AR061850A1 - Derivados de pirimidina, proceso de preparacion y composiciones farmaceuticas que los contienen - Google Patents

Derivados de pirimidina, proceso de preparacion y composiciones farmaceuticas que los contienen

Info

Publication number
AR061850A1
AR061850A1 ARP070103042A ARP070103042A AR061850A1 AR 061850 A1 AR061850 A1 AR 061850A1 AR P070103042 A ARP070103042 A AR P070103042A AR P070103042 A ARP070103042 A AR P070103042A AR 061850 A1 AR061850 A1 AR 061850A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
alkyl
optionally
saturated
heteroatoms
Prior art date
Application number
ARP070103042A
Other languages
English (en)
Spanish (es)
Inventor
Christopher Thomas Halsall
David Alan Rudge
Iain Simpson
Richard Andrew Ward
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR061850A1 publication Critical patent/AR061850A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
ARP070103042A 2006-07-06 2007-07-06 Derivados de pirimidina, proceso de preparacion y composiciones farmaceuticas que los contienen AR061850A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81887806P 2006-07-06 2006-07-06

Publications (1)

Publication Number Publication Date
AR061850A1 true AR061850A1 (es) 2008-09-24

Family

ID=38857945

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070103042A AR061850A1 (es) 2006-07-06 2007-07-06 Derivados de pirimidina, proceso de preparacion y composiciones farmaceuticas que los contienen

Country Status (19)

Country Link
US (1) US7709471B2 (US07846941-20101207-C00217.png)
EP (1) EP2046793A2 (US07846941-20101207-C00217.png)
JP (1) JP2009542613A (US07846941-20101207-C00217.png)
KR (1) KR20090038895A (US07846941-20101207-C00217.png)
CN (1) CN101511836A (US07846941-20101207-C00217.png)
AR (1) AR061850A1 (US07846941-20101207-C00217.png)
AU (1) AU2007270931A1 (US07846941-20101207-C00217.png)
BR (1) BRPI0714045A2 (US07846941-20101207-C00217.png)
CA (1) CA2656936A1 (US07846941-20101207-C00217.png)
CL (1) CL2007001973A1 (US07846941-20101207-C00217.png)
EC (1) ECSP099044A (US07846941-20101207-C00217.png)
IL (1) IL196207A0 (US07846941-20101207-C00217.png)
MX (1) MX2009000220A (US07846941-20101207-C00217.png)
NO (1) NO20090052L (US07846941-20101207-C00217.png)
RU (1) RU2009103810A (US07846941-20101207-C00217.png)
TW (1) TW200808325A (US07846941-20101207-C00217.png)
UY (1) UY30472A1 (US07846941-20101207-C00217.png)
WO (1) WO2008003958A2 (US07846941-20101207-C00217.png)
ZA (1) ZA200900073B (US07846941-20101207-C00217.png)

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KR101157848B1 (ko) * 2007-03-22 2012-07-11 다케다 야쿠힌 고교 가부시키가이샤 Ｐｌｋ１ 저해제로서 유용한 치환된 피리미도디아제핀
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
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WO2009042711A1 (en) * 2007-09-25 2009-04-02 Takeda Pharmaceutical Company Limited Polo-like kinase inhibitors
CA2700979C (en) 2007-09-28 2017-06-20 Cyclacel Limited Pyrimidine derivatives as protein kinase inhibitors
WO2009067547A1 (en) * 2007-11-19 2009-05-28 Takeda Pharmaceutical Company Limited Polo-like kinase inhibitors
NZ586720A (en) 2008-01-09 2012-11-30 Array Biopharma Inc Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor
EP2247578B1 (en) 2008-01-09 2013-05-22 Array Biopharma, Inc. Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
WO2009153197A1 (en) * 2008-06-18 2009-12-23 F. Hoffmann-La Roche Ag Halo-substituted pyrimidodiazepines as plkl inhibitors
EP2370445B1 (en) * 2008-12-03 2014-07-23 The Scripps Research Institute Stem cell cultures
EP3255047B1 (en) * 2009-01-06 2021-06-30 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and uses in treating disorders
ES2604667T3 (es) 2009-06-17 2017-03-08 Vertex Pharmaceuticals Incorporated Inhibidores de la replicación de virus de influenza
TWI399551B (zh) * 2009-06-26 2013-06-21 Senao Networks Inc Burner device and burner method
CN103492391A (zh) * 2009-09-25 2014-01-01 沃泰克斯药物股份有限公司 用于制备用作蛋白激酶抑制剂的嘧啶衍生物的方法
CA2773742C (en) 2009-09-25 2017-12-05 Vertex Pharmaceuticals Incorporated Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
US8466155B2 (en) 2009-10-02 2013-06-18 Boehringer Ingelheim International Gmbh Pyrimidines
US8673275B2 (en) 2010-03-02 2014-03-18 Basf Se Block copolymers and their use
US20110218295A1 (en) * 2010-03-02 2011-09-08 Basf Se Anionic associative rheology modifiers
CA2822057A1 (en) 2010-12-16 2012-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
SG194045A1 (en) 2011-04-01 2013-11-29 Genentech Inc Combinations of akt inhibitor compounds and abiraterone, and methods of use
KR20140022053A (ko) 2011-04-01 2014-02-21 제넨테크, 인크. Akt 및 mek 억제제 화합물의 조합물, 및 사용 방법
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
GB201205752D0 (en) * 2012-03-30 2012-05-16 Cyclacel Ltd Treatment
EP3068776B1 (en) 2013-11-13 2019-05-29 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
MX2016006200A (es) 2013-11-13 2016-08-08 Vertex Pharma Metodos para preparar inhibidores de la replicacion de virus de influenza.
GB201403536D0 (en) 2014-02-28 2014-04-16 Cancer Rec Tech Ltd Inhibitor compounds
EP3294717B1 (en) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Methods of preparing inhibitors of influenza viruses replication
EP3294735B8 (en) 2015-05-13 2022-01-05 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
WO2017007634A1 (en) 2015-07-06 2017-01-12 The Board Of Regents Of The University Of Texas System Benzamide or benzamine compounds useful as anticancer agents for the treatment of human cancers
WO2017177092A1 (en) * 2016-04-07 2017-10-12 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and methods of treating pi3k-mediated disorders
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WO2022145989A1 (ko) * 2020-12-31 2022-07-07 (주) 업테라 선택적 plk1 억제제로서의 피리미도디아제핀 유도체
MX2024001774A (es) 2021-08-10 2024-04-24 Uppthera Inc Compuesto inductor de la degradacion de plk1 novedoso.
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CN113999244B (zh) * 2021-12-30 2022-05-20 北京鑫开元医药科技有限公司 一种4H-吡喃并[2,3-c]吡啶-4-酮类化合物及其制备方法
CN114392258B (zh) * 2021-12-30 2024-04-16 北京朗瑞邦科技有限公司 一种4H-吡喃并[2,3-c]吡啶-4-酮类化合物药物制剂及其制备方法
TW202345806A (zh) 2022-03-31 2023-12-01 美商艾伯維有限公司 噻唑并〔５，４－ｂ〕吡啶ｍａｌｔ－１抑制劑

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US6806272B2 (en) 2001-09-04 2004-10-19 Boehringer Ingelheim Pharma Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
US6861422B2 (en) 2003-02-26 2005-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
EA008778B1 (ru) 2003-02-26 2007-08-31 Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг Дигидроптеридиноны, способ их получения и их применение в качестве лекарственных средств
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Also Published As

Publication number Publication date
EP2046793A2 (en) 2009-04-15
UY30472A1 (es) 2008-02-29
ECSP099044A (es) 2009-02-27
WO2008003958A3 (en) 2008-03-06
AU2007270931A1 (en) 2008-01-10
CN101511836A (zh) 2009-08-19
KR20090038895A (ko) 2009-04-21
MX2009000220A (es) 2009-01-22
BRPI0714045A2 (pt) 2012-12-11
JP2009542613A (ja) 2009-12-03
NO20090052L (no) 2009-01-28
TW200808325A (en) 2008-02-16
CL2007001973A1 (es) 2008-04-04
US20080009482A1 (en) 2008-01-10
CA2656936A1 (en) 2008-01-10
IL196207A0 (en) 2009-09-22
US7709471B2 (en) 2010-05-04
RU2009103810A (ru) 2010-08-20
WO2008003958A2 (en) 2008-01-10
ZA200900073B (en) 2010-06-30

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