BR112013025630A2 - derivados de piridopirazina e seu uso - Google Patents

derivados de piridopirazina e seu uso

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Publication number
BR112013025630A2
BR112013025630A2 BR112013025630A BR112013025630A BR112013025630A2 BR 112013025630 A2 BR112013025630 A2 BR 112013025630A2 BR 112013025630 A BR112013025630 A BR 112013025630A BR 112013025630 A BR112013025630 A BR 112013025630A BR 112013025630 A2 BR112013025630 A2 BR 112013025630A2
Authority
BR
Brazil
Prior art keywords
pyridopyrazine
pyridopyrazine derivatives
derivatives
mammals
enzymes
Prior art date
Application number
BR112013025630A
Other languages
English (en)
Inventor
Eckhard Günther
Gilbert Mueller
Irene Seipelt
Lars Blumenstein
Matthias Gerlach
Michael Teifel
Tilmann Schuster
Original Assignee
Æterna Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Æterna Zentaris Gmbh filed Critical Æterna Zentaris Gmbh
Publication of BR112013025630A2 publication Critical patent/BR112013025630A2/pt

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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Abstract

resumo patente de invenção:"derivados de piridopirazina e seu uso". a presente invenção fornece novos compostos de piridopirazina que são adequados para o tratamento ou prevenção de estados fisiológicos e/ou patofisiológicos mediados e/ou modulados por séries de reação de transdução de sinal e/ou enzimas em mamíferos e em particular em humanos.
BR112013025630A 2011-04-06 2012-04-04 derivados de piridopirazina e seu uso BR112013025630A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161472245P 2011-04-06 2011-04-06
EP11161248A EP2508184A1 (en) 2011-04-06 2011-04-06 Pyridopyrazine derivatives and their use
PCT/EP2012/056142 WO2012136694A1 (en) 2011-04-06 2012-04-04 Pyridopyrazine derivatives and their use

Publications (1)

Publication Number Publication Date
BR112013025630A2 true BR112013025630A2 (pt) 2016-12-27

Family

ID=44350566

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013025630A BR112013025630A2 (pt) 2011-04-06 2012-04-04 derivados de piridopirazina e seu uso

Country Status (19)

Country Link
US (2) US8791118B2 (pt)
EP (3) EP2508184A1 (pt)
JP (2) JP2014510125A (pt)
KR (2) KR20140025443A (pt)
CN (2) CN103826636A (pt)
AR (2) AR085844A1 (pt)
AU (2) AU2012238681A1 (pt)
BR (1) BR112013025630A2 (pt)
CA (2) CA2832321A1 (pt)
ES (1) ES2552515T3 (pt)
IL (2) IL228433A0 (pt)
MX (2) MX2013011444A (pt)
NZ (1) NZ615578A (pt)
PL (1) PL2694067T3 (pt)
RU (2) RU2013146618A (pt)
SG (2) SG194097A1 (pt)
TW (2) TWI564299B (pt)
WO (2) WO2012136694A1 (pt)
ZA (2) ZA201306862B (pt)

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WO2018237383A1 (en) * 2017-06-23 2018-12-27 The Trustees Of Columbia University In The City Of New York METHODS OF PREVENTING AND TREATING DISEASES CHARACTERIZED BY SYNAPTIC DYSFUNCTION AND NEURODEGENERATION, INCLUDING ALZHEIMER'S DISEASE
WO2019238933A1 (en) * 2018-06-15 2019-12-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of pi3kc2b inhibitors for the preservation of vascular endothelial cell barrier integrity
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IL228433A0 (en) 2013-12-31
AU2012238678B2 (en) 2016-11-17
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WO2012136691A1 (en) 2012-10-11
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