AR075935A1 - Derivados de quinoxalina y su uso para el tratamiento de tumores benignos y malignos - Google Patents
Derivados de quinoxalina y su uso para el tratamiento de tumores benignos y malignosInfo
- Publication number
- AR075935A1 AR075935A1 ARP100100940A ARP100100940A AR075935A1 AR 075935 A1 AR075935 A1 AR 075935A1 AR P100100940 A ARP100100940 A AR P100100940A AR P100100940 A ARP100100940 A AR P100100940A AR 075935 A1 AR075935 A1 AR 075935A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- substituted
- unsubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicacion 1: Derivados de quinoxalina caracterizados porque tienen la formula general 1 en la cual X es: oxígeno o azufre; R1 es hidrogeno, alquilo C1-12 sustituido o no sustituido, ciano, halogeno, R2/R3 son hidrogeno, alquilo C1-12 sustituido o no sustituido, R4 es hidrogeno, alquilo C1-12 sustituido o no sustituido, cicloalquilo no sustituido o sustituido, heterociclilo no sustituido o sustituido, arilo no sustituido o sustituido, heteroarilo no sustituido o sustituido, alquilarilo no sustituido o sustituido, alquilheteroarilo no sustituido o sustituido, y R5-R8 son hidrogeno, alquilo C1-12 sustituido o no sustituido, arilo no sustituido o sustituido, heteroarilo no sustituido o sustituido, halogeno, ciano, hidroxilo, alcoxi C1-12, amino, carboxilo, alcoxicarbonilo, carboxialquilo o alcoxicarbonilalquilo, alcoxicarbonilamino, alcoxicarbonilaminoalquilo, y con la condicion de que al menos uno de los sustituyentes R5-R8 es un arilo no sustituido o sustituido o heteroarilo radical, y donde los sustituyentes se seleccionan entre el grupo que consiste en F, Cl, Br, I, CN, CF3, NH2, NH-alquilo, NH-arilo, N(alquil)2, NH-CO-alquilo, NH-CO-arilo, NH-CO-heteroarilo, NH-SO2-alquilo, NH-SO2-arilo, NH-SO2-heteroarilo, NH-CO-NH-alquilo, NH-CO-NH-arilo, NH-CO-NH-heteroarilo, NH-C(O)O-alquilo, NH-C(O)O-arilo, NH-C(O)O-heteroarilo, NO2, SH, S-alquilo, OH, OCF3, O-alquilo, O-arilo, O-CO-alquilo, O-CO-arilo, O-CO-heteroarilo, O-C(O)O-alquilo, O-C(O)O-arilo, O-C(O)O-heteroarilo, O-CO-NH-alquilo, O-CO-N(alquil)2, O-CO-NH-arilo, O-CO-NH-heteroarilo, OSO3H, OSO2-alquilo, OSO2-arilo, OSO2-heteroarilo, OP(O)OH)2, alquil-P(O)(OH)2CHO, CO2H, C(O)O-alquilo, C(O)O-arilo, C(O)O-heteroarilo, CO-alquilo, CO-arilo, CO-heteroarilo, SO3H, SO2-NH2, SO2-NH-alquilo, SO2-NH-arilo, SO2-NH-heteroarilo, alquilo, cicloalquilo, heterociclilo, arilo y heteroarilo, donde los radicales ôalquiloö, ôcicloalquiloö, ôheterocicliloö, ôariloö y ôheteroariloö también pueden estar sustituidos, sus sales, hidratos y solvatos aceptables fisiologicamente, donde los compuestos de la formula general (1) y sus sales, hidratos o solvatos pueden encontrarse presentes en forma de sus racematos, enantiomeros y/o diastereomeros, o en forma de mezclas de sus enantiomeros y/o diastereomeros, en forma de los tautomeros y sus formar polimorficas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16595309P | 2009-04-02 | 2009-04-02 | |
| EP09157141A EP2241557A1 (de) | 2009-04-02 | 2009-04-02 | Chinoxalin-Derivate und deren Anwendung zur Behandlung gutartiger und bösartiger Tumorerkrankungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR075935A1 true AR075935A1 (es) | 2011-05-04 |
Family
ID=40886691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100100940A AR075935A1 (es) | 2009-04-02 | 2010-03-25 | Derivados de quinoxalina y su uso para el tratamiento de tumores benignos y malignos |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8394801B2 (es) |
| EP (2) | EP2241557A1 (es) |
| JP (1) | JP5583201B2 (es) |
| KR (1) | KR20110136888A (es) |
| CN (1) | CN102378758A (es) |
| AR (1) | AR075935A1 (es) |
| AU (1) | AU2010233983A1 (es) |
| BR (1) | BRPI1010306A2 (es) |
| CA (1) | CA2757138A1 (es) |
| CO (1) | CO6501171A2 (es) |
| EC (1) | ECSP11011363A (es) |
| IL (1) | IL215025A0 (es) |
| MX (1) | MX2011010329A (es) |
| NZ (1) | NZ595064A (es) |
| PE (1) | PE20120766A1 (es) |
| RU (1) | RU2532914C2 (es) |
| SG (1) | SG175014A1 (es) |
| TW (1) | TWI464150B (es) |
| UA (1) | UA105211C2 (es) |
| WO (1) | WO2010115719A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102464675A (zh) * | 2010-11-12 | 2012-05-23 | 上海医药工业研究院 | 具有抗肿瘤活性的金络合物及其可药用衍生物 |
| US9029378B2 (en) | 2011-07-26 | 2015-05-12 | Gruenenthal Gmbh | Substituted bicyclic aromatic carboxamide and urea compounds as vanilloid receptor ligands |
| JP2018525371A (ja) * | 2015-07-30 | 2018-09-06 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | アリール置換された二環式ヘテロアリール化合物 |
| JP7160688B2 (ja) * | 2016-05-24 | 2022-10-25 | ジェネンテック， インコーポレイテッド | Ｃｂｐ／ｅｐ３００の複素環式インヒビターおよびがんの処置におけるそれらの使用 |
| CN110698418B (zh) * | 2019-09-11 | 2022-07-01 | 广西师范大学 | 一种3-芳胺基喹喔啉-2-甲酰胺类衍生物及其制备方法和应用 |
| CN115463217B (zh) * | 2021-06-11 | 2024-03-12 | 深圳埃格林医药有限公司 | 己酸羟孕酮在增强肿瘤治疗效果中的应用 |
| CN114605391B (zh) * | 2022-02-21 | 2024-01-26 | 广州六顺生物科技股份有限公司 | 喹喔啉类衍生物及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPN842196A0 (en) | 1996-03-05 | 1996-03-28 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
| US6159978A (en) | 1997-05-28 | 2000-12-12 | Aventis Pharmaceuticals Product, Inc. | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases |
| US6180632B1 (en) | 1997-05-28 | 2001-01-30 | Aventis Pharmaceuticals Products Inc. | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases |
| ATE493389T1 (de) | 1997-05-28 | 2011-01-15 | Aventis Pharma Inc | Chinoxalin-derivate die den von blutplättchen abstammenden wachstumsfaktor und/oder p56lck- tyrosinkinase hemmen |
| US6245760B1 (en) | 1997-05-28 | 2001-06-12 | Aventis Pharmaceuticals Products, Inc | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases |
| RU2217426C2 (ru) | 1998-06-01 | 2003-11-27 | Шионоги Энд Ко., Лтд. | Цианиминохиноксалиновые производные, способ их получения (варианты), промежуточные соединения и фармацевтическая композиция |
| UA76977C2 (en) * | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
| WO2003101444A1 (en) * | 2002-05-29 | 2003-12-11 | Millennium Pharmaceuticals, Inc. | Diarylurea compounds and derivatives as chk-1 inhibitors for the treatment of cancer |
| US20070254894A1 (en) | 2006-01-10 | 2007-11-01 | Kane John L Jr | Novel small molecules with selective cytotoxicity against human microvascular endothelial cell proliferation |
| WO2008015423A1 (en) | 2006-08-01 | 2008-02-07 | Sentinel Oncology Limited | Quinoline and quinoxaline n-oxides as chk-1 inhibitors |
| WO2008141065A1 (en) | 2007-05-10 | 2008-11-20 | Smithkline Beecham Corporation | Quinoxaline derivatives as p13 kinase inhibitors |
| EP1990342A1 (en) * | 2007-05-10 | 2008-11-12 | AEterna Zentaris GmbH | Pyridopyrazine Derivatives, Process of Manufacturing and Uses thereof |
-
2009
- 2009-04-02 EP EP09157141A patent/EP2241557A1/de not_active Withdrawn
-
2010
- 2010-03-25 PE PE2011001740A patent/PE20120766A1/es not_active Application Discontinuation
- 2010-03-25 AU AU2010233983A patent/AU2010233983A1/en not_active Abandoned
- 2010-03-25 WO PCT/EP2010/053891 patent/WO2010115719A1/en active Application Filing
- 2010-03-25 SG SG2011071610A patent/SG175014A1/en unknown
- 2010-03-25 JP JP2012502582A patent/JP5583201B2/ja not_active Expired - Fee Related
- 2010-03-25 RU RU2011138477/04A patent/RU2532914C2/ru not_active IP Right Cessation
- 2010-03-25 MX MX2011010329A patent/MX2011010329A/es active IP Right Grant
- 2010-03-25 EP EP10710051A patent/EP2419411A1/en not_active Withdrawn
- 2010-03-25 TW TW099108919A patent/TWI464150B/zh not_active IP Right Cessation
- 2010-03-25 KR KR1020117026033A patent/KR20110136888A/ko not_active Application Discontinuation
- 2010-03-25 CA CA2757138A patent/CA2757138A1/en not_active Abandoned
- 2010-03-25 CN CN201080014936XA patent/CN102378758A/zh active Pending
- 2010-03-25 NZ NZ595064A patent/NZ595064A/xx unknown
- 2010-03-25 AR ARP100100940A patent/AR075935A1/es unknown
- 2010-03-25 BR BRPI1010306A patent/BRPI1010306A2/pt not_active IP Right Cessation
- 2010-03-25 US US12/731,243 patent/US8394801B2/en not_active Expired - Fee Related
- 2010-03-25 UA UAA201111539A patent/UA105211C2/ru unknown
-
2011
- 2011-09-07 IL IL215025A patent/IL215025A0/en unknown
- 2011-09-30 CO CO11128635A patent/CO6501171A2/es active IP Right Grant
- 2011-09-30 EC EC2011011363A patent/ECSP11011363A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ595064A (en) | 2013-10-25 |
| SG175014A1 (en) | 2011-11-28 |
| RU2532914C2 (ru) | 2014-11-20 |
| EP2419411A1 (en) | 2012-02-22 |
| KR20110136888A (ko) | 2011-12-21 |
| AU2010233983A1 (en) | 2011-10-06 |
| RU2011138477A (ru) | 2013-05-10 |
| JP5583201B2 (ja) | 2014-09-03 |
| TWI464150B (zh) | 2014-12-11 |
| US20100266538A1 (en) | 2010-10-21 |
| JP2012522741A (ja) | 2012-09-27 |
| PE20120766A1 (es) | 2012-07-19 |
| IL215025A0 (en) | 2011-11-30 |
| ECSP11011363A (es) | 2011-10-31 |
| WO2010115719A1 (en) | 2010-10-14 |
| US8394801B2 (en) | 2013-03-12 |
| CO6501171A2 (es) | 2012-08-15 |
| MX2011010329A (es) | 2011-10-17 |
| BRPI1010306A2 (pt) | 2017-05-16 |
| EP2241557A1 (de) | 2010-10-20 |
| TW201100391A (en) | 2011-01-01 |
| UA105211C2 (ru) | 2014-04-25 |
| CN102378758A (zh) | 2012-03-14 |
| CA2757138A1 (en) | 2010-10-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |