AR057867A1 - Inhibidores de pde y combinaciones de los mismos para el tratamiento de trastornos urologicos - Google Patents
Inhibidores de pde y combinaciones de los mismos para el tratamiento de trastornos urologicosInfo
- Publication number
- AR057867A1 AR057867A1 ARP060104226A ARP060104226A AR057867A1 AR 057867 A1 AR057867 A1 AR 057867A1 AR P060104226 A ARP060104226 A AR P060104226A AR P060104226 A ARP060104226 A AR P060104226A AR 057867 A1 AR057867 A1 AR 057867A1
- Authority
- AR
- Argentina
- Prior art keywords
- pde
- treatment
- polypeptide
- test compound
- bladder
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Gynecology & Obstetrics (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
Abstract
Composiciones farmacologicas que comprenden inhibidores de PDE-5 y PDE-4, solos o en combinacion, para el tratamiento de trastornos urologicos que comprenden hiperplasia prostática benigna (HPB), síntomas del tracto urinario inferior (STUI) y en particular síntomas irritativos provocados por obstruccion de la salida de la vejiga (OSV) inducida por HPB. Procedimientos de deteccion selectiva para tales inhibidores de PDE-5 y PDE-4 para uso, solos y en combinacion, en la preparacion de medicamentos para el tratamiento de dichos trastornos urologicos. Reivindicacion 1: Un procedimiento de deteccion selectiva para inhibidores de PDE-5 utiles como agentes terapéuticos en el tratamiento de una enfermedad comprendida en un grupo de enfermedades constituido por hiperplasia prostática benigna (HPB), obstruccion de la salida de la vejiga (OSV) y síntomas del tracto urinario inferior (STUI), que comprende las etapas de i) poner en contacto un compuesto de ensayo con un polipéptido de PDE-5, ii) determinar la actividad del polipéptido de PDE-5 a una cierta concentracion del compuesto de ensayo o en ausencia de dicho compuesto de ensayo, iii) determinar la actividad de dicho polipéptido de PDE-5 a una concentracion diferente de dicho compuesto de ensayo, iv) seleccionar al menos un compuesto con efecto inhibitorio sobre el polipéptido de PDE-5. Reivindicacion 15: Una composicion farmacéutica que contiene al menos un compuesto seleccionado del grupo vardenafilo, sildenafilo, tadalafilo, udenafilo, dasantafilo, avanafilo, SLx2101 y LAS34179 o una sal, un hidrato o un hidrato de una sal de los mismos, para el tratamiento de vejiga neurogénica, vejiga hiperactiva y cistitis intersticial.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05021261 | 2005-09-29 | ||
EP06007776 | 2006-04-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR057867A1 true AR057867A1 (es) | 2007-12-26 |
Family
ID=37831473
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060104226A AR057867A1 (es) | 2005-09-29 | 2006-09-27 | Inhibidores de pde y combinaciones de los mismos para el tratamiento de trastornos urologicos |
Country Status (23)
Country | Link |
---|---|
US (1) | US20090186896A1 (es) |
EP (1) | EP1931797A2 (es) |
JP (1) | JP2009509984A (es) |
KR (1) | KR20080056250A (es) |
AR (1) | AR057867A1 (es) |
AU (1) | AU2006299232A1 (es) |
BR (1) | BRPI0616633A2 (es) |
CA (1) | CA2623657A1 (es) |
CR (1) | CR9840A (es) |
DO (1) | DOP2006000207A (es) |
EC (1) | ECSP088311A (es) |
GT (1) | GT200600442A (es) |
IL (1) | IL190201A0 (es) |
MA (1) | MA29880B1 (es) |
NO (1) | NO20081973L (es) |
PE (1) | PE20070587A1 (es) |
RU (1) | RU2435588C2 (es) |
SG (1) | SG166106A1 (es) |
SV (1) | SV2009002851A (es) |
TN (1) | TNSN08147A1 (es) |
TW (1) | TW200804603A (es) |
UY (1) | UY29816A1 (es) |
WO (1) | WO2007039075A2 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007113243A2 (en) * | 2006-03-31 | 2007-10-11 | Investigación Y Clínica Andrológicas S.L. | Use of pde 5 inhibitors for the treatment of overactive bladder |
EP2144605A1 (en) * | 2007-05-12 | 2010-01-20 | Bayer HealthCare AG | sGC STIMULATORS, sGC ACTIVATORS AND COMBINATIONS FOR THE TREATMENT OF UROLOGICAL DISORDERS |
US20110171195A1 (en) * | 2007-06-15 | 2011-07-14 | Duke University | Methods and compositions for treating urinary tract infections using agents that mimic or elevate cyclic amp |
JP2010540621A (ja) * | 2007-10-02 | 2010-12-24 | ドン ア ファーマシューティカル カンパニー リミテッド | 良性前立腺肥大症および下部尿路症状の治療または予防用組成物、およびその治療または予防方法 |
EP2222639A1 (en) * | 2007-11-21 | 2010-09-01 | Decode Genetics EHF | Biaryl pde4 inhibitors for treating pulmonary and cardiovascular disorders |
EP2156847A1 (en) * | 2008-08-19 | 2010-02-24 | Sanofi-Aventis | New combination of active ingredients containing an alpha1-antagonist and a PDE 4 inhibitor. |
EP2266568A1 (en) | 2009-05-26 | 2010-12-29 | Æterna Zentaris GmbH | Use of LHRH antagonists in combination with PDE V inhibitors for the treatment of sex hormone dependent disorders |
EP2266567A1 (en) | 2009-05-26 | 2010-12-29 | Æterna Zentaris GmbH | Use of cetrorelix in combination with PDE V inhibitors for the treatment of sex hormone dependent disorders |
JP2011184433A (ja) * | 2010-02-09 | 2011-09-22 | Daiichi Sankyo Healthcare Co Ltd | バルデナフィル含有内服液剤組成物 |
TWI617553B (zh) | 2013-03-13 | 2018-03-11 | 美國禮來大藥廠 | 吖丁啶基氧苯基吡咯啶化合物 |
KR102239291B1 (ko) * | 2013-06-28 | 2021-04-14 | 한미약품 주식회사 | 타다라필 또는 이의 약학적으로 허용가능한 염을 포함하는 저작정 제제 |
WO2015089105A1 (en) | 2013-12-09 | 2015-06-18 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
CA2933250A1 (en) * | 2013-12-11 | 2015-06-18 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
KR20240122604A (ko) | 2014-08-12 | 2024-08-12 | 주식회사 메지온 | 유데나필 조성물을 이용하여 폰탄 환자에서 심근 성능을 개선시키는 방법 |
WO2016033776A1 (en) | 2014-09-04 | 2016-03-10 | Eli Lilly And Company | Crystalline (2s) -3- [ (3s, 4s) -3- [ (1r) -1-hydroxyethyl] -4- (4-methoxy-3- { [1- (5-methylpyridin-2-yl) azetidin-3-yl] oxy} phenyl) -3-methylpyrrolidin-1-yl] -3-oxopropane-1, 2-diol |
AR101696A1 (es) | 2014-09-12 | 2017-01-04 | Lilly Co Eli | Compuestos de azetidiniloxifenilpirrolidina |
PL3562485T3 (pl) * | 2018-03-23 | 2020-11-16 | Laboratoires Major | Niehormonalne kompozycje i sposoby antykoncepcji u mężczyzn z wykorzystaniem (r)-silodozyny |
EP3914701A4 (en) * | 2019-01-23 | 2022-10-19 | Path Therapeutics Inc. | METHODS OF TREATMENT OF EPILEPSY VIA PHOSPHODIESTERASE 4-(PDE4) INHIBITION |
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CU23063A3 (es) * | 1997-11-12 | 2005-07-19 | Bayer Ag | Imidazotriazinonas 2-fenil sustituidas como inhibidores de fosfodiesterasas |
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UA67802C2 (uk) * | 1998-10-23 | 2004-07-15 | Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. | Фармацевтична композиція з контрольованим вивільненням інгібітора цгмф фде-5 (варіанти), спосіб її одержання та спосіб лікування еректильної дисфункції |
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EP2144605A1 (en) * | 2007-05-12 | 2010-01-20 | Bayer HealthCare AG | sGC STIMULATORS, sGC ACTIVATORS AND COMBINATIONS FOR THE TREATMENT OF UROLOGICAL DISORDERS |
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2006
- 2006-09-16 JP JP2008532632A patent/JP2009509984A/ja active Pending
- 2006-09-16 AU AU2006299232A patent/AU2006299232A1/en not_active Abandoned
- 2006-09-16 EP EP06777192A patent/EP1931797A2/en not_active Ceased
- 2006-09-16 US US11/992,779 patent/US20090186896A1/en not_active Abandoned
- 2006-09-16 KR KR1020087010192A patent/KR20080056250A/ko not_active Application Discontinuation
- 2006-09-16 WO PCT/EP2006/009040 patent/WO2007039075A2/en active Application Filing
- 2006-09-16 BR BRPI0616633-4A patent/BRPI0616633A2/pt not_active Application Discontinuation
- 2006-09-16 RU RU2008116547/15A patent/RU2435588C2/ru not_active IP Right Cessation
- 2006-09-16 SG SG201007122-3A patent/SG166106A1/en unknown
- 2006-09-16 CA CA002623657A patent/CA2623657A1/en not_active Abandoned
- 2006-09-27 AR ARP060104226A patent/AR057867A1/es not_active Application Discontinuation
- 2006-09-28 DO DO2006000207A patent/DOP2006000207A/es unknown
- 2006-09-28 TW TW095135881A patent/TW200804603A/zh unknown
- 2006-09-28 UY UY29816A patent/UY29816A1/es not_active Application Discontinuation
- 2006-09-28 PE PE2006001188A patent/PE20070587A1/es not_active Application Discontinuation
- 2006-09-29 GT GT200600442A patent/GT200600442A/es unknown
-
2008
- 2008-03-17 IL IL190201A patent/IL190201A0/en unknown
- 2008-03-26 EC EC2008008311A patent/ECSP088311A/es unknown
- 2008-03-26 SV SV2008002851A patent/SV2009002851A/es not_active Application Discontinuation
- 2008-03-27 CR CR9840A patent/CR9840A/es not_active Application Discontinuation
- 2008-03-28 TN TNP2008000147A patent/TNSN08147A1/en unknown
- 2008-04-23 MA MA30864A patent/MA29880B1/fr unknown
- 2008-04-24 NO NO20081973A patent/NO20081973L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MA29880B1 (fr) | 2008-10-03 |
US20090186896A1 (en) | 2009-07-23 |
CR9840A (es) | 2008-10-31 |
JP2009509984A (ja) | 2009-03-12 |
WO2007039075A3 (en) | 2007-06-21 |
NO20081973L (no) | 2008-06-20 |
IL190201A0 (en) | 2008-11-03 |
BRPI0616633A2 (pt) | 2011-06-28 |
DOP2006000207A (es) | 2007-07-15 |
TNSN08147A1 (en) | 2009-07-14 |
GT200600442A (es) | 2007-05-15 |
SV2009002851A (es) | 2009-01-14 |
SG166106A1 (en) | 2010-11-29 |
WO2007039075A2 (en) | 2007-04-12 |
PE20070587A1 (es) | 2007-08-17 |
ECSP088311A (es) | 2008-06-30 |
TW200804603A (en) | 2008-01-16 |
EP1931797A2 (en) | 2008-06-18 |
RU2008116547A (ru) | 2009-11-10 |
AU2006299232A1 (en) | 2007-04-12 |
RU2435588C2 (ru) | 2011-12-10 |
KR20080056250A (ko) | 2008-06-20 |
UY29816A1 (es) | 2007-04-30 |
CA2623657A1 (en) | 2007-04-12 |
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