AR072272A1 - Piridin-2-onas y piridazin-3-onas sustituidas utiles para el tratamiento de enfermedades autoinmunes e inflamatorias causadas por una activacion aberrante de las celulas b, y composiciones farmaceuticas que las contienen. - Google Patents
Piridin-2-onas y piridazin-3-onas sustituidas utiles para el tratamiento de enfermedades autoinmunes e inflamatorias causadas por una activacion aberrante de las celulas b, y composiciones farmaceuticas que las contienen.Info
- Publication number
- AR072272A1 AR072272A1 ARP090102276A ARP090102276A AR072272A1 AR 072272 A1 AR072272 A1 AR 072272A1 AR P090102276 A ARP090102276 A AR P090102276A AR P090102276 A ARP090102276 A AR P090102276A AR 072272 A1 AR072272 A1 AR 072272A1
- Authority
- AR
- Argentina
- Prior art keywords
- halogen
- alkyl
- optionally substituted
- hydroxy
- lower alkyl
- Prior art date
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Reivindicacion 1: Un compuesto de las formulas 1, 2, 3 o 4 en las que: R es H, -R1, -R1-R2-R3, -R1-R3 o -R2-R3; en los que R1 es arilo, heteroarilo, cicloalquilo o heterocicloalquilo y está opcionalmente sustituido por R1'; dicho R1' es alquilo inferior, hidroxi, hidroxialquilo inferior, alcoxi inferior, halogeno, nitro, amino, cicloalquilo, heterocicloalquilo, ciano o haloalquilo inferior; R2 es -C(=O), -C(=O)O, -C(=O)N(R2'), -(CH2)q o -S(=O)2; dicho R2' es H o alquilo inferior; y q es el numero 1, 2 o 3; R3 es H o R4; dicho R4 es alquilo inferior, alcoxi inferior, heteroalquilo inferior, arilo, arilalquilo, alquilarilo, heteroarilo, alquil-heteroarilo, heteroarilalquilo, cicloalquilo, alquil-cicloalquilo, cicloalquilalquilo, heterocicloalquilo, alquil-heterocicloalquilo o heterocicloalquil-alquilo, y está opcionalmente sustituido por uno o más alquilo inferior, hidroxi, oxo, hidroxialquilo inferior, alcoxi inferior, halogeno, nitro, amino, ciano, alquilsulfonilo inferior o haloalquilo inferior; X es CH o N; Y1 es H o alquilo inferior; Y2 es Y2a o Y2b; dicho Y2a es H o halogeno; e Y2b es alquilo inferior, opcionalmente sustituido con uno o más Y2b'; e Y2b' es hidroxi, alcoxi inferior o halogeno; cada Y2' es con independencia Y2'a o Y2'b; dicho Y2'a es halogeno; e Y2'b es alquilo inferior, opcionalmente sustituido con uno o más Y2'b'; dicho Y2'b' es hidroxi, alcoxi inferior o halogeno; n es el numero 0, 1, 2 o 3; Y3 es H, halogeno o alquilo inferior, dicho alquilo inferior está opcionalmente sustituido por uno o más sustituyentes elegidos entre el grupo formado por hidroxi, alcoxi inferior, amino y halogeno; m es el numero 0 o 1; Y4 es Y4a, Y4b Y4c o Y4d; en los que Y4a es H o halogeno; Y4b es alquilo inferior, opcionalmente sustituido con uno o más sustituyentes elegidos entre el grupo formado por haloalquilo inferior, halogeno, hidroxi, amino y alcoxi inferior; Y4c es cicloalquilo inferior, opcionalmente sustituido con uno o más sustituyentes elegidos entre el grupo formado por alquilo inferior, haloalquilo inferior, halogeno, hidroxi, amino y alcoxi inferior; y Y4d es amino, opcionalmente sustituido con uno o más alquilo inferior; o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US7527708P | 2008-06-24 | 2008-06-24 |
Publications (1)
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AR072272A1 true AR072272A1 (es) | 2010-08-18 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ARP090102276A AR072272A1 (es) | 2008-06-24 | 2009-06-22 | Piridin-2-onas y piridazin-3-onas sustituidas utiles para el tratamiento de enfermedades autoinmunes e inflamatorias causadas por una activacion aberrante de las celulas b, y composiciones farmaceuticas que las contienen. |
Country Status (25)
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US (4) | US7902194B2 (es) |
EP (1) | EP2297142B1 (es) |
JP (1) | JP5536049B2 (es) |
KR (1) | KR101299867B1 (es) |
CN (3) | CN103408533B (es) |
AR (1) | AR072272A1 (es) |
AU (1) | AU2009264400B2 (es) |
BR (1) | BRPI0914657A2 (es) |
CA (1) | CA2728016C (es) |
CL (1) | CL2010001483A1 (es) |
CO (1) | CO6382183A2 (es) |
CR (1) | CR11815A (es) |
EC (1) | ECSP10010709A (es) |
ES (1) | ES2552320T3 (es) |
HK (2) | HK1152940A1 (es) |
IL (1) | IL209141A0 (es) |
MA (1) | MA32487B1 (es) |
MX (1) | MX2010013191A (es) |
NZ (2) | NZ588819A (es) |
PE (1) | PE20100851A1 (es) |
RU (1) | RU2500680C2 (es) |
TW (1) | TWI396537B (es) |
UA (1) | UA103327C2 (es) |
WO (1) | WO2009156284A1 (es) |
ZA (1) | ZA201007816B (es) |
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