CO5570676A2 - Nuevos compuestos de alquilo con efecto antagonico de la hcm y medicamentos que contienen estos compuestos - Google Patents

Nuevos compuestos de alquilo con efecto antagonico de la hcm y medicamentos que contienen estos compuestos

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Publication number
CO5570676A2
CO5570676A2 CO05052294A CO05052294A CO5570676A2 CO 5570676 A2 CO5570676 A2 CO 5570676A2 CO 05052294 A CO05052294 A CO 05052294A CO 05052294 A CO05052294 A CO 05052294A CO 5570676 A2 CO5570676 A2 CO 5570676A2
Authority
CO
Colombia
Prior art keywords
replaced
bridge
atom
group
compounds
Prior art date
Application number
CO05052294A
Other languages
English (en)
Inventor
Lotz Ralf Richard Hermann
Lehmann-Lint Thorsten
Martin Lenter
Rudolf Klaus
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of CO5570676A2 publication Critical patent/CO5570676A2/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

1.- Compuestos de alquino de fórmula generalen la cual R1, R2 son, en forma independiente entre sí, H, un grupo alquilo C1-8 o cicloalquilo C3-7 opcionalmente sustituido con el radical R11, donde un grupo -CH2- puede estar reemplazado en la posición 3 ó 4 de un grupo cicloalquilo de 5, 6 ó 7 miembros por -O-, -S- o -NR13-, o un radical fenilo o piridinilo opcionalmente mono o polisustituido con el radical R12 y/o monosustituido con nitro, o R1 y R2 forman un puente alquileno C2-8, en el que - uno o dos grupos -CH2- pueden estar reemplazados, en forma independiente entre sí, por -CH=N- o -CH=CH- y/o - uno o dos grupos -CH2-, en forma independiente entre sí, pueden estar reemplazados por -O-, -S-, -SO, -(SO2)-, -C=N-R18, -C=N-O-R18, -CO-, -C(=CH2)- o -NR13- de modo tal que los heteroátomos no estén unidos entre sí en forma directa, donde en el puente alquileno definido con anterioridad pueden estar reemplazados uno o varios átomos de H por R14, y donde el puente alquileno definido con anterioridad puede estar sustituido con uno o dos grupos Cy carbo- o heterocíclicos iguales o diferentes de modo tal que la unión entre el puente alquileno y el grupo Cy se realiza - a través de un enlace simple o doble, - a través de un átomo de C común, formando un sistema de anillos espirocíclicos, - a través de dos átomos de C y/o N comunes adyacentes, formando un sistema de anillos bicíclicos condensados o - a través de tres o más átomos de C y/o N, formando un sistema de anillos en puente, X es un enlace simple o un puente alquileno C1-6, en el que - un grupo -CH2- puede estar reemplazado por -CH=CH- o -C=C- y/o - uno o dos grupos -CH2-, en forma independiente entre sí, pueden estar reemplazados por -O-, -S-, -(SO)-, -(SO2)-, -CO- o -NR4- de modo tal que cada uno de dos átomos de O, S o N o un átomo de O con un átomo de S no estén unidos entre sí de forma directa, donde el puente X puede estar unido con R1 incluyendo el átomo de N unido con R1 y X, formando un grupo heterocíclico, donde el puente X también puede estar unido adicionalmente con R2, incluyendo el átomo de N unido con R2 y X, formando un grupo heterocíclico, ...
CO05052294A 2002-10-31 2005-05-27 Nuevos compuestos de alquilo con efecto antagonico de la hcm y medicamentos que contienen estos compuestos CO5570676A2 (es)

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HRP20050384A2 (en) 2006-06-30
JP2006511492A (ja) 2006-04-06
UY28050A1 (es) 2004-05-31
EP1558578A1 (de) 2005-08-03
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TW200413346A (en) 2004-08-01
AU2003300507A1 (en) 2004-05-25
EA200500595A1 (ru) 2005-12-29
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CN1732154A (zh) 2006-02-08
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