AR084766A1 - Compuesto biciclico para modular los receptores acoplados a la proteina g - Google Patents
Compuesto biciclico para modular los receptores acoplados a la proteina gInfo
- Publication number
- AR084766A1 AR084766A1 ARP120100005A ARP120100005A AR084766A1 AR 084766 A1 AR084766 A1 AR 084766A1 AR P120100005 A ARP120100005 A AR P120100005A AR P120100005 A ARP120100005 A AR P120100005A AR 084766 A1 AR084766 A1 AR 084766A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- alkylamino
- cycloalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
La presente se refiere a un compuesto bicíclico para modular los receptores acoplados a la proteína G. El compuesto provee prevenir o tratar una enfermedad asociada con la modulación de los receptores acoplados a la proteína G, particularmente los receptores GPR119 acoplados a la proteína G.Reivindicación 1: Un compuesto seleccionado del grupo que consiste en un derivado heteroarilo bicíclico que tiene la fórmula (1), una de sus sales aceptables desde el punto de vista farmacéutico, uno de sus hidratos, y uno de sus solvatos, en donde, X es S o NR1, R1 es H o alquilo C1-4; E es arilo C6-14 o heteroarilo C2-13, en donde E está sustituido en forma opcional con uno a tres sustituyentes seleccionados del grupo que consiste en halógeno, -NO2, -CN, -CF3, alquilo C1-6, cicloalquilo C3-8, -NH2, alquilamino C1-6, dialquilamino C1-6, alcoxi C1-6, -S-alquilo C1-6, -S(O)2-alquilo C1-6, -S(O)2-alquilamino C1-6, -S(O)2-dialquilamino C1-6, -C(O)-alquilo C1-6, carboxilo, -C(O)2-alquilo C1-6, -C(O)-alquilamino C1-6, -C(O)-dialquilamino C1-6, arilo C6-14, heteroarilo C1-13 y heterocicloalquilo C2-13, en donde dichos sustituyentes arilo, heteroarilo y heterocicloalquilo están sustituidos en forma opcional, cada uno en forma independiente y adicional, con alquilo C1-6, halógeno, dialquilamino C1-6 o alcoxi C1-6; e Y es OR2 o NR2R3, en donde R2 y R3 son cada uno en forma independiente H, -OH, alquilo C1-6, cicloalquilo C3-8 o heterocicloalquilo C4-13, o R2 y R3 están fusionados con el átomo de nitrógeno para formar heterociclo C2-9, y en donde R2 y R3 están sustituidos en forma opcional con uno a tres sustituyentes seleccionados del grupo que consiste en alquilo C1-6, alcoxi C1-6, -C(O)-alquilo C1-6, -C(O)-arilo C6-14, -C(O)-heteroarilo C1-13, -C(O)2-alquilo C1-6, -C(O)2-arilo C6-14, -C(O)2-heteroarilo C1-13, -C(O)-alquilamino C1-6, -C(O)-dialquilamino C1-6, cicloalquilo C3-8, heterocicloalquilo C3-13, arilo C6-14 y heteroarilo C1-13, en donde dichos sustituyentes arilo, heteroarilo, cicloalquilo y heterocicloalquilo están sustituidos en forma opcional, cada uno en forma independiente y adicional, con alquilo C1-6, halógeno, dialquilamino C1-6, alcoxi C1-6, cicloalquilo C3-8 o arilo C6-14.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20110000250 | 2011-01-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR084766A1 true AR084766A1 (es) | 2013-06-26 |
Family
ID=46457813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120100005A AR084766A1 (es) | 2011-01-03 | 2012-01-03 | Compuesto biciclico para modular los receptores acoplados a la proteina g |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8853213B2 (es) |
| EP (1) | EP2661438A4 (es) |
| JP (1) | JP2014501274A (es) |
| KR (1) | KR20120079015A (es) |
| CN (1) | CN103328482A (es) |
| AR (1) | AR084766A1 (es) |
| TW (1) | TW201309702A (es) |
| WO (1) | WO2012093809A2 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2878625A1 (en) | 2012-07-11 | 2014-01-16 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| AU2013312477B2 (en) * | 2012-09-06 | 2018-05-31 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| WO2014074700A1 (en) * | 2012-11-08 | 2014-05-15 | Arena Pharmaceuticals, Inc. | Antagonists of gpr119 receptor and the treatment of disorders related thereto |
| AR097617A1 (es) | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
| TR201807881T4 (tr) | 2013-12-19 | 2018-06-21 | Idorsia Pharmaceuticals Ltd | Antibakteriyel 1h-ındazol ve 1h-ındol türevleri. |
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| KR20170005105A (ko) | 2014-05-16 | 2017-01-11 | 액테리온 파마슈티칼 리미티드 | 항균성 퀴나졸린-４(３ｈ)-온 유도체 |
| UA118722C2 (uk) | 2014-11-19 | 2019-02-25 | Ідорсія Фармасьютікалз Лтд | Антибактеріальні бензотіазольні похідні |
| AR105889A1 (es) | 2015-09-03 | 2017-11-22 | Actelion Pharmaceuticals Ltd | Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos |
| CN110099898B (zh) * | 2016-10-24 | 2023-07-25 | 优曼尼蒂治疗公司 | 化合物及其用途 |
| EP3700934A4 (en) | 2017-10-24 | 2021-10-27 | Yumanity Therapeutics, Inc. | COMPOUNDS AND USES OF THESE COMPOUNDS |
| WO2020002090A1 (de) | 2018-06-25 | 2020-01-02 | Bayer Aktiengesellschaft | Substituierte thiazolylpyrrolone sowie deren salze und ihre verwendung als herbizide wirkstoffe |
| WO2021115286A1 (zh) * | 2019-12-10 | 2021-06-17 | 成都倍特药业股份有限公司 | 一种可用作shp2抑制剂的含氮杂原子的六元并五元芳环衍生物 |
| CN112321466A (zh) * | 2020-11-23 | 2021-02-05 | 华东师范大学 | 一种苯唑草酮关键中间体的合成方法 |
| CN114524826A (zh) * | 2022-02-18 | 2022-05-24 | 郑州猫眼农业科技有限公司 | 7-溴-4-氯噻吩并[3,2-d]嘧啶的制备工艺 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69603240T2 (de) | 1995-05-12 | 2000-01-05 | Neurogen Corp | Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden |
| WO1997049706A1 (en) | 1996-06-25 | 1997-12-31 | Novartis Ag | SUBSTITUTED 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES AND THE USE THEREOF |
| CA2552598A1 (en) * | 2004-01-06 | 2005-07-21 | Taisho Pharmaceutical Co., Ltd. | Thienopyrimidine and thienopyridine derivatives substituted with cyclic amino group |
| MY148521A (en) | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
| ES2388967T3 (es) | 2007-05-04 | 2012-10-22 | Bristol-Myers Squibb Company | Agonistas [6,6]- y [6,7]-bicíclicos del receptor GPR119 acoplado a la proteína G |
| EP2152707B1 (en) * | 2007-05-04 | 2012-06-20 | Bristol-Myers Squibb Company | [6,5]-bicyclic gpr119 g protein-coupled receptor agonists |
| US20130096141A1 (en) * | 2010-06-18 | 2013-04-18 | Bernard R. Neustadt | Bicyclic heterocycle derivatives and methods of use thereof |
-
2011
- 2011-12-29 WO PCT/KR2011/010304 patent/WO2012093809A2/en active Application Filing
- 2011-12-29 US US13/997,415 patent/US8853213B2/en not_active Expired - Fee Related
- 2011-12-29 CN CN2011800640394A patent/CN103328482A/zh active Pending
- 2011-12-29 KR KR1020110146537A patent/KR20120079015A/ko not_active Application Discontinuation
- 2011-12-29 JP JP2013547355A patent/JP2014501274A/ja not_active Withdrawn
- 2011-12-29 EP EP11854581.3A patent/EP2661438A4/en not_active Withdrawn
-
2012
- 2012-01-02 TW TW101100038A patent/TW201309702A/zh unknown
- 2012-01-03 AR ARP120100005A patent/AR084766A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP2661438A2 (en) | 2013-11-13 |
| CN103328482A (zh) | 2013-09-25 |
| WO2012093809A3 (en) | 2012-11-08 |
| TW201309702A (zh) | 2013-03-01 |
| JP2014501274A (ja) | 2014-01-20 |
| US20130274268A1 (en) | 2013-10-17 |
| US8853213B2 (en) | 2014-10-07 |
| EP2661438A4 (en) | 2014-06-11 |
| KR20120079015A (ko) | 2012-07-11 |
| WO2012093809A2 (en) | 2012-07-12 |
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Legal Events
| Date | Code | Title | Description |
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| FA | Abandonment or withdrawal |