AR079269A1 - Procedimiento para la preparacion de dronedarona - Google Patents

Procedimiento para la preparacion de dronedarona

Info

Publication number
AR079269A1
AR079269A1 ARP100104488A ARP100104488A AR079269A1 AR 079269 A1 AR079269 A1 AR 079269A1 AR P100104488 A ARP100104488 A AR P100104488A AR P100104488 A ARP100104488 A AR P100104488A AR 079269 A1 AR079269 A1 AR 079269A1
Authority
AR
Argentina
Prior art keywords
chlorine
general formula
iodine atom
hydroxyl
hydroxyl group
Prior art date
Application number
ARP100104488A
Other languages
English (en)
Inventor
Nagy Marianna Csatarine
Zsolt Dombrady
Antal Friesz
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR079269A1 publication Critical patent/AR079269A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Abstract

Y los intermediarios del procedimiento de preparacion. Reivindicacion 1: Procedimiento para la preparacion de N-[2-n-butil-3-{4-[(3-dibutilamino)-propoxi]benzoil}-1-benzofuran-5-il]metanosulfonamida de formula (1) y sus sales farmacéuticamente aceptables, caracterizado porque un derivado de benzofurano de formula general (2) donde X representa un átomo de cloro, bromo o yodo, un grupo hidroxilo o hidroxilo activado- se somete a reaccion con dibutilamina y, si se desea, se forma la sal del producto. Reivindicacion 32: Los compuestos de formula general (2) en la cual X es un átomo de cloro, bromo o yodo, un grupo hidroxilo o hidroxilo activado. Reivindicacion 34: Los compuestos de formula general (5) en la cual X es un átomo de cloro, bromo o yodo, un grupo hidroxilo o hidroxilo activado. Reivindicacion 36: Los compuestos de formula general (6) en la cual X es un átomo de cloro o yodo, un grupo hidroxilo o hidroxilo activado.
ARP100104488A 2009-12-08 2010-12-06 Procedimiento para la preparacion de dronedarona AR079269A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0900759A HUP0900759A2 (en) 2009-12-08 2009-12-08 Novel process for producing dronedarone

Publications (1)

Publication Number Publication Date
AR079269A1 true AR079269A1 (es) 2012-01-04

Family

ID=89989418

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100104488A AR079269A1 (es) 2009-12-08 2010-12-06 Procedimiento para la preparacion de dronedarona

Country Status (16)

Country Link
US (2) US8501971B2 (es)
EP (1) EP2509971A1 (es)
JP (1) JP2013512944A (es)
CN (1) CN102741238A (es)
AR (1) AR079269A1 (es)
AU (1) AU2010329655B2 (es)
BR (1) BR112012013753A2 (es)
CA (1) CA2781647A1 (es)
HU (1) HUP0900759A2 (es)
IL (1) IL220170A0 (es)
MX (1) MX2012006654A (es)
RU (1) RU2012128568A (es)
SG (1) SG181562A1 (es)
TW (1) TW201144291A (es)
UY (1) UY33094A (es)
WO (1) WO2011070380A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0900759A2 (en) * 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
IT1398317B1 (it) * 2010-02-23 2013-02-22 Chimico Internaz Spa Lab Nuovo procedimento per la preparazione del dronedarone.
FR2957079B1 (fr) 2010-03-02 2012-07-27 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
FR2958291B1 (fr) 2010-04-01 2013-07-05 Sanofi Aventis Procede de preparation de derives d'amino-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
WO2012004658A2 (en) * 2010-07-09 2012-01-12 Frichem Private Limited Process for preparation of n-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]methanesulfonamide, acid addition salts and product thereof
FR2962731B1 (fr) 2010-07-19 2012-08-17 Sanofi Aventis Procede de preparation de derives d'amino-benzoyl-benzofurane
FR2963006B1 (fr) 2010-07-21 2013-03-15 Sanofi Aventis Procede de preparation de derives de nitro-benzofurane
HUP1000386A2 (en) 2010-07-22 2012-05-29 Sanofi Sa Novel process for producing dronedarone
WO2012032545A1 (en) 2010-09-08 2012-03-15 Cadila Healthcare Limited Processes for preparing dronedarone and its intermediates
CN102653530A (zh) * 2011-03-04 2012-09-05 浙江省医学科学院 一种苯并呋喃衍生物的制备方法及其应用
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
WO2013014479A1 (en) * 2011-07-26 2013-01-31 Sanofi Reductive animation process for preparation of dronedarone using aldehyde intermediary compound
WO2013014478A1 (en) * 2011-07-26 2013-01-31 Sanofi Reductive amination process for preparation of dronedarone using carboxyl intermediary compound
FR2983198B1 (fr) * 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
US9382223B2 (en) 2012-02-22 2016-07-05 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
WO2013178337A1 (en) 2012-05-31 2013-12-05 Sanofi Process for preparation of dronedarone by grignard reaction

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
FR2817864B1 (fr) 2000-12-11 2003-02-21 Sanofi Synthelabo Derive de methanesulfonamido-benzofurane, son procede de preparation et son utilisation comme intermediaire de synthese
FR2817865B1 (fr) 2000-12-11 2005-02-18 Sanofi Synthelabo Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
IL146389A0 (en) * 2001-11-08 2002-07-25 Isp Finetech Ltd Process for the preparation of dronedarone
FR2833262A1 (fr) 2001-12-06 2003-06-13 Rhodia Chimie Sa Procede de monosulfonylation d'un compose de type aminobenzofuranne ou aminobenzothiophene
DE10237819A1 (de) 2002-08-19 2004-03-04 Bayer Ag 5-Nitrobenzofurane
CN101153012B (zh) * 2006-09-29 2010-06-23 北京德众万全药物技术开发有限公司 一种决奈达隆关键中间体的新的制备方法
TW201107303A (en) 2009-05-27 2011-03-01 Sanofi Aventis Process for the production of benzofurans
UY32657A (es) 2009-05-27 2010-12-31 Sanofi Aventis Procedimiento para la fabricación de productos intermedios de dronedarona
HUP0900759A2 (en) * 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
FR2957079B1 (fr) 2010-03-02 2012-07-27 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
FR2958291B1 (fr) 2010-04-01 2013-07-05 Sanofi Aventis Procede de preparation de derives d'amino-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
FR2962731B1 (fr) 2010-07-19 2012-08-17 Sanofi Aventis Procede de preparation de derives d'amino-benzoyl-benzofurane
FR2963006B1 (fr) 2010-07-21 2013-03-15 Sanofi Aventis Procede de preparation de derives de nitro-benzofurane
HUP1000386A2 (en) 2010-07-22 2012-05-29 Sanofi Sa Novel process for producing dronedarone
FR2973027A1 (fr) 2011-03-24 2012-09-28 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
HUP1100166A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Reductive amination process for preparation of dronedarone using amine intermediary compound

Also Published As

Publication number Publication date
CA2781647A1 (en) 2011-06-16
SG181562A1 (en) 2012-07-30
TW201144291A (en) 2011-12-16
US20130261321A1 (en) 2013-10-03
US20120289717A1 (en) 2012-11-15
HUP0900759A2 (en) 2011-11-28
HU0900759D0 (en) 2010-01-28
UY33094A (es) 2011-07-29
US8889734B2 (en) 2014-11-18
AU2010329655A1 (en) 2012-06-21
BR112012013753A2 (pt) 2015-09-15
RU2012128568A (ru) 2014-01-20
WO2011070380A1 (en) 2011-06-16
MX2012006654A (es) 2012-06-25
AU2010329655B2 (en) 2014-01-16
US8501971B2 (en) 2013-08-06
EP2509971A1 (en) 2012-10-17
IL220170A0 (en) 2012-07-31
CN102741238A (zh) 2012-10-17
JP2013512944A (ja) 2013-04-18

Similar Documents

Publication Publication Date Title
AR079269A1 (es) Procedimiento para la preparacion de dronedarona
AR082296A1 (es) Procedimiento para la preparacion de dronedarona
AR068403A1 (es) Proceso e intermediarios para la preparacion de inhibidores de integrasa
CY1123817T1 (el) Μεθοδος για την παρασκευη ενωσεων που ειναι χρησιμες ως αναστολεις sglt
CO7081155A2 (es) Inhibidores de serina/treonina cinasa
AR079843A1 (es) Procedimiento para la preparacion de dronedarona
WO2013066718A3 (en) Inhibitors of the renal outer medullary potassium channel
TN2011000540A1 (en) Inhibitors of the renal outer medullary potassium channel
BR112016006395A2 (pt) sistema de sustentação de turbina eólica flutuante
AR063449A1 (es) Proceso quimico para derivados de quinazolina, intermediarios
CL2023000154A1 (es) Proceso para preparar tapinarof; compuestos intermediarios; solvato de tapinarof; forma cristalina y composición farmacéutica que la comprende (sol. div. 202001226).
ES2565332T3 (es) Proceso para la fabricación de alquenonas
WO2015142903A3 (en) Method of controlling lactate production with piperdine-dione derivatives
MA48798B1 (fr) Procédé de production d'ozanimod
MX369642B (es) Sales de dasatinib.
CL2017000773A1 (es) Proceso para la producción de granulados de sulfato de potasio y el granulado de sulfato de potasio obtenido a partir del mismo, así como también su uso.
AR080656A1 (es) Sintesis de magnolol y sus compuestos analogos, y composicion farmaceutica
ES2578377A1 (es) Compuestos moduladores del sensor neuronal de calcio dream y sus usos terapéuticos.
AR113800A1 (es) Proceso para compuesto de ácido benzoil fórmico y compuesto de piridazina
AR102246A1 (es) Compuestos aromáticos sustituidos y composiciones farmacéuticas para la prevención y tratamiento de osteoporosis, usos
BR112017021277A2 (pt) Síntese de 1-[2-(2,4-dimetil-fenilsulfanil)-fenil] piperazina
JP2016539168A5 (es)
BR112017010932A2 (pt) método para recuperar cristais de ácido succínico com o uso de tensoativos durante a cristalização e cristais resultantes
AR105010A1 (es) Composiciones inmunógenas
WO2011067348A3 (en) Mek inhibitor salts and solvates thereof

Legal Events

Date Code Title Description
FB Suspension of granting procedure