AR056216A1 - Derivados de piridopirazina y su uso - Google Patents
Derivados de piridopirazina y su usoInfo
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- AR056216A1 AR056216A1 ARP060104948A ARP060104948A AR056216A1 AR 056216 A1 AR056216 A1 AR 056216A1 AR P060104948 A ARP060104948 A AR P060104948A AR P060104948 A ARP060104948 A AR P060104948A AR 056216 A1 AR056216 A1 AR 056216A1
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- alkyl
- aryl
- heteroaryl
- cycloalkyl
- heterocyclyl
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Abstract
La presente pone a disposicion compuestos de piridopirazina, que son apropiados para el tratamiento o la prevencion de estados fisiologicos y/o patofisiologicos en mamíferos mediados y/o modulados por vías de transduccion de senales y/o enzimas, en especial en el ser humano. Reivindicacion 1: Uso de un compuesto de acuerdo con la formula general (1) en donde los sustituyentes R1, R2, R3, R4 tienen el siguiente significado: R1 y R2 pueden ser, de modo independiente entre sí: (i) hidrogeno, (ii) hidroxilo, (iii) halogeno, (iv) alquilo, en donde el radical alquilo está saturado y puede estar compuesto de 1 a 8 átomos de C, (v) arilo no sustituido o sustituido, en donde el radical arilo puede estar mono- o polisustituido con F, Cl, Br, I, CF3, CN, NH2, NH-alquilo, NH-cicloalquilo, NH-heterociclilo, NH-arilo, NH-heteroarilo, NH-alquil-cicloalquilo, NH-alquil-heterociclilo, NH-alquil-arilo, NH-alquil-heteroarilo, NH-alquil-NH2, NH-alquil-OH, N(alquilo)2, NHC(O)-alquilo, NHC(O)- cicloalquilo, NHC(O)-heterociclilo, NHC(O)-arilo, NHC(O)-heteroarilo, NHC(O)-alquil-arilo, NHC(O)-alquilheteroarilo, NHSO2-alquilo, NHSO2-cicloalquilo, NHSO2-heterociclilo, NHSO2-arilo, NHSO2-heteroarilo, NHSO2-alquil-arilo, NHSO2-alquil- heteroarilo, NO2, SH, S-alquilo, S-arilo, S-heteroarilo, OH, OCF3, O-alquilo, O-cicloalquilo, O-heterociclilo, O-arilo, O-heteroarilo, O-alquil-cicloalquilo, O-alquil-heterociclilo, O-alquilarilo, O-alquilheteroarilo, O-alquil-OH, O-(CH2)n-O, OC(O)- alquilo, OC(O)-cicloalquilo, OC(O)-heterociclilo, OC(O)-arilo, OC(O)-heteroarilo, OC(O)-alquilarilo, OC(O)-alquil-heteroarilo, OSO3H, OSO2-alquilo, OSO2-cicloalquilo, OSO2-heterociclilo, OSO2-arilo, OSO2-heteroarilo, OSO2-alquil-arilo, OSO2-alquil- heteroarilo, OP(O)(OH)2, C(O)-alquilo, C(O)-arilo, C(O)-heteroarilo, CO2H, CO2-alquilo, CO2-cicloalquilo, CO2-heterociclilo, CO2-arilo, CO2-heteroarilo, CO2-alquil-cicloalquilo, CO2-alquil-heterociclilo, CO2-alquil-arilo, CO2-alquil-heteroarilo, C(O)-NH2, C(O)NH-alquilo, C(O)NH-cicloalquilo, C(O)NH-heterociclilo, C(O)NH-arilo, C(O)NH-heteroarilo, C(O)NH-alquil-cicloalquilo, C(O)NH-alquil-heterociclilo, C(O)NH-alquil-heteroarilo, C(O)N(alquilo)2, C(O)N(cicloalquilo)2, C(O)N(heteroarilo)2, C(O)N(arilo)2, SO-alquilo, SO-arilo, SO2-alquilo, SO2-arilo, SO2NH2, SO2NH-alquilo, SO2NH-arilo, SO2NH-heteroarilo, SO2NH-alquil-arilo, SO3H, SO2O-alquilo, SO2O-arilo, SO2O-alquil-arilo, alquilo, cicloalquilo, heterociclilo, arilo o heteroarilo, igual o diferente, n puede adoptar el valor 1, 2 o 3, y los sustituyentes de alquilo, cicloalquilo, heterociclilo, arilo, heteroarilo, alquil-cicloalquilo, alquil-heterociclilo, alquil-arilo y alquil-heteroarilo pueden estar, a su vez, sustituidos, (vi) heteroarilo no sustituido o sustituido, en donde el radical heteroarilo puede estar mono- o polisustituido con F, Cl, Br, I, CF3, CN, NH2, NH-alquilo, NH-cicloalquilo, NH-heterociclilo, NH-arilo, NH-heteroarilo, NH-alquil-cicloalquilo, NH- alquil-heterociclilo, NH-alquil-arilo, NH-alquil-heteroarilo, NH-alquil-NH2, NH-alquil-OH, N(alquilo)2, NHC(O)-alquilo, NHC(O)-cicloalquilo, NHC(O)-heterociclilo, NHC(O)-arilo, NHC(O)-heteroarilo, NHC(O)-alquil-arilo, NHC(O)-alquil-heteroarilo, NHSO2-alquilo, NHSO2-cicloalquilo, NHSO2-heterociclilo, NHSO2-arilo, NHSO2-heteroarilo, NHSO2-alquil-arilo, NHSO2-alquil-heteroarilo, NO2, SH, S-alquilo, S-arilo, S-heteroarilo, OH, OCF3, O-alquilo, O-cicloalquilo, O-arilo, O-heteroarilo, O-alquil- cicloalquilo, O-alquil-heterociclilo, O-alquil-arilo, O-alquil-heteroarilo, OC(O)-alquilo, OC(O)-cicloalquilo, OC(O)-heterociclilo, OC(O)-arilo, OC(O)-heteroarilo, OC(O)-alquil-heteroarilo, OSO3H, OSO2-alquilo, OSO2-cicloalquilo, OSO2-heterociclilo, OSO2-arilo, OSO2-heteroarilo, OSO2-alquil-arilo, OSO2-alquil-heteroarilo, OP(O)(OH)2, C(O)-alquilo, C(O)-arilo, C(O)-heteroarilo, CO2H, CO2-alquilo, CO2-cicloalquilo, CO2-heterociclilo, CO2-arilo, CO2-heteroarilo, CO2-alquil-cicloalquilo, CO2-alquil- heterociclilo, CO2-alquil-arilo, CO2-alquil-heteroarilo, C(O)-NH2, C(O)NH-alquilo, C(O)NH-cicloalquilo, C(O)NH-heterociclilo, C(O)NH-arilo, C(O)NH-heteroarilo, C(O)NH-alquil-cicloalquilo, C(O)NH-alquil-heterociclilo, C(O)NH-alquil-arilo, C(O)NH- alquil-heteroarilo, C(O)N(alquilo)2, C(O)N(cicloalquilo)2, C(O)N(arilo)2, C(O)N(heteroarilo)2, SO2NH2, SO2NH-alquilo, SO2NH-arilo, SO2NH-heteroarilo, SO2NH-alquil-arilo, SO3H, SO2O-alquilo, SO2O-arilo, SO2O-alquil-arilo, alquilo, cicloalquilo, heterociclilo, arilo o heteroarilo, igual o diferente, y los sustituyentes de alquilo, cicloalquilo, heterociclilo, arilo y heteroarilo pueden estar, a su vez, sustituidos, (vii) OR5, en donde R5 puede ser alquilo, cicloalquilo, heterociclilo, arilo, heteroarilo, alquilcicloalquilo, alquil-heterociclilo, alquil-arilo o alquil-heteroarilo, y los sustituyentes de alquilo, cicloalquilo, heterociclilo, arilo, heteroarilo, alquil-cicloalquilo, alquil-heterociclilo, alquilarilo o alquil- heteroarilo pueden estar, a su vez, sustituidos, (viii) SR6, en donde R6 puede ser alquilo, cicloalquilo, heterociclilo, arilo, heteroarilo, alquil-cicloalquilo, alquil-heterociclilo, alquil-arilo o alquil-heteroarilo, y los sustituyentes de alquilo, cicloalquilo, heterociclilo, arilo y heteroarilo, alquil-cicloalquilo, alquil-heterociclilo, alquil-arilo, alquil-heteroarilo pueden estar, a su vez, sustituidos, (ix) NR7R8, en donde R7 y R8 pueden ser, de modo independiente entre sí, hidrogeno, alquilo, cicloalquilo, heterociclilo, arilo, heteroarilo, alquil-cicloalquilo, alquil-heterociclilo, alquil-arilo o alquil-heteroarilo, y los sustituyentes de alquilo, cicloalquilo, heterociclilo, arilo y heteroarilo, alquil-cicloalquilo, alquil heterociclilo alquil-arilo o alquil-heteroarilo pueden estar, a su vez, sustituidos, o R7 y R8 son juntos cicloalquilo o heterociclilo, en donde cicloalquilo y heterociclilo pueden estar, a su vez, sustituidos; R3 y R4 pueden ser, de modo independiente entre sí, hidrogeno o NR9R10, con la condicion de que, cuando R3 = NR9R10, R4 = H, y cuando R4 = NR9R10, R3 = H, en donde R9 puede ser hidrogeno, alquilo, cicloalquilo, heterociclilo, arilo, heteroarilo, alquil-cicloalquilo, alquil- heterociclilo, alquil-arilo o alquil-heteroarilo, y los sustituyentes de alquilo, cicloalquilo, heterociclilo, arilo y heteroarilo, alquil-cicloalquilo, alquil heterociclilo alquil-arilo o alquil-heteroarilo pueden estar, a su vez, sustituidos, y R10 puede ser a) -C(Y)NR11R12, en donde Y = O, S y R11 y R12 son, de modo independiente entre sí, (i) hidrogeno, (ii) alquilo no sustituido o sustituido, en donde el radical alquilo puede estar mono- o polisustituido con F, Cl, Br, I, CF3, CN, NH2, NH-alquilo, NH-cicloalquilo, NH-heterociclilo, NH-arilo, NH-heteroarilo, NH-alquil-cicloalquilo, NH-alquil-heterociclilo, NH-alquil-arilo, NH-alquil-heteroarilo, N(alquilo)2, NHC(O)-alquilo, NHC(O)-cicloalquilo, NHC(O)-heterociclilo, NHC(O)-arilo, NHC(O)-heteroarilo, NHC(O)-alquil-arilo, NHC(O)-alquil-heteroarilo, NHSO2-alquilo, NHSO2-cicloalquilo, NHSO2-heterociclilo, NHSO2-arilo, NHSO2-heteroarilo, NHSO2-alquil-arilo, NHSO2-alquil-heteroarilo, NO2, SH, S-alquilo, S-cicloalquilo, S- heterociclilo, S-arilo, S-heteroarilo, OH, OCF3, O-alquilo, O-cicloalquilo, O-heterociclilo, O-arilo, O-heteroarilo, O-alquil-cicloalquilo, O-alquil-heterociclilo, O-alquilarilo, O-alquilheteroarilo, OC(O)-alquilo, OC(O)-cicloalquilo, OC(O)- heterociclilo, OC(O)-arilo, OC(O)-heteroarilo, OC(O)-alquil-arilo, OC(O)-alquil-heteroarilo, OSO3H, OSO2-alquilo, OSO2-cicloalquilo, OSO2-heterociclilo, OSO2-arilo, OSO2-heteroarilo, OSO2-alquil-arilo, OSO2-alquil-heteroarilo, OP(O)(OH)2, C(O)- alquilo, C(O)-arilo, C(O)-heteroarilo, CO2H, CO2-alquilo, CO2-cicloalquilo, CO2-heterociclilo, CO2-arilo, CO2-heteroarilo, CO2-alquil-cicloalquilo, CO2-alquil-heterociclilo, CO2-alquil-arilo, CO2-alquil-heteroarilo, C(O)-NH2, C(O)NH-alquilo, C(O)NH- cicloalquilo, C(O)NH-heterociclilo, C(O)NH-arilo, C(O)NH-heteroarilo, C(O)NH-alquil-cicloalquilo, C(O)NH-alquil-heterociclilo, C(O)NH-alquil-arilo, C(O)NH-alquil-heteroarilo, C(O)N(alquilo)2, C(O)N(cicloalquilo)2, C(O)N(heteroarilo)2, C(O)N(arilo)2, SO-alquilo, SO-arilo, SO2-alquilo, SO2-arilo, SO2NH2, SO2NH-alquilo, SO2NH-arilo, SO2NH-heteroarilo, SO2NH-alquil-arilo, SO3H, SO2O-alquilo, SO2O-arilo, SO2O-alquil-arilo, cicloalquilo, heterociclilo, arilo o heteroarilo, igual o diferente, (iii) cicloalquilo no sustituido o sustituido, en donde el radical cicloalquilo puede estar mono- o polisustituido con F, Cl, Br, I, NH2, NH-alquilo, NH-cicloalquilo, NH-heterociclilo, NH-arilo, NH-heteroarilo, NH-alquil-arilo, NH-alquil-heteroarilo, N(alquilo)2, NHC(O)-alquilo, NHC(O)-cicloalquilo, NHC(O)-heterociclilo, NHC(O)-arilo, NHC(O)-heteroarilo, NHC(O)-alquil-arilo, NHC(O)-alquil-heteroarilo, NHSO2-alquilo, NHSO2-cicloalquilo, NHSO2-heterociclilo, NHSO2-arilo, NHSO2-heteroarilo, NHSO2- alquil-arilo, NHSO2-alquil-heteroarilo, OH, O-alquilo, O-cicloalquilo, O-heterociclilo, O-arilo, O-heteroarilo, O-alquilarilo, O-alquilheteroarilo, OC(O)-alquilo, OC(O)-cicloalquilo, OC(O)-heterociclilo, OC(O)-arilo, OC(O)-heteroarilo, OC(O)-alquil- arilo, OC(O)-alquil-heteroarilo, OSO3H, OSO2-alquilo, OSO2-cicloalquilo, OSO2-heterociclilo, OSO2-arilo, OSO2-heteroarilo, OSO2-alquil-arilo, OSO2-alquil-heteroarilo, OP(O)(OH)2, CO2H, CO2-alquilo, CO2-cicloalquilo, CO2-heterociclilo, CO2-arilo, CO2- heteroarilo, CO2-alquil-cicloalquilo, CO2-alquil-heterociclilo, CO2-alquil-arilo, CO2-alquil-heteroarilo, C(O)-NH2, C(O)NH-alquilo, C(O)NH-cicloalquilo, C(O)NH-heterociclilo, C(O)NH-arilo, C(O)NH-heteroarilo, C(O)NH-alquil-cicloalquilo, C(O)NH- alquil-heterociclilo, C(O)NH-alquil-arilo, C(O)NH-alquil-heteroarilo, C(O)N(alquilo)2, C(O)N(cicloalquilo)2, C(O)N(heteroarilo)2, C(O)N(arilo)2, alquilo o arilo, igual o diferente, (iv) heterociclilo no sustituido o sustituido, en donde el radical heterociclilo puede estar mono- o polisustituido con OH, O-alquilo, O-arilo, NH2, NH-alquilo, NH-arilo, alquilo, alquil-arilo, o aril
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US73570705P | 2005-11-11 | 2005-11-11 | |
EP05024692A EP1790342A1 (de) | 2005-11-11 | 2005-11-11 | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
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EP (2) | EP1790342A1 (es) |
JP (1) | JP5448450B2 (es) |
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CA (1) | CA2628186A1 (es) |
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HK (1) | HK1125823A1 (es) |
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NO (1) | NO20082509L (es) |
NZ (1) | NZ595879A (es) |
PL (1) | PL1962854T3 (es) |
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Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090118139A1 (en) * | 2000-11-07 | 2009-05-07 | Caliper Life Sciences, Inc. | Microfluidic method and system for enzyme inhibition activity screening |
WO2007054556A1 (de) * | 2005-11-11 | 2007-05-18 | Æterna Zentaris Gmbh | Neue pyridopyrazine und deren verwendung als modulatoren von kinasen |
US9139630B2 (en) | 2006-07-11 | 2015-09-22 | Rutgers, The State University Of New Jersey | Compositions and methods for preparing recombinant MG53 and methods for optimizing same |
US9458465B2 (en) * | 2007-12-04 | 2016-10-04 | Rutgers, The State University Of New Jersey | Compositions and methods to modulate cell membrane resealing |
US7893066B2 (en) * | 2006-10-05 | 2011-02-22 | Gilead Palo Alto, Inc. | Pyridol[2,3-B]pyrazinones for use as stearoyl CoA desaturase inhibitors |
EP1990342A1 (en) * | 2007-05-10 | 2008-11-12 | AEterna Zentaris GmbH | Pyridopyrazine Derivatives, Process of Manufacturing and Uses thereof |
US8399483B2 (en) | 2007-12-21 | 2013-03-19 | Ucb Pharma S.A. | Quinoxaline and quinoline derivatives as kinase inhibitors |
WO2010045374A1 (en) * | 2008-10-15 | 2010-04-22 | Gilead Palo Alto, Inc. | 3-hydroquinazolin-4-one derivatives for use as stearoyl coa desaturase inhibitors |
WO2010052448A2 (en) * | 2008-11-05 | 2010-05-14 | Ucb Pharma S.A. | Fused pyrazine derivatives as kinase inhibitors |
GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
US20130123340A1 (en) * | 2010-05-11 | 2013-05-16 | Peking University, Office Of Technology Transfer | Compositions and methods for the treatment and prevention of cardiac ischemic injury |
EP2635908B1 (en) | 2010-11-05 | 2015-08-19 | University of Medicine and Dentistry of New Jersey | Serum mg53 as a diagnostic marker for tissue injury |
GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
EP2508184A1 (en) | 2011-04-06 | 2012-10-10 | Æterna Zentaris GmbH | Pyridopyrazine derivatives and their use |
WO2013018733A1 (ja) | 2011-07-29 | 2013-02-07 | 富士フイルム株式会社 | 1,5-ナフチリジン誘導体又はその塩 |
GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
EP2944637B1 (en) * | 2013-01-11 | 2020-02-19 | FUJIFILM Corporation | Nitrogen-containing heterocylic compound or salt thereof |
GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
WO2015144804A1 (en) | 2014-03-26 | 2015-10-01 | Astex Therapeutics Ltd | Combinations |
CA2943687C (en) | 2014-03-26 | 2024-02-13 | Astex Therapeutics Ltd | Combinations of an fgfr inhibitor and an igf1r inhibitor |
JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
WO2016203335A1 (en) * | 2015-06-18 | 2016-12-22 | Pfizer Inc. | Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors |
JP6898919B2 (ja) | 2015-09-23 | 2021-07-07 | ヤンセン ファーマシューティカ エヌ.ベー. | 新規化合物 |
CN108137546B (zh) | 2015-09-23 | 2021-07-27 | 詹森药业有限公司 | 双杂芳基取代的1,4-苯并二氮杂卓化合物及其用于治疗癌症的用途 |
CN107619388A (zh) * | 2016-07-13 | 2018-01-23 | 南京天印健华医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
US11117894B2 (en) | 2017-06-22 | 2021-09-14 | City Of Hope | Pyridopyrazine compounds and uses thereof |
US20210238605A1 (en) * | 2018-06-15 | 2021-08-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of pi3kc2b inhibitors for the preservation of vascular endothelial cell barrier integrity |
CN111892597B (zh) * | 2020-09-01 | 2023-07-25 | 山西天宏达安医药科技有限公司 | 一种喹喔啉基吡啶并吡嗪类化合物及其制备方法与应用 |
Family Cites Families (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3209004A (en) | 1963-05-17 | 1965-09-28 | American Home Prod | 3, 6-diamino-n-(2, 2-dialkoxyethyl) pyrido[2, 3-b] pyrazine-2-carboxamides |
US3180868A (en) | 1963-07-24 | 1965-04-27 | American Home Prod | 3, 6-diamino-n-(substituted)pyrido[2, 3-b]-pyrazine-2-carboxamides |
US3809695A (en) | 1967-04-19 | 1974-05-07 | Degussa | 2,6-dichloro-3-nitro-pyridine |
JPS5053394A (es) | 1973-09-20 | 1975-05-12 | ||
US4082845A (en) | 1977-04-25 | 1978-04-04 | Merck & Co., Inc. | 3-(1-Piperazinyl)-pyrido[2,3-b]pyrazines |
US5480883A (en) | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US5710158A (en) | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
CA2172750A1 (en) | 1995-03-28 | 1996-09-29 | Shinzo Seko | Process for producing aminonitropyridines |
UA71555C2 (en) | 1997-10-06 | 2004-12-15 | Zentaris Gmbh | Methods for modulating function of serine/threonine protein kinases by 5-azaquinoline derivatives |
CA2315720A1 (en) | 1997-12-22 | 1999-07-01 | Bayer Corporation | Inhibition of p38 kinase activity using substituted heterocyclic ureas |
AU2879799A (en) | 1998-02-26 | 1999-09-15 | Neurogen Corporation | 4-(4-piperidylmethylamino) substituted heteroaryl fused pyridines: gaba brain receptor ligands |
US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
KR20010101203A (ko) | 1998-12-15 | 2001-11-14 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | Mek 저해제의 이식 조직 거부를 예방하기 위한 용도 |
YU45401A (sh) | 1998-12-22 | 2004-07-15 | Warner-Lambert Company | Antikancerogena kombinacija |
KR100785363B1 (ko) | 2000-04-25 | 2007-12-18 | 이코스 코포레이션 | 인간 포스파티딜-이노시톨 3-키나제 델타의 억제제 |
YU2503A (sh) | 2000-07-19 | 2006-05-25 | Warner-Lambert Company | Oksigenovani estri 4-jodo fenilamino benzhidroksamskih kiselina |
EP1326610B1 (en) | 2000-10-12 | 2006-11-15 | Merck & Co., Inc. | Aza-and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
US7432270B2 (en) | 2001-05-05 | 2008-10-07 | Smithkline Beecham P.L.C. | N-aroyl cyclic amines |
MXPA04002397A (es) | 2001-09-14 | 2004-12-02 | Methylgene Inc | Inhibidores de histona deacetilasa. |
TW200406410A (en) | 2002-01-29 | 2004-05-01 | Glaxo Group Ltd | Compounds |
AU2003239302A1 (en) | 2002-01-29 | 2003-09-02 | Glaxo Group Limited | Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them |
WO2003068223A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Corporation | Aryl ureas with raf kinase and angiogenesis inhibiting activity |
CA2480800C (en) | 2002-04-08 | 2008-09-23 | Mark T. Bilodeau | Inhibitors of akt activity |
US20060142178A1 (en) | 2002-04-08 | 2006-06-29 | Barnett Stanley F | Method of treating cancer |
WO2003086403A1 (en) | 2002-04-08 | 2003-10-23 | Merck & Co., Inc. | Inhibitors of akt activity |
JP4903997B2 (ja) | 2002-07-02 | 2012-03-28 | サザン リサーチ インスティチュート | FtsZの阻害剤およびそれらの用途 |
WO2004017950A2 (en) | 2002-08-22 | 2004-03-04 | Piramed Limited | Phosphadidylinositol 3,5-biphosphate inhibitors as anti-viral agents |
CA2500727A1 (en) | 2002-10-03 | 2004-04-15 | Targegen, Inc. | Vasculostatic agents and methods of use thereof |
US20040102360A1 (en) * | 2002-10-30 | 2004-05-27 | Barnett Stanley F. | Combination therapy |
US20040092521A1 (en) | 2002-11-12 | 2004-05-13 | Altenbach Robert J. | Bicyclic-substituted amines as histamine-3 receptor ligands |
AR042461A1 (es) | 2002-12-13 | 2005-06-22 | Neurogen Corp | Analogos 2-sustituidos de quinazolin-4-il - amina. composiciones farmaceuticas |
DE10323345A1 (de) * | 2003-05-23 | 2004-12-16 | Zentaris Gmbh | Neue Pyridopyrazine und deren Verwendung als Kinase-Inhibitoren |
CA2524525C (en) * | 2003-05-23 | 2012-01-03 | Zentaris Gmbh | Novel pyridopyrazines and use thereof as kinase modulators |
KR101132599B1 (ko) | 2003-06-05 | 2012-06-21 | 아에테르나 젠타리스 게엠베하 | 아폽토시스 유도 효과를 갖는 인돌 유도체 |
WO2005007099A2 (en) * | 2003-07-10 | 2005-01-27 | Imclone Systems Incorporated | Pkb inhibitors as anti-tumor agents |
SE0302304D0 (sv) | 2003-08-27 | 2003-08-27 | Astrazeneca Ab | Novel compounds |
WO2005023771A1 (ja) | 2003-09-05 | 2005-03-17 | Ono Pharmaceutical Co., Ltd. | ケモカインレセプターアンタゴニストおよびその医薬用途 |
AU2004270740A1 (en) | 2003-09-09 | 2005-03-17 | Neurogen Corporation | 4 - heterobicyclyamino - substituted quinazolines and analogues therof as capsaicin - antagonists |
AU2004297235A1 (en) | 2003-12-04 | 2005-06-23 | Vertex Pharmaceuticals Incorporated | Quinoxalines useful as inhibitors of protein kinases |
WO2005061519A1 (en) | 2003-12-19 | 2005-07-07 | Takeda San Diego, Inc. | Kinase inhibitors |
US20050165028A1 (en) | 2004-01-23 | 2005-07-28 | Norman Mark H. | Vanilloid receptor ligands and their use in treatments |
DE102004017932A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
US20050256118A1 (en) | 2004-05-12 | 2005-11-17 | Altenbach Robert J | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
US7098222B2 (en) | 2004-05-12 | 2006-08-29 | Abbott Laboratories | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
US7205316B2 (en) | 2004-05-12 | 2007-04-17 | Abbott Laboratories | Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands |
US20050256309A1 (en) | 2004-05-12 | 2005-11-17 | Altenbach Robert J | Tri-and bi-cyclic heteroaryl histamine-3 receptor ligands |
EP1796466A4 (en) | 2004-06-15 | 2009-09-02 | Glaxo Group Ltd | ANTIBACTERIAL AGENTS |
GB0413955D0 (en) | 2004-06-22 | 2004-07-28 | Syngenta Participations Ag | Chemical compounds |
GB0413953D0 (en) | 2004-06-22 | 2004-07-28 | Syngenta Participations Ag | Chemical compounds |
WO2006014580A1 (en) | 2004-07-08 | 2006-02-09 | Glaxo Group Limited | Antibacterial agents |
US7648984B2 (en) | 2004-07-13 | 2010-01-19 | Glaxo Group Limited | Antibacterial agents |
US20070270417A1 (en) | 2004-07-22 | 2007-11-22 | Glaxo Group Limited | Antibacterial Agents |
EP1781669B1 (en) | 2004-08-02 | 2010-10-13 | Glaxo Group Limited | Antibacterial agents |
WO2006020561A2 (en) | 2004-08-09 | 2006-02-23 | Glaxo Group Limited | Antibacterial agents |
DE102004041163A1 (de) | 2004-08-25 | 2006-03-02 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
EP1786812B1 (en) | 2004-09-03 | 2011-11-09 | Merck Serono SA | Pyridine methylene azolidinones and their use as phosphoinositide inhibitors |
JP2006137723A (ja) | 2004-11-15 | 2006-06-01 | Kyowa Hakko Kogyo Co Ltd | スルホンアミド誘導体 |
US20090137558A1 (en) | 2004-12-03 | 2009-05-28 | Peakdale Molecular Limited | Pyridine based compounds useful as intermediates for pharmaceutical or agricultural end-products |
CA2592900A1 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
JP2008528598A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
JP2008528587A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
JP2008528588A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
JP2008528586A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
JP2008530111A (ja) | 2005-02-14 | 2008-08-07 | メルク エンド カムパニー インコーポレーテッド | Akt活性の阻害剤 |
US20070032493A1 (en) | 2005-05-26 | 2007-02-08 | Synta Pharmaceuticals Corp. | Method for treating B cell regulated autoimmune disorders |
WO2006128129A2 (en) | 2005-05-26 | 2006-11-30 | Synta Pharmaceuticals Corp. | Method for treating cancer |
NZ565749A (en) | 2005-08-26 | 2010-12-24 | Serono Lab | Pyrazine derivatives and use as PI3K inhibitors |
KR101396783B1 (ko) | 2005-10-07 | 2014-05-21 | 엑셀리시스, 인코포레이티드 | 포스파티딜이노시톨 3-키나아제 억제제 및 이의 사용 방법 |
WO2007054556A1 (de) | 2005-11-11 | 2007-05-18 | Æterna Zentaris Gmbh | Neue pyridopyrazine und deren verwendung als modulatoren von kinasen |
-
2005
- 2005-11-11 EP EP05024692A patent/EP1790342A1/de not_active Withdrawn
-
2006
- 2006-10-11 UA UAA200807895A patent/UA95464C2/ru unknown
- 2006-11-10 CN CN200680047112.6A patent/CN101330918B/zh not_active Expired - Fee Related
- 2006-11-10 NZ NZ595879A patent/NZ595879A/xx unknown
- 2006-11-10 JP JP2008539444A patent/JP5448450B2/ja not_active Expired - Fee Related
- 2006-11-10 ES ES06849272.7T patent/ES2543962T3/es active Active
- 2006-11-10 PL PL06849272T patent/PL1962854T3/pl unknown
- 2006-11-10 US US11/558,493 patent/US8937068B2/en not_active Expired - Fee Related
- 2006-11-10 RU RU2008123219/15A patent/RU2487713C2/ru not_active IP Right Cessation
- 2006-11-10 SG SG10201401061XA patent/SG10201401061XA/en unknown
- 2006-11-10 TW TW095141709A patent/TWI423973B/zh not_active IP Right Cessation
- 2006-11-10 WO PCT/EP2006/068323 patent/WO2007079999A2/de active Application Filing
- 2006-11-10 BR BRPI0618451-0A patent/BRPI0618451A2/pt not_active IP Right Cessation
- 2006-11-10 CA CA002628186A patent/CA2628186A1/en not_active Abandoned
- 2006-11-10 EP EP06849272.7A patent/EP1962854B1/de active Active
- 2006-11-10 AU AU2006334721A patent/AU2006334721B2/en not_active Ceased
- 2006-11-13 AR ARP060104948A patent/AR056216A1/es unknown
-
2008
- 2008-04-25 ZA ZA200803867A patent/ZA200803867B/xx unknown
- 2008-04-30 IL IL191160A patent/IL191160A/en not_active IP Right Cessation
- 2008-06-03 NO NO20082509A patent/NO20082509L/no not_active Application Discontinuation
- 2008-06-11 KR KR1020087014066A patent/KR101473662B1/ko active IP Right Grant
-
2009
- 2009-03-12 HK HK09102357.4A patent/HK1125823A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP5448450B2 (ja) | 2014-03-19 |
NO20082509L (no) | 2008-07-23 |
CA2628186A1 (en) | 2007-07-19 |
HK1125823A1 (zh) | 2009-08-21 |
AU2006334721B2 (en) | 2011-08-11 |
RU2008123219A (ru) | 2009-12-20 |
CN101330918B (zh) | 2015-09-02 |
WO2007079999A3 (de) | 2007-10-04 |
EP1962854A2 (de) | 2008-09-03 |
TW200736253A (en) | 2007-10-01 |
EP1962854B1 (de) | 2015-05-06 |
EP1790342A1 (de) | 2007-05-30 |
JP2009515854A (ja) | 2009-04-16 |
NZ595879A (en) | 2013-07-26 |
UA95464C2 (en) | 2011-08-10 |
ZA200803867B (en) | 2009-05-27 |
BRPI0618451A2 (pt) | 2011-08-30 |
CN101330918A (zh) | 2008-12-24 |
US20070123494A1 (en) | 2007-05-31 |
AU2006334721A1 (en) | 2007-07-19 |
SG10201401061XA (en) | 2014-07-30 |
US8937068B2 (en) | 2015-01-20 |
RU2487713C2 (ru) | 2013-07-20 |
IL191160A0 (en) | 2008-12-29 |
WO2007079999A2 (de) | 2007-07-19 |
KR20080068116A (ko) | 2008-07-22 |
PL1962854T3 (pl) | 2015-10-30 |
TWI423973B (zh) | 2014-01-21 |
IL191160A (en) | 2016-03-31 |
KR101473662B1 (ko) | 2014-12-17 |
ES2543962T3 (es) | 2015-08-26 |
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