UY28050A1 - Nuevos compuestos de alquino con efecto antagonico de la hcm y medicamentos que contienen estos compuestos. - Google Patents

Nuevos compuestos de alquino con efecto antagonico de la hcm y medicamentos que contienen estos compuestos.

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Publication number
UY28050A1
UY28050A1 UY28050A UY28050A UY28050A1 UY 28050 A1 UY28050 A1 UY 28050A1 UY 28050 A UY28050 A UY 28050A UY 28050 A UY28050 A UY 28050A UY 28050 A1 UY28050 A1 UY 28050A1
Authority
UY
Uruguay
Prior art keywords
compounds
hcm
alkin
new
medicines containing
Prior art date
Application number
UY28050A
Other languages
English (en)
Inventor
Stephan Georg Muller
Dirk Stenkamp
Philipp Lustenberger
Gerald Jurgen Roth
Thorsten Lehmann-Lintz
Klaus Rufolf
Original Assignee
Boehringer Ingelheim Pharma
Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma, Co Kg filed Critical Boehringer Ingelheim Pharma
Publication of UY28050A1 publication Critical patent/UY28050A1/es

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/48—Aldehydo radicals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

La presente invención se refiere a compustos de alquino de fórmula general I en donde los grupos y radicales A,B,W,X,Y,Z,R1 y R2 presentan los significados indicados en la reivindicación 1. Además, la invención se refiere a medicamentos que contienen al menos un alquino conforme a la invención. Debido a la mactividad antagonista del receptor de la HCM, los medicamentos de la invención son apropiados para el tratamiento de trastornos metabólicos y/o alimentarios, en especial de la obesidad, bulimia, anorexia, hiperfagia y diabetes.
UY28050A 2002-10-31 2003-10-29 Nuevos compuestos de alquino con efecto antagonico de la hcm y medicamentos que contienen estos compuestos. UY28050A1 (es)

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