CO5570676A2 - Nuevos compuestos de alquilo con efecto antagonico de la hcm y medicamentos que contienen estos compuestos - Google Patents
Nuevos compuestos de alquilo con efecto antagonico de la hcm y medicamentos que contienen estos compuestosInfo
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- CO5570676A2 CO5570676A2 CO05052294A CO05052294A CO5570676A2 CO 5570676 A2 CO5570676 A2 CO 5570676A2 CO 05052294 A CO05052294 A CO 05052294A CO 05052294 A CO05052294 A CO 05052294A CO 5570676 A2 CO5570676 A2 CO 5570676A2
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- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract
1.- Compuestos de alquino de fórmula generalen la cual R1, R2 son, en forma independiente entre sí, H, un grupo alquilo C1-8 o cicloalquilo C3-7 opcionalmente sustituido con el radical R11, donde un grupo -CH2- puede estar reemplazado en la posición 3 ó 4 de un grupo cicloalquilo de 5, 6 ó 7 miembros por -O-, -S- o -NR13-, o un radical fenilo o piridinilo opcionalmente mono o polisustituido con el radical R12 y/o monosustituido con nitro, o R1 y R2 forman un puente alquileno C2-8, en el que - uno o dos grupos -CH2- pueden estar reemplazados, en forma independiente entre sí, por -CH=N- o -CH=CH- y/o - uno o dos grupos -CH2-, en forma independiente entre sí, pueden estar reemplazados por -O-, -S-, -SO, -(SO2)-, -C=N-R18, -C=N-O-R18, -CO-, -C(=CH2)- o -NR13- de modo tal que los heteroátomos no estén unidos entre sí en forma directa, donde en el puente alquileno definido con anterioridad pueden estar reemplazados uno o varios átomos de H por R14, y donde el puente alquileno definido con anterioridad puede estar sustituido con uno o dos grupos Cy carbo- o heterocíclicos iguales o diferentes de modo tal que la unión entre el puente alquileno y el grupo Cy se realiza - a través de un enlace simple o doble, - a través de un átomo de C común, formando un sistema de anillos espirocíclicos, - a través de dos átomos de C y/o N comunes adyacentes, formando un sistema de anillos bicíclicos condensados o - a través de tres o más átomos de C y/o N, formando un sistema de anillos en puente, X es un enlace simple o un puente alquileno C1-6, en el que - un grupo -CH2- puede estar reemplazado por -CH=CH- o -C=C- y/o - uno o dos grupos -CH2-, en forma independiente entre sí, pueden estar reemplazados por -O-, -S-, -(SO)-, -(SO2)-, -CO- o -NR4- de modo tal que cada uno de dos átomos de O, S o N o un átomo de O con un átomo de S no estén unidos entre sí de forma directa, donde el puente X puede estar unido con R1 incluyendo el átomo de N unido con R1 y X, formando un grupo heterocíclico, donde el puente X también puede estar unido adicionalmente con R2, incluyendo el átomo de N unido con R2 y X, formando un grupo heterocíclico, ...
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US7351719B2 (en) | 2002-10-31 | 2008-04-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds |
US7592373B2 (en) | 2003-12-23 | 2009-09-22 | Boehringer Ingelheim International Gmbh | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds |
EP1809614B1 (en) | 2004-04-08 | 2014-05-07 | TargeGen, Inc. | Benzotriazine inhibitors of kinases |
DE102004017932A1 (de) * | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
DE102004017934A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
DE102004017933A1 (de) * | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
DE102004017935A1 (de) * | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
US7524862B2 (en) | 2004-04-14 | 2009-04-28 | Boehringer Ingelheim International Gmbh | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds |
DE102004017930A1 (de) * | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
GB0413605D0 (en) * | 2004-06-17 | 2004-07-21 | Addex Pharmaceuticals Sa | Novel compounds |
MX2007002208A (es) | 2004-08-25 | 2007-05-08 | Targegen Inc | Compuestos hetrociclicos y metodos de uso. |
CN101084212A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶介导剂的用途 |
AR051092A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa |
BRPI0515483A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos para o tratamento de doenças mediadas por enzimas estearoil-coa desaturase |
AR051090A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
US7829712B2 (en) | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
CN101083993A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途 |
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-
2002
- 2002-10-31 DE DE10250708A patent/DE10250708A1/de not_active Ceased
-
2003
- 2003-10-25 AU AU2003300507A patent/AU2003300507B2/en not_active Ceased
- 2003-10-25 EP EP10179237A patent/EP2357173A1/de not_active Withdrawn
- 2003-10-25 ES ES03809734T patent/ES2413387T3/es not_active Expired - Lifetime
- 2003-10-25 DK DK03809734.1T patent/DK1558578T3/da active
- 2003-10-25 CA CA2504160A patent/CA2504160C/en not_active Expired - Fee Related
- 2003-10-25 EP EP03809734A patent/EP1558578B1/de not_active Expired - Lifetime
- 2003-10-25 UA UAA200505138A patent/UA80162C2/uk unknown
- 2003-10-25 MX MXPA05003629A patent/MXPA05003629A/es active IP Right Grant
- 2003-10-25 KR KR1020057007667A patent/KR20050084911A/ko not_active Application Discontinuation
- 2003-10-25 PL PL03376415A patent/PL376415A1/xx not_active Application Discontinuation
- 2003-10-25 BR BR0314839-4A patent/BR0314839A/pt not_active Expired - Fee Related
- 2003-10-25 CN CN2003801026352A patent/CN1732154B/zh not_active Expired - Fee Related
- 2003-10-25 EA EA200500595A patent/EA013013B1/ru not_active IP Right Cessation
- 2003-10-25 RS YUP-2005/0331A patent/RS20050331A/sr unknown
- 2003-10-25 WO PCT/EP2003/011887 patent/WO2004039780A1/de active Application Filing
- 2003-10-25 JP JP2004547566A patent/JP4883909B2/ja not_active Expired - Fee Related
- 2003-10-29 UY UY28050A patent/UY28050A1/es not_active Application Discontinuation
- 2003-10-29 PE PE2003001091A patent/PE20040608A1/es not_active Application Discontinuation
- 2003-10-30 TW TW092130308A patent/TWI316059B/zh not_active IP Right Cessation
- 2003-10-31 AR ARP030103994A patent/AR041734A1/es not_active Suspension/Interruption
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2005
- 2005-02-09 ZA ZA200501163A patent/ZA200501163B/en unknown
- 2005-02-11 NO NO20050749A patent/NO20050749L/no not_active Application Discontinuation
- 2005-04-27 EC EC2005005764A patent/ECSP055764A/es unknown
- 2005-04-29 HR HR20050384A patent/HRP20050384A2/hr not_active Application Discontinuation
- 2005-05-27 CO CO05052294A patent/CO5570676A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PL376415A1 (en) | 2005-12-27 |
BR0314839A (pt) | 2005-08-30 |
KR20050084911A (ko) | 2005-08-29 |
EP2357173A1 (de) | 2011-08-17 |
HRP20050384A2 (en) | 2006-06-30 |
JP2006511492A (ja) | 2006-04-06 |
UY28050A1 (es) | 2004-05-31 |
EP1558578A1 (de) | 2005-08-03 |
WO2004039780A1 (de) | 2004-05-13 |
CA2504160C (en) | 2011-12-06 |
TW200413346A (en) | 2004-08-01 |
AU2003300507A1 (en) | 2004-05-25 |
EA200500595A1 (ru) | 2005-12-29 |
MXPA05003629A (es) | 2005-09-30 |
JP4883909B2 (ja) | 2012-02-22 |
ZA200501163B (en) | 2006-11-29 |
DE10250708A1 (de) | 2004-05-19 |
CN1732154A (zh) | 2006-02-08 |
NO20050749L (no) | 2005-05-23 |
AR041734A1 (es) | 2005-05-26 |
CA2504160A1 (en) | 2004-05-13 |
RS20050331A (en) | 2007-11-15 |
ES2413387T3 (es) | 2013-07-16 |
WO2004039780A8 (de) | 2004-07-15 |
ECSP055764A (es) | 2005-07-06 |
UA80162C2 (en) | 2007-08-27 |
CN1732154B (zh) | 2010-09-08 |
DK1558578T3 (da) | 2013-06-17 |
EP1558578B1 (de) | 2013-03-13 |
EA013013B1 (ru) | 2010-02-26 |
AU2003300507B2 (en) | 2010-12-23 |
PE20040608A1 (es) | 2004-10-27 |
TWI316059B (en) | 2009-10-21 |
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