AR051300A1 - Derivados de indol como inhibidores de la adenilato ciclasa soluble - Google Patents

Derivados de indol como inhibidores de la adenilato ciclasa soluble

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Publication number
AR051300A1
AR051300A1 ARP050104008A ARP050104008A AR051300A1 AR 051300 A1 AR051300 A1 AR 051300A1 AR P050104008 A ARP050104008 A AR P050104008A AR P050104008 A ARP050104008 A AR P050104008A AR 051300 A1 AR051300 A1 AR 051300A1
Authority
AR
Argentina
Prior art keywords
alkyl
acyl
optionally
aryl
polysubstituted
Prior art date
Application number
ARP050104008A
Other languages
English (en)
Inventor
Ulf Boemer
Martin Fritsch
Gernot Langer
Anne Mengel
Duy Nguyen
Seock-Kyu Khim
Knut Eis
Bernd Menzenbach
Bernd Buchmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102004047272A external-priority patent/DE102004047272A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of AR051300A1 publication Critical patent/AR051300A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente se refiere a derivados de indol como inhibidores de la adenilato ciclasa soluble, su preparacion y su uso como medicamento. Reivindicacion 1: Compuestos caracterizados porque responden a la formula general (1) en la cual R1 es H, halogeno, CF3, cicloalquilo C3-6 que es opcionalmente polisaturado y opcionalmente polisustituido o es el grupo alquilo C1-6, arilo C1-6, acilo C1-6, halo-alquilo C1-6, alquilo C1-6-alquilo C1-6, alquilo C1-6-acilo C1-6, acilo C1-6-acilo C1-6, alquilo C1-6-arilo C1-6, arilo C1-6-alquilo C1-6 o CF3, en el cual alquilo C1-6, arilo C1-6, acilo C1-6, halo-alquilo C1-6, alquilo C1-6-alquilo C1-6, alquilo C1-6-acilo C1-6, acilo C1-6-acilo C1-6, alquilo C1-6-arilo C1-6 o arilo C1-6-alquilo C1-6 opcionalmente puede estar interrumpido una o varia veces, en forma igual o diferente por O, S o N o es el grupo sulfonil-alquilo C1-6, sulfonamida o ciano; R2 es halogeno, CF3, cicloalquilo C3-6 que es opcionalmente polisaturado y opcionalmente polisustituido o es el grupo alquilo C1-6, arilo C1-6, acilo C1-6, halo-alquilo C1-6, alquilo C1-6-alquilo C1-6, alquilo C1-6-acilo C1-6, acilo C1-6-acilo C1-6, alquilo C1-6-arilo C1-6, arilo C1-6-alquilo C1-6 o CF3, en el cual alquilo C1-6, arilo C1-6, acilo C1-6, halo-alquilo C1-6, alquilo C1-6-alquilo C1-6, alquilo C1-6-acilo C1-6, acilo C1-6-acilo C1-6, alquilo C1-6-arilo C1-6 o arilo C1-6-alquilo C1-6 opcionalmente puede estar interrumpido una o varia veces, en forma igual o diferente por O, S o N o es el grupo sulfonil-alquilo C1-6, sulfonamida o ciano; R3 es arilo C6-12, que opcionalmente puede estar mono o polisustituido en forma igual o diferente con halogeno, con alquilo C1-6 o acilo C1-6, que opcionalmente puede estar mono o polisustituido o que puede estar sustituido con alcoxi C1-6, hidroxi, ciano, CO2-(alquilo C1-6), N-(alquilo C1-6)2, CO-NR4R5 o con CF3, es heteroarilo C5-12, que opcionalmente puede estar mono o polisustituido en forma igual o diferente con halogeno, con alquilo C1-6, acilo C1-6, alcoxi C1-6, hidroxi, ciano, CO2-(alquilo C1-6), N-(alquilo C1-6)2, CO-NR4R5 o con CF3 o es cicloalquilo C3-6 que opcionalmente puede estar mono o polisustituido en forma igual o diferente con halogeno, CF3, hidroxi, ciano, CO2-(alquilo C1-6), alquilo C1-6, acilo C1-6, N-(alquilo C1-6)2, CO-NR4R5 o alcoxi C1-6; R4 es H, cicloalquilo C3-6 que opcionalmente puede estar mono o polisustituido en forma igual o diferente con alquilo C1-6, acilo C1-6, alcoxi C1-6 o CF3, es arilo C6-12, que opcionalmente puede estar mono o polisustituido en forma igual o diferente con halogeno, con alquilo C1-6, acilo C1-6, alcoxi C1-6, N-alquilo C1-6-alquilo C1-6, CF3 o ciano o es heteroarilo C5-12, que opcionalmente puede estar mono o polisustituido en forma igual o diferente con halogeno, con alquilo C1-6, acilo C1-6, alcoxi C1-6, N-alquilo C1-6-alquilo C1-6, CF3 o ciano o es alquilo C1-6 que puede estar sustituido de cualquier manera; R5 es H, cicloalquilo C3- 6 que opcionalmente puede estar mono o polisustituido en forma igual o diferente con alquilo C1-6, acilo C1-6, alcoxi C1-6 o CF3, es arilo C6-12, que opcionalmente puede estar mono o polisustituido en forma igual o diferente con halogeno, con alquilo C1-6, acilo C1-6, alcoxi C1-6, N-alquilo C1-6-alquilo C1-6, CF3 o ciano o es heteroarilo C5-12, que opcionalmente puede estar mono o polisustituido en forma igual o diferente con halogeno, con alquilo C1-6, acilo C1-6, alcoxi C1-6, N-alquilo C1-6-alquilo C1-6, CF3 o ciano o es alquilo C1-6 que puede estar sustituido de cualquier manera; R4 y R5 forman juntos un anillo de 5-8 miembros, que puede contener otros heteroátomos y X es el grupo sulfonilo, (CH2)n o carbonilo; Y es carbonilo o (CH2)n; Z es N, y n es 0-4.
ARP050104008A 2004-09-24 2005-09-26 Derivados de indol como inhibidores de la adenilato ciclasa soluble AR051300A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004047272A DE102004047272A1 (de) 2004-09-24 2004-09-24 Inhibitoren der löslichen Adenylatzyklase

Publications (1)

Publication Number Publication Date
AR051300A1 true AR051300A1 (es) 2007-01-03

Family

ID=37600950

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050104008A AR051300A1 (es) 2004-09-24 2005-09-26 Derivados de indol como inhibidores de la adenilato ciclasa soluble

Country Status (24)

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US (1) US20080004268A1 (es)
EP (1) EP1802572B1 (es)
JP (1) JP2008514572A (es)
KR (1) KR20070054685A (es)
CN (1) CN101084189A (es)
AR (1) AR051300A1 (es)
AT (1) ATE429419T1 (es)
AU (1) AU2005287481A1 (es)
BR (1) BRPI0516057A (es)
CA (1) CA2581492A1 (es)
CR (1) CR9058A (es)
DE (1) DE502005007158D1 (es)
EA (1) EA200700555A1 (es)
GT (1) GT200500268A (es)
IL (1) IL181739A0 (es)
MX (1) MX2007003287A (es)
MY (1) MY142839A (es)
NO (1) NO20072078L (es)
PA (1) PA8646301A1 (es)
PE (1) PE20060696A1 (es)
SV (1) SV2006002238A (es)
TW (1) TW200615260A (es)
UY (1) UY29141A1 (es)
ZA (1) ZA200703307B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070225284A1 (en) * 2006-03-23 2007-09-27 Bernd Buchmann Inhibitors of soluble adenylate cyclase
CN102262159B (zh) 2010-05-27 2014-03-26 李建远 用于检测生育相关人睾丸和附睾表达305种精子定位蛋白的方法
WO2017190050A1 (en) * 2016-04-28 2017-11-02 Cornell University Inhibitors of soluble adenylyl cyclase
EP3676255A1 (en) 2017-08-29 2020-07-08 Rutgers, The State University University Of New Jersey Therapeutic indazoles
WO2019046465A2 (en) * 2017-08-29 2019-03-07 Rutgers, The State University Of New Jersey THERAPEUTIC INDOLES
CN108096244B (zh) * 2018-01-25 2020-11-24 昆明医科大学 1-氢-2-吲哚酮-3-苄基/取代苄基-3-甲酸酯类化合物的用途
EP3851853A1 (en) * 2020-01-17 2021-07-21 Biotechnologicky Ustav AV CR, v.v.i. Method for separation of sperm with undamaged intact heads from sperm with damaged heads and somatic cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000002851A1 (en) * 1998-07-08 2000-01-20 Aventis Pharma Deutschland Gmbh Sulfur substituted sulfonylaminocarboxylic acid n-arylamides, their preparation, their use and pharmaceutical preparations comprising them
US7442805B2 (en) * 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7417066B2 (en) * 2005-06-08 2008-08-26 Schering Ag Inhibitors of soluble adenylate cyclase
US20070225284A1 (en) * 2006-03-23 2007-09-27 Bernd Buchmann Inhibitors of soluble adenylate cyclase

Also Published As

Publication number Publication date
PA8646301A1 (es) 2006-09-08
ATE429419T1 (de) 2009-05-15
SV2006002238A (es) 2006-06-26
EP1802572A1 (de) 2007-07-04
MY142839A (en) 2011-01-14
UY29141A1 (es) 2006-04-28
IL181739A0 (en) 2007-07-04
CN101084189A (zh) 2007-12-05
MX2007003287A (es) 2007-10-11
KR20070054685A (ko) 2007-05-29
GT200500268A (es) 2006-10-10
BRPI0516057A (pt) 2008-08-19
EP1802572B1 (de) 2009-04-22
AU2005287481A1 (en) 2006-03-30
TW200615260A (en) 2006-05-16
EA200700555A1 (ru) 2007-10-26
DE502005007158D1 (de) 2009-06-04
US20080004268A1 (en) 2008-01-03
PE20060696A1 (es) 2006-08-01
CR9058A (es) 2007-10-04
JP2008514572A (ja) 2008-05-08
NO20072078L (no) 2007-05-31
CA2581492A1 (en) 2006-03-30
ZA200703307B (en) 2009-05-27

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