UA103327C2 - Substituted pyridin-2-ones and pyridazin-3-ones - Google Patents
Substituted pyridin-2-ones and pyridazin-3-onesInfo
- Publication number
- UA103327C2 UA103327C2 UAA201100578A UAA201100578A UA103327C2 UA 103327 C2 UA103327 C2 UA 103327C2 UA A201100578 A UAA201100578 A UA A201100578A UA A201100578 A UAA201100578 A UA A201100578A UA 103327 C2 UA103327 C2 UA 103327C2
- Authority
- UA
- Ukraine
- Prior art keywords
- ones
- pyridazin
- compounds
- btk
- phenyl
- Prior art date
Links
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
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- C07—ORGANIC CHEMISTRY
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
Abstract
В заявке описаны производные 5-фенил-1Н-пиридин-2-она и 6-фенил-2Н-пиридазин-3-она общих формул I-IV:, (I), (II), (III), (IV)где переменные R, X, Y, Y, Y, Y, Y, n и m являются такими, как описано в данном изобретении, которые ингибируют Btk.Соединения, раскрытые в данном изобретении, применимы для модулирования активности Btk и для лечения заболеваний, связанных с чрезмерной активностью Btk.Кроме того, соединения применимы для лечения воспалительных и аутоиммунных заболеваний, связанных с аберрантной пролиферацией В-клеток, таких как ревматоидный артрит.В заявке также описаны композиции, которые содержат соединения формул I-IV и по крайней мере один носитель, разжижитель или инертный наполнитель.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7527708P | 2008-06-24 | 2008-06-24 | |
| PCT/EP2009/057320 WO2009156284A1 (en) | 2008-06-24 | 2009-06-15 | Novel substituted pyridin-2-ones and pyridazin-3-ones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA103327C2 true UA103327C2 (en) | 2013-10-10 |
Family
ID=40972952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201100578A UA103327C2 (en) | 2008-06-24 | 2009-06-15 | Substituted pyridin-2-ones and pyridazin-3-ones |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US7902194B2 (ru) |
| EP (1) | EP2297142B1 (ru) |
| JP (1) | JP5536049B2 (ru) |
| KR (1) | KR101299867B1 (ru) |
| CN (3) | CN103408533B (ru) |
| AR (1) | AR072272A1 (ru) |
| AU (1) | AU2009264400B2 (ru) |
| BR (1) | BRPI0914657A2 (ru) |
| CA (1) | CA2728016C (ru) |
| CL (1) | CL2010001483A1 (ru) |
| CO (1) | CO6382183A2 (ru) |
| CR (1) | CR11815A (ru) |
| EC (1) | ECSP10010709A (ru) |
| ES (1) | ES2552320T3 (ru) |
| HK (2) | HK1152940A1 (ru) |
| IL (1) | IL209141A0 (ru) |
| MA (1) | MA32487B1 (ru) |
| MX (1) | MX2010013191A (ru) |
| NZ (2) | NZ601700A (ru) |
| PE (1) | PE20100851A1 (ru) |
| RU (1) | RU2500680C2 (ru) |
| TW (1) | TWI396537B (ru) |
| UA (1) | UA103327C2 (ru) |
| WO (1) | WO2009156284A1 (ru) |
| ZA (1) | ZA201007816B (ru) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200900396A (en) * | 2007-04-10 | 2009-01-01 | Kudos Pharm Ltd | Phthalazinone derivatives |
| DK2300459T3 (da) * | 2008-07-02 | 2013-09-02 | Hoffmann La Roche | Nye fenylpyrazinoner som kinasehæmmere |
| US8299077B2 (en) * | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
| CA2748414A1 (en) * | 2009-04-24 | 2010-10-28 | F. Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
| MY160349A (en) * | 2010-05-07 | 2017-02-28 | Gilead Connecticut Inc | Pyridone and aza-pyridone compounds and methods of use |
| AR082590A1 (es) * | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
| JP5842004B2 (ja) * | 2010-09-01 | 2016-01-13 | ジーアイリード コネチカット インコーポレーテッドＧｉｌｅａｄ Ｃｏｎｎｅｃｔｉｃｕｔ，Ｉｎｃ． | ピリダジノン、その製造方法及びその使用方法 |
| TW201311669A (zh) | 2011-08-17 | 2013-03-16 | Hoffmann La Roche | 布魯頓氏酪胺酸激酶（ｂｒｕｔｏｎ’ｓ ｔｙｒｏｓｉｎｅ ｋｉｎａｓｅ）之抑制劑 |
| UA111756C2 (uk) | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
| AR088643A1 (es) * | 2011-11-03 | 2014-06-25 | Genentech Inc | Compuestos de 8-fluoroftalazin-1(2h)-ona |
| MX2014005285A (es) | 2011-11-03 | 2014-05-30 | Hoffmann La Roche | Compuestos biciclicos de piperazina. |
| EP2773639B1 (en) | 2011-11-03 | 2017-04-26 | F. Hoffmann-La Roche AG | Alkylated piperazine compounds as inhibitors of btk activity |
| CA2854603A1 (en) | 2011-12-09 | 2013-06-13 | F. Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
| WO2013148603A1 (en) | 2012-03-27 | 2013-10-03 | Takeda Pharmaceutical Company Limited | Cinnoline derivatives as as btk inhibitors |
| AU2013293087B2 (en) | 2012-07-24 | 2017-08-31 | Pharmacyclics Llc | Mutations associated with resistance to inhibitors of Bruton's tyrosine kinase (BTK) |
| GEP201706748B (en) | 2012-08-10 | 2017-10-10 | Boehringer Ingelheim Int | Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors |
| RU2015111133A (ru) * | 2012-09-13 | 2016-11-10 | Ф. Хоффманн-Ля Рош Аг | Ингибиторы тирозинкиназы брутона |
| WO2014076104A1 (en) * | 2012-11-16 | 2014-05-22 | F. Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
| JP6089124B2 (ja) | 2013-03-05 | 2017-03-01 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ブルトン型チロシンキナーゼの阻害薬 |
| JO3377B1 (ar) | 2013-03-11 | 2019-03-13 | Takeda Pharmaceuticals Co | مشتقات بيريدينيل وبيريدينيل مندمج |
| CN104177338B (zh) * | 2013-05-22 | 2018-04-03 | 南京勇山生物科技有限公司 | 一类布鲁顿激酶抑制剂 |
| CN110698481B (zh) * | 2013-07-03 | 2023-02-28 | 豪夫迈·罗氏有限公司 | 杂芳基吡啶酮和氮杂-吡啶酮酰胺化合物 |
| CN105764502A (zh) | 2013-07-26 | 2016-07-13 | 现代化制药公司 | 改善比生群及其类似物及衍生物的治疗益处的组合方法 |
| EA201690127A1 (ru) | 2013-07-30 | 2016-07-29 | Джилид Коннектикут, Инк. | Состав на основе ингибиторов syk |
| NZ715776A (en) | 2013-07-30 | 2017-04-28 | Gilead Connecticut Inc | Polymorph of syk inhibitors |
| WO2015082583A1 (en) | 2013-12-05 | 2015-06-11 | F. Hoffmann-La Roche Ag | Heteroaryl pyridone and aza-pyridone compounds with electrophilic functionality |
| EP3080099B1 (en) * | 2013-12-13 | 2018-04-11 | F.Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
| TWI735853B (zh) | 2013-12-23 | 2021-08-11 | 美商克洛諾斯生技有限公司 | 脾酪胺酸激酶抑制劑 |
| TW201702218A (zh) | 2014-12-12 | 2017-01-16 | 美國杰克森實驗室 | 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法 |
| EP3402789B1 (en) * | 2016-01-13 | 2020-03-18 | Boehringer Ingelheim International Gmbh | Isoquinolones as btk inhibitors |
| AU2017240609B2 (en) | 2016-03-31 | 2021-07-15 | Takeda Pharmaceutical Company Limited | Isoquinolinyl triazolone complexes |
| JP2019529419A (ja) | 2016-09-19 | 2019-10-17 | エムイーアイ ファーマ，インク． | 併用療法 |
| CA3073871A1 (en) | 2017-08-25 | 2019-02-28 | Gilead Sciences, Inc. | Polymorphs of syk inhibitors |
| BR112020012635A2 (pt) | 2017-12-22 | 2020-12-01 | Ravenna Pharmaceuticals, Inc. | derivados de aminopiridina como inibidores de fosfatidilinositol fosfato quinase |
| WO2020172431A1 (en) | 2019-02-22 | 2020-08-27 | Gilead Sciences, Inc. | Solid forms of condensed pyrazines as syk inhibitors |
| EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
| TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
| JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1070056T1 (en) * | 1998-03-14 | 2004-12-31 | Altana Pharma Ag | Phthalazinone pde iii/iv inhibitors |
| CN1636005A (zh) * | 1999-06-03 | 2005-07-06 | 克诺尔股份有限公司 | 苯并噻嗪酮和苯并噁嗪酮化合物 |
| DZ3223A1 (fr) * | 1999-10-19 | 2001-04-26 | Merck & Co Inc | Inhibiteurs de tyrosine kinases |
| AU2003270489A1 (en) | 2002-09-09 | 2004-03-29 | Cellular Genomics, Inc. | 6-ARYL-IMIDAZO(1,2-a)PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF |
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