PE20200608A1 - Nuevos derivados de azaquinolina - Google Patents

Nuevos derivados de azaquinolina

Info

Publication number
PE20200608A1
PE20200608A1 PE2019002610A PE2019002610A PE20200608A1 PE 20200608 A1 PE20200608 A1 PE 20200608A1 PE 2019002610 A PE2019002610 A PE 2019002610A PE 2019002610 A PE2019002610 A PE 2019002610A PE 20200608 A1 PE20200608 A1 PE 20200608A1
Authority
PE
Peru
Prior art keywords
hydrogen
trifluorophenyl
naphthyridine
morpholin
carboxamide
Prior art date
Application number
PE2019002610A
Other languages
English (en)
Inventor
Nils Griebenow
Wei Zhuang
Adeline Kohler
Daniel Kulke
Claudia Bohm
Kirsten Borngen
Thomas Ilg
Hans-Georg Schwarz
Werner Hallenbach
Ulrich Gorgens
Walter Hubsch
Bernd Alig
Iring Heisler
Isa Jana Irina Janssen
Original Assignee
Bayer Animal Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Animal Health Gmbh filed Critical Bayer Animal Health Gmbh
Publication of PE20200608A1 publication Critical patent/PE20200608A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se refiere a compuestos derivados de azaquinolona de la formula general (I), donde A es A1 o A2; o es 0, 1, 2, 3 o 4; R es hidrogeno, halogeno, entre otros; X e Y se seleccionan independientemente del grupo que consiste en CR7R8, O, S y N-R9; o forman conjuntamente un miembro del anillo seleccionado del grupo que consiste en -C(O)-O-, -C(O)-NR9-, entre otros; T se selecciona de T1- T6; R1 es hidrogeno, ciano, -CHO, entre otros; R10 es hidrogeno, -OH, alquilo-C1-C4 y alcoxi-C1-C4; R11 es hidrogeno, alquilo-C1-C4 y alcoxi-C1-C4; o R10 y R11 forman, junto con el carbono al que estan unidos, un anillo de 3 a 6 miembros. Son compuestos preferidos: N-[(4S)-3,4-dihidro-2H-1-benzopiran-4-il]-4-(morfolin-4-il)-8-(2,3,5-trifluorofenil)-1,7-naftiridina-3-carboxamida; N-[(4S)-3,4-dihidro-2H-cromen-4-il]-4-(morfolin-4-il)-8-(2,3,5-trifluorofenil)-1,7-naftiridina-3-carboxamida, entre otros. Dichos compuestos interactuan eficazmente con los Slo-1 de los nematodos logrando su paralisis e inhibicion, siendo util en el tratamiento o prevencion de infecciones por helmintos gastrointestinales y extraintestinales. Tambien se refiere a una composicion farmaceutica que comprende dicho compuesto.
PE2019002610A 2017-06-30 2018-06-22 Nuevos derivados de azaquinolina PE20200608A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17179149 2017-06-30
PCT/EP2018/066776 WO2019002132A1 (en) 2017-06-30 2018-06-22 NEW AZAQUINOLINE DERIVATIVES

Publications (1)

Publication Number Publication Date
PE20200608A1 true PE20200608A1 (es) 2020-03-10

Family

ID=59269946

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2019002610A PE20200608A1 (es) 2017-06-30 2018-06-22 Nuevos derivados de azaquinolina

Country Status (21)

Country Link
US (1) US11485733B2 (es)
EP (1) EP3615527B1 (es)
JP (1) JP7210483B2 (es)
KR (1) KR20200020911A (es)
CN (1) CN110770227B (es)
AR (1) AR112216A1 (es)
AU (1) AU2018293627B2 (es)
BR (1) BR112019028181A2 (es)
CA (1) CA3068350A1 (es)
CL (1) CL2019003892A1 (es)
CO (1) CO2019014484A2 (es)
CR (1) CR20190595A (es)
DK (1) DK3615527T3 (es)
IL (1) IL271607B2 (es)
MX (1) MX2019015895A (es)
PE (1) PE20200608A1 (es)
PH (1) PH12019502851A1 (es)
TW (1) TWI799429B (es)
UA (1) UA125800C2 (es)
UY (1) UY37789A (es)
WO (1) WO2019002132A1 (es)

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EP3615527B1 (en) 2024-03-06
CN110770227B (zh) 2024-03-01
IL271607B1 (en) 2023-03-01
IL271607A (en) 2020-02-27
RU2020103733A (ru) 2021-07-30
CL2019003892A1 (es) 2020-07-10
AU2018293627B2 (en) 2022-07-21
TWI799429B (zh) 2023-04-21
AR112216A1 (es) 2019-10-02
UY37789A (es) 2019-01-31
DK3615527T3 (da) 2024-05-06
TW201904961A (zh) 2019-02-01
JP2020525444A (ja) 2020-08-27
JP7210483B2 (ja) 2023-01-23
IL271607B2 (en) 2023-07-01
MX2019015895A (es) 2020-02-07
BR112019028181A2 (pt) 2020-07-07
CN110770227A (zh) 2020-02-07
AU2018293627A1 (en) 2019-12-12
CR20190595A (es) 2020-03-03
KR20200020911A (ko) 2020-02-26
WO2019002132A1 (en) 2019-01-03
PH12019502851A1 (en) 2020-10-19
EP3615527A1 (en) 2020-03-04
UA125800C2 (uk) 2022-06-08
CO2019014484A2 (es) 2020-01-17
CA3068350A1 (en) 2019-01-03
RU2020103733A3 (es) 2021-10-22
US11485733B2 (en) 2022-11-01
US20200131175A1 (en) 2020-04-30

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