AR065767A1 - Derivados de fenilquinazolinas,composiciones farmaceuticas que los contienen,metodo de preparacion de los mismos y usos para el tratamiento del cancer. - Google Patents
Derivados de fenilquinazolinas,composiciones farmaceuticas que los contienen,metodo de preparacion de los mismos y usos para el tratamiento del cancer.Info
- Publication number
- AR065767A1 AR065767A1 ARP080101080A ARP080101080A AR065767A1 AR 065767 A1 AR065767 A1 AR 065767A1 AR P080101080 A ARP080101080 A AR P080101080A AR P080101080 A ARP080101080 A AR P080101080A AR 065767 A1 AR065767 A1 AR 065767A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- substituted
- hydrogen
- heterocycloalkyl
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 36
- 229910052739 hydrogen Inorganic materials 0.000 abstract 18
- 239000001257 hydrogen Substances 0.000 abstract 18
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 16
- 125000001072 heteroaryl group Chemical group 0.000 abstract 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 13
- 125000003545 alkoxy group Chemical group 0.000 abstract 12
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 10
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 10
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 abstract 9
- 150000002431 hydrogen Chemical group 0.000 abstract 9
- 125000001475 halogen functional group Chemical group 0.000 abstract 8
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 7
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 7
- -1 pyrido [3,2-d] pyrimidinyl Chemical group 0.000 abstract 7
- 125000003282 alkyl amino group Chemical group 0.000 abstract 6
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 6
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000001188 haloalkyl group Chemical group 0.000 abstract 5
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 4
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 4
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 3
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000004689 alkyl amino carbonyl alkyl group Chemical group 0.000 abstract 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000002431 aminoalkoxy group Chemical group 0.000 abstract 1
- 125000005097 aminocarbonylalkyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000005059 halophenyl group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91816007P | 2007-03-14 | 2007-03-14 | |
| US96261707P | 2007-07-30 | 2007-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR065767A1 true AR065767A1 (es) | 2009-07-01 |
Family
ID=39760053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080101080A AR065767A1 (es) | 2007-03-14 | 2008-03-14 | Derivados de fenilquinazolinas,composiciones farmaceuticas que los contienen,metodo de preparacion de los mismos y usos para el tratamiento del cancer. |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8222263B2 (enExample) |
| EP (2) | EP2134695A4 (enExample) |
| JP (1) | JP5577104B2 (enExample) |
| KR (1) | KR20090130051A (enExample) |
| CN (1) | CN101679308B (enExample) |
| AR (1) | AR065767A1 (enExample) |
| AU (1) | AU2008224941C1 (enExample) |
| BR (1) | BRPI0808772A2 (enExample) |
| CA (1) | CA2680796A1 (enExample) |
| CO (1) | CO6231031A2 (enExample) |
| EA (1) | EA018441B1 (enExample) |
| GE (1) | GEP20135925B (enExample) |
| IL (1) | IL200603A (enExample) |
| MX (1) | MX2009009786A (enExample) |
| NZ (2) | NZ579480A (enExample) |
| SG (1) | SG179418A1 (enExample) |
| TW (1) | TWI430798B (enExample) |
| WO (1) | WO2008112913A1 (enExample) |
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| CN116621722A (zh) * | 2023-07-14 | 2023-08-22 | 甘肃帝邦升防水材料科技有限公司 | 超耐候柔性tpo自粘防水卷材及其制备方法 |
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| US6004979A (en) * | 1991-02-07 | 1999-12-21 | Hoechst Marion Roussel | Nitrogenous bicycles |
| NZ325248A (en) * | 1995-12-23 | 1999-09-29 | Pfizer Res & Dev | Quinoline and quinazoline compounds useful in therapy |
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| US7105667B2 (en) * | 2001-05-01 | 2006-09-12 | Bristol-Myers Squibb Co. | Fused heterocyclic compounds and use thereof |
| PE20030008A1 (es) * | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
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| AU2004225965A1 (en) | 2003-03-25 | 2004-10-14 | Vertex Pharmaceuticals Incorporated | Thiazoles useful as inhibitors of protein kinases |
| US20050009817A1 (en) * | 2003-04-30 | 2005-01-13 | Jennifer Savoy | Substituted heteroaryls |
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| US8067608B2 (en) * | 2003-09-29 | 2011-11-29 | The Johns Hopkins University | Hedgehog pathway antagonists |
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| JP4903133B2 (ja) * | 2004-04-30 | 2012-03-28 | ジェネンテック，インコーポレイティド | ヘッジホッグシグナル伝達のキノキサリン阻害剤 |
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| GT200500321A (es) | 2004-11-09 | 2006-09-04 | Compuestos y composiciones como inhibidores de proteina kinase. | |
| WO2006113261A2 (en) * | 2005-04-14 | 2006-10-26 | Bristol-Myers Squibb Company | Inhibitors of 11-beta hydroxysteroid dehydrogenase type i |
| WO2006128129A2 (en) | 2005-05-26 | 2006-11-30 | Synta Pharmaceuticals Corp. | Method for treating cancer |
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| JP2009542816A (ja) * | 2006-06-16 | 2009-12-03 | グラクソ グループ リミテッド | 新規化合物 |
| WO2007147109A2 (en) * | 2006-06-16 | 2007-12-21 | Glaxo Group Limited | Novel compounds |
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- 2008-03-13 EA EA200970856A patent/EA018441B1/ru not_active IP Right Cessation
- 2008-03-13 CA CA002680796A patent/CA2680796A1/en not_active Abandoned
- 2008-03-13 EP EP12180902A patent/EP2527330A1/en not_active Withdrawn
- 2008-03-13 MX MX2009009786A patent/MX2009009786A/es active IP Right Grant
- 2008-03-13 JP JP2009553783A patent/JP5577104B2/ja not_active Expired - Fee Related
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- 2008-03-13 WO PCT/US2008/056883 patent/WO2008112913A1/en not_active Ceased
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- 2012-06-04 US US13/487,594 patent/US8754092B2/en active Active
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| WO2008112913A1 (en) | 2008-09-18 |
| AU2008224941B2 (en) | 2012-12-20 |
| IL200603A0 (en) | 2010-05-17 |
| KR20090130051A (ko) | 2009-12-17 |
| TW200843777A (en) | 2008-11-16 |
| AU2008224941C1 (en) | 2013-06-27 |
| CA2680796A1 (en) | 2008-09-18 |
| US20090105211A1 (en) | 2009-04-23 |
| EP2527330A1 (en) | 2012-11-28 |
| US20120245139A1 (en) | 2012-09-27 |
| NZ598251A (en) | 2013-06-28 |
| TWI430798B (zh) | 2014-03-21 |
| AU2008224941A1 (en) | 2008-09-18 |
| GEP20135925B (en) | 2013-10-10 |
| CN101679308B (zh) | 2014-05-07 |
| EA200970856A1 (ru) | 2010-04-30 |
| BRPI0808772A2 (pt) | 2014-08-12 |
| MX2009009786A (es) | 2009-09-24 |
| IL200603A (en) | 2014-08-31 |
| JP2010521487A (ja) | 2010-06-24 |
| US8796294B2 (en) | 2014-08-05 |
| SG179418A1 (en) | 2012-04-27 |
| EP2134695A4 (en) | 2011-05-25 |
| US8754092B2 (en) | 2014-06-17 |
| EP2134695A1 (en) | 2009-12-23 |
| US8222263B2 (en) | 2012-07-17 |
| JP5577104B2 (ja) | 2014-08-20 |
| US20120238570A1 (en) | 2012-09-20 |
| CN101679308A (zh) | 2010-03-24 |
| CO6231031A2 (es) | 2010-12-20 |
| NZ579480A (en) | 2012-03-30 |
| EA018441B1 (ru) | 2013-08-30 |
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