AR079269A1 - PROCEDURE FOR THE PREPARATION OF DRONEDARONA - Google Patents
PROCEDURE FOR THE PREPARATION OF DRONEDARONAInfo
- Publication number
- AR079269A1 AR079269A1 ARP100104488A ARP100104488A AR079269A1 AR 079269 A1 AR079269 A1 AR 079269A1 AR P100104488 A ARP100104488 A AR P100104488A AR P100104488 A ARP100104488 A AR P100104488A AR 079269 A1 AR079269 A1 AR 079269A1
- Authority
- AR
- Argentina
- Prior art keywords
- chlorine
- general formula
- iodine atom
- hydroxyl
- hydroxyl group
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 8
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 6
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 4
- 229910052801 chlorine Inorganic materials 0.000 abstract 4
- 239000000460 chlorine Substances 0.000 abstract 4
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 4
- 229910052740 iodine Chemical group 0.000 abstract 4
- 229910052794 bromium Inorganic materials 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- JQVDAXLFBXTEQA-UHFFFAOYSA-N dibutylamine Chemical compound CCCCNCCCC JQVDAXLFBXTEQA-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 150000001907 coumarones Chemical class 0.000 abstract 1
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Y los intermediarios del procedimiento de preparacion. Reivindicacion 1: Procedimiento para la preparacion de N-[2-n-butil-3-{4-[(3-dibutilamino)-propoxi]benzoil}-1-benzofuran-5-il]metanosulfonamida de formula (1) y sus sales farmacéuticamente aceptables, caracterizado porque un derivado de benzofurano de formula general (2) donde X representa un átomo de cloro, bromo o yodo, un grupo hidroxilo o hidroxilo activado- se somete a reaccion con dibutilamina y, si se desea, se forma la sal del producto. Reivindicacion 32: Los compuestos de formula general (2) en la cual X es un átomo de cloro, bromo o yodo, un grupo hidroxilo o hidroxilo activado. Reivindicacion 34: Los compuestos de formula general (5) en la cual X es un átomo de cloro, bromo o yodo, un grupo hidroxilo o hidroxilo activado. Reivindicacion 36: Los compuestos de formula general (6) en la cual X es un átomo de cloro o yodo, un grupo hidroxilo o hidroxilo activado.And the intermediaries of the preparation procedure. Claim 1: Process for the preparation of N- [2-n-butyl-3- {4 - [(3-dibutylamino) -propoxy] benzoyl} -1-benzofuran-5-yl] methanesulfonamide of formula (1) and its pharmaceutically acceptable salts, characterized in that a benzofuran derivative of the general formula (2) where X represents a chlorine, bromine or iodine atom, an activated hydroxyl or hydroxyl group - is reacted with dibutylamine and, if desired, the product salt Claim 32: The compounds of the general formula (2) in which X is a chlorine, bromine or iodine atom, an activated hydroxyl or hydroxyl group. Claim 34: The compounds of the general formula (5) in which X is a chlorine, bromine or iodine atom, an activated hydroxyl or hydroxyl group. Claim 36: The compounds of general formula (6) in which X is a chlorine or iodine atom, an activated hydroxyl or hydroxyl group.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0900759A HUP0900759A2 (en) | 2009-12-08 | 2009-12-08 | Novel process for producing dronedarone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR079269A1 true AR079269A1 (en) | 2012-01-04 |
Family
ID=89989418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100104488A AR079269A1 (en) | 2009-12-08 | 2010-12-06 | PROCEDURE FOR THE PREPARATION OF DRONEDARONA |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8501971B2 (en) |
| EP (1) | EP2509971A1 (en) |
| JP (1) | JP2013512944A (en) |
| CN (1) | CN102741238A (en) |
| AR (1) | AR079269A1 (en) |
| AU (1) | AU2010329655B2 (en) |
| BR (1) | BR112012013753A2 (en) |
| CA (1) | CA2781647A1 (en) |
| HU (1) | HUP0900759A2 (en) |
| IL (1) | IL220170A0 (en) |
| MX (1) | MX2012006654A (en) |
| RU (1) | RU2012128568A (en) |
| SG (1) | SG181562A1 (en) |
| TW (1) | TW201144291A (en) |
| UY (1) | UY33094A (en) |
| WO (1) | WO2011070380A1 (en) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0900759A2 (en) * | 2009-12-08 | 2011-11-28 | Sanofi Aventis | Novel process for producing dronedarone |
| IT1398317B1 (en) * | 2010-02-23 | 2013-02-22 | Chimico Internaz Spa Lab | NEW PROCEDURE FOR DRONEDARONE PREPARATION. |
| FR2957079B1 (en) | 2010-03-02 | 2012-07-27 | Sanofi Aventis | PROCESS FOR THE SYNTHESIS OF CETOBENZOFURAN DERIVATIVES |
| FR2958290B1 (en) | 2010-03-30 | 2012-10-19 | Sanofi Aventis | PROCESS FOR THE PREPARATION OF SULFONAMIDO-BENZOFURAN DERIVATIVES |
| FR2958291B1 (en) | 2010-04-01 | 2013-07-05 | Sanofi Aventis | PROCESS FOR PREPARING AMINO-BENZOFURAN DERIVATIVES |
| HUP1000330A2 (en) | 2010-06-18 | 2011-12-28 | Sanofi Sa | Process for the preparation of dronedarone and the novel intermediates |
| WO2012004658A2 (en) * | 2010-07-09 | 2012-01-12 | Frichem Private Limited | Process for preparation of n-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]methanesulfonamide, acid addition salts and product thereof |
| FR2962731B1 (en) | 2010-07-19 | 2012-08-17 | Sanofi Aventis | PROCESS FOR THE PREPARATION OF AMINO-BENZOYL-BENZOFURAN DERIVATIVES |
| FR2963006B1 (en) | 2010-07-21 | 2013-03-15 | Sanofi Aventis | PROCESS FOR THE PREPARATION OF NITRO-BENZOFURAN DERIVATIVES |
| HUP1000386A2 (en) | 2010-07-22 | 2012-05-29 | Sanofi Sa | Novel process for producing dronedarone |
| WO2012032545A1 (en) | 2010-09-08 | 2012-03-15 | Cadila Healthcare Limited | Processes for preparing dronedarone and its intermediates |
| CN102653530A (en) * | 2011-03-04 | 2012-09-05 | 浙江省医学科学院 | Preparation method and application of benzofuran derivate |
| HUP1100165A2 (en) | 2011-03-29 | 2012-12-28 | Sanofi Sa | Process for preparation of dronedarone by n-butylation |
| HUP1100167A2 (en) | 2011-03-29 | 2012-11-28 | Sanofi Sa | Process for preparation of dronedarone by mesylation |
| WO2013014479A1 (en) * | 2011-07-26 | 2013-01-31 | Sanofi | Reductive animation process for preparation of dronedarone using aldehyde intermediary compound |
| WO2013014478A1 (en) * | 2011-07-26 | 2013-01-31 | Sanofi | Reductive amination process for preparation of dronedarone using carboxyl intermediary compound |
| FR2983198B1 (en) * | 2011-11-29 | 2013-11-15 | Sanofi Sa | PROCESS FOR THE PREPARATION OF 5-AMINO-BENZOYL-BENZOFURAN DERIVATIVES |
| EP2617718A1 (en) | 2012-01-20 | 2013-07-24 | Sanofi | Process for preparation of dronedarone by the use of dibutylaminopropanol reagent |
| US9221778B2 (en) | 2012-02-13 | 2015-12-29 | Sanofi | Process for preparation of dronedarone by removal of hydroxyl group |
| WO2013121234A1 (en) | 2012-02-14 | 2013-08-22 | Sanofi | Process for the preparation of dronedarone by oxidation of a sulphenyl group |
| WO2013124745A1 (en) | 2012-02-22 | 2013-08-29 | Sanofi | Process for preparation of dronedarone by oxidation of a hydroxyl group |
| WO2013178337A1 (en) | 2012-05-31 | 2013-12-05 | Sanofi | Process for preparation of dronedarone by grignard reaction |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2665444B1 (en) * | 1990-08-06 | 1992-11-27 | Sanofi Sa | AMINO-BENZOFURAN, BENZOTHIOPHENE OR INDOLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE COMPOSITIONS CONTAINING THEM. |
| FR2817864B1 (en) | 2000-12-11 | 2003-02-21 | Sanofi Synthelabo | METHANESULFONAMIDO-BENZOFURANE DERIVATIVE, ITS PREPARATION METHOD AND ITS USE AS A SYNTHESIS INTERMEDIATE |
| FR2817865B1 (en) | 2000-12-11 | 2005-02-18 | Sanofi Synthelabo | AMINOALKOXYBENZOYLE DERIVATIVE IN SALT FORM, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF AS SYNTHESIS INTERMEDIATE |
| IL146389A0 (en) * | 2001-11-08 | 2002-07-25 | Isp Finetech Ltd | Process for the preparation of dronedarone |
| FR2833262A1 (en) | 2001-12-06 | 2003-06-13 | Rhodia Chimie Sa | PROCESS FOR MONOSULFONYLATION OF AN AMINOBENZOFURANNE OR AMINOBENZOTHIOPHENE COMPOUND |
| DE10237819A1 (en) | 2002-08-19 | 2004-03-04 | Bayer Ag | 5-Nitrobenzofurane |
| CN101153012B (en) * | 2006-09-29 | 2010-06-23 | 北京德众万全药物技术开发有限公司 | Novel method of producing dronedarone key intermediate |
| UY32656A (en) | 2009-05-27 | 2010-12-31 | Sanofi Aventis | PROCEDURE TO PRODUCE BENZOFURANS |
| TW201111354A (en) | 2009-05-27 | 2011-04-01 | Sanofi Aventis | Process for the production of Dronedarone intermediates |
| HUP0900759A2 (en) * | 2009-12-08 | 2011-11-28 | Sanofi Aventis | Novel process for producing dronedarone |
| HUP1000010A2 (en) | 2010-01-08 | 2011-11-28 | Sanofi Sa | Process for producing dronedarone |
| FR2957079B1 (en) | 2010-03-02 | 2012-07-27 | Sanofi Aventis | PROCESS FOR THE SYNTHESIS OF CETOBENZOFURAN DERIVATIVES |
| FR2958290B1 (en) | 2010-03-30 | 2012-10-19 | Sanofi Aventis | PROCESS FOR THE PREPARATION OF SULFONAMIDO-BENZOFURAN DERIVATIVES |
| FR2958291B1 (en) | 2010-04-01 | 2013-07-05 | Sanofi Aventis | PROCESS FOR PREPARING AMINO-BENZOFURAN DERIVATIVES |
| HUP1000330A2 (en) | 2010-06-18 | 2011-12-28 | Sanofi Sa | Process for the preparation of dronedarone and the novel intermediates |
| FR2962731B1 (en) | 2010-07-19 | 2012-08-17 | Sanofi Aventis | PROCESS FOR THE PREPARATION OF AMINO-BENZOYL-BENZOFURAN DERIVATIVES |
| FR2963006B1 (en) | 2010-07-21 | 2013-03-15 | Sanofi Aventis | PROCESS FOR THE PREPARATION OF NITRO-BENZOFURAN DERIVATIVES |
| HUP1000386A2 (en) | 2010-07-22 | 2012-05-29 | Sanofi Sa | Novel process for producing dronedarone |
| FR2973027A1 (en) | 2011-03-24 | 2012-09-28 | Sanofi Aventis | PROCESS FOR THE SYNTHESIS OF CETOBENZOFURAN DERIVATIVES |
| HUP1100165A2 (en) | 2011-03-29 | 2012-12-28 | Sanofi Sa | Process for preparation of dronedarone by n-butylation |
| HUP1100167A2 (en) | 2011-03-29 | 2012-11-28 | Sanofi Sa | Process for preparation of dronedarone by mesylation |
| HUP1100166A2 (en) | 2011-03-29 | 2012-12-28 | Sanofi Sa | Reductive amination process for preparation of dronedarone using amine intermediary compound |
-
2009
- 2009-12-08 HU HU0900759A patent/HUP0900759A2/en unknown
-
2010
- 2010-11-23 JP JP2012542624A patent/JP2013512944A/en not_active Withdrawn
- 2010-11-23 CN CN2010800629901A patent/CN102741238A/en active Pending
- 2010-11-23 BR BR112012013753A patent/BR112012013753A2/en not_active IP Right Cessation
- 2010-11-23 MX MX2012006654A patent/MX2012006654A/en not_active Application Discontinuation
- 2010-11-23 AU AU2010329655A patent/AU2010329655B2/en not_active Ceased
- 2010-11-23 EP EP10809325A patent/EP2509971A1/en not_active Withdrawn
- 2010-11-23 SG SG2012041927A patent/SG181562A1/en unknown
- 2010-11-23 CA CA2781647A patent/CA2781647A1/en not_active Abandoned
- 2010-11-23 RU RU2012128568/04A patent/RU2012128568A/en not_active Application Discontinuation
- 2010-11-23 WO PCT/HU2010/000128 patent/WO2011070380A1/en active Application Filing
- 2010-12-06 AR ARP100104488A patent/AR079269A1/en unknown
- 2010-12-07 TW TW099142501A patent/TW201144291A/en unknown
- 2010-12-08 UY UY33094A patent/UY33094A/en not_active Application Discontinuation
-
2012
- 2012-05-24 US US13/479,615 patent/US8501971B2/en active Active
- 2012-06-04 IL IL220170A patent/IL220170A0/en unknown
-
2013
- 2013-05-30 US US13/905,624 patent/US8889734B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US8501971B2 (en) | 2013-08-06 |
| WO2011070380A1 (en) | 2011-06-16 |
| EP2509971A1 (en) | 2012-10-17 |
| US8889734B2 (en) | 2014-11-18 |
| MX2012006654A (en) | 2012-06-25 |
| IL220170A0 (en) | 2012-07-31 |
| JP2013512944A (en) | 2013-04-18 |
| HUP0900759A2 (en) | 2011-11-28 |
| BR112012013753A2 (en) | 2015-09-15 |
| AU2010329655A1 (en) | 2012-06-21 |
| US20120289717A1 (en) | 2012-11-15 |
| CN102741238A (en) | 2012-10-17 |
| US20130261321A1 (en) | 2013-10-03 |
| AU2010329655B2 (en) | 2014-01-16 |
| TW201144291A (en) | 2011-12-16 |
| CA2781647A1 (en) | 2011-06-16 |
| RU2012128568A (en) | 2014-01-20 |
| SG181562A1 (en) | 2012-07-30 |
| UY33094A (en) | 2011-07-29 |
| HU0900759D0 (en) | 2010-01-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR079269A1 (en) | PROCEDURE FOR THE PREPARATION OF DRONEDARONA | |
| AR082296A1 (en) | PROCEDURE FOR THE PREPARATION OF DRONEDARONA | |
| AR068403A1 (en) | PROCESS AND INTERMEDIARIES FOR THE PREPARATION OF INTEGRASA INHIBITORS | |
| CY1123817T1 (en) | METHOD OF PREPARING COMPOUNDS USEFUL AS SGLT INHIBITORS | |
| CO7081155A2 (en) | Serine / Threonine Kinase Inhibitors | |
| AR079843A1 (en) | PROCEDURE FOR THE PREPARATION OF DRONEDARONA | |
| BR112016006395A2 (en) | floating wind turbine support system | |
| AR063449A1 (en) | CHEMICAL PROCESS FOR QUINAZOLINE DERIVATIVES, INTERMEDIARIES | |
| UA106611C2 (en) | Inhibitors of potassium channels external medullary kidney | |
| MA48798B1 (en) | OZANIMOD PRODUCTION PROCESS | |
| RU2018132264A (en) | INTERMEDIATE PRODUCTS IN ERYBULIN SYNTHESIS AND RELATED SYNTHESIS METHODS | |
| NZ605444A (en) | Salt and solvates of a tetrahydroisoquinoline derivative | |
| AR080656A1 (en) | SYNTHESIS OF MAGNOLOL AND ITS ANALOG COMPOUNDS, AND PHARMACEUTICAL COMPOSITION | |
| ES2578377A1 (en) | Modulator composites of the calcium dream neural sensor and its therapeutic uses. (Machine-translation by Google Translate, not legally binding) | |
| AR115273A1 (en) | METHOD FOR THE PREPARATION OF PHENOXICARBOXYLIC ACID HERBICIDE | |
| NZ728643A (en) | Efficient and scalable synthesis of 2-(1’h-indole-3’-carbonyl)-thiazole-4-carboxylic acid methyl ester and its structural analogs | |
| AR113800A1 (en) | PROCESS FOR BENZOYL FORMIC ACID COMPOUND AND PYRIDAZINE COMPOUND | |
| BR112017021277A2 (en) | SYNTHESIS OF 1- [2- (2,4-DIMETHYL-PHENYLSULFANYL) -FENY] PYPERAZINE | |
| AR101319A1 (en) | QUIRAL RESOLUTION OF THE ESTERS OF THE ACID 4-ARIL-2-TIAZOL-2-IL-1,4-DIHYDROPIRIMIDIN-5-CARBOXYL | |
| ES2611776T3 (en) | Use of tungsten salts (VI) for the treatment of female sterility in non-diabetic mammals | |
| JP2014517037A5 (en) | ||
| AR088775A1 (en) | PRIMARY AMINE DIAZENIODIOLATE DIAZENIODIOLATE DERIVATIVES | |
| ECSP066867A (en) | PROCESS TO PREPARE DERIVATIVES OF N-ARIL-PIPERAZINA | |
| AR099475A1 (en) | ESPIRO-OXAZOLONAS | |
| AR062638A1 (en) | Phenyloxyaniline derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |