilo, cicloalquilo, heterociclilo, arilo y heteroarilo, alquil-cicloalquilo, alquil-heterociclilo, alquil-arilo, alquil-heteroarilo pueden estar, a su vez, sustituidos, (ix) NR7R8, en donde R7 y R8 pueden ser, de modo independiente entre sí, hidrogeno, alquilo, cicloalquilo, heterociclilo, arilo, heteroarilo, alquil-cicloalquilo, alquil-heterociclilo, alquil-arilo o alquil-heteroarilo, y los sustituyentes de alquilo, cicloalquilo, heterociclilo, arilo y heteroarilo, alquil-cicloalquilo, alquil heterociclilo alquil-arilo o alquil-heteroarilo pueden estar, a su vez, sustituidos, o R7 y R8 son juntos cicloalquilo o heterociclilo, en donde cicloalquilo y heterociclilo pueden estar, a su vez, sustituidos; R3 y R4 pueden ser, de modo independiente entre sí, hidrogeno o NR9R10, con la condicion de que, cuando R3 = NR9R10, R4 = H, y cuando R4 = NR9R10, R3 = H, en donde R9 puede ser hidrogeno, alquilo, cicloalquilo, heterociclilo, arilo, heteroarilo, alquil-cicloalquilo, alquil- heterociclilo, alquil-arilo o alquil-heteroarilo, y los sustituyentes de alquilo, cicloalquilo, heterociclilo, arilo y heteroarilo, alquil-cicloalquilo, alquil heterociclilo alquil-arilo o alquil-heteroarilo pueden estar, a su vez, sustituidos, y R10 puede ser a) -C(Y)NR11R12, en donde Y = O, S y R11 y R12 son, de modo independiente entre sí, (i) hidrogeno, (ii) alquilo no sustituido o sustituido, en donde el radical alquilo puede estar mono- o polisustituido con F, Cl, Br, I, CF3, CN, NH2, NH-alquilo, NH-cicloalquilo, NH-heterociclilo, NH-arilo, NH-heteroarilo, NH-alquil-cicloalquilo, NH-alquil-heterociclilo, NH-alquil-arilo, NH-alquil-heteroarilo, N(alquilo)2, NHC(O)-alquilo, NHC(O)-cicloalquilo, NHC(O)-heterociclilo, NHC(O)-arilo, NHC(O)-heteroarilo, NHC(O)-alquil-arilo, NHC(O)-alquil-heteroarilo, NHSO2-alquilo, NHSO2-cicloalquilo, NHSO2-heterociclilo, NHSO2-arilo, NHSO2-heteroarilo, NHSO2-alquil-arilo, NHSO2-alquil-heteroarilo, NO2, SH, S-alquilo, S-cicloalquilo, S- heterociclilo, S-arilo, S-heteroarilo, OH, OCF3, O-alquilo, O-cicloalquilo, O-heterociclilo, O-arilo, O-heteroarilo, O-alquil-cicloalquilo, O-alquil-heterociclilo, O-alquilarilo, O-alquilheteroarilo, OC(O)-alquilo, OC(O)-cicloalquilo, OC(O)- heterociclilo, OC(O)-arilo, OC(O)-heteroarilo, OC(O)-alquil-arilo, OC(O)-alquil-heteroarilo, OSO3H, OSO2-alquilo, OSO2-cicloalquilo, OSO2-heterociclilo, OSO2-arilo, OSO2-heteroarilo, OSO2-alquil-arilo, OSO2-alquil-heteroarilo, OP(O)(OH)2, C(O)- alquilo, C(O)-arilo, C(O)-heteroarilo, CO2H, CO2-alquilo, CO2-cicloalquilo, CO2-heterociclilo, CO2-arilo, CO2-heteroarilo, CO2-alquil-cicloalquilo, CO2-alquil-heterociclilo, CO2-alquil-arilo, CO2-alquil-heteroarilo, C(O)-NH2, C(O)NH-alquilo, C(O)NH- cicloalquilo, C(O)NH-heterociclilo, C(O)NH-arilo, C(O)NH-heteroarilo, C(O)NH-alquil-cicloalquilo, C(O)NH-alquil-heterociclilo, C(O)NH-alquil-arilo, C(O)NH-alquil-heteroarilo, C(O)N(alquilo)2, C(O)N(cicloalquilo)2, C(O)N(heteroarilo)2, C(O)N(arilo)2, SO-alquilo, SO-arilo, SO2-alquilo, SO2-arilo, SO2NH2, SO2NH-alquilo, SO2NH-arilo, SO2NH-heteroarilo, SO2NH-alquil-arilo, SO3H, SO2O-alquilo, SO2O-arilo, SO2O-alquil-arilo, cicloalquilo, heterociclilo, arilo o heteroarilo, igual o diferente, (iii) cicloalquilo no sustituido o sustituido, en donde el radical cicloalquilo puede estar mono- o polisustituido con F, Cl, Br, I, NH2, NH-alquilo, NH-cicloalquilo, NH-heterociclilo, NH-arilo, NH-heteroarilo, NH-alquil-arilo, NH-alquil-heteroarilo, N(alquilo)2, NHC(O)-alquilo, NHC(O)-cicloalquilo, NHC(O)-heterociclilo, NHC(O)-arilo, NHC(O)-heteroarilo, NHC(O)-alquil-arilo, NHC(O)-alquil-heteroarilo, NHSO2-alquilo, NHSO2-cicloalquilo, NHSO2-heterociclilo, NHSO2-arilo, NHSO2-heteroarilo, NHSO2- alquil-arilo, NHSO2-alquil-heteroarilo, OH, O-alquilo, O-cicloalquilo, O-heterociclilo, O-arilo, O-heteroarilo, O-alquilarilo, O-alquilheteroarilo, OC(O)-alquilo, OC(O)-cicloalquilo, OC(O)-heterociclilo, OC(O)-arilo, OC(O)-heteroarilo, OC(O)-alquil- arilo, OC(O)-alquil-heteroarilo, OSO3H, OSO2-alquilo, OSO2-cicloalquilo, OSO2-heterociclilo, OSO2-arilo, OSO2-heteroarilo, OSO2-alquil-arilo, OSO2-alquil-heteroarilo, OP(O)(OH)2, CO2H, CO2-alquilo, CO2-cicloalquilo, CO2-heterociclilo, CO2-arilo, CO2- heteroarilo, CO2-alquil-cicloalquilo, CO2-alquil-heterociclilo, CO2-alquil-arilo, CO2-alquil-heteroarilo, C(O)-NH2, C(O)NH-alquilo, C(O)NH-cicloalquilo, C(O)NH-heterociclilo, C(O)NH-arilo, C(O)NH-heteroarilo, C(O)NH-alquil-cicloalquilo, C(O)NH- alquil-heterociclilo, C(O)NH-alquil-arilo, C(O)NH-alquil-heteroarilo, C(O)N(alquilo)2, C(O)N(cicloalquilo)2, C(O)N(heteroarilo)2, C(O)N(arilo)2, alquilo o arilo, igual o diferente, (iv) heterociclilo no sustituido o sustituido, en donde el radical heterociclilo puede estar mono- o polisustituido con OH, O-alquilo, O-arilo, NH2, NH-alquilo, NH-arilo, alquilo, alquil-arilo, o aril
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US73570705P | 2005-11-11 | 2005-11-11 | |
EP05024692A EP1790342A1 (de) | 2005-11-11 | 2005-11-11 | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
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US (1) | US8937068B2 (es) |
EP (2) | EP1790342A1 (es) |
JP (1) | JP5448450B2 (es) |
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CN (1) | CN101330918B (es) |
AR (1) | AR056216A1 (es) |
AU (1) | AU2006334721B2 (es) |
BR (1) | BRPI0618451A2 (es) |
CA (1) | CA2628186A1 (es) |
ES (1) | ES2543962T3 (es) |
HK (1) | HK1125823A1 (es) |
IL (1) | IL191160A (es) |
NO (1) | NO20082509L (es) |
NZ (1) | NZ595879A (es) |
PL (1) | PL1962854T3 (es) |
RU (1) | RU2487713C2 (es) |
SG (1) | SG10201401061XA (es) |
TW (1) | TWI423973B (es) |
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-
2005
- 2005-11-11 EP EP05024692A patent/EP1790342A1/de not_active Withdrawn
-
2006
- 2006-10-11 UA UAA200807895A patent/UA95464C2/ru unknown
- 2006-11-10 US US11/558,493 patent/US8937068B2/en not_active Expired - Fee Related
- 2006-11-10 SG SG10201401061XA patent/SG10201401061XA/en unknown
- 2006-11-10 AU AU2006334721A patent/AU2006334721B2/en not_active Ceased
- 2006-11-10 WO PCT/EP2006/068323 patent/WO2007079999A2/de active Application Filing
- 2006-11-10 CN CN200680047112.6A patent/CN101330918B/zh not_active Expired - Fee Related
- 2006-11-10 NZ NZ595879A patent/NZ595879A/xx unknown
- 2006-11-10 RU RU2008123219/15A patent/RU2487713C2/ru not_active IP Right Cessation
- 2006-11-10 BR BRPI0618451-0A patent/BRPI0618451A2/pt not_active IP Right Cessation
- 2006-11-10 ES ES06849272.7T patent/ES2543962T3/es active Active
- 2006-11-10 PL PL06849272T patent/PL1962854T3/pl unknown
- 2006-11-10 EP EP06849272.7A patent/EP1962854B1/de active Active
- 2006-11-10 TW TW095141709A patent/TWI423973B/zh not_active IP Right Cessation
- 2006-11-10 CA CA002628186A patent/CA2628186A1/en not_active Abandoned
- 2006-11-10 JP JP2008539444A patent/JP5448450B2/ja not_active Expired - Fee Related
- 2006-11-13 AR ARP060104948A patent/AR056216A1/es unknown
-
2008
- 2008-04-25 ZA ZA200803867A patent/ZA200803867B/xx unknown
- 2008-04-30 IL IL191160A patent/IL191160A/en not_active IP Right Cessation
- 2008-06-03 NO NO20082509A patent/NO20082509L/no not_active Application Discontinuation
- 2008-06-11 KR KR1020087014066A patent/KR101473662B1/ko active IP Right Grant
-
2009
- 2009-03-12 HK HK09102357.4A patent/HK1125823A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1962854B1 (de) | 2015-05-06 |
RU2487713C2 (ru) | 2013-07-20 |
CN101330918B (zh) | 2015-09-02 |
ES2543962T3 (es) | 2015-08-26 |
PL1962854T3 (pl) | 2015-10-30 |
JP2009515854A (ja) | 2009-04-16 |
KR20080068116A (ko) | 2008-07-22 |
WO2007079999A2 (de) | 2007-07-19 |
EP1790342A1 (de) | 2007-05-30 |
TWI423973B (zh) | 2014-01-21 |
WO2007079999A3 (de) | 2007-10-04 |
UA95464C2 (en) | 2011-08-10 |
US8937068B2 (en) | 2015-01-20 |
IL191160A (en) | 2016-03-31 |
EP1962854A2 (de) | 2008-09-03 |
CN101330918A (zh) | 2008-12-24 |
TW200736253A (en) | 2007-10-01 |
AU2006334721B2 (en) | 2011-08-11 |
KR101473662B1 (ko) | 2014-12-17 |
SG10201401061XA (en) | 2014-07-30 |
HK1125823A1 (zh) | 2009-08-21 |
NO20082509L (no) | 2008-07-23 |
AU2006334721A1 (en) | 2007-07-19 |
NZ595879A (en) | 2013-07-26 |
BRPI0618451A2 (pt) | 2011-08-30 |
RU2008123219A (ru) | 2009-12-20 |
US20070123494A1 (en) | 2007-05-31 |
CA2628186A1 (en) | 2007-07-19 |
ZA200803867B (en) | 2009-05-27 |
IL191160A0 (en) | 2008-12-29 |
JP5448450B2 (ja) | 2014-03-19 |
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