AR064683A1 - Procedimiento para la extraccion de una proteina presente en la leche - Google Patents
Procedimiento para la extraccion de una proteina presente en la lecheInfo
- Publication number
- AR064683A1 AR064683A1 ARP070105952A ARP070105952A AR064683A1 AR 064683 A1 AR064683 A1 AR 064683A1 AR P070105952 A ARP070105952 A AR P070105952A AR P070105952 A ARP070105952 A AR P070105952A AR 064683 A1 AR064683 A1 AR 064683A1
- Authority
- AR
- Argentina
- Prior art keywords
- protein
- milk
- extraction
- procedure
- protein present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
- A61D19/04—Instruments or methods for reproduction or fertilisation for embryo transplantation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
- B01D15/327—Reversed phase with hydrophobic interaction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3847—Multimodal interactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Reproductive Health (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Dairy Products (AREA)
Abstract
La presente solicitud se refiere a un procedimiento para la extraccion de una proteína presente en la leche, que tiene por lo menos, incluyendo los siguientes pasos de a) descremar y desgrasar dicha leche, b) transferir la fraccion desgrasada y descremada que contiene dicha proteína a un sopote cromatográfico sobre el cual está injertado un ligando que es simultáneamente hidrofobo y ionico bajo condiciones de pH que permiten que dicha proteína sea capturada sobre dicho soporte, siendo dicho pH mayor que 4,6, c) eluir la proteína, d) purificar la fraccion eluida retirando las proteínas de la leche de dicha fraccion eluida, y e) recuperar dicha proteína.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0611536A FR2910786B1 (fr) | 2006-12-29 | 2006-12-29 | "procede d'extraction d'une proteine presente dans du lait" |
Publications (1)
Publication Number | Publication Date |
---|---|
AR064683A1 true AR064683A1 (es) | 2009-04-22 |
Family
ID=38182268
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070105952A AR064683A1 (es) | 2006-12-29 | 2007-12-28 | Procedimiento para la extraccion de una proteina presente en la leche |
Country Status (13)
Country | Link |
---|---|
US (2) | US8492524B2 (es) |
EP (1) | EP2134191A2 (es) |
JP (1) | JP5196590B2 (es) |
KR (1) | KR101294751B1 (es) |
CN (2) | CN101600358B (es) |
AR (1) | AR064683A1 (es) |
AU (1) | AU2008214544B2 (es) |
BR (1) | BRPI0805838A2 (es) |
CA (1) | CA2673583C (es) |
FR (1) | FR2910786B1 (es) |
IL (1) | IL199360A (es) |
TW (2) | TWI496542B (es) |
WO (1) | WO2008099077A2 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0416950B8 (pt) | 2003-12-01 | 2021-05-25 | Novo Nordisk Healthcare Ag | métodos para remover vírus de uma composição do fator vii líquida, para inativar vírus em uma composição do fator vii líquida, e para eliminar em alto nível a presença de vírus ativos em uma composição do fator vii líquida. |
FR2901707B1 (fr) | 2006-05-31 | 2017-09-29 | Lab Francais Du Fractionnement | Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis |
FR2910786B1 (fr) * | 2006-12-29 | 2017-08-11 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies (Lfb) | "procede d'extraction d'une proteine presente dans du lait" |
FR2942232B1 (fr) | 2009-02-19 | 2015-03-13 | Lfb Biotechnologies | Moyens pour la purification d'une proteine de la coagulation et procedes pour sa mise en oeuvre |
FR2942231B1 (fr) | 2009-02-19 | 2015-03-20 | Lfb Biotechnologies | Acides nucleiques se liant specifiquement au facteur vii/viia humain, et utilisations |
FR2942233B1 (fr) * | 2009-02-19 | 2015-03-13 | Lfb Biotechnologies | Moyens pour la purification d'une proteine du plasma sanguin, et procedes pour sa mise en oeuvre |
FR2947181B1 (fr) | 2009-06-26 | 2012-05-04 | Lfb Biotechnologies | Composition de facteur vii |
WO2011112075A1 (en) * | 2010-03-11 | 2011-09-15 | N.V. Nutricia | Controlling the texture of high-protein nutritional compositions comprising micellar casein |
US9364021B2 (en) * | 2011-09-09 | 2016-06-14 | Tairob Ltd. | Method for preparing micro-foam whipped milk for cappuccino or a method for whipping other liquids containing proteins, using an apparatus |
EP2687595B1 (en) * | 2012-07-19 | 2018-05-30 | Laboratoire Français du Fractionnement et des Biotechnologies | Method for purifying transgenic factor VII |
FR3006591B1 (fr) | 2013-06-11 | 2016-05-06 | Lab Francais Du Fractionnement | Composition de facteur vii presentant un point isoelectrique substantiellement homogene |
CN106793793A (zh) * | 2014-10-06 | 2017-05-31 | 预层析股份有限公司 | 来自含有聚集的酪蛋白的混合物的可溶性蛋白的分离 |
FR3034419B1 (fr) * | 2015-04-02 | 2017-12-15 | Lab Francais Du Fractionnement | Procede de purification d'une proteine recombinante therapeutique a partir d'un lait transgenique |
CN110177878B (zh) * | 2016-12-29 | 2023-11-03 | Asc治疗公司 | 转基因动物和生物生产方法 |
FR3076294B1 (fr) | 2017-12-29 | 2022-01-28 | Lab Francais Du Fractionnement | Procede de purification d'anticorps a partir de lait brut |
GB201815053D0 (en) * | 2018-09-14 | 2018-10-31 | Dublin Institute Of Tech | Method |
US11326176B2 (en) * | 2019-11-22 | 2022-05-10 | Mozza Foods, Inc. | Recombinant micelle and method of in vivo assembly |
CN112159458A (zh) * | 2020-09-28 | 2021-01-01 | 靡特洛 | 一种从过期变质牛奶中提取牛奶蛋白的方法 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4229342A (en) * | 1977-05-18 | 1980-10-21 | Rhone-Poulenc Industries | Process for extracting proteins from milk using silica and anion exchange resins |
NL8204923A (nl) | 1982-12-21 | 1984-07-16 | Stichting Nl I Zuivelonderzoek | Werkwijze voor het bereiden van een precipitaat van caseine en wei-eiwit alsmede aldus bereid precipitaat. |
GR860984B (en) | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
DE122007000007I2 (de) | 1986-04-09 | 2010-12-30 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
US6984772B1 (en) | 1994-02-18 | 2006-01-10 | Virginia Tech Intellectual Properties, Inc. | Transgenic non-human mammals producing fibrinogen in their milk |
FR2677652B1 (fr) | 1991-06-12 | 2005-05-27 | Agronomique Inst Nat Rech | Procede de preparation d'une proteine d'interet dans le lait d'un animal transgenique, produit obtenu et cellule eucaryote utilisee. |
US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
GB9408717D0 (en) | 1994-05-03 | 1994-06-22 | Biotech & Biolog Scien Res | DNA sequences |
US6713662B1 (en) | 1994-07-27 | 2004-03-30 | Pharming Intellectual Property B.V. | Production of collagen in the milk of transgenic mammals |
US5880327A (en) | 1994-09-21 | 1999-03-09 | American National Red Cross | Transgenic mammals expressing human coagulation factor VIII |
US6268487B1 (en) * | 1996-05-13 | 2001-07-31 | Genzyme Transgenics Corporation | Purification of biologically active peptides from milk |
US6183803B1 (en) * | 1999-06-11 | 2001-02-06 | Biosante Pharmaceuticals, Inc. | Method for processing milk |
ATE420108T1 (de) * | 2001-07-20 | 2009-01-15 | Campina Bv | Verfahren zur herstellung von preparationen aus milchprodukten, welche wachstumsfaktoren (tgf- beta und igf-1), lactoperoxidase und immunglobuline mit niedriger gegenseitiger verunreinigung enthalten |
US20040117862A1 (en) * | 2002-03-11 | 2004-06-17 | Cooper Julian D. | Production of high levels of transgenic factor VII with engineered stability and its therapeutic uses |
US20040219255A1 (en) * | 2002-06-05 | 2004-11-04 | Rust Henry C | Injection molding head |
FR2841747B1 (fr) | 2002-07-02 | 2004-08-20 | Cie Laitiere Europeenne | Isolat de proteines de lait et procede pour sa preparation |
US6911323B2 (en) * | 2002-09-25 | 2005-06-28 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
JP4247880B2 (ja) * | 2002-12-24 | 2009-04-02 | Tdk株式会社 | 電子部品の製造方法 |
AU2003261387A1 (en) | 2003-02-24 | 2004-09-17 | Gtc Biotherapeutics, Inc. | Methods of tangential flow filtration and an apparatus therefore |
WO2005089040A2 (en) * | 2004-03-23 | 2005-09-29 | Chr. Hansen A/S | Method of producing chymosin c and uses thereof |
JP2008500972A (ja) * | 2004-05-14 | 2008-01-17 | キリンファーマ株式会社 | 免疫グロブリンの精製方法 |
KR20080006601A (ko) * | 2005-04-11 | 2008-01-16 | 메다렉스, 인코포레이티드 | 단백질 정제 방법 |
FR2910786B1 (fr) * | 2006-12-29 | 2017-08-11 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies (Lfb) | "procede d'extraction d'une proteine presente dans du lait" |
-
2006
- 2006-12-29 FR FR0611536A patent/FR2910786B1/fr not_active Expired - Fee Related
-
2007
- 2007-12-28 AR ARP070105952A patent/AR064683A1/es not_active Application Discontinuation
- 2007-12-31 TW TW096151238A patent/TWI496542B/zh not_active IP Right Cessation
- 2007-12-31 TW TW102125880A patent/TWI519239B/zh not_active IP Right Cessation
-
2008
- 2008-01-02 CN CN200880001548.0A patent/CN101600358B/zh not_active Expired - Fee Related
- 2008-01-02 CN CN201410119941.7A patent/CN103910778A/zh active Pending
- 2008-01-02 BR BRPI0805838-5A patent/BRPI0805838A2/pt not_active IP Right Cessation
- 2008-01-02 WO PCT/FR2008/000007 patent/WO2008099077A2/fr active Application Filing
- 2008-01-02 US US12/520,826 patent/US8492524B2/en not_active Expired - Fee Related
- 2008-01-02 EP EP08761732A patent/EP2134191A2/fr not_active Withdrawn
- 2008-01-02 KR KR1020097013591A patent/KR101294751B1/ko not_active IP Right Cessation
- 2008-01-02 CA CA2673583A patent/CA2673583C/en not_active Expired - Fee Related
- 2008-01-02 JP JP2009543512A patent/JP5196590B2/ja not_active Expired - Fee Related
- 2008-01-02 AU AU2008214544A patent/AU2008214544B2/en not_active Ceased
-
2009
- 2009-06-15 IL IL199360A patent/IL199360A/en not_active IP Right Cessation
-
2013
- 2013-06-05 US US13/910,517 patent/US20130295646A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN101600358A (zh) | 2009-12-09 |
EP2134191A2 (fr) | 2009-12-23 |
IL199360A (en) | 2013-05-30 |
CA2673583A1 (en) | 2008-08-21 |
JP2010514746A (ja) | 2010-05-06 |
TWI519239B (zh) | 2016-02-01 |
FR2910786A1 (fr) | 2008-07-04 |
AU2008214544A1 (en) | 2008-08-21 |
BRPI0805838A2 (pt) | 2011-08-30 |
JP5196590B2 (ja) | 2013-05-15 |
CA2673583C (en) | 2013-06-11 |
CN101600358B (zh) | 2014-05-07 |
TW200838437A (en) | 2008-10-01 |
US8492524B2 (en) | 2013-07-23 |
TWI496542B (zh) | 2015-08-21 |
WO2008099077A2 (fr) | 2008-08-21 |
WO2008099077A3 (fr) | 2009-05-07 |
US20090281283A1 (en) | 2009-11-12 |
KR101294751B1 (ko) | 2013-08-12 |
TW201350024A (zh) | 2013-12-16 |
FR2910786B1 (fr) | 2017-08-11 |
CN103910778A (zh) | 2014-07-09 |
KR20090113825A (ko) | 2009-11-02 |
IL199360A0 (en) | 2010-03-28 |
AU2008214544B2 (en) | 2013-06-20 |
US20130295646A1 (en) | 2013-11-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed, e.g., due to non-payment of fee |