AR079258A1 - Emulsion oftalmica - Google Patents
Emulsion oftalmicaInfo
- Publication number
- AR079258A1 AR079258A1 ARP100104473A ARP100104473A AR079258A1 AR 079258 A1 AR079258 A1 AR 079258A1 AR P100104473 A ARP100104473 A AR P100104473A AR P100104473 A ARP100104473 A AR P100104473A AR 079258 A1 AR079258 A1 AR 079258A1
- Authority
- AR
- Argentina
- Prior art keywords
- emulsion
- emulsion according
- oil
- present
- amount
- Prior art date
Links
- 239000000839 emulsion Substances 0.000 title abstract 22
- 239000003921 oil Substances 0.000 abstract 6
- 239000004094 surface-active agent Substances 0.000 abstract 6
- 150000003904 phospholipids Chemical class 0.000 abstract 4
- OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 abstract 3
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 abstract 3
- 229920000926 Galactomannan Polymers 0.000 abstract 3
- 230000002209 hydrophobic effect Effects 0.000 abstract 3
- 229920000642 polymer Polymers 0.000 abstract 3
- 244000007835 Cyamopsis tetragonoloba Species 0.000 abstract 2
- 239000008346 aqueous phase Substances 0.000 abstract 2
- 230000003232 mucoadhesive effect Effects 0.000 abstract 2
- 239000012071 phase Substances 0.000 abstract 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical group OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 239000005662 Paraffin oil Substances 0.000 abstract 1
- 239000004264 Petrolatum Substances 0.000 abstract 1
- 229920002807 Thiomer Polymers 0.000 abstract 1
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 abstract 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- -1 hydroxypropyl Chemical group 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000002480 mineral oil Substances 0.000 abstract 1
- 235000010446 mineral oil Nutrition 0.000 abstract 1
- 229940066842 petrolatum Drugs 0.000 abstract 1
- 235000019271 petrolatum Nutrition 0.000 abstract 1
- 229920005862 polyol Polymers 0.000 abstract 1
- 150000003077 polyols Chemical class 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/017—Mixtures of compounds
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/14—Derivatives of phosphoric acid
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/34—Higher-molecular-weight carboxylic acid esters
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La emulsion tiene una combinacion unica de ingredientes que promueve la estabilidad de pequenas gotitas de aceite dentro de la emulsion. La emulsion también incluye un polímero mucoadhesivo que facilita la administracion de un lípido a la superficie ocular. Reivindicacion 1: Una emulsion oftálmica, la cual comprende: agua que forma una fase acuosa; aceite que forma una fase oleosa; un agente tensioactivo hidrofílico; un agente tensioactivo hidrofobico; un fosfolípido cargado; borato; y un polímero galactomanano mucoadhesivo; en la cual: i) la fase oleosa está en gotitas dentro de la fase acuosa y las gotitas tienen un diámetro promedio que no es mayor de alrededor de 1000 nm, pero que es de por lo menos 10 nm; y ii) el borato y el polímero galactomanano actuan conjuntamente para formar un gel luego de la instilacion de la emulsion en un ojo de un individuo. Reivindicacion 2: Una emulsion de acuerdo con la reivindicacion 1, en la cual el aceite es un hidrocarburo seleccionado entre aceite mineral, aceite de parafina y petrolato. Reivindicacion 3: Una emulsion de acuerdo con la reivindicacion 1 o 2, en la cual el aceite es de por lo menos 0,1% p/v y no mayor de alrededor de 5% p/v. Reivindicacion 5: Una emulsion de acuerdo con la reivindicacion 1, 2, 3 y 4, en la cual el agente tensioactivo hidrofílico está presente en la emulsion en una cantidad que es de por lo menos alrededor de 0,08% p/v y está presente en la emulsion en una cantidad que no es mayor de alrededor de 0,8% p/v. Reivindicacion 7: Una emulsion de acuerdo con cualquiera de las reivindicaciones precedentes, en la cual el agente tensioactivo hidrofílico es polioxietileno-40-estearato. Reivindicacion 8: Una emulsion de acuerdo con cualquiera de las reivindicaciones precedentes, en la cual el agente tensioactivo hidrofobico está presente en la emulsion en una cantidad que es de por lo menos alrededor de 0,11% p/v y está presente en la emulsion en una cantidad que no es mayor de alrededor de 2,0% p/v. Reivindicacion 10: Una emulsion de acuerdo con cualquiera de las reivindicaciones precedentes, en la cual el agente tensioactivo hidrofobico es sorbitan triestearato. Reivindicacion 11: Una emulsion de acuerdo con cualquiera de las reivindicaciones precedentes, en la cual el polímero galactomanano mucoadhesivo está seleccionado entre el grupo integrado por guar e hidroxipropil guar. Reivindicacion 14: Una emulsion de acuerdo con cualquiera de las reivindicaciones precedentes, en la cual el fosfolípido cargado es un fosfolípido denominado dimiristoil fosfatidilglicerol. Reivindicacion 15: Una emulsion de acuerdo con cualquiera de las reivindicaciones precedentes, en la cual el fosfolípido está presente en la emulsion en una concentracion desde alrededor de 0,05 a 7,0 por ciento en peso. Reivindicacion 16: Una emulsion de acuerdo con cualquiera de las reivindicaciones precedentes, la cual además comprende un sistema regulador de borato/poliol. Reivindicacion 17: Una emulsion de acuerdo con cualquiera de las reivindicaciones precedentes, la cual además comprende un compuesto polimérico de amonio cuaternario como conservante anti-microbiano.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26620709P | 2009-12-03 | 2009-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR079258A1 true AR079258A1 (es) | 2012-01-04 |
Family
ID=43447032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100104473A AR079258A1 (es) | 2009-12-03 | 2010-12-03 | Emulsion oftalmica |
Country Status (27)
| Country | Link |
|---|---|
| US (7) | US20110136912A1 (es) |
| EP (1) | EP2506830B1 (es) |
| JP (2) | JP5859976B2 (es) |
| KR (1) | KR101734347B1 (es) |
| CN (3) | CN107485602A (es) |
| AR (1) | AR079258A1 (es) |
| AU (1) | AU2010325994B2 (es) |
| BR (1) | BR112012013039B1 (es) |
| CA (1) | CA2780304C (es) |
| CY (1) | CY1118270T1 (es) |
| DK (1) | DK2506830T3 (es) |
| ES (1) | ES2605033T3 (es) |
| HK (1) | HK1169320A1 (es) |
| HR (1) | HRP20161546T1 (es) |
| HU (1) | HUE029786T2 (es) |
| LT (1) | LT2506830T (es) |
| MX (1) | MX343997B (es) |
| NZ (1) | NZ599952A (es) |
| PL (1) | PL2506830T3 (es) |
| PT (1) | PT2506830T (es) |
| RS (1) | RS55300B1 (es) |
| SG (1) | SG181478A1 (es) |
| SI (1) | SI2506830T1 (es) |
| SM (1) | SMT201600424B (es) |
| TW (1) | TWI478730B (es) |
| WO (1) | WO2011068955A1 (es) |
| ZA (1) | ZA201203291B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201336527A (zh) * | 2012-02-10 | 2013-09-16 | Alcon Res Ltd | 具增強的穩定性之水性藥學組成物 |
| EP2630952A1 (en) | 2012-02-23 | 2013-08-28 | Novagali Pharma S.A. | Self-preserved oil dispersions comprising boric acid |
| WO2015080249A1 (ja) * | 2013-11-29 | 2015-06-04 | ロート製薬株式会社 | 眼科用又は耳鼻科用水性組成物 |
| TWI658828B (zh) * | 2014-10-31 | 2019-05-11 | 中國醫藥大學 | 用於舒緩及減輕近視之醫藥組合物及其製備方法與用途 |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| WO2017035408A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
| CN105496955A (zh) * | 2015-12-11 | 2016-04-20 | 北京蓝丹医药科技有限公司 | 一种二氟泼尼酯眼用乳剂及其制备方法 |
| EP3939591A1 (en) | 2016-06-27 | 2022-01-19 | Achillion Pharmaceuticals, Inc. | Quinazoline and indole compounds to treat medical disorders |
| IL294069B2 (en) | 2017-03-01 | 2023-11-01 | Achillion Pharmaceuticals Inc | Aryl, heteroaryl and heterocyclic pharmaceutical compounds for the treatment of medical disorders |
| US11730699B2 (en) | 2018-02-21 | 2023-08-22 | Alcon Inc. | Lipid-based ophthalmic emulsion |
| TW201938141A (zh) * | 2018-02-21 | 2019-10-01 | 瑞士商諾華公司 | 基於脂質的眼用乳劑 |
| WO2019165420A1 (en) * | 2018-02-26 | 2019-08-29 | R.P. Scherer Technologies, Llc | Pharmaceutical dosage form for an emulsion of simethicone and loperamide |
| CN111787953B (zh) * | 2018-02-27 | 2022-12-09 | 久光制药株式会社 | 乳化凝胶组合物 |
| US20230022157A1 (en) | 2018-08-20 | 2023-01-26 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement factor d medical disorders |
| JP7504088B2 (ja) | 2018-10-16 | 2024-06-21 | ジョージア ステイト ユニバーシティー リサーチ ファウンデーション インコーポレイテッド | 医学的障害の治療のための一酸化炭素プロドラッグ |
| EP3890746A4 (en) | 2018-12-06 | 2022-08-10 | Lipicare Life Sciences Ltd. | VITAMIN D MICROEMULSIONS AND THEIR USES |
| EP3893842A1 (en) * | 2018-12-10 | 2021-10-20 | Eternatear, Inc. | Ophthalmic formulations providing durable ocular lubrication |
| CN113144207A (zh) * | 2021-02-07 | 2021-07-23 | 山西利普达医药科技有限公司 | 一种包括聚季铵盐-1的组合物及其应用 |
| US11213551B1 (en) | 2021-04-05 | 2022-01-04 | Korb Research, Llc. | Ocular treatment compositions and methods of use thereof |
| EP4104817A1 (en) | 2021-06-17 | 2022-12-21 | Skeye Pharma GbR | Ophthalmic composition comprising astragaloside iv |
| EP4104818A1 (en) | 2021-06-17 | 2022-12-21 | Skeye Pharma GbR | Ophthalmic composition comprising xanthohumol |
| CN114533672B (zh) * | 2022-03-03 | 2023-12-26 | 南京臣功制药股份有限公司 | 一种维生素k1纳米乳剂及其制备方法 |
| US11471475B1 (en) * | 2022-03-08 | 2022-10-18 | Ralph P. Stone | Ophthalmic suspension vehicles and related methods for pharmaceutical ingredient delivery |
| US11679078B1 (en) | 2022-03-08 | 2023-06-20 | EternaTear, Inc. | Ophthalmic formulations and related methods |
| WO2023217620A1 (en) * | 2022-05-07 | 2023-11-16 | Bayer Aktiengesellschaft | Low drift tank mix additive for low, medium, and high spray volume application |
| CN119233755A (zh) * | 2022-05-07 | 2024-12-31 | 拜耳公司 | 用于低、中等和高喷雾量施用的低漂移水性液体制剂 |
| EP4302767B1 (en) | 2022-07-04 | 2024-10-02 | Skeye Pharma GmbH | Ophthalmic composition comprising eriocitrin for treating dry eye syndrome |
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| FR2787326B1 (fr) * | 1998-12-17 | 2001-01-26 | Oreal | Nanoemulsion a base d'esters gras de glycerol, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique |
| WO2002003916A2 (en) * | 2000-07-07 | 2002-01-17 | Collaborative Technologies, Inc. | Compositions and methods for preparing dispersions of thickened oils |
| FR2811564B1 (fr) * | 2000-07-13 | 2002-12-27 | Oreal | Nanoemulsion contenant des polymeres non ioniques, et ses utilisations notamment dans les domaines cosmetique, dermatologique, pharmaceutique et/ou ophtalmologique |
| US20050080043A1 (en) * | 2000-09-20 | 2005-04-14 | Lee Shahinian | Self-preserved antibacterial nasal, inhalable, and topical ophthalmic preparations and medications |
| FR2819427B1 (fr) * | 2001-01-18 | 2003-04-11 | Oreal | Nanoemulsion translucide, son procede de fabrication et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique |
| US7027520B2 (en) | 2001-08-30 | 2006-04-11 | Thomson Licensing | Method and apparatus for simultaneously retrieving portions of a data stream from different channels |
| US20050196370A1 (en) * | 2003-03-18 | 2005-09-08 | Zhi-Jian Yu | Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye |
| EP1727520A2 (en) * | 2003-12-09 | 2006-12-06 | Medcrystalforms, Llc | Method of preparation of mixed phase co-crystals with active agents |
| EP1701708A2 (en) * | 2003-12-29 | 2006-09-20 | Alza Corporation | Novel drug compositions and dosage forms of topiramate |
| GB0501192D0 (en) * | 2005-01-20 | 2005-03-02 | Resolution Chemicals Ltd | Stable prostaglandin-containing compositions |
| EP1954245A2 (en) * | 2005-11-15 | 2008-08-13 | Baxter International Inc. | Compositions of lipoxygenase inhibitors |
| US20080026013A1 (en) * | 2006-07-28 | 2008-01-31 | Laura Rabinovich-Guilatt | Compositions containing quaternary ammonium compounds |
| CA2685534A1 (en) * | 2007-04-30 | 2008-11-06 | Living Proof, Inc. | Use of matrix metalloproteinase inhibitors in skin care |
| AR071834A1 (es) * | 2008-04-26 | 2010-07-21 | Alcon Res Ltd | Sistema polimerico de lagrimas artificiales |
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