AR072666A1 - Derivados de nip tiazol como inhibidores de la 11-beta-hidroxiesteroide deshidrogenasa-1 (11-b-hsd-1) - Google Patents
Derivados de nip tiazol como inhibidores de la 11-beta-hidroxiesteroide deshidrogenasa-1 (11-b-hsd-1)Info
- Publication number
- AR072666A1 AR072666A1 ARP090101563A ARP090101563A AR072666A1 AR 072666 A1 AR072666 A1 AR 072666A1 AR P090101563 A ARP090101563 A AR P090101563A AR P090101563 A ARP090101563 A AR P090101563A AR 072666 A1 AR072666 A1 AR 072666A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- aryl
- heteroaryl
- hydroxyl
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
Abstract
Uso de tales compuestos para el tratamiento y la prevencion de síndrome metabolico, diabetes, resistencia a la insulina, obesidad, trastornos de los lípidos, glaucoma, osteoporosis, trastornos cognitivos, ansiedad, depresion, trastornos inmunes, hipertension y otras enfermedades y condiciones patologicas. Reivindicacion 1: Uso de un derivado de tiazol de acuerdo con la formula (1), en donde: R1, R2 son, de modo independiente entre sí, alquilo, cicloalquilo o heterociclilo, en donde el alquilo, cicloalquilo o heterociclilo está opcionalmente sustituido con al menos un sustituyentes seleccionado de alquilo, cicloalquilo o hidroxilo, o R1, R2 y el nitrogeno al que están unidos forman un anillo mono- o bicíclico saturado que contiene 3-20, con preferencia, 6-10 átomos, que opcionalmente contiene al menos otro heteroátomo seleccionado de N, S u O y que opcionalmente está sustituido con al menos un sustituyente seleccionado de halogeno, alquilo, hidroxilo, =O (oxígeno del carbonilo), arilo o heteroarilo; R3 es alquilo, cicloalquilo, cicloalquil-alquilo, arilo, aril-alquilo, heteroarilo o heteroaril-alquilo, en donde dicho alquilo, cicloalquilo, cicloalquil-alquilo, arilo, aril-alquilo, heteroarilo o heteroaril-alquilo está opcionalmente sustituido con al menos un sustituyente seleccionado de halogeno, hidroxilo, C(O)OH, CN, C(O)-NH2, carbamoilo, acetamida, alquilo, arilo, fenilo, metoxi-fenilo, fluorofenilo, fenoxi, ariloxi, alquiloxi, alquil C1-4-oxi, metoxi, trifluorometilo, trifluorometoxi, trifluorometiltio, alquiloxicarbonilo, alquil C1-4-oxicarbonilo, alquilcarbonilo, alquil C1-4-carbonilo, R4R5-N-alquilo C1-4-oxi o alquil C1-4-S(O)n, en donde n es 0, 1 o 2; R4, R5 son, de modo independiente entre sí, alquilo o cicloalquilo; X es un enlace directo, C(O), C(O)O, S(O)2 o C(O)NH; y sus sales, derivados, profármacos, solvatos y estereoisomeros fisiologicamente aceptables, incluyendo sus mezclas en todas las proporciones, como inhibidor de 11-b-HSD-1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08290424 | 2008-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR072666A1 true AR072666A1 (es) | 2010-09-15 |
Family
ID=40935480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090101563A AR072666A1 (es) | 2008-05-05 | 2009-04-30 | Derivados de nip tiazol como inhibidores de la 11-beta-hidroxiesteroide deshidrogenasa-1 (11-b-hsd-1) |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8546575B2 (es) |
| EP (1) | EP2271405B1 (es) |
| JP (1) | JP5735412B2 (es) |
| KR (1) | KR101604366B1 (es) |
| CN (1) | CN102015026B (es) |
| AR (1) | AR072666A1 (es) |
| AU (1) | AU2009243812B2 (es) |
| BR (1) | BRPI0911497B8 (es) |
| CA (1) | CA2723431C (es) |
| CO (1) | CO6331305A2 (es) |
| EA (2) | EA201300759A1 (es) |
| EC (1) | ECSP10010656A (es) |
| ES (1) | ES2432383T3 (es) |
| IL (1) | IL208989A (es) |
| MX (1) | MX2010011917A (es) |
| NZ (1) | NZ589691A (es) |
| WO (1) | WO2009135581A2 (es) |
| ZA (1) | ZA201008723B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5220848B2 (ja) * | 2007-06-01 | 2013-06-26 | エフ．ホフマン−ラ ロシュ アーゲー | ピペリジンアミド誘導体 |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2015005305A1 (ja) | 2013-07-09 | 2015-01-15 | 小野薬品工業株式会社 | Ａｌｘｒ作動化合物 |
| CN104910083A (zh) * | 2015-07-13 | 2015-09-16 | 佛山市赛维斯医药科技有限公司 | 烷氧苯基三氮唑亚砜类11β-HSD1抑制剂、制备方法及其用途 |
| CN104910084A (zh) * | 2015-07-13 | 2015-09-16 | 佛山市赛维斯医药科技有限公司 | 末端胺基取代的三氮唑亚砜类化合物、其制备方法及其用途 |
| EP3235813A1 (en) | 2016-04-19 | 2017-10-25 | Cidqo 2012, S.L. | Aza-tetra-cyclo derivatives |
| BR112020004356A2 (pt) * | 2017-09-08 | 2020-12-01 | Pi Industries Ltd. | novos compostos heterocíclicos fungicidas |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7754709B2 (en) * | 2003-06-10 | 2010-07-13 | Solvay Pharmaceuticals Bv | Tetracyclic thiophenepyrimidinone compounds as inhibitors of 17β hydroxysteroid dehydrogenase compounds |
| US20070231263A1 (en) * | 2004-04-13 | 2007-10-04 | Jun Qiu | Human G protein-coupled receptor and modulators thereof for the treatment of hyperglycemia and related disorders |
| EP1637529A1 (en) | 2004-09-20 | 2006-03-22 | 4Sc Ag | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof |
| DE102006010923A1 (de) * | 2006-03-09 | 2007-09-13 | Saltigo Gmbh | Verfahren zur Herstellung von Chlor-1,4-dimethoxybenzol |
| WO2007104557A2 (en) * | 2006-03-15 | 2007-09-20 | 4Sc Ag | Novel heterocyclic nf-kb inhibitors |
| EA200801838A1 (ru) * | 2006-03-15 | 2009-02-27 | 4ЭсЦэ АГ | НОВЫЕ ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ NF-kB |
-
2009
- 2009-04-08 US US12/991,016 patent/US8546575B2/en active Active
- 2009-04-08 AU AU2009243812A patent/AU2009243812B2/en not_active Ceased
- 2009-04-08 KR KR1020107027260A patent/KR101604366B1/ko active IP Right Grant
- 2009-04-08 NZ NZ589691A patent/NZ589691A/xx not_active IP Right Cessation
- 2009-04-08 EP EP09741800.8A patent/EP2271405B1/en active Active
- 2009-04-08 EA EA201300759A patent/EA201300759A1/ru unknown
- 2009-04-08 MX MX2010011917A patent/MX2010011917A/es active IP Right Grant
- 2009-04-08 CN CN200980116875.5A patent/CN102015026B/zh active Active
- 2009-04-08 EA EA201001737A patent/EA018920B1/ru not_active IP Right Cessation
- 2009-04-08 WO PCT/EP2009/002607 patent/WO2009135581A2/en active Application Filing
- 2009-04-08 CA CA2723431A patent/CA2723431C/en active Active
- 2009-04-08 BR BRPI0911497A patent/BRPI0911497B8/pt active IP Right Grant
- 2009-04-08 JP JP2011507806A patent/JP5735412B2/ja active Active
- 2009-04-08 ES ES09741800T patent/ES2432383T3/es active Active
- 2009-04-30 AR ARP090101563A patent/AR072666A1/es unknown
-
2010
- 2010-10-28 IL IL208989A patent/IL208989A/en active IP Right Grant
- 2010-10-29 CO CO10134879A patent/CO6331305A2/es not_active Application Discontinuation
- 2010-12-02 EC EC2010010656A patent/ECSP10010656A/es unknown
- 2010-12-03 ZA ZA2010/08723A patent/ZA201008723B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL208989A (en) | 2014-01-30 |
| US8546575B2 (en) | 2013-10-01 |
| ZA201008723B (en) | 2012-01-25 |
| CA2723431C (en) | 2016-11-22 |
| KR101604366B1 (ko) | 2016-03-17 |
| AU2009243812A1 (en) | 2009-11-12 |
| ECSP10010656A (es) | 2011-01-31 |
| JP5735412B2 (ja) | 2015-06-17 |
| CA2723431A1 (en) | 2009-11-12 |
| WO2009135581A2 (en) | 2009-11-12 |
| CN102015026A (zh) | 2011-04-13 |
| NZ589691A (en) | 2012-11-30 |
| MX2010011917A (es) | 2010-11-26 |
| EA201300759A1 (ru) | 2013-11-29 |
| BRPI0911497B1 (pt) | 2021-01-26 |
| IL208989A0 (en) | 2011-01-31 |
| CO6331305A2 (es) | 2011-10-20 |
| BRPI0911497B8 (pt) | 2021-05-25 |
| BRPI0911497A2 (pt) | 2019-01-15 |
| EP2271405B1 (en) | 2013-07-24 |
| EP2271405A2 (en) | 2011-01-12 |
| WO2009135581A9 (en) | 2010-11-11 |
| EA201001737A1 (ru) | 2011-06-30 |
| ES2432383T3 (es) | 2013-12-03 |
| US20110060007A1 (en) | 2011-03-10 |
| KR20110004468A (ko) | 2011-01-13 |
| AU2009243812B2 (en) | 2014-06-05 |
| WO2009135581A3 (en) | 2010-08-19 |
| JP2011521907A (ja) | 2011-07-28 |
| EA018920B1 (ru) | 2013-11-29 |
| CN102015026B (zh) | 2015-11-25 |
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