AR082296A1 - Procedimiento para la preparacion de dronedarona - Google Patents
Procedimiento para la preparacion de dronedaronaInfo
- Publication number
- AR082296A1 AR082296A1 ARP110102619A ARP110102619A AR082296A1 AR 082296 A1 AR082296 A1 AR 082296A1 AR P110102619 A ARP110102619 A AR P110102619A AR P110102619 A ARP110102619 A AR P110102619A AR 082296 A1 AR082296 A1 AR 082296A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkoxy
- alkyl
- general formula
- preparation
- formula
- Prior art date
Links
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 150000001907 coumarones Chemical class 0.000 abstract 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Reivindicación 1: Procedimiento para la preparación de N-[2-n-butil-3{4-[(3-di-n-butilamino)propoxi]benzoil}benzofuran-5-il]-metanosulfonamida de fórmula (1) y sus sales farmacéuticamente aceptables, caracterizado porque el grupo acilo del derivado benzofurano de la fórmula general (2), donde R representa un grupo alquilo-, alcoxi- o arilo- se escinde en forma selectiva y, si se lo desea, el compuesto resultante de fórmula (1) se transforma en su sal.Reivindicación 15: El compuesto de fórmula general (2) donde R representa un grupo alquilo-, alcoxi- o arilo. Reivindicación 16: Los compuestos de fórmula general (3) donde R representa un grupo alquilo-, alcoxi- o arilo. Reivindicación 17: Los compuestos de fórmula general (4) donde R representa un grupo alquilo-, alcoxi- o arilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1000386A HUP1000386A2 (en) | 2010-07-22 | 2010-07-22 | Novel process for producing dronedarone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR082296A1 true AR082296A1 (es) | 2012-11-28 |
Family
ID=89989842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110102619A AR082296A1 (es) | 2010-07-22 | 2011-07-20 | Procedimiento para la preparacion de dronedarona |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8816103B2 (es) |
| EP (1) | EP2595978A1 (es) |
| JP (1) | JP2013532653A (es) |
| KR (1) | KR20130042575A (es) |
| CN (1) | CN103228639A (es) |
| AR (1) | AR082296A1 (es) |
| AU (1) | AU2011281353A1 (es) |
| BR (1) | BR112013001555A2 (es) |
| CA (1) | CA2805829A1 (es) |
| HU (1) | HUP1000386A2 (es) |
| MX (1) | MX2013000905A (es) |
| RU (1) | RU2013107770A (es) |
| SG (1) | SG187138A1 (es) |
| TW (1) | TW201219381A (es) |
| WO (1) | WO2012010913A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0900759A2 (en) | 2009-12-08 | 2011-11-28 | Sanofi Aventis | Novel process for producing dronedarone |
| HUP1000010A2 (en) | 2010-01-08 | 2011-11-28 | Sanofi Sa | Process for producing dronedarone |
| FR2958290B1 (fr) | 2010-03-30 | 2012-10-19 | Sanofi Aventis | Procede de preparation de derives de sulfonamido-benzofurane |
| HUP1000330A2 (en) | 2010-06-18 | 2011-12-28 | Sanofi Sa | Process for the preparation of dronedarone and the novel intermediates |
| HUP1100167A2 (en) | 2011-03-29 | 2012-11-28 | Sanofi Sa | Process for preparation of dronedarone by mesylation |
| HUP1100165A2 (en) | 2011-03-29 | 2012-12-28 | Sanofi Sa | Process for preparation of dronedarone by n-butylation |
| FR2983198B1 (fr) | 2011-11-29 | 2013-11-15 | Sanofi Sa | Procede de preparation de derives de 5-amino-benzoyl-benzofurane |
| EP2617718A1 (en) | 2012-01-20 | 2013-07-24 | Sanofi | Process for preparation of dronedarone by the use of dibutylaminopropanol reagent |
| WO2013121235A2 (en) | 2012-02-13 | 2013-08-22 | Sanofi | Process for preparation of dronedarone by removal of hydroxyl group |
| WO2013121234A1 (en) * | 2012-02-14 | 2013-08-22 | Sanofi | Process for the preparation of dronedarone by oxidation of a sulphenyl group |
| WO2013124745A1 (en) | 2012-02-22 | 2013-08-29 | Sanofi | Process for preparation of dronedarone by oxidation of a hydroxyl group |
| WO2013178337A1 (en) | 2012-05-31 | 2013-12-05 | Sanofi | Process for preparation of dronedarone by grignard reaction |
| TW201536763A (zh) * | 2013-08-27 | 2015-10-01 | Gilead Sciences Inc | 製備決奈達隆或其鹽類之製程 |
| CN103450124B (zh) * | 2013-08-30 | 2016-03-09 | 江苏九九久科技股份有限公司 | 决奈达隆合成方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2665444B1 (fr) | 1990-08-06 | 1992-11-27 | Sanofi Sa | Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant. |
| FR2817864B1 (fr) | 2000-12-11 | 2003-02-21 | Sanofi Synthelabo | Derive de methanesulfonamido-benzofurane, son procede de preparation et son utilisation comme intermediaire de synthese |
| FR2817865B1 (fr) | 2000-12-11 | 2005-02-18 | Sanofi Synthelabo | Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese |
| IL146389A0 (en) * | 2001-11-08 | 2002-07-25 | Isp Finetech Ltd | Process for the preparation of dronedarone |
| WO2006093801A1 (en) * | 2005-02-25 | 2006-09-08 | Abbott Laboratories | Thiadiazine derivatives useful as anti-infective agents |
| TW201107303A (en) | 2009-05-27 | 2011-03-01 | Sanofi Aventis | Process for the production of benzofurans |
| TW201111354A (en) | 2009-05-27 | 2011-04-01 | Sanofi Aventis | Process for the production of Dronedarone intermediates |
| HUP0900759A2 (en) | 2009-12-08 | 2011-11-28 | Sanofi Aventis | Novel process for producing dronedarone |
| HUP1000010A2 (en) | 2010-01-08 | 2011-11-28 | Sanofi Sa | Process for producing dronedarone |
| US20130046103A1 (en) * | 2010-02-10 | 2013-02-21 | Mapi Pharma Limited | Preparation of benzofurans and use thereof as synthetic intermediates |
| FR2957079B1 (fr) | 2010-03-02 | 2012-07-27 | Sanofi Aventis | Procede de synthese de derives de cetobenzofurane |
| CN101838252B (zh) * | 2010-05-27 | 2016-05-04 | 北京德众万全医药科技有限公司 | 2-正丁基-5-取代氨基苯并呋喃及其制备方法 |
| FR2973027A1 (fr) | 2011-03-24 | 2012-09-28 | Sanofi Aventis | Procede de synthese de derives de cetobenzofurane |
| HUP1100165A2 (en) | 2011-03-29 | 2012-12-28 | Sanofi Sa | Process for preparation of dronedarone by n-butylation |
| HUP1100166A2 (en) | 2011-03-29 | 2012-12-28 | Sanofi Sa | Reductive amination process for preparation of dronedarone using amine intermediary compound |
| HUP1100167A2 (en) | 2011-03-29 | 2012-11-28 | Sanofi Sa | Process for preparation of dronedarone by mesylation |
-
2010
- 2010-07-22 HU HU1000386A patent/HUP1000386A2/hu unknown
-
2011
- 2011-07-13 AU AU2011281353A patent/AU2011281353A1/en not_active Abandoned
- 2011-07-13 WO PCT/HU2011/000067 patent/WO2012010913A1/en active Application Filing
- 2011-07-13 EP EP11746608.6A patent/EP2595978A1/en not_active Withdrawn
- 2011-07-13 MX MX2013000905A patent/MX2013000905A/es not_active Application Discontinuation
- 2011-07-13 KR KR1020137004394A patent/KR20130042575A/ko not_active Application Discontinuation
- 2011-07-13 BR BR112013001555A patent/BR112013001555A2/pt not_active Application Discontinuation
- 2011-07-13 JP JP2013520223A patent/JP2013532653A/ja not_active Withdrawn
- 2011-07-13 RU RU2013107770/04A patent/RU2013107770A/ru not_active Application Discontinuation
- 2011-07-13 SG SG2013004270A patent/SG187138A1/en unknown
- 2011-07-13 CN CN2011800358726A patent/CN103228639A/zh active Pending
- 2011-07-13 CA CA2805829A patent/CA2805829A1/en not_active Abandoned
- 2011-07-20 AR ARP110102619A patent/AR082296A1/es unknown
- 2011-07-21 TW TW100125718A patent/TW201219381A/zh unknown
-
2013
- 2013-01-14 US US13/740,505 patent/US8816103B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| SG187138A1 (en) | 2013-02-28 |
| CA2805829A1 (en) | 2012-01-26 |
| US20130131358A1 (en) | 2013-05-23 |
| EP2595978A1 (en) | 2013-05-29 |
| RU2013107770A (ru) | 2014-08-27 |
| TW201219381A (en) | 2012-05-16 |
| CN103228639A (zh) | 2013-07-31 |
| BR112013001555A2 (pt) | 2016-05-24 |
| AU2011281353A1 (en) | 2013-02-07 |
| US8816103B2 (en) | 2014-08-26 |
| JP2013532653A (ja) | 2013-08-19 |
| WO2012010913A1 (en) | 2012-01-26 |
| KR20130042575A (ko) | 2013-04-26 |
| MX2013000905A (es) | 2013-02-27 |
| HU1000386D0 (en) | 2010-10-28 |
| HUP1000386A2 (en) | 2012-05-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |