AR048954A1 - Proceso para la preparacion de telmisartan. composiciones farmaceuticas - Google Patents

Proceso para la preparacion de telmisartan. composiciones farmaceuticas

Info

Publication number
AR048954A1
AR048954A1 ARP050101919A ARP050101919A AR048954A1 AR 048954 A1 AR048954 A1 AR 048954A1 AR P050101919 A ARP050101919 A AR P050101919A AR P050101919 A ARP050101919 A AR P050101919A AR 048954 A1 AR048954 A1 AR 048954A1
Authority
AR
Argentina
Prior art keywords
telmisartan
preparation
pharmaceutical compositions
formula
methyl
Prior art date
Application number
ARP050101919A
Other languages
English (en)
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd filed Critical Cipla Ltd
Publication of AR048954A1 publication Critical patent/AR048954A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

La presente se refiere a composiciones farmacéuticas que lo contienen. Reivindicacion 1: Un proceso para la preparacion de telmisartán de formula (1), o una sal farmacéuticamente aceptable de dicho compuesto: caracterizado porque 1H-Bencimidazol-2- n-propil-4-metil-6-(1'-metilbencimidazol-2'-ilo) de formula (2) y metil-4-(bromometil)bifenil-2-carboxilato de formula (3) se someten a condensacion e hidrolisis e una sola etapa.
ARP050101919A 2004-05-11 2005-05-11 Proceso para la preparacion de telmisartan. composiciones farmaceuticas AR048954A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0410471A GB2414019A (en) 2004-05-11 2004-05-11 One-step preparation of telmisartan by condensation and hydrolysis

Publications (1)

Publication Number Publication Date
AR048954A1 true AR048954A1 (es) 2006-06-14

Family

ID=32526813

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050101919A AR048954A1 (es) 2004-05-11 2005-05-11 Proceso para la preparacion de telmisartan. composiciones farmaceuticas

Country Status (15)

Country Link
US (1) US8691999B2 (es)
EP (1) EP1748990B1 (es)
JP (1) JP5160219B2 (es)
KR (1) KR101183034B1 (es)
AR (1) AR048954A1 (es)
AT (1) ATE399157T1 (es)
AU (1) AU2005240836B2 (es)
CA (1) CA2566431C (es)
DE (1) DE602005007734D1 (es)
ES (1) ES2308494T3 (es)
GB (1) GB2414019A (es)
NZ (1) NZ551255A (es)
PT (1) PT1748990E (es)
WO (1) WO2005108375A1 (es)
ZA (1) ZA200609290B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006044754A2 (en) 2004-10-18 2006-04-27 Dr. Reddy's Laboratories Ltd. Process for preparing telmisartan
WO2006136916A2 (en) * 2005-06-20 2006-12-28 Glenmark Pharmaceuticals Limited Substantially pure micronized particles of telmisartan and pharmaceutical compositions containing same
CN101172968B (zh) * 2006-11-01 2010-05-12 浙江天宇药业有限公司 2-正丙基-4甲基-6-(甲基苯并咪唑-2-基)苯并咪唑盐及其制备方法
CZ302272B6 (cs) 2007-07-09 2011-01-19 Zentiva, A. S. Zpusob výroby 4´-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-karboxylové kyseliny (telmisartanu)
WO2009123483A1 (en) 2008-03-31 2009-10-08 Zaklady Farmaceutyczne Polpharma Sa Process for preparation of telmisartan
EP2123648A1 (en) 2008-05-20 2009-11-25 Chemo Ibérica, S.A. A process for the preparation of Telmisartan.
WO2010018441A2 (en) * 2008-08-11 2010-02-18 Cadila Pharmaceuticals Ltd. An improved process for the preparation of substantially pure telmisartan
KR100893652B1 (ko) * 2008-11-10 2009-04-17 주식회사종근당 신규한 텔미사르탄 아연염 및 그의 제조방법
EP2443094B1 (en) * 2009-06-19 2013-03-20 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of telmisartan
JP5711888B2 (ja) * 2010-01-26 2015-05-07 株式会社Ｄｎｐファインケミカル宇都宮 テルミサルタンアルキルエステルの製造法
KR20110094751A (ko) * 2010-02-17 2011-08-24 동화약품주식회사 텔미사탄의 개선된 제조방법
EA025946B1 (ru) 2010-10-27 2017-02-28 Крка, Товарна Здравил, Д. Д., Ново Место Многослойная фармацевтическая композиция, содержащая телмисартан и амлодипин
CN102219746B (zh) * 2011-04-07 2014-02-26 威海迪素制药有限公司 替米沙坦杂质b的制备方法
CN102212034B (zh) * 2011-04-14 2014-02-26 威海迪素制药有限公司 替米沙坦杂质b的制备方法
CN102267949A (zh) * 2011-06-14 2011-12-07 张长利 替米沙坦制备新工艺
KR101607661B1 (ko) * 2013-12-24 2016-03-31 주식회사 파마코스텍 텔미사르탄의 신규 제조 방법
JP6284861B2 (ja) * 2014-09-03 2018-02-28 株式会社トクヤマ テルミサルタンの製造方法
CN106008356B (zh) * 2016-06-07 2023-02-28 浙江华海药业股份有限公司 一种替米沙坦的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591762A (en) 1991-02-06 1997-01-07 Dr. Karl Thomae Gmbh Benzimidazoles useful as angiotensin-11 antagonists
SI9210098B (sl) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
DE4408497A1 (de) * 1994-03-14 1995-09-21 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US6416487B1 (en) 1997-07-30 2002-07-09 Renal Tech International Llc Method of removing beta-2 microglobulin from blood
WO2000027397A1 (en) * 1998-11-06 2000-05-18 Glaxo Group Limited Antihypertensive medicaments containing lacidipine and telmisartan
DE19901921C2 (de) * 1999-01-19 2001-01-04 Boehringer Ingelheim Pharma Polymorphe von Telmisartan, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung eines Arzneimittels
US6358986B1 (en) * 1999-01-19 2002-03-19 Boehringer Ingelheim Pharma Kg Polymorphs of telmisartan
CN1182122C (zh) * 2001-07-30 2004-12-29 中国科学院上海药物研究所 替米沙坦的合成新路线
CN1204124C (zh) 2001-10-15 2005-06-01 中国科学院上海药物研究所 替米沙坦的一种制备路线
DE10201725A1 (de) * 2002-01-18 2003-08-14 Boehringer Ingelheim Pharma Verfahren zur Herstellung und Reinigung von 1,7'-Dimethyl-2'-propyl-2,5'-bi-1H-benzimidazol
DE10314702A1 (de) * 2003-03-31 2004-10-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Telmisartan

Also Published As

Publication number Publication date
EP1748990B1 (en) 2008-06-25
KR101183034B1 (ko) 2012-09-17
GB0410471D0 (en) 2004-06-16
PT1748990E (pt) 2008-09-10
CA2566431C (en) 2013-04-09
KR20070012546A (ko) 2007-01-25
WO2005108375A1 (en) 2005-11-17
AU2005240836A1 (en) 2005-11-17
JP2007537222A (ja) 2007-12-20
ATE399157T1 (de) 2008-07-15
NZ551255A (en) 2010-03-26
ES2308494T3 (es) 2008-12-01
AU2005240836B2 (en) 2010-09-23
US8691999B2 (en) 2014-04-08
EP1748990A1 (en) 2007-02-07
DE602005007734D1 (de) 2008-08-07
US20080015359A1 (en) 2008-01-17
GB2414019A (en) 2005-11-16
CA2566431A1 (en) 2005-11-17
JP5160219B2 (ja) 2013-03-13
ZA200609290B (en) 2008-05-28

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