AR050434A1 - Derivados de ciclohexano como inhibidores de cotransportador de na+ - glucosa; composiciones farmaceuticas que los contienen como principio activo y el uso de los mismos en el tratamiento de la diabates tipo i y ii y de la obesidad - Google Patents

Derivados de ciclohexano como inhibidores de cotransportador de na+ - glucosa; composiciones farmaceuticas que los contienen como principio activo y el uso de los mismos en el tratamiento de la diabates tipo i y ii y de la obesidad

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Publication number
AR050434A1
AR050434A1 ARP050103066A ARP050103066A AR050434A1 AR 050434 A1 AR050434 A1 AR 050434A1 AR P050103066 A ARP050103066 A AR P050103066A AR P050103066 A ARP050103066 A AR P050103066A AR 050434 A1 AR050434 A1 AR 050434A1
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Argentina
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group
substituted
alkyl
diabetes
alkoxy
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ARP050103066A
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English (en)
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H Matsuoka
T Sato
M Nishimoto
N Shimma
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Chugai Pharmaceutical Co Ltd
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Publication of AR050434A1 publication Critical patent/AR050434A1/es

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Abstract

Se proveen derivados de ciclohexano con accion de disminucion del nivel de glucosa en la sangre y propiedades adecuadas como fármacos tales como durabilidad del efecto del fármaco y estabilidad metabolica y seguridad, y proveer composiciones farmacéuticas que se usan para la prevencion y el tratamiento de diabetes tal como diabetes insulinodependiente (diabetes tipo I) y diabetes insulinoindependiente (diabetes tipo I) y diabetes insulinoindependiente (diabetes tipo II), complicaciones diabéticas y enfermedades tales como la obesidad causada por hiperglucemia. Reivindicacion 1: Un compuesto representado por la formula (1), en donde: A es -O-, -CH2-, o -NH-; n es un entero seleccionado de 0 y 1; R6 y R7 son cada uno independientemente un átomo de hidrogeno o un grupo alquilo C1-6; m es un entero seleccionado de 1 a 3; Q está seleccionado de Q1-Q5 representado por las formulas (2), en donde: R1, R2, R3, R4, y R5 están seleccionados cada uno, de modo independiente entre sí, de un átomo de hidrogeno, un grupo hidroxi, un grupo alquilo C1-6 que puede estar sustituido con uno o más Ra, un grupo alcoxi C1-6 que puede estar sustituido con uno o más Ra, un grupo aralcoxi C7-14 que puede estar sustituido con uno o más Rb, y -OC(=O)Rx; Rx es un grupo alquilo C1-6 que puede estar sustituido con uno o más Ra, un grupo arilo que puede estar sustituido con uno o más Rb, un grupo heteroarilo que puede estar sustituido con uno o más Rb, un grupo alcoxi C1-6 que puede estar sustituido con uno o más Ra, o -NReRf; Ar1 es un grupo arileno grupo que puede estar sustituido con uno o más Rb, o un grupo heteroarileno que puede estar sustituido con uno o más Rb; en donde el grupo heteroarileno puede formar un anillo fusionado con un carbociclo aromático o un heterociclo aromático; Ar2 es un grupo arilo que puede estar sustituido con: uno o más Rb, o un grupo heteroarilo que puede estar sustituido con uno o más Rb; Ra está seleccionado, cada uno de modo independiente entre sí, de un átomo de halogeno, un grupo hidroxi, un grupo ciano, un grupo nitro, un grupo carboxilo, un grupo alcoxi C1-6 se puede sustituir con uno o más Rc, un grupo arilo que puede estar sustituido con uno o más Rd, un grupo ariloxi que puede estar sustituido con uno o más Rd, un grupo heteroarilo que puede estar sustituido con uno o más Rd, un grupo heteroariloxi que puede ser sustituido con uno o más Rd, un grupo mercapto, un grupo alquiltio C1-6, un grupo alquilsulfinilo C1-6, un grupo alquilsulfonilo C1-6, -NRfRg, y un grupo alquilcarbonilo C1-6 que puede estar sustituido con uno o más Rc; Rb está seleccionado, cada uno de modo independiente entre sí, de un grupo alquilo C1-6 que puede estar sustituido con uno o más Rc, un grupo alquenilo C1-6 que puede ser sustituido con uno o más Rc, un grupo cicloalquilo C3-8 que puede estar sustituido con uno o más R, un grupo aralquilo C7-14 que puede estar sustituido con uno o más Rd, un átomo de halogeno, un grupo hidroxi, un grupo ciano, un grupo nitro, un grupo carboxilo, un grupo alcoxi C1-6 que puede estar sustituido con uno o más Rc, un grupo arilo que puede estar sustituido con uno o más Rd, un grupo ariloxi que puede estar sustituido con uno o más Rd, un grupo heteroarilo que puede estar sustituido con Rd, un grupo heteroariloxi que puede estar sustituido con Rd, un grupo mercapto, un grupo alquiltio C1-6, un grupo alquilsulfinilo C1-6, un grupo alquilsulfonilo C1-6, -NRfRg, un grupo alquilcarbonilo C1-6 que puede estar sustituido con uno o más Rc, un grupo alquilenodioxi C1-3, un grupo heterociclilo, -CO2Ri, y -CONRiRj; Rc está seleccionado, cada uno de modo independiente entre sí, de un átomo de halogeno, un grupo hidroxi, un grupo ciano, un grupo nitro, un grupo carboxilo, un grupo alcoxi C1-6 que puede estar sustituido con uno o más átomos de halogeno, un grupo arilo que puede estar sustituido con uno o más Rd, un grupo ariloxi que puede estar sustituido con uno o más Rd, un grupo heteroarilo que puede estar sustituido con uno o más Rd, un grupo heteroariloxi que puede estar sustituido con uno o más Rd, un grupo amino, un grupo alquilamino C1-6, y un grupo di(alquil C1-6)amino; Rd está seleccionado, cada uno de modo independiente entre sí, de un grupo alquilo C1-6 que puede estar sustituido con uno o más átomos de halogeno, un grupo alcoxi C1-6 que puede estar sustituido con uno o más átomos de halogeno, un grupo aralquilo C7-14 que puede estar sustituido con uno o más átomos de halogeno, un átomo de halogeno, un grupo hidroxi, un grupo ciano, un grupo nitro, un grupo amino, un grupo alquilamino C1-6, y un grupo di(alquil C1-6)amino; Re es un átomo de hidrogeno, un grupo alquilo C1-6 que puede estar sustituido con uno o más Rc, un grupo arilo que puede estar sustituido con uno o más Rd, o un grupo heteroarilo que puede estar sustituido con uno o más Rd; Rf es un átomo de hidrogeno, o un grupo alquilo C1-6 que puede estar sustituido con uno o más Rc; Rg es un átomo de hidrogeno, un grupo alquilo C1-6 puede estar sustituido con uno o más Rc, un grupo alquilcarbonilo C1-6 que puede estar sustituido con uno o más Rc, un grupo arilo que puede estar sustituido con uno o más Rd, un grupo heteroarilo que puede estar sustituido con uno o más Rd, un grupo carbamoilo, un grupo alcoxi C1-6 que puede estar sustituido con uno o más Rc, o un grupo alquilsulfonilo C1-6 grupo que puede estar sustituido con uno o más Rc; Re y Rf, y Rf y Rg pueden formar juntos un heterociclo de 4 a 7 miembros con el átomo de nitrogeno al que están unidos, respectivamente; y Ri y Rj son cada uno independientemente seleccionado de un átomo de hidrogeno, un grupo alquilo C1-6 que puede estar sustituido con uno o más Rc, un grupo cicloalquilo C3-8 que puede estar sustituido con uno o más Rc, y un grupo aralquilo C7-14 grupo que puede estar sustituido con uno o más Rd; o uno de sus profármacos o sales farmacéuticamente aceptables.
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EP1783110A1 (en) 2007-05-09
NO20070046L (no) 2007-04-26
MX2007001019A (es) 2007-04-12
AU2005265772B2 (en) 2011-04-07
WO2006011469A1 (ja) 2006-02-02
KR20070038572A (ko) 2007-04-10
IL180916A0 (en) 2007-07-04
HK1103393A1 (en) 2007-12-21
TW200606129A (en) 2006-02-16
NZ552761A (en) 2010-01-29
RU2007106865A (ru) 2008-09-10
JPWO2006011469A1 (ja) 2008-05-01
EP1783110A4 (en) 2009-11-11
US20080318874A1 (en) 2008-12-25
CA2573777A1 (en) 2006-02-02
BRPI0513752A (pt) 2008-05-13
JP5095212B2 (ja) 2012-12-12
RU2394015C2 (ru) 2010-07-10
AU2005265772A1 (en) 2006-02-02

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