AR060686A1 - Purificacion de trombina - Google Patents

Purificacion de trombina

Info

Publication number
AR060686A1
AR060686A1 ARP060102209A ARP060102209A AR060686A1 AR 060686 A1 AR060686 A1 AR 060686A1 AR P060102209 A ARP060102209 A AR P060102209A AR P060102209 A ARP060102209 A AR P060102209A AR 060686 A1 AR060686 A1 AR 060686A1
Authority
AR
Argentina
Prior art keywords
thrombin
molecular weight
methods
preparation
purity
Prior art date
Application number
ARP060102209A
Other languages
English (en)
Spanish (es)
Original Assignee
King Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/140,374 external-priority patent/US20060270014A1/en
Application filed by King Pharmaceuticals Inc filed Critical King Pharmaceuticals Inc
Publication of AR060686A1 publication Critical patent/AR060686A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
ARP060102209A 2005-05-26 2006-05-26 Purificacion de trombina AR060686A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/140,374 US20060270014A1 (en) 2005-05-26 2005-05-26 Thrombin purification
US11/440,678 US20060270015A1 (en) 2005-05-26 2006-05-24 Thrombin purification

Publications (1)

Publication Number Publication Date
AR060686A1 true AR060686A1 (es) 2008-07-10

Family

ID=37452881

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102209A AR060686A1 (es) 2005-05-26 2006-05-26 Purificacion de trombina

Country Status (11)

Country Link
US (2) US20060270015A1 (enExample)
EP (1) EP1885387A4 (enExample)
JP (1) JP2008541731A (enExample)
KR (1) KR20080019583A (enExample)
AR (1) AR060686A1 (enExample)
BR (1) BRPI0610339A2 (enExample)
CA (1) CA2609520A1 (enExample)
IL (1) IL186790A0 (enExample)
MX (1) MX2007014571A (enExample)
NZ (1) NZ564058A (enExample)
WO (1) WO2006127990A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2687968C (en) * 2007-06-15 2016-09-27 Zymogenetics, Inc. Stabilized thrombin compositions
US8451208B2 (en) 2008-03-03 2013-05-28 Samsung Display Co., Ltd. Organic light emitting display device and method of driving the same
US20160264954A1 (en) * 2015-03-13 2016-09-15 Vitrum Biologies Inc. Method of stabilizing thrombin and composition thereof
IL261190A (en) * 2018-08-16 2019-01-31 Omrix Biopharmaceuticals Ltd Stable liquid preparations of thrombin
GB2579630A (en) * 2018-12-07 2020-07-01 Biotherapy Services Ltd Methods and compositions
WO2020210087A1 (en) * 2019-04-12 2020-10-15 Affirmed Pharma, Llc Rusalatide acetate compositions
KR102624098B1 (ko) 2021-05-13 2024-01-11 주식회사 덴하우스 순수도가 향상된 트롬빈 대량 정제 방법

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4363319A (en) * 1980-06-30 1982-12-14 Applied Medical Devices, Inc. Ready-to-use bandage incorporating a coagulant composition and method of preparing same
US4965203A (en) * 1987-01-28 1990-10-23 Warner-Lambert Company Purified thrombin preparations
US5200340A (en) * 1987-05-22 1993-04-06 Zymogenetics, Inc. Thrombin-activated tissue plasminogen activators
US5281528A (en) * 1989-12-18 1994-01-25 Warner-Lambert Company Process for purified thromboplastin for ultra-pure thrombin preparation
IE73210B1 (en) * 1990-01-24 1997-05-07 Warner Lambert Co Process for the production of thrombin and high purity thrombin preparation thereby obtained
JP3404038B2 (ja) * 1991-12-31 2003-05-06 ザイモジェネティクス，インコーポレイティド トロンビンの製造方法
US5527692A (en) * 1991-12-31 1996-06-18 Zymogenetics, Inc. Methods for producing thrombin
WO1998057678A2 (en) * 1997-06-18 1998-12-23 Cohesion Technologies, Inc. Compositions containing thrombin and microfibrillar collagen
US6096872A (en) * 1997-10-14 2000-08-01 Ortho Diagnostic Systems, Inc. Viral clearance process
US5981254A (en) * 1997-10-30 1999-11-09 Haemacure Corporation Process for producing thrombin from plasma
US6780411B2 (en) * 1998-05-01 2004-08-24 Zymogenetics, Inc. Tissue sealant compositions
DE10012732A1 (de) * 2000-03-18 2001-09-20 Aventis Behring Gmbh Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
DE10220711B4 (de) * 2002-05-10 2016-10-13 Gkn Driveline International Gmbh Gegenbahngelenk mit gleicher Orientierung von gegenüberliegenden Bahnpaaren
GB0216002D0 (en) * 2002-07-10 2002-08-21 Nat Blood Authority Process and composition

Also Published As

Publication number Publication date
WO2006127990A3 (en) 2007-12-13
MX2007014571A (es) 2008-02-07
US20060270015A1 (en) 2006-11-30
EP1885387A4 (en) 2009-05-06
NZ564058A (en) 2010-07-30
EP1885387A2 (en) 2008-02-13
IL186790A0 (en) 2008-02-09
US20080280343A1 (en) 2008-11-13
JP2008541731A (ja) 2008-11-27
KR20080019583A (ko) 2008-03-04
WO2006127990A2 (en) 2006-11-30
CA2609520A1 (en) 2006-11-30
BRPI0610339A2 (pt) 2010-06-22

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