AR071756A1 - Agente para el tratamiento y/o la prevencion de una enfermedad autoinmune y para la formacion de celulas t reguladoras. procedimientos. - Google Patents

Agente para el tratamiento y/o la prevencion de una enfermedad autoinmune y para la formacion de celulas t reguladoras. procedimientos.

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Publication number
AR071756A1
AR071756A1 ARP090101665A ARP090101665A AR071756A1 AR 071756 A1 AR071756 A1 AR 071756A1 AR P090101665 A ARP090101665 A AR P090101665A AR P090101665 A ARP090101665 A AR P090101665A AR 071756 A1 AR071756 A1 AR 071756A1
Authority
AR
Argentina
Prior art keywords
hil
prevention
agent
treatment
autoimmune disease
Prior art date
Application number
ARP090101665A
Other languages
English (en)
Inventor
Daniela Paulsen
Nina Brunner
Dorothy Bray
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41152787&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR071756(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of AR071756A1 publication Critical patent/AR071756A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells

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Abstract

Agente para el tratamiento y/o la prevencion de una enfermedad autoinmune, un agente para la formacion de celulas T reguladoras (Treg) en un ser vivo, as¡ como diversos procedimientos, en los que se usan los agentes segun la invencion. Reivindicacion 1: Uso de una mute¡na de interleuquina-2 humana (mute¡na de hIL-2) o una de sus partes, que est  numerada segun la hIL-2 de tipo salvaje y que presenta una sustitucion de amino cido en al menos una de las posiciones 20, 88 o 126, para preparar un medicamento para el tratamiento y/o la prevencion de una enfermedad autoinmune. Reivindicacion 2: Uso de acuerdo con la reivindicacion 1, caracterizado porque por sustitucion en la posicion 88 se intercambia una asparagina por arginina (hIL-2-N88R), o por una glicina (hIL-2-N88G) o por una isoleucina (hIL-2-N88I). Reivindicacion 3: Uso de acuerdo con la reivindicacion 1 o 2, caracterizado porque por sustitucion en la posicion 20 se intercambia un  cido asp rtico por una histidina (hIL-2-D20H) o por una isoleucina (hIL-2-D20H) o por una tirosina (hIL-2-D20Y). Reivindicacion 4: Uso de acuerdo con una de las reivindicaciones precedentes, caracterizado porque por sustitucion en la posicion 126 se intercambia una glutamina por una leucina (hIL-2-Q126L). Reivindicacion 7: Uso de acuerdo con una de las reivindicaciones precedentes, caracterizado porque el medicamento presenta adicionalmente un inmunosupresor. Reivindicacion 11: Medicamento para el tratamiento y/o la prevencion de una enfermedad autoinmune, caracterizado porque presenta la mute¡na de hIL-2 o una parte de ella segun el uso de acuerdo con una de las reivindicaciones 1 a 10. Reivindicacion 21: Agente para la formacion de celulas T reguladoras (Treg) en un ser vivo, caracterizado porque presenta la mute¡na de hIL-2 o una parte de ella segun el uso de acuerdo con una de las reivindicaciones 12 a 20.
ARP090101665A 2008-05-08 2009-05-08 Agente para el tratamiento y/o la prevencion de una enfermedad autoinmune y para la formacion de celulas t reguladoras. procedimientos. AR071756A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102008023820A DE102008023820A1 (de) 2008-05-08 2008-05-08 Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen

Publications (1)

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AR071756A1 true AR071756A1 (es) 2010-07-14

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ARP090101665A AR071756A1 (es) 2008-05-08 2009-05-08 Agente para el tratamiento y/o la prevencion de una enfermedad autoinmune y para la formacion de celulas t reguladoras. procedimientos.

Country Status (28)

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US (4) US20110150826A1 (es)
EP (1) EP2288372B1 (es)
JP (2) JP5651583B2 (es)
KR (3) KR101687506B1 (es)
CN (2) CN102088996A (es)
AR (1) AR071756A1 (es)
AT (1) ATE544465T1 (es)
AU (1) AU2009244039B2 (es)
BR (1) BRPI0912411B8 (es)
CA (1) CA2723761C (es)
CL (1) CL2009001099A1 (es)
CY (1) CY1112469T1 (es)
DE (1) DE102008023820A1 (es)
DK (1) DK2288372T3 (es)
ES (1) ES2378957T3 (es)
HR (1) HRP20120296T1 (es)
IL (3) IL209128A (es)
MX (1) MX2010012214A (es)
PE (1) PE20091967A1 (es)
PL (1) PL2288372T3 (es)
PT (1) PT2288372E (es)
RU (1) RU2531936C2 (es)
SI (1) SI2288372T1 (es)
TW (1) TWI510622B (es)
UA (1) UA102099C2 (es)
UY (1) UY31816A (es)
WO (1) WO2009135615A2 (es)
ZA (1) ZA201008129B (es)

Families Citing this family (61)

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Publication number Priority date Publication date Assignee Title
DE102008023820A1 (de) 2008-05-08 2009-11-12 Aicuris Gmbh & Co. Kg Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen
WO2010085495A1 (en) 2009-01-21 2010-07-29 Amgen Inc. Compositions and methods of treating inflammatory and autoimmune diseases
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